WO2006010620A3 - Sels d'olanzapine et leur conversion en bases libres d'olanzapine - Google Patents

Sels d'olanzapine et leur conversion en bases libres d'olanzapine Download PDF

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Publication number
WO2006010620A3
WO2006010620A3 PCT/EP2005/008218 EP2005008218W WO2006010620A3 WO 2006010620 A3 WO2006010620 A3 WO 2006010620A3 EP 2005008218 W EP2005008218 W EP 2005008218W WO 2006010620 A3 WO2006010620 A3 WO 2006010620A3
Authority
WO
WIPO (PCT)
Prior art keywords
olanzapine
salts
conversion
free base
base
Prior art date
Application number
PCT/EP2005/008218
Other languages
English (en)
Other versions
WO2006010620A2 (fr
Inventor
Igor Simonic
Roman Lenarsic
Berta Kotar-Jordan
Rok Zupet
Joze Gnidovec
Original Assignee
Krka Tovarna Zdravil D D Novo
Igor Simonic
Roman Lenarsic
Berta Kotar-Jordan
Rok Zupet
Joze Gnidovec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil D D Novo, Igor Simonic, Roman Lenarsic, Berta Kotar-Jordan, Rok Zupet, Joze Gnidovec filed Critical Krka Tovarna Zdravil D D Novo
Priority to EP05779020A priority Critical patent/EP1781665A2/fr
Publication of WO2006010620A2 publication Critical patent/WO2006010620A2/fr
Publication of WO2006010620A3 publication Critical patent/WO2006010620A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des sels d'olanzapine intermédiaires utiles de conversion pour isoler l'olanzapine de mélanges réactifs complexes. Lesdits sels peuvent servir à la production de bases d'olanzapine d'une pureté suffisante pour être employées en pharmacie et pouvant facilement être converties avec de forts rendements en la forme 1 polymorphe de l'olanzapine anhydre.
PCT/EP2005/008218 2004-07-28 2005-07-28 Sels d'olanzapine et leur conversion en bases libres d'olanzapine WO2006010620A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05779020A EP1781665A2 (fr) 2004-07-28 2005-07-28 Sels d'olanzapine et leur conversion en bases libres d'olanzapine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200400219A SI21850A (sl) 2004-07-28 2004-07-28 Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
SIP-200400219 2004-07-28

Publications (2)

Publication Number Publication Date
WO2006010620A2 WO2006010620A2 (fr) 2006-02-02
WO2006010620A3 true WO2006010620A3 (fr) 2006-06-08

Family

ID=35448338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/008218 WO2006010620A2 (fr) 2004-07-28 2005-07-28 Sels d'olanzapine et leur conversion en bases libres d'olanzapine

Country Status (3)

Country Link
EP (1) EP1781665A2 (fr)
SI (1) SI21850A (fr)
WO (1) WO2006010620A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058773A1 (fr) 2002-12-24 2004-07-15 Teva Pharmaceutical Industries Ltd. Nouvelles formes cristallines d'olanzapine, procedes pour les preparer et procede pour preparer des formes cristallines d'olanzapine connues
PL377084A1 (pl) * 2005-09-15 2007-03-19 Koźluk Tomasz Nobilus Ent Nowe związki olanzapiny i sposób ich wytwarzania
WO2007138376A1 (fr) 2006-06-01 2007-12-06 Aurobindo Pharma Limited Procédé amélioré de préparation de la forme i d'olanzapine
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
KR20090045233A (ko) 2006-07-10 2009-05-07 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
PL381564A1 (pl) 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
EP2450039A1 (fr) 2010-11-08 2012-05-09 PAION UK Ltd. Régime de dosage permettant la sédation avec CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
EP4146656A4 (fr) * 2020-05-05 2024-06-26 Syneurx International (Taiwan) Corp. Sels de neuroceutiques et leurs utilisations

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0454436A1 (fr) * 1990-04-25 1991-10-30 Lilly Industries Limited Composés pharmaceutiques
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
WO2003055438A2 (fr) * 2001-12-24 2003-07-10 Sun Pharmaceutical Industries Limited Forme cristalline de 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno [2,3-b][1,5]benzodiazepine
WO2003101997A1 (fr) * 2002-05-31 2003-12-11 Geneva Pharmaceuticals, Inc. Procédé de préparation d'une forme cristalline i d'olanzapine
WO2004094433A1 (fr) * 2003-04-22 2004-11-04 EGIS Gyógyszergyár Rt. Nouveaux polymorphismes du chlorhydrate d'olanzapine
WO2005070937A1 (fr) * 2004-01-27 2005-08-04 Synthon B.V. Procede de fabrication d'olanzapine sous forme polymorphe i

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0454436A1 (fr) * 1990-04-25 1991-10-30 Lilly Industries Limited Composés pharmaceutiques
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
WO2003055438A2 (fr) * 2001-12-24 2003-07-10 Sun Pharmaceutical Industries Limited Forme cristalline de 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno [2,3-b][1,5]benzodiazepine
WO2003101997A1 (fr) * 2002-05-31 2003-12-11 Geneva Pharmaceuticals, Inc. Procédé de préparation d'une forme cristalline i d'olanzapine
WO2004094433A1 (fr) * 2003-04-22 2004-11-04 EGIS Gyógyszergyár Rt. Nouveaux polymorphismes du chlorhydrate d'olanzapine
WO2005070937A1 (fr) * 2004-01-27 2005-08-04 Synthon B.V. Procede de fabrication d'olanzapine sous forme polymorphe i

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OERTHER, S.; AHLENIUS, S.: "Atypical antipsychotics and dopamine D1 receptor agonism: an in vivo experimental study using core temperature measurements in the rat", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 292, no. 2, 2000, pages 731 - 736, XP002359329 *
See also references of EP1781665A2 *

Also Published As

Publication number Publication date
EP1781665A2 (fr) 2007-05-09
WO2006010620A2 (fr) 2006-02-02
SI21850A (sl) 2006-02-28

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