WO2006008266A3 - Factor xi-binding proteins - Google Patents

Factor xi-binding proteins Download PDF

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Publication number
WO2006008266A3
WO2006008266A3 PCT/EP2005/053387 EP2005053387W WO2006008266A3 WO 2006008266 A3 WO2006008266 A3 WO 2006008266A3 EP 2005053387 W EP2005053387 W EP 2005053387W WO 2006008266 A3 WO2006008266 A3 WO 2006008266A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor
binding proteins
proteins
methods
identifying
Prior art date
Application number
PCT/EP2005/053387
Other languages
French (fr)
Other versions
WO2006008266A2 (en
Inventor
Soeren Oestergaard
Original Assignee
Novo Nordisk Healthcare Ag
Soeren Oestergaard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2004/000810 external-priority patent/WO2005049070A1/en
Application filed by Novo Nordisk Healthcare Ag, Soeren Oestergaard filed Critical Novo Nordisk Healthcare Ag
Publication of WO2006008266A2 publication Critical patent/WO2006008266A2/en
Publication of WO2006008266A3 publication Critical patent/WO2006008266A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel peptides that specifically bind human Factor XI and related proteins are provided, as are methods of using such proteins, methods of identifying such proteins, and additional related compounds, compositions, and methods.
PCT/EP2005/053387 2004-07-23 2005-07-14 Factor xi-binding proteins WO2006008266A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DKPA200401141 2004-07-23
DKPA200401141 2004-07-23
US59300004P 2004-07-30 2004-07-30
US60/593,000 2004-07-30
DKPCT/DK2004/000810 2004-11-22
PCT/DK2004/000810 WO2005049070A1 (en) 2003-11-20 2004-11-22 Therapeutic use of factor xi
EP05101584.0 2005-03-02
EP05101584 2005-03-02

Publications (2)

Publication Number Publication Date
WO2006008266A2 WO2006008266A2 (en) 2006-01-26
WO2006008266A3 true WO2006008266A3 (en) 2006-08-03

Family

ID=35785588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/053387 WO2006008266A2 (en) 2004-07-23 2005-07-14 Factor xi-binding proteins

Country Status (1)

Country Link
WO (1) WO2006008266A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0742483A1 (en) * 1995-05-04 1996-11-13 Kodak Limited Method of processing photographic silver halide materials
WO2005049070A1 (en) * 2003-11-20 2005-06-02 Novo Nordisk Health Care Ag Therapeutic use of factor xi

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0742483A1 (en) * 1995-05-04 1996-11-13 Kodak Limited Method of processing photographic silver halide materials
WO2005049070A1 (en) * 2003-11-20 2005-06-02 Novo Nordisk Health Care Ag Therapeutic use of factor xi

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BAGLIA F A ET AL: "A binding site for the kringle II domain of prothrombin in the Apple 1 domain of factor XI", JOURNAL OF BIOLOGICAL CHEMISTRY 13 OCT 2000 UNITED STATES, vol. 275, no. 41, 13 October 2000 (2000-10-13), pages 31954 - 31962, XP002368767, ISSN: 0021-9258 *
BAGLIA F A ET AL: "A binding site for thrombin in the apple 1 domain of factor XI", JOURNAL OF BIOLOGICAL CHEMISTRY 1996 UNITED STATES, vol. 271, no. 7, 1996, pages 3652 - 3658, XP002368765, ISSN: 0021-9258 *
BAGLIA F A ET AL: "Factor XI interacts with the leucine-rich repeats of glycoprotein Ib[alpha] on the activated platelet", JOURNAL OF BIOLOGICAL CHEMISTRY 19 NOV 2004 UNITED STATES, vol. 279, no. 47, 19 November 2004 (2004-11-19), pages 49323 - 49329, XP002368770, ISSN: 0021-9258 *
BAGLIA F A ET AL: "Identification of a binding site for glycoprotein Ib[alpha] in the Apple 3 domain of factor XI", JOURNAL OF BIOLOGICAL CHEMISTRY 29 OCT 2004 UNITED STATES, vol. 279, no. 44, 29 October 2004 (2004-10-29), pages 45470 - 45476, XP002368769, ISSN: 0021-9258 *
DATABASE EMBL [online] 1 October 2003 (2003-10-01), "Hypothetical protein from Rhodopirellula baltica", XP002368915, accession no. Q7UW18_RHOBA Database accession no. Q7UW18 *
HO D H ET AL: "A binding site for heparin in the apple 3 domain of factor XI", JOURNAL OF BIOLOGICAL CHEMISTRY 26 JUN 1998 UNITED STATES, vol. 273, no. 26, 26 June 1998 (1998-06-26), pages 16382 - 16390, XP002368766, ISSN: 0021-9258 *
MONDORF K ET AL: "SCREENING OF COMBINATORIAL PEPTIDE LIBRARIES: IDENTIFICATION OF LIGANDS FOR AFFINITY PURIFICATION OF PROTEINS USING A RADIOLOGICAL APPROACH", JOURNAL OF PEPTIDE RESEARCH, BLACKWELL PUBLISHING LTD., OXFORD, GB, vol. 52, no. 6, December 1998 (1998-12-01), pages 526 - 536, XP000788960, ISSN: 1397-002X *
SUGI T ET AL: "Certain autoantibodies to phosphatidylethanolamine (aPE) recognize factor XI and prekallikrein independently or in addition to the kininogens", JOURNAL OF AUTOIMMUNITY 01 NOV 2001 UNITED KINGDOM, vol. 17, no. 3, 1 November 2001 (2001-11-01), pages 207 - 214, XP002368768, ISSN: 0896-8411 *
WONG D W S ET AL: "IDENTIFYING PEPTIDE LIGANDS FOR BARLEY ALPHA-AMYLASE 1 USING COMBINATORIAL PHAGE DISPLAY LIBRARIES", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 46, no. 9, 1998, pages 3852 - 3857, XP002927084, ISSN: 0021-8561 *

Also Published As

Publication number Publication date
WO2006008266A2 (en) 2006-01-26

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