WO2006012693A1 - Biocidal compositions and a biocidal composition delivery system - Google Patents
Biocidal compositions and a biocidal composition delivery system Download PDFInfo
- Publication number
- WO2006012693A1 WO2006012693A1 PCT/AU2005/001161 AU2005001161W WO2006012693A1 WO 2006012693 A1 WO2006012693 A1 WO 2006012693A1 AU 2005001161 W AU2005001161 W AU 2005001161W WO 2006012693 A1 WO2006012693 A1 WO 2006012693A1
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- WO
- WIPO (PCT)
- Prior art keywords
- biocidal composition
- gsc
- surfactant
- glutaraldehyde
- biocidal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2072—Aldehydes-ketones
Definitions
- This invention relates to biological decontamination.
- particulate the invention relates to a biological decontamiaator which is effective against bio-agents such, as Anthrax (Bacillus anthracis) and Golden Staph (Staphylococcus aureus).
- bio-agents such as Anthrax (Bacillus anthracis) and Golden Staph (Staphylococcus aureus).
- Anthrax Bacillus anthracis
- Golden Staph Staphylococcus aureus
- Spme products can only decontaminate one particle form of contaminate e.g, bacteria, chemical agents or spores.
- the present invention seeks to meet this need or at least to provide the public with a viable alternative Summary of the Invention:
- a biocidal composition comprising; a biocide; and a surfactant
- the invention also provides a delivery system for a biocidal composition
- a delivery system for a biocidal composition comprising: a biocide reservoir/source operably connected to a plurality of spray nozzles; a compressed air reservoir/source operably connected to the plurality of spray nozzles; a first valve cootrolling the delivery of biocide from the reservoir/source; a second valve controlling the delivery of compressed air from the reservoir/source; and a controller, operable to control the opening of the valves.
- the surfactant can include a colloidal surfactant.
- biocidal composition comprises:
- composition comprises:
- the invention provides a system that includes one or more pressure switches attached to bomb-protection film which activate the controller when the film is stretched by the blast of a bomb or similar device.
- the controller when the controller is activated it also acts to close down any air- conditioning plant that may be associated with the system.
- the system includes a manual switch to activate the controller.
- the system includes a manual mechanical override device configured to activate a third valve and a fourth valve which allows the delivery of the biocide and compressed air, respectively, to the plurality of spray nozzles,
- a biocidal composition according to the invention is a two-part formulation that, in use, is diluted with water or other inert ingredients at a ratio of 1 : 1 : 18 (one part A to one part B to IS parts diluent).
- Part A consists of the active biocides and
- Part B consists of surfactants and colloidal agents.
- Part A Mix 80% - 100% glutaraldehyde with 0% - 20% octbilinone. (This should be mixed for at least 30 seconds.)
- Part B Mix 50% Colloidal Surfactant with 50% water. (Mixing procedure is to add water then add the surfactant and mix gently for at least 20 seconds.)
- Final Composition - Mix 1 Part A with 1 Part B with 18 parts of inert ingredient, e.g. water. The procedure for mixing is inert(s) + Part A + Part B, then mix/stir well; (e.g. in a 2OL container add IS litres of water, then 1 litre of Part A, then 1 litre of Part B. then mix/stir well for at least 5 seconds),
- composition is based on using colloids and surfactants with high pH (9 - 15) to buffer the lower pH of certain active ingredients (2 - 7), This also allows the surfactants and colloids to act as hyper-wetting agents, which allows the actives to be delivered more efficiently.
- the present composition is effective because it uses a colloidal surfactant (CS) as a delivering agent and a small amount of active biocide (e.g. glutaraldehyde).
- CS colloidal surfactant
- active biocide e.g. glutaraldehyde
- the CS in the formula breaks down the protein shells around sporicidal bacteria, which then. allows the active to more effectively kill the cell; this works the same way against the bio-agents.
- the CS is effective at delivering the active, relatively small amounts of active can be used while still achieving excellent results.
- the CS is also useful to spread the formula as a travelling agent through porous surfaces; e.g. dust, dirt or fabric and like materials.
- the advantages of the formula/product include that it can be effective against Anthrax and other sporicidal bacteria in 30 mine. It is effective against chemical contaminates and the product also has fungicidal, virucidal, sporicidal & tuberculocidal properties, In particular the product is not corrosive and is 100% based on bio-degradable materials.
- the product can be provided in a concentrate form which can be diluted with any inert ingredients, such as water and ami-freeze. This allows easy transportation and storage of the product. Therefore the product is not highly toxic and does not contain large amounts of active ingredients.
- the product has travelling agents to allow it to break surface tension, and therefore it can be effective on soil and similar porous surfaces.
- the product can be water based.
- Figure 1 is a schematic layout of a delivery system according to the invention.
- FIG. 1 Shown schematically in Figure 1, is a system for the delivery of a biocidal composition according to the invention.
- the system is adapted to deliver the bi ⁇ cide by sprinkler into a closed environment (such as a room) in the event of a biological attack, such as by bomb or letter or the like.
- the system includes a vessel (1) containing biocide and another vessel (2) containing compressed air.
- Each vessel is connected via a discrete plumbing conduit, (3) and (4) respectively, to a series of ejector/atomiser heads (5). Delivery of the contents of the vessels to the conduits is electrically controlled by two solenoid valves, (12) and (13) respectively.
- the solenoid valves are connected by an electric circuit (6) via aft electronic control box (9),
- the control box and solenoids are powered by an AC electric source (7) with a battery back-up power supply (8).
- the control box is activated by one or more pressure switches (10) attached to bomb protection film, which are triggered by the stretching of the film that occurs in response to the blast of a bomb.
- Toe control box also can be activated manually (such as when a suspicious parcel is opened) by a forced manual switch (11).
- a non-electrical forced mechanical lever (14) is provided to operate mechanical valves (15) and (16) so that the system can be activated in the case of failure of the electric/electronic control.
- atomised biocide is dispersed by the ejector heads and the room's air-conditioning (if present) is shut-down to stop air movement interfering with the dispersal of the biocide throughout the room.
- Appendix A is a report of the effectiveness of a biocidal composition ("GSC-2000”) in decontaminating biological agents.
- Appendix B is a report of testing of GSC-2000 as a decontaminant of Bacillus s ⁇ p. spores.
- Appendix A Effectiveness of GSC-2000
- the objective of this test is to determine the effectiveness of aerosolized GSC-2000 as a sterilent against two strains of Bacillus anthracis (BA) spores and a non-pathogenic simulant [Bacillus sublilte (BG)] spores. o. Optimum decontamination conditions were established for the GSC-2000, which was dis-heldd by the Hydro-Force (Salt Lake City, Utah) PureMist TM Fogger, Data obtained from simulants were used for tests performed on BA.
- the test objective is to determine the effectiveness of aerosolized GSC-2000 as a sterilent against two strains of BA spores and non-pathogenic BG spores.
- GSC-20QQ was sprayed on to surfaces with a known amount of biological agent and then sampled to determine the decontamination effect.
- GSC 2000 is sold in two concentrated parts, Part A and Part B.
- the dilution rate for GSC 2000 is 1 Part A to 1 Part B to 18 parts water.
- This cleaning component consists of a broad- spectrum quaternary ammonia compound that acts as, an antimicrobial agent OSC-2000 is a strong alkaline solution having a pH of 10.27.
- the Hydro-Force PureMistTM fogger is a commercially available spray system that is compact and portable.
- the PureMist fogger is capable of 95 percent of its output to particles of 20 microns with the ability to increase to a heavy setting with output of 95 percent below 60 mi ⁇ crons.
- the unit has an adjustable flow control valve, corrosion-proof supply tank, a flexible 32- inch directional base and a 2-stage, variable output motor.
- GSC 2000 is a proprietary, two part component which works by breaking the textile surface tension allowing the antimicrobial component to carry through and decontaminate the textile.
- the average weight (replicate of 4 rounds) of water that was delivered from the nozzle was 49 grams per round. From this it was determined that 49 ml liquid is delivered in each round of application.
- a reduction in the spore growth at 6-log or more was considered as an effective sterilant.
- the GSC-2000 (100 ⁇ L) evaporated within 30 minutes, Any exposure time beyond 30 min- utes has no enhanced effect. Exposure of 20 minutes is not adequate to have a killing effect on the spores as seen from other trials. This shows that the amount of GSC kept in contact with the spot is important
- GSC-2000 is capable of killing BG spores when exposed in wet slurry or dry spots.
- GSO2Q00 spray may be a capable decontam inant against loosely at ⁇ tached spores on interior surfaces, More work is needed to prove tms potential effect.
- the objective of this study was to evaluate the effectiveness of deco ⁇ tam kation formulations to inactivate Bacillus anthracis Ames spores in solution, These formulations included Great Southern Coatings (GSC) 2000 in which the active component (glutaraldehyde) was present or absent Two formulations from Great Southern C ⁇ atings were provided and tested. The first Jot received ms designated as GSC 2000-1 -Lot 1 (no glutaraldehyde present) and GSC 2000-2-Lot 1 (glutaraldehyde present). The second lot of the formulation containing glutaraldehyde was designated GSC 2000-2-Lot 2. High Test Hypochlorite (HTH) at a concentration of 5% was used as a positive control.
- GSC 2000-1 -Lot 1 no glutaraldehyde present
- GSC 2000-2-Lot 1 glutaraldehyde present
- GSC 2000-2-Lot 1 and 5% HTH decreased the number of viable B, anthracis Ames spores after 30 minutes by 3,40 and >7.21 log reductions, respectively,
- the GSC 2000-1-Lot 1 did not reduce the viability of B. antbracis Ames spores after 30 minutes.
- GSC 2000-2-Lot 2 formulation and 5% HTH completely neutralized viable M. anthracis Arties spores, corresponding to log reductions in viable spores of >8.09.
- GSC 2000 from Great Southern Coatings (GSC) has been reported to be a potential decontammant.
- GSC 2000 solution consists of two active ingredients, a quaternary ammonium compound and an active surface agent, Part A contains benzalkonium chloride, octhilinone, and glutaraldehyde.
- Part B is a surfactant that was developed by GSC and is a proprietary item. This study tested GSC 2000 formulations with and without the presence of glutaraldehyde.
- MARCORSYSCOM has requested the Battelle Medical Research and Evaluation Facility perform decontamination testing with Bacillus amhracis Ames spores, The objective of this study was to evaluate the efficacy of these products as well as 5% HTH to neutralize B, amhracis Ames spores within 30 minutes in suspension testing.
- the decontamination solutions were prepared according to the instructions of each manufacturer and used within one hour of testing. Initially, two formulations from Great Southern Coatings were provided and tested, which were designated as GSC 2000- 1-Lot 1 (no glutaraldehyde present) and GSC 2000-2-Lot 1 (glutaraldehyde present). A second lot of the formulation containing glutaraldehyde was also provided in this study by Great Southern Coatings, and was designated GSC 2000-2-Lot 2. All GSC 2000 formulations were mixed as instructed by the manufacturer, which consisted of combining 1;1 :18 ratios of Part A, Part B, and sterile water.
- the biological agent used for testing was Bacillus anthracis Ames strain spores produced according to Battelle SOP Number MRJEF. X-074. Spore stocks were enumerated and diluted in sterile water to an approximate concentration of 1 x 10 9 colony forming units (CFU)/mL.
- Each decontaminant was tested in triplicate. Testing was conducted following MREF Method No. 92/Microbiology. Tests were conducted by combining 100 ⁇ L of the stock 1 x 10 9 CFU/mL (1 x 10 8 total CFU) B. anthracis spores with 1.0 mL of test material (GSC 2000 Formulations 1 or 2, or 5% HTH) in a 2.0 mL tube. Phosphate buffered saline (PBS) was used as a "no decon" control A spore-free (blank) tube was run in parallel with each test material as a control for any bacterial growth other than B. anthracis.
- PBS Phosphate buffered saline
- test material or control was allowed to mix for 30 minutes at room temperature on a rotating platform mixer.
- the entire contents of the tube were centrifuged at 20,800 x g for 5 minutes.
- the supernatant was removed, the pellet resuspended in 1.0 mL of PBS, and centrifuged at 20,800 x g for 5 minutes.
- the supernatant was removed and the spore pellet was resuspended In 1.0 rnL sterile PBS.
- the spore suspension was serially diluted through 1 O -7 in sterile PBS.
- One hundred microliters of each serial dilution was plated onto tryptio soy agar (TSA) plates in triplicate, allowed to dry, incubated overnight at 37°C, and enumerated.
- TSA tryptio soy agar
- the plates were enumerated as described in Battelle SOP Number MREF. X-054 , Only plates having 25-250 colonies were considered in determining the plate count, with the exception of samples where low colony counts were observed due to the decontamination process. For colony counts below 25 colonies, enumeration data were calculated folio-wing Battelle SOP Number MREF. X-1 12. The colony forming units (CFU)ZmL was determined by multiplying the average number of colonies per plate by the reciprocal of the dilution.
- Direct-infusion electr ⁇ spray mass spectrometry was used to confirm the presence and/or absence of glutaraldehyde in Part A ofthe GSC 2000- ⁇ -L ⁇ t 1, GSC 2000-2-Lot 1, and GSC 2000-2-Lot 2 formulations.
- the testing was conducted according to Battelle SOP Number MRER III-034, "Standard Operating Procedure (SOP) for the General Use, Calibration, and Maintenance of Mass Spectrometer Systems,"
- SOP Standard Operating Procedure
- a Micromass Quattro II tandem mass spectrometer was used to analyze three formulations of decontaminants and compare the spectra obtained to the spectrum of a glutaraldehyde standard.
- Glutaraldehyde was obtained as a 25°/* aqueous solution (Sigma, St. Louis, MO; Lot 042K53001 Exp 5/05).
- a 2,5 ⁇ g/mL solution of gt ⁇ taraidehyde was prepared in 50/50 water/acetonitrile with 2 inM formic acid and 2 m ⁇ f ammonium formate solvent, and analyzed by direct infusion positive ion eleotrospr ⁇ y ionization mass spectrometry (BSI-MS) and ESI-tandem mass spectrometry (ESI-MSMS).
- BSI-MS direct infusion positive ion eleotrospr ⁇ y ionization mass spectrometry
- ESI-MSMS ESI-tandem mass spectrometry
- GSC 2000-1-Lot 1, GSC 2000-2-Lot I, and 5% High Test Hypochlorite were evaluated for neutralization effectiveness against Bacillus anthracis Ames spores, using PBS as the control.
- the GSC 2000-1-Lot 1 and GSC 2000-2-Lot 1 formulations were prepared as instructed by the vendor (see Section 2.1). • GSC 2000-1-Lot 1 Fart A was a pale yellow mixture with a creamy texture; GSC 2000-2- Lot 1 Part A was similar, but a darker brown color. Part B for GSC 2000-1-Lot 1 and GSC 2000-2-Lot 1 were identical - a clear, straw yellow, high-viscous mixture.
- GSC 2000-1 -Lot 1 went into solution and was slightly opaque with some foaming, probably due to the surfactant from Part B.
- GSC 2000-2-L ⁇ t 1 did not go entirely into solution and was slightly opaque with some foaming, probably due Io the surfactant from Part B.
- Table 1 shows the calculated inoculum, total spores, and log reduction of Bacillus anthrack Ames spores exposed to each test material.
- One-hundred microliters of a 9.80 x 10 6 CFWmL spore suspension was used as the inoculum, which corresponds to an inoculum concentration of 9,80 x 10 7 CFU.
- Spores were exposed to each test material for 30 minutes and log reductions for the test materials were calculated based upon the total viable spores treated with PBS.
- both GSC 2000-2- Lot 1 and 5% HTH were effective in Teducing viable B, anthracis Ames spores having log reductions of 3.40 and ⁇ 7.21, respectively. No decreases in viable S, anthracis Ames spores were observed when exposed to GSC 2000-1-Lot 1,
- TaT Bacillus anthracis Ames Spore Suspension Testing (GSC 20QO-I-LOt 1; GSC 2000-2-Lot 1 5% HTH .
- the GSC 2000-2-Lot 2 was a new mixture received at the Battelle MREF; therefore, GSC 2000-2-Lot 2 should be considered separate from GSC 2000-2-Lot 1 that was tested previously ( Figure 2)
- the GSC 2000- 2-Lot 2 was prepared as instructed by the vendor.
- GSC 2000-2-Lot 2 Part A was a clear, yellow-brown mixture with an odor characteristic of glutaraldehyde
- GSC 2000-2-Lot 2 Part B was a clear, straw yellow, high-viscous mixture. When mixed, GSC 2000-2-Lot 2 went into solution and was clear with some foaming, probably due to the surfactant from Part B,
- FIG. 1 Part A of GSC 2000 Formulations, (A) GCS 2000-1-Lot: 1; (B) GSC 2000- 2-Lot 1 ⁇ (C) GSC 2000-2-Lot 2.
- Table 2 shows the calculated inoculum, total spores, and iog reduction of Bacillus amhracis Ames spores exposed to the revised GSC 2000-2-Lot 2, 5% High Test Hypochlorite;, and PBS in suspension.
- One-hundred microliters of a 1.06 x 10 9 CFWmL spore suspension was used as the inoculum, which corresponds to an inoculum concentration of 1.06 x 10 8 CFLT.
- Glutaraldehyde has a molecular weight of 100, and in the ESI source the glutaraldehyde is protonated to form a precursor ion with amassxharge ratio (m/z) of 101.
- the ESI-MS spectrum of glutaraldehyde shows the presence of a molecular species having an m/z of 101.33 ( Figure 3). Fragmenting the m/z 101 precursor ion results in fragments of rn/z 83, 73, $9, 57, 55, 4I 1 and 31 ( Figure 4).
- ESI-MS spectra of GSC 200(M»Lot 1 showed an abundance of precursor ions at m/z 102 and 214 were present with little to no presence of m/z 101, indicating little to no glutaraldehyde present in this sample (Figure 5).
- ESI-MS/MS spectra were obtained from m/z 102 and 214 and are shown in Figures 6 and 7, respectively.
- the even mass precursor ions may indicate the presence of an odd number of nitrogens (e.g. amines), which would be consistent with the presence of the quaternary ammonium compound in GSC 2000. All three of these spectra match the ESI-MS and ESI-MS/MS spectra obtained from the GSC 2000-2-Lot 1 sample.
- a second round of testing with GSC 2000-2-Lot 2 (containing glutaraldehyde) was conducted. Following 30 minutes of suspension testing, both the GSC 2000-2-Lot 2 and 5% HTH completely neutralized viable B. antkracis Ames spores, corresponding to log reductions in viable spores of ⁇ 8.09.
- Chemical analysis of Part A from GSC 2000-2- Lot 2 by ESI-MS revealed a spectrum containing a number of precursor ions that were not present in Part A of the GSC 2000-2-Lot 1 sample. Furthermore, an abundant peak at m/z 101 was present in Part A of the GSC 2000-2-Lot 2 sample, which was similar to the m/z 101 observed in the glutaraldehyde standard.
- the MS/MS spectrum of the rn/z 101 peak in Part A of GSC 2000-2-Lot 2 was similar to the ESI-MS/MS spectrum of the glutaraldehyde standard, indicating that Part A of the GSC 2000-2-Lot 2 sample contained glutaraldehyde.
Abstract
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AU2004904376A AU2004904376A0 (en) | 2004-08-05 | FGS bio defense | |
AU2004904376 | 2004-08-05 | ||
AU2005900008A AU2005900008A0 (en) | 2004-12-29 | Biocidal compositions and a biocidal composition delivery system | |
AU2005900008 | 2004-12-29 |
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01153603A (en) * | 1987-12-11 | 1989-06-15 | Dainippon Ink & Chem Inc | Slime controller for petroleum fuel |
US5762650A (en) * | 1996-08-23 | 1998-06-09 | Olin Corporation | Biocide plus surfactant for protecting carpets |
EP0728414B1 (en) * | 1995-02-27 | 1998-11-04 | Rohm And Haas Company | Microemulsion compositions of 3-isothiazolone compounds |
US5891922A (en) * | 1997-08-20 | 1999-04-06 | Preserve International, Preserve, Inc. | Cleaning and disinfectant biocide composition, and method for cleaning animal husbandry surfaces |
US6559189B2 (en) * | 1999-04-28 | 2003-05-06 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
US6566574B1 (en) * | 1998-06-30 | 2003-05-20 | Sandia Corporation | Formulations for neutralization of chemical and biological toxants |
US6635676B2 (en) * | 1999-04-28 | 2003-10-21 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
US6656919B1 (en) * | 2002-01-11 | 2003-12-02 | Clarence L. Baugh | Method and a product for the rapid decontamination and sterilization of bacterial endospores |
-
2005
- 2005-08-04 WO PCT/AU2005/001161 patent/WO2006012693A1/en not_active Application Discontinuation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01153603A (en) * | 1987-12-11 | 1989-06-15 | Dainippon Ink & Chem Inc | Slime controller for petroleum fuel |
EP0728414B1 (en) * | 1995-02-27 | 1998-11-04 | Rohm And Haas Company | Microemulsion compositions of 3-isothiazolone compounds |
US5762650A (en) * | 1996-08-23 | 1998-06-09 | Olin Corporation | Biocide plus surfactant for protecting carpets |
US5891922A (en) * | 1997-08-20 | 1999-04-06 | Preserve International, Preserve, Inc. | Cleaning and disinfectant biocide composition, and method for cleaning animal husbandry surfaces |
US6566574B1 (en) * | 1998-06-30 | 2003-05-20 | Sandia Corporation | Formulations for neutralization of chemical and biological toxants |
US6559189B2 (en) * | 1999-04-28 | 2003-05-06 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
US6635676B2 (en) * | 1999-04-28 | 2003-10-21 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
US6656919B1 (en) * | 2002-01-11 | 2003-12-02 | Clarence L. Baugh | Method and a product for the rapid decontamination and sterilization of bacterial endospores |
Non-Patent Citations (1)
Title |
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DATABASE WPI Week 198930, Derwent World Patents Index; Class C02, AN 1989-216454 * |
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