WO2006005420A1 - Composition pour le blanchiment des dents - Google Patents

Composition pour le blanchiment des dents Download PDF

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Publication number
WO2006005420A1
WO2006005420A1 PCT/EP2005/006759 EP2005006759W WO2006005420A1 WO 2006005420 A1 WO2006005420 A1 WO 2006005420A1 EP 2005006759 W EP2005006759 W EP 2005006759W WO 2006005420 A1 WO2006005420 A1 WO 2006005420A1
Authority
WO
WIPO (PCT)
Prior art keywords
tooth whitening
composition
composition according
whitening composition
monofluorophosphate
Prior art date
Application number
PCT/EP2005/006759
Other languages
English (en)
Inventor
Stephane Lefort
Original Assignee
Unilever N.V.
Unilever Plc
Hindustan Lever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever N.V., Unilever Plc, Hindustan Lever Limited filed Critical Unilever N.V.
Publication of WO2006005420A1 publication Critical patent/WO2006005420A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a composition for whitening the teeth.
  • WO 91/14650 discloses a dental composition for treating teeth surfaces.
  • the compositions disclosed therein aarree hhiigghh vviissccoossiittyy ccoommppoossiittiioo:ns which comprise either bleaching agents or fluoride.
  • WO 00/28955 discloses dental whitening compositions of high viscosity optionally comprising adjuvants such as fluoride.
  • dental bleaches which may comprise, as desensitizing agent, sodium fluoride.
  • US 4 687 663 discloses an oral composition comprising sorbitol, water, Veegum ® and sodium fluoride.
  • the disclosure also includes several other formulations comprising Carbopol ® instead of Veegum ® . However, none of these also comprises sodium fluoride.
  • US 5 217 710 discloses an oral composition for whitening the teeth comprising Lutrol F127 ® as structurant and sodium monofluorophosphate as flouride ion source.
  • Table III is shown how a formulation comprising sodium monofluorophosphate, hydrogen peroxide and Pluronic F127 is inherently unstable with no peroxide being recovered in stability trials.
  • monofluorophosphate salts have an unexpected stabilising effect in whitening compositions according to the invention.
  • the present invention provides a tooth whitening product according to claim 1.
  • Suitable fluoride salts include the monofluorophosphates, especially the alkali-metal monofluorophosphates such as sodium monofluorophosphate. Preferably, from 500 to 2000 ppm, more preferably from 700 to 1700 ppm and most preferably 800 to 1600 ppm of a free fluoride ion is added as a monofluorophosphate salt. Typically, 1450 ppm is generated by sodium monofluorophosphate at 1.11% by weight of the composition.
  • composition of the invention preferably comprises water at from 10 to 70% by weight, preferably from 25 to 60% by weight and especially preferably from 35 to 45% by weight.
  • the composition also comprises a tooth whitening agent which is preferably a bleaching material.
  • Preferred bleaching materials include those which are capable of generating peroxyl radicals in water. Examples include hydrogen peroxide and carbamide peroxide. Other examples include N- phthalimido hexanoic peroxy acid (PAP) .
  • PAP N- phthalimido hexanoic peroxy acid
  • the tooth whitening agent is a bleaching agent selected from hydrogen peroxide or carbamide peroxide, it is present at from 1 to 30% by weight of the invention, preferably from 10 to 20% by weight and more preferably from 13 to 18% by weight.
  • the composition also comprises a polycarboxylic acid structurant.
  • the structurant is preferably present at from 1 to 30% by weight depending on the material used.
  • the most preferred structurant is Carbopol ® 980 because it provides a tackiness to the product which improves its stickiness to the oral hard surfaces and retains the bleaching agent at the surface for up to three minutes after application. It also provides the most optimal conditions for monofluorophosphate to exert its stabilising benefit.
  • the composition may also comprise a humectant.
  • humectant is compatible with a peroxide generating species.
  • examples include glycerine, propylene glycol and short chain polyethylene glycols.
  • Such short chain polyethylene glycols include those with a chain length comprising 400 repeating units or less, e.g. PEG 200 and PEG 400.
  • the most preferred humectant is glycerine.
  • the humectant is present at from 20 to 65%, more preferably from 30 to 50% and especially preferably 40% by weight of the composition.
  • the humectant and water together comprise from 60 to 90%, preferably from 75 to 85% by weight of the composition.
  • said composition has a viscosity of from 40 000 to 300 000 centipoise measured on a Brookfield viscometer at 25°C, at 5 rpm and with a TA spindle. More preferably the viscosity as measured in the same way is from 140 000 to 220 000 cps.
  • the composition according to the invention has a pH preferably ranging from 4.5 to 7.5, preferably from 4.5 to 6 and especially from 5 to 5.5. A pH of from 5 to 5.5 is particularly preferable where the composition comprises as structurant Carbopol ® at from 0.5 to 2% by weight of the composition. This careful balancing of the pH enables the composition to have just the right viscosity to allow for
  • the composition may also comprise a buffering agent such as ammonium or sodium hydroxide. These may be present at from 0.15 to 0.6 % by weight of the composition in order to maintain the pH accordingly.
  • a buffering agent such as ammonium or sodium hydroxide.
  • composition is preferably visually clear by which is meant that it scores-3 or more on a font card, i.e. that through a 1 ml cuvette a font of size -3 can be read.
  • composition is also preferably colourless. This is beneficial since the product is gradually washed away within a few minutes of application and it would be undesirable for a coloured product to remain visible between the teeth thereafter.
  • the oral composition according to the invention is a leave-on product, i.e. one which is intended to be applied to the teeth and then left for a period of time before being rinsed by salivation and mechanical discruption.
  • a leave-on product i.e. one which is intended to be applied to the teeth and then left for a period of time before being rinsed by salivation and mechanical discruption.
  • This is in contrast to most of the prior art compositions which are to be applied to the teeth as part of a brushing regime and are rinsed off shortly after.
  • the oral composition according to the invention may also comprise further ingredients which are common in the art, such as:
  • antimicrobial agents e.g. Triclosan, chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis- (4-chloro- 6-bromophenol) ;
  • anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.;
  • plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates
  • vitamins such as Vitamins A, C and E;
  • desensitising agents e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts; - S -
  • anti-calculus agents e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc. ;
  • biomolecules e.g. bacteriocins, antibodies, enzymes, etc.
  • flavours e.g. peppermint and spearmint oils
  • proteinaceous materials such as collagen
  • pharmaceutically acceptable carriers e.g. starch, sucrose, water or water/alcohol systems etc.;
  • surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
  • particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.;
  • binders and thickeners such as sodium carboxymethyl- cellulose, xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol ® ;
  • polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included;
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • Liposomes may also be used to improve delivery or stability of active ingredients.
  • composition may be in any form common in the art, e.g. toothpaste, gel, mousse, aerosol, gum, lozenge, powder, cream, etc. and may also be formulated into systems for use in dual-compartment type dispensers.
  • a second aspect of the invention provides for a kit comprising a composition according to the first aspect and an applicator for applying said composition to the surfaces of the tooth.
  • the kit preferably comprises a single container and a plurality of applicators, preferably from 5 to 50 applicators. The most preferred number is applicati corresponding to a four week application schedule.
  • the container according to the kit of the invention is typically a jar or plastic receptacle of between 5 and 50 ml in volume.
  • the applicator is made from a natural material such as wood pulp, paper or cotton.
  • a third aspect of the invention provides for a method of whitening the teeth using a kit according to the second aspect of the invention, said method characterised by the following steps:
  • a formulation is provided according to the composition of the invention. It is made by normal processes.
  • a leave-on gel product according to Example 1 comprising 1000 ppm sodium monofluorophosphate took 18 hours to liquefaction at 90 0 C while the same formulation with 1000 ppm sodium fluoride instead of sodium monofluorophosphate took 12 hours.
  • the improved stability of the leave-one gel is due to the surprising effect of SMFP.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Composition pour le blanchiment des dents comprenant de l'eau, un structurant d'acide polycarboxylique et un agent de blanchiment des dents, caractérisée par un sel de monofluorophosphate.
PCT/EP2005/006759 2004-07-15 2005-06-22 Composition pour le blanchiment des dents WO2006005420A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04254243 2004-07-15
EP04254243.1 2004-07-15

Publications (1)

Publication Number Publication Date
WO2006005420A1 true WO2006005420A1 (fr) 2006-01-19

Family

ID=34930491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/006759 WO2006005420A1 (fr) 2004-07-15 2005-06-22 Composition pour le blanchiment des dents

Country Status (1)

Country Link
WO (1) WO2006005420A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041280A (en) * 1987-10-01 1991-08-20 Epilady Usa, Inc. Toothpaste composition for stain removal
EP0559262A1 (fr) * 1992-03-05 1993-09-08 Unilever N.V. Gels de peroxide stabilisés contenant du fluoride
US6190644B1 (en) * 1996-11-21 2001-02-20 The Procter & Gamble Company Dentifrice compositions containing polyphosphate and monofluorophosphate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041280A (en) * 1987-10-01 1991-08-20 Epilady Usa, Inc. Toothpaste composition for stain removal
EP0559262A1 (fr) * 1992-03-05 1993-09-08 Unilever N.V. Gels de peroxide stabilisés contenant du fluoride
US6190644B1 (en) * 1996-11-21 2001-02-20 The Procter & Gamble Company Dentifrice compositions containing polyphosphate and monofluorophosphate

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