WO2006008076A3 - Procedes et agents stimulant la reponse immunitaire - Google Patents

Procedes et agents stimulant la reponse immunitaire Download PDF

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Publication number
WO2006008076A3
WO2006008076A3 PCT/EP2005/007690 EP2005007690W WO2006008076A3 WO 2006008076 A3 WO2006008076 A3 WO 2006008076A3 EP 2005007690 W EP2005007690 W EP 2005007690W WO 2006008076 A3 WO2006008076 A3 WO 2006008076A3
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WO
WIPO (PCT)
Prior art keywords
methods
immune response
agents stimulating
jam
stimulating
Prior art date
Application number
PCT/EP2005/007690
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English (en)
Other versions
WO2006008076A8 (fr
WO2006008076A2 (fr
Inventor
Alberto Mantovani
Elisabetta Dejana
Original Assignee
Univ Degli Studi Milano
Alberto Mantovani
Elisabetta Dejana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Milano, Alberto Mantovani, Elisabetta Dejana filed Critical Univ Degli Studi Milano
Publication of WO2006008076A2 publication Critical patent/WO2006008076A2/fr
Publication of WO2006008076A8 publication Critical patent/WO2006008076A8/fr
Publication of WO2006008076A3 publication Critical patent/WO2006008076A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des agents supprimant l'activité de la protéine JAM-A ou inactivant le gène JAM-A dans des cellules dendritiques de mammifères, ainsi que l'utilisation de ces agents en tant qu'immunostimulants.
PCT/EP2005/007690 2004-07-16 2005-07-14 Procedes et agents stimulant la reponse immunitaire WO2006008076A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58837004P 2004-07-16 2004-07-16
US60/588,370 2004-07-16

Publications (3)

Publication Number Publication Date
WO2006008076A2 WO2006008076A2 (fr) 2006-01-26
WO2006008076A8 WO2006008076A8 (fr) 2006-03-30
WO2006008076A3 true WO2006008076A3 (fr) 2006-07-27

Family

ID=35426967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/007690 WO2006008076A2 (fr) 2004-07-16 2005-07-14 Procedes et agents stimulant la reponse immunitaire

Country Status (1)

Country Link
WO (1) WO2006008076A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2909092B1 (fr) 2006-11-24 2012-10-19 Pf Medicament Nouveaux anticorps anti-proliferation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024897A1 (fr) * 1996-12-04 1998-06-11 F.Hoffmann-La Roche Ag Molecule d'adhesion jonctionnelle (jam), proteine transmembranaire de jonctions serrees

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024897A1 (fr) * 1996-12-04 1998-06-11 F.Hoffmann-La Roche Ag Molecule d'adhesion jonctionnelle (jam), proteine transmembranaire de jonctions serrees

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CERA MARIA ROSARIA ET AL: "Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice.", THE JOURNAL OF CLINICAL INVESTIGATION. SEP 2004, vol. 114, no. 5, September 2004 (2004-09-01), pages 729 - 738, XP002364082, ISSN: 0021-9738 *
INES MARTIN-PADURA ET AL: "JUNCTIONAL ADHESION MOLECULE, A NOVEL MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY THAT DISTRIBUTES AT INTERCELLULAR JUNCTIONS AND MODULATES MONOCYTE TRANSMIGRATION", JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, US, vol. 142, no. 1, 13 July 1998 (1998-07-13), pages 117 - 127, XP002935706, ISSN: 0021-9525 *
LECHNER F ET AL: "Antibodies to the junctional adhesion molecule cause disruption of endothelial cells and do not prevent leukocyte influx into the meninges after viral or bacterial infection.", THE JOURNAL OF INFECTIOUS DISEASES. SEP 2000, vol. 182, no. 3, September 2000 (2000-09-01), pages 978 - 982, XP002364023, ISSN: 0022-1899 *
NAIK MEGHNA U ET AL: "Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration.", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. DEC 2003, vol. 23, no. 12, December 2003 (2003-12-01), pages 2165 - 2171, XP002364081, ISSN: 1524-4636 *
NAIK U P ET AL: "Junctional adhesion molecule 1 (JAM-1)", JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS 2003 ITALY, vol. 17, no. 4, 2003, pages 341 - 347, XP002364080, ISSN: 0393-974X *
WANG F ET AL: "STIMULATORY ANTIBODY-INDUCED ACTIVATION AND SELECTIVE TRANSLOCATIONOF PROTEIN KINASE C ISOENZYMES IN HUMAN PLATELETS", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 311, no. 2, 1995, pages 401 - 406, XP002060055, ISSN: 0264-6021 *

Also Published As

Publication number Publication date
WO2006008076A8 (fr) 2006-03-30
WO2006008076A2 (fr) 2006-01-26

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