WO2006004922A1 - Crystalline form iv of linezolid - Google Patents

Crystalline form iv of linezolid Download PDF

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Publication number
WO2006004922A1
WO2006004922A1 PCT/US2005/023272 US2005023272W WO2006004922A1 WO 2006004922 A1 WO2006004922 A1 WO 2006004922A1 US 2005023272 W US2005023272 W US 2005023272W WO 2006004922 A1 WO2006004922 A1 WO 2006004922A1
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WO
WIPO (PCT)
Prior art keywords
linezolid
crystalline
crystalline linezolid
slurry
solvent
Prior art date
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PCT/US2005/023272
Other languages
French (fr)
Other versions
WO2006004922B1 (en
Inventor
Judith Aronhime
Tamas Koltai
Viviana Braude
Serguei Fine
Tamar Niddam
Original Assignee
Teva Pharmaceutical Industries Ltd.
Teva Pharmaceutical Usa, Inc.
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Publication date
Application filed by Teva Pharmaceutical Industries Ltd., Teva Pharmaceutical Usa, Inc. filed Critical Teva Pharmaceutical Industries Ltd.
Priority to CA002572054A priority Critical patent/CA2572054A1/en
Priority to EP05790033A priority patent/EP1658275A1/en
Priority to JP2006524972A priority patent/JP2007504173A/en
Publication of WO2006004922A1 publication Critical patent/WO2006004922A1/en
Publication of WO2006004922B1 publication Critical patent/WO2006004922B1/en
Priority to IL180358A priority patent/IL180358A0/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2

Definitions

  • the present invention relates to a novel crystalline form of linezolid (Form IV) as well as to novel methods of preparing and using Form IV.
  • Linezolid [(S)-N- [ [3 -(3-Fluoro-4-morpholinyl)phenyl] -2-oxo-5 -oxazolidinyljmethyl] acetamide] is an antimicrobial agent.
  • Linezolid is an oxazolidinone, having the empirical formula C 16 H 2 QFN 3 O 4 and the following structure:
  • Linezolid is described in The Merck Index (13th edition, Monograph number: 05526, CAS Registry Number: 165800-03-3) as white crystals, with a melting point of 181.5- 182.5°.
  • Linezolid, as well as a process for its preparation, is disclosed in U.S. Patent No. 5,688,792 (Example 5), European Patent No. 717738, Israeli Patent No. 110,802, Canadian Patent No. 2,168,560, and International Patent Publication WO 95/07271.
  • Crystalline Form II linezolid is disclosed in U.S. Patent No. 6,559,305.
  • Linezolid is marketed in the United States by Pfizer, Inc. as an injection, tablets, and oral suspension under the name ZYVOX®. Its main indications are nosocomial pneumonia, skin and skin-structure infections, and vancomycin-resistant Enterococcus faecium infections.
  • the present invention relates to the solid state physical properties of Linezolid. These properties can be influenced by controlling the conditions under which Linezolid is obtained in solid form.
  • Solid state physical properties include, for example, the flowability of the milled solid. Flowability affects the ease with which the material is handled during processing into a pharmaceutical product. Glidants are often added to improve the flowability of a non-compacted solid composition and to improve the accuracy of dosing. When particles of the powdered compound do not flow past each other easily, a formulation specialist must take that fact into account in developing a tablet or capsule formulation, which may necessitate the use of glidants such as colloidal silicon dioxide, talc, starch or tribasic calcium phosphate.
  • Crystal forms with platelet shape have better flowability than crystals with needle shape (M. Rouhi, The Right Stuff; Chemical & Engineering News; 24 th Feb. 2003). Crystals with plate shape are more advantageous than those with needle shape for injection. A suspension of plate-shaped crystals maybe injected through a smaller needle with greater ease than a suspension of needle-shaped crystals. (S.R. Byrn et al. Solid-State Chemistry of Drugs 2 nd Edition pg.4).
  • Another important solid state property of a pharmaceutical compound is its rate of dissolution in aqueous fluid.
  • the rate of dissolution of an active ingredient in a patient's stomach fluid can have therapeutic consequences since it imposes an upper limit on the rate at which an orally-administered active ingredient can reach the patient's bloodstream.
  • the rate of dissolution is also a consideration in formulating syrups, elixirs and other liquid medicaments.
  • the solid state form of a compound may also affect its behavior on compaction and its storage stability.
  • the present invention provides linezolid crystalline Form IV.
  • Form IV is characterized by a powder X-ray diffraction (PXRD) pattern with peaks at about 13.5, 18.0, 21.1, 22.2 and 25.4 ⁇ 0.2 degrees 2 theta.
  • Form IV may be further characterized by PXRD peaks at about 7.5, 18.7, 19.9, 27.7 and 28.4 ⁇ 0.2 degrees 2 theta.
  • Form TV may be further characterized by a PXRD pattern substantially as depicted in Figure 1.
  • the crystalline linezolid Form IV of the present invention is polymorphically pure, i.e., contains less than about 10% Form II, preferably less than about 5% Form II, and even more preferably less than about 1% Form ⁇ , and most preferably, less than about 0.5% Form II (by weight).
  • the crystalline linezolid Form IV of the present invention is anhydrous, and is stable against transformation into Form II upon storage at a relative humidity of about 0% to about 100% at room temperature for at least 10 days.
  • the present invention also provides crystalline linezolid Form IV that is enantiomerically pure with respect to its R-enantiomer, i.e., containing less than about 0.1% area by HPLC of the R-enantiomer, preferably less than about 0.02% area by HPLC of the R-enantiomer.
  • the novel crystalline linezolid Form IV is in the form of irregular plate crystals when observed under the microscope.
  • Another embodiment of the present invention is a novel method of making crystalline linezolid Form IV that comprises spray-drying a solution of linezolid at a temperature of at least 5O 0 C.
  • Also described in the present invention is another process for preparing crystalline linezolid Form IV comprising the step of heating crystalline linezolid Form II.
  • Form IV may also be prepared comprising the step of heating a slurry of form II in an aromatic solvent.
  • Another aspect of the present invention is the preparation of Form II from a slurry of Form IV in water or an organic solvent.
  • the crystalline linezolid Form IV provided by the present invention has a preferred maximum particle size of 500 ⁇ m.
  • Another embodiment of the present invention is a pharmaceutical formulation comprising a therapeutically effective amount of crystalline linezolid Form IV, combined with a pharmaceutically acceptable excipient or carrier.
  • a further embodiment of the present invention is a method for treating a patient suffering from a gram positive bacterial infection, using a formulation containing a therapeutically effective amount of crystalline linezolid Form IV.
  • Figure 1 is a powder X-Ray diffractogram of crystalline linezolid Form IV.
  • Figure 2a-2c is an FTIR spectrum of crystalline linezolid Form IV obtained with the mineral oil mull technique.
  • Figure 2d-2f is an FTIR spectrum of crystalline Linezolid Form IV obtaind with the DRIFT technique.
  • Figure 3 is a DSC thermogram of crystalline linezolid Form IV.
  • Figure 4a-4d is an FTRaman spectrum of crystalline linezolid Form IV.
  • Figure 5 shows the needle shape of crystals of crystalline linezolid Form II as seen through a microscope.
  • Figure 6 shows the plate shape of crystals of crystalline linezolid Form IV as seen through a microscope.
  • Figure 7 also shows the plate shape of crystals of crystalline linezolid Form IV as seen through a microscope.
  • Figure 8 is a DSC thermogram of crystalline linezolid Form II.
  • spray drying broadly refers to processes involving breaking up liquid mixtures into small droplets (atomization) and rapidly removing solvent from the mixture.
  • spray-drying apparatus there is a strong driving force for evaporation of solvent from the droplets, which maybe provided by a heated drying gas.
  • Spray-drying processes and equipment are described in Perry's Chemical Engineer's Handbook, pgs. 20-54 to 20-57 (Sixth Edition 1984).
  • the typical spray-drying apparatus comprises a drying chamber, atomizing means for atomizing a solvent-containing feed into the drying chamber, a source of heated drying gas that flows into the drying chamber to remove solvent from the atomized-solvent-containing feed, an outlet for the products of drying, and product collection means located downstream of the drying chamber.
  • atomizing means for atomizing a solvent-containing feed into the drying chamber
  • source of heated drying gas that flows into the drying chamber to remove solvent from the atomized-solvent-containing feed
  • an outlet for the products of drying and product collection means located downstream of the drying chamber.
  • the product collection means includes a cyclone connected to the drying apparatus. In the cyclone, the particles produced during spray-drying are separated from the drying gas and evaporated solvent, allowing the particles to be collected.
  • a filter may also be used to separate and collect the particles produced by spray-drying.
  • the process of the invention is not limited to the use of such drying apparatuses as described above.
  • “Therapeutically effective amount” means the amount of a crystalline form that, when administered to a patient for treating a disease or other undesirable medical condition, is sufficient to have a beneficial effect with respect to that disease or condition.
  • the "therapeutically effective amount” will vary depending on the crystalline form, the disease or condition and its severity, and the age, weight, etc., of the patient to be treated. Determining the therapeutically effective amount of a given crystalline form is within the ordinary skill of the art and requires no more than routine experimentation.
  • the present invention provides crystalline linezolid Form IV, characterized by a powder X-ray diffraction (PXRD) pattern with peaks at about 13.5, 18.0, 21.1, 22.2, and 25.4 ⁇ 0.2 degrees 2 theta.
  • Form IV may be further characterized by PXRD peaks at about 7.5, 18.7, 19.9, 27.7, and 28.4 ⁇ 0.2 degrees 2 theta.
  • Form IV may be further characterized by a PXRD pattern substantially as depicted in Figure 1.
  • Crystalline linezolid Form IV may be further characterized by an FTIR spectrum with peaks at about 3333, 2817, 1732, 1661, 1540, 1515, 1335, 1256, 1229, 1200, 1213, 1148, 1080, 1059, 1050, 903, 825, 755, and 662 cm "1 .
  • Crystalline linezolid Form IV may be further characterized by an FTIR spectrum substantially as depicted in Figure 2a-2c or in Figure 2d-2f. The most characteristic FTIR peaks are 2817, 1335, 1229, 1200, and 662 cm "1 .
  • Crystalline linezolid Form IV may also be characterized by a differential scanning calorimetry (DSC) thermogram substantially as depicted in Figure 3.
  • Form IV has a characteristic DSC thermogram compared to the DSC thermogram of Form II ( Figure 8).
  • Form II has a sharp endothermic peak around 155 0 C, followed by a sharp exothermic peak at around 16O 0 C, and another sharp endothermic peak at around 18O 0 C, which corresponds to the final melting of linezolid.
  • Form IV has only one sharp endothermic peak, which corresponds to the final melting of linezolid.
  • Crystalline linezolid Form IV may be further characterized by an FTRaman spectrum having peaks at about 2975, 2930, 2865, 1083, and 750 cm "1 . Crystalline linezolid Form IV may be further characterized by an FTRaman spectrum substantially as depicted in Figure 4a-4d.
  • the invention also provides crystalline linezolid Form TV, which has about 0.1% water by weight.
  • Form IV may also be characterized by a weight loss measured by thermal gravimetric analysis (TGA) of about 0.1% by weight.
  • TGA thermal gravimetric analysis
  • This embodiment of Form IV is anhydrous.
  • the present invention includes crystalline linezolid Form IV which has about 0.1 % or less water by weight.
  • the crystalline linezolid Form IV of the present invention can be made in the form of irregular plate crystals.
  • the previously known crystalline linezolid Form II forms needle shaped crystals.
  • the flowability of crystals with an irregular plate shape of the present invention is much better than the flowability of crystals with needle shape.
  • Another advantage of the irregular plate crystals is that they are easier to work with than needle shaped linezolid of the prior art.
  • the bulk properties of the crystalline linezolid Form IV of the present invention are advantageous compared to those of the prior art linezolid.
  • the difference between the needle-shaped crystals of Form II and the plate-shaped crystals of Form IV can be appreciated by a comparison of Figure 5 (Form II) with Figure 6 (Form IV) or Figure 7 (also Form IV).
  • the crystalline linezolid Form IV provided in the present invention is enantiomerically pure.
  • Enantiomerically pure linezolid Form IV contains the unwanted R-enantiomer at a level of less than about 0.1% area by HPLC.
  • the enantiomerically pure linezolid Form IV of the present invention contains less than about 0.02% area by HPLC of the R-enantiomer.
  • the crystalline linezolid Form IV of the present invention is also polymorphically pure. Thus, it contains less than about 10% Form II, preferably less than about 5% Form II, and even more preferably less than about 1% Form II, and most preferably, less than about 0.5% Form II (by weight).
  • the present invention provides a novel method of making crystalline linezolid Form IV by spray-drying a solution of linezolid at a temperature of at least 5O 0 C.
  • This method comprises dissolving linezolid in a polar organic solvent at about room temperature, pumping the obtained solution into a spray dryer and contacting it with a nitrogen gas at a temperature of at least 5O 0 C until Form IV is obtained.
  • the polar organic solvent is methanol.
  • the present invention provides another process for preparing crystalline linezolid Form IV comprising the step of heating crystalline linezolid Form II to a temperature of at least 85°C, preferably for at least one hour.
  • Form IV may also be prepared by heating a slurry of Form II in an organic solvent.
  • the slurry is produced by combining Form II with an aromatic solvent at room temperature, followed by heating for one hour to induce partial dissolution.
  • the partially clear slurry is then filtered and the obtained solid is dried, providing crystals that were analyzed by PXRD and shown to be linezolid Form IV.
  • Preferred organic solvents are aromatic solvents and more preferably, xylene and toluene.
  • Another preferred solvent is a silicon fluid.
  • Enantiomerically pure Form IV is prepared by slurrying Form II in an organic solvent, as described above, and using Form II that contains a maximum of 0.1% of the R- enantiomer. Preferably, the Form II contains less than about 0.02% of the R- enantiomer.
  • Form II and the solvents used in the slurrying processes are preferably combined at 25 0 C, providing a slurry that is heated, preferably to reflux, when an aromatic solvent is used, and more preferably, to 14O 0 C, when a silicon fluid is used.
  • the isolated linezolid Form IV is dried, preferably in an oven, preferably by heating to a temperature of 50 0 C.
  • the invention encompasses a process for the transformation of Form IV into Form II comprising combining Form IV at room temperature with water or with an organic solvent selected from the group consisting of a ketone, a straight or branched C 1 -C 4 alcohol, an ester, an aromatic solvent, and a nitrile, to obtain a slurry, and maintaining the slurry for at least about one hour.
  • the slurry is then filtered, providing crystals of Form II, which are then dried and analyzed by PXRD.
  • the temperature of the reaction is preferably room temperature.
  • the slurry is maintained for at least about one hour, preferably for about one hour to about 24 hours.
  • Form rV has proven to be stable and non-hygroscopic between 0-100 % RH.
  • Form IV has proven to be stable at 25°C, 40 0 C, and 55°C for a minimum of 3 months.
  • the particle size distribution (PSD) of the active ingredient is one of the key parameters of a formulation.
  • the following main methods may be employed: sieves, sedimentation, electrozone sensing (coulter counter), microscopy, Low Angle Laser Light Scattering (LALLS).
  • the crystalline linezolid Form rV of the present invention has a preferred maximum particle size of 500 ⁇ m.
  • the particle size is less than 300 ⁇ m, less than 200 ⁇ m, less than 100 ⁇ m, or even less than 50 ⁇ m.
  • Another embodiment of the present invention is a pharmaceutical formulation comprising a therapeutically effective amount of crystalline linezolid Form IV, combined with a pharmaceutically acceptable excipient or carrier.
  • Another embodiment of the present invention is a method for treating a patient suffering from a gram positive bacterial infection, comprising the step of administering to the patient the pharmaceutical formulation comprising a therapeutically effective amount of crystalline linezolid Form IV.
  • the crystalline linezolid Form IV of the present invention used to prepare pharmaceutical formulations may be substantially pure with respect to other crystalline forms, i.e., the pharmaceutical formulations may contain less than about 10%, preferably less than about 5%, and even more preferably less than about 1% (by weight) of other crystalline forms of linezolid. hi particular, the pharmaceutical formulations may contain less than about 10%, preferably less than about 5%, and more preferably less than about 1%, and even more preferably less than 0.5% (by weight) of crystalline linezolid Form II. Li certain embodiments, the pharmaceutical formulations may contain less than about 10%, preferably less than about 5%, and even more preferably less than about 1% (by weight) of amorphous linezolid.
  • pharmaceutical formulations of the present invention may contain crystalline linezolid Form IV in a mixture with other forms of linezolid.
  • the pharmaceutical formulations of the present invention may contain one or more excipients. Excipients are added to the formulation for a variety of purposes.
  • Diluents may be added to the formulations of the present invention. Diluents increase the bulk of a solid pharmaceutical composition, and may make a pharmaceutical dosage form containing the composition easier for the patient and care giver to handle. Diluents for solid compositions include, for example, microcrystalline cellulose (e.g., AVICEL®), rnicrofine cellulose, lactose, starch, pregelatinized starch, calcium carbonate, calcium sulfate, sugar, dextrates, dextrin, dextrose, dibasic calcium phosphate dihydrate, tribasic calcium phosphate, kaolin, magnesium carbonate, magnesium oxide, maltodextrin, mannitol, polymethacrylates (e.g., EUDRAGIT®), potassium chloride, powdered cellulose, sodium chloride, sorbitol, and talc.
  • microcrystalline cellulose e.g., AVICEL®
  • rnicrofine cellulose lactose
  • Solid pharmaceutical compositions that are compacted into a dosage form, such as a tablet may include excipients whose functions include helping to bind the active ingredient and other excipients together after compression.
  • Binders for solid pharmaceutical compositions include acacia, alginic acid, carbomer (e.g., carbopol), carboxymethylcellulose sodium, dextrin, ethyl cellulose, gelatin, guar gum, hydrogenated vegetable oil, hydroxyethyl cellulose, hydroxypropyl cellulose (e.g., KLUCEL®), hydroxypropyl methyl cellulose (e.g., METHOCEL®), liquid glucose, magnesium aluminum silicate, maltodextrin, methylcellulose, polymethacrylates, povidone (e.g., KOLLIDON®, PLASDONE®), pregelatinized starch, sodium alginate, and starch.
  • carbomer e.g., carbopol
  • carboxymethylcellulose sodium, dextrin eth
  • the dissolution rate of a compacted solid pharmaceutical composition in the patient's stomach may be increased by the addition of a disintegrant to the composition.
  • Disintegrants include alginic acid, carboxymethylcellulose calcium, carboxymethylcellulose sodium (e.g., AC-DI-SOL®, PRIMELLOSE®), colloidal silicon dioxide, croscarmellose sodium, crospovidone (e.g., KOLLIDON®,
  • POLYPLASDONE® guar gum
  • magnesium aluminum silicate methyl cellulose, microcrystalline cellulose, polacrilin potassium, powdered cellulose, pregelatinized starch, sodium alginate, sodium starch glycolate (e.g., EXPLOTAB®), and starch.
  • Glidants can be added to improve the flowability of a non-compacted solid composition and to improve the accuracy of dosing.
  • Excipients that may function as glidants include colloidal silicon dioxide, magnesium trisilicate, powdered cellulose, starch, talc, and tribasic calcium phosphate.
  • a dosage form such as a tablet
  • the composition is subjected to pressure from a punch and dye.
  • Some excipients and active ingredients have a tendency to adhere to the surfaces of the punch and dye, which can cause the product to have pitting and other surface irregularities.
  • a lubricant can be added to the composition to reduce adhesion and ease the release of the product from the dye.
  • Lubricants include magnesium stearate, calcium stearate, glyceryl monostearate, glyceryl palmitostearate, hydrogenated castor oil, hydrogenated vegetable oil, mineral oil, polyethylene glycol, sodium benzoate, sodium lauryl sulfate, sodium stearyl fumarate, stearic acid, talc, and zinc stearate.
  • Flavoring agents and flavor enhancers make the dosage form more palatable to the patient.
  • Common flavoring agents and flavor enhancers for pharmaceutical products include maltol, vanillin, ethyl vanillin, menthol, citric acid, fumaric acid, ethyl maltol, and tartaric acid.
  • Solid and liquid compositions may also be dyed using any pharmaceutically acceptable colorant to improve their appearance and/or facilitate patient identification of the product and unit dosage level.
  • the present invention is not intended to encompass true solutions of crystalline linezolid Form IV whereupon the crystal structure of the novel Form IV and the properties that characterize the novel crystalline form of the present invention are lost.
  • the use of the novel form to prepare such solutions e.g., so as to deliver linezolid in a liquid pharmaceutical formulation
  • compositions prepared using Form IV of the present invention are dissolved or suspended in a liquid carrier such as water, vegetable oil, alcohol, polyethylene glycol, propylene glycol, or glycerin.
  • a liquid carrier such as water, vegetable oil, alcohol, polyethylene glycol, propylene glycol, or glycerin.
  • Liquid pharmaceutical compositions may contain emulsifying agents to disperse uniformly throughout the composition an active ingredient or other excipient that is not soluble in the liquid carrier.
  • Emulsifying agents that may be useful in liquid compositions of the present invention include, for example, gelatin, egg yolk, casein, cholesterol, acacia, tragacanth, chondrus, pectin, methyl cellulose, carbomer, cetostearyl alcohol, and cetyl alcohol.
  • Liquid pharmaceutical compositions may also contain a viscosity enhancing agent to improve the mouth-feel of the product and/or coat the lining of the gastrointestinal tract.
  • Such agents include acacia, alginic acid bentonite, carbomer, carboxymethylcellulose calcium or sodium, cetostearyl alcohol, methyl cellulose, ethylcellulose, gelatin guar gum, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, maltodextrin, polyvinyl alcohol, povidone, propylene carbonate, propylene glycol alginate, sodium alginate, sodium starch glycolate, starch tragacanth, and xanthan gum.
  • Sweetening agents such as sorbitol, saccharin, sodium saccharin, sucrose, aspartame, fructose, mannitol, and invert sugar may be added to improve the taste.
  • Preservatives and chelating agents such as alcohol, sodium benzoate, butylated hydroxyl toluene, butylated hydroxyanisole, and ethylenediamine tetraacetic acid may be added at levels safe for ingestion to improve storage stability.
  • a liquid composition may also contain a buffer such as guconic acid, lactic acid, citric acid or acetic acid, sodium guconate, sodium lactate, sodium citrate, or sodium acetate. Selection of excipients and the amounts used may be readily determined by the formulation scientist based upon experience and consideration of standard procedures and reference works in the field.
  • a buffer such as guconic acid, lactic acid, citric acid or acetic acid, sodium guconate, sodium lactate, sodium citrate, or sodium acetate.
  • the solid compositions of the present invention include powders, granulates, aggregates and compacted compositions.
  • the dosages include dosages suitable for oral, buccal, rectal, parenteral (including subcutaneous, intramuscular, and intravenous), inhalant, and ophthalmic administration. Although the most suitable administration in any given case will depend on the nature and severity of the condition being treated, the most preferred route of the present invention is oral.
  • the dosages may be conveniently presented in unit dosage form and prepared by any of the methods well-known in the pharmaceutical arts.
  • Dosage forms include solid dosage forms like tablets, powders, capsules, suppositories, sachets, troches and lozenges, as well as liquid syrups, suspensions and elixirs.
  • the dosage of GEODON may be used as guidance.
  • the oral dosage form of the present invention is preferably in the form of an oral capsule having a dosage of about 10 mg to about 160 mg, more preferably from about 20 mg to about 80 mg, and most preferably capsules of 20, 40, 60 and 80 mg.
  • Daily dosages may include 1, 2, or more capsules per day.
  • the dosage form of the present invention may be a capsule containing the composition, preferably a powdered or granulated solid composition of the invention, within either a hard or soft shell.
  • the shell may be made from gelatin and optionally contain a plasticizer such as glycerin and sorbitol, and an opacifying agent or colorant.
  • a composition for tableting or capsule filling may be prepared by wet granulation.
  • wet granulation some or all of the active ingredients and excipients in powder form are blended and then further mixed in the presence of a liquid, typically water, that causes the powders to clump into granules.
  • the granulate is screened and/or milled, dried and then screened and/or milled to the desired particle size.
  • the granulate may then be tableted, or other excipients may be added prior to tableting, such as a glidant and/or a lubricant.
  • a tableting composition may be prepared conventionally by dry blending.
  • the blended composition of the actives and excipients may be compacted into a slug or a sheet and then comminuted into compacted granules. The compacted granules may subsequently be compressed into a tablet.
  • a blended composition may be compressed directly into a compacted dosage form using direct compression techniques.
  • Direct compression produces a more uniform tablet without granules.
  • Excipients that are particularly well suited for direct compression tableting include microcrystalline cellulose, spray dried lactose, dicalcium phosphate dihydrate and colloidal silica. The proper use of these and other excipients in direct compression tableting is known to those in the art with experience and skill in particular formulation challenges of direct compression tableting.
  • a capsule filling of the present invention may comprise any of the aforementioned blends and granulates that were described with reference to tableting, however, they are not subjected to a final tableting step.
  • compositions and dosage forms may be formulated into compositions and dosage forms according to methods known in the art.
  • the crystalline linezolid Form IV of the present invention may be used in pharmaceutical formulations or compositions as a single active ingredient or as a mixture together with other crystalline forms of linezolid or with amorphous linezolid.
  • the pharmaceutical formulations or compositions of the present invention contain 25-100% by weight, especially 50-100% by weight, of crystalline linezolid Form IV, based on the total amount of linezolid in the formulation or composition.
  • crystalline linezolid Form IV based on the total amount of linezolid in the formulation or composition.
  • such an amount of crystalline linezolid Form is preferred.
  • IV is 75-100% by weight, especially 90-100% by weight. Highly preferred is an amount of 95-100% by weight.
  • Powder X-ray diffraction data were obtained by methods known in the art using a
  • DSC analysis was done using a Mettler 821 Star 0 .
  • the weight of the samples was about 5 mg; the samples were scanned at a rate of 10°C/min from 3O 0 C to 25O 0 C.
  • the oven was constantly purged with nitrogen gas at a flow rate of 40 ml/min. Standard 70 ⁇ l alumina crucibles covered by lids with 1 hole were used.
  • IR analysis was done using a Perkin Elmer SPECTRUM ONE FT-IR spectrometer in DRIFT mode or using mineral oil mull technique. The samples in the 4000-400 cm "1 interval were scanned 16 times with 4.0 cm '1 resolution.
  • the FTRaman analysis was performed by Bruker RFS-100/S Raman spectrometer.
  • the scanning parameters were:
  • Aperture Setting 10.0mm;
  • Low Pass Filter 16 IkHz; Source Setting Laser: 9394.0 cm "1 , 1600 mW;
  • Crystalline linezolid Form IV may be prepared by heating crystalline linezolid Form II to a temperature higher than 85°C. Crystalline linezolid Form IV is obtained by keeping crystalline linezolid Form II at a temperature of between 85-175 0 C. As an example, crystalline linezolid Form ⁇ was kept at a temperature of 17O 0 C during one hour. The polymorphic form of crystalline linezolid Form II was changed to crystalline linezolid Form IV. The crystalline linezolid Form IV obtained at 17O 0 C was chemically stable.
  • Crystalline (S)-N-(4-morpholinyl-3 -fluorophenyl)-2-oxo-5 -oxazolidiny 1-methyl acetamide (Form II having an (R)-Linezolid content of 0.02%) (2.2 g) was mixed with xylene (20 ml) at 25 0 C. The mixture was heated to reflux and stirred for one hour to induce partial dissolution. The clearer slurry was then filtered and the obtained crystals were dried at 50 C in an oven overnight. The crystals obtained were analyzed by PXRD and shown to be Linezolid Form IV, with the same enantiomeric content.
  • Example 5 preparation of crystalline linezolid Form IV by reslurrying Form II in toluene
  • Crystalline (S)-N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl acetamide (Form II having an (R)-Linezolid content of 0.02%) (2.2 g) was mixed with toluene (20 ml) at 25 0 C. The mixture was heated to reflux and stirred for one hour to induce partial dissolution. The clearer slurry was then filtered and the obtained crystals were dried at 50 0 C in an oven overnight. The crystals obtained were analyzed by PXRD and shown to be Linezolid Form IV, with the same enantiomeric content.
  • Example 6 preparation of crystalline linezolid Form IV by reslurrying Form II in a silicon fluid
  • Crystalline (S)-N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl acetamide (Form II having an (R)-Linezolid content of 0.02%) (2.2 g) was mixed with a silicon fluid (20 ml) at 25 0 C. The mixture was heated to 14O 0 C and stirred for one hour to induce partial dissolution. The clearer slurry was then filtered and the obtained crystals were dried at 50 C in an oven overnight. The crystals obtained were analyzed by PXRD and shown to be Linezolid Form IV, with the same enantiomeric content
  • Example 7 preparation of crystalline linezolid Form II from a slurry of Form IV
  • a slurry of linezolid Form IV was produced by combining linezolid Form IV (2.0 g) with one of the solvents listed below, at room temperature. The slurry was then stirred for 1 to 24 hours, followed by filtering and drying the obtained crystals. The crystals were analyzed by PXRD and shown to be Form II of Linezolid, as summarized in the following Table 3:

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Abstract

The present invention provides a novel crystalline form of linezolid referred to herein as Form IV as well as methods for the preparation and use of Form IV. The present invention provides pharmaceutical compositions that comprise therapeutically effective amounts of Form IV that can be used to treat patients suffering from gram­positive bacterial infections. Various processes for making crystalline linezolid Form IV are disclosed.

Description

CRYSTALLINE FORM IV OF LINEZOLID
Cross-reference to Related Applications
This application claims the benefit of provisional applications Serial Numbers 60/584,371, filed June 29, 2004; 60/584,283, filed June 30, 2004; 60/601,086, filed August 12, 2004; 60/602,227, filed August 17, 2004; 60/633,887, filed December 7, 2004; 60/656,646, filed February 24, 2005; 60/656,778, filed February 24, 2005; 60/678,440, filed May 5, 2005; and 60/684,410, filed May 24, 2005; which are incorporated herein by reference.
Field of the Invention
The present invention relates to a novel crystalline form of linezolid (Form IV) as well as to novel methods of preparing and using Form IV.
Background of the Invention
Linezolid [(S)-N- [ [3 -(3-Fluoro-4-morpholinyl)phenyl] -2-oxo-5 -oxazolidinyljmethyl] acetamide] is an antimicrobial agent. Linezolid is an oxazolidinone, having the empirical formula C16H2QFN3O4 and the following structure:
Figure imgf000002_0001
Linezolid is described in The Merck Index (13th edition, Monograph number: 05526, CAS Registry Number: 165800-03-3) as white crystals, with a melting point of 181.5- 182.5°. Linezolid, as well as a process for its preparation, is disclosed in U.S. Patent No. 5,688,792 (Example 5), European Patent No. 717738, Israeli Patent No. 110,802, Canadian Patent No. 2,168,560, and International Patent Publication WO 95/07271.
Crystalline Form II linezolid is disclosed in U.S. Patent No. 6,559,305.
Linezolid is marketed in the United States by Pfizer, Inc. as an injection, tablets, and oral suspension under the name ZYVOX®. Its main indications are nosocomial pneumonia, skin and skin-structure infections, and vancomycin-resistant Enterococcus faecium infections.
The present invention relates to the solid state physical properties of Linezolid. These properties can be influenced by controlling the conditions under which Linezolid is obtained in solid form. Solid state physical properties include, for example, the flowability of the milled solid. Flowability affects the ease with which the material is handled during processing into a pharmaceutical product. Glidants are often added to improve the flowability of a non-compacted solid composition and to improve the accuracy of dosing. When particles of the powdered compound do not flow past each other easily, a formulation specialist must take that fact into account in developing a tablet or capsule formulation, which may necessitate the use of glidants such as colloidal silicon dioxide, talc, starch or tribasic calcium phosphate.
Crystal forms with platelet shape have better flowability than crystals with needle shape (M. Rouhi, The Right Stuff; Chemical & Engineering News; 24th Feb. 2003). Crystals with plate shape are more advantageous than those with needle shape for injection. A suspension of plate-shaped crystals maybe injected through a smaller needle with greater ease than a suspension of needle-shaped crystals. (S.R. Byrn et al. Solid-State Chemistry of Drugs 2nd Edition pg.4).
Another important solid state property of a pharmaceutical compound is its rate of dissolution in aqueous fluid. The rate of dissolution of an active ingredient in a patient's stomach fluid can have therapeutic consequences since it imposes an upper limit on the rate at which an orally-administered active ingredient can reach the patient's bloodstream. The rate of dissolution is also a consideration in formulating syrups, elixirs and other liquid medicaments. The solid state form of a compound may also affect its behavior on compaction and its storage stability.
These practical physical characteristics are influenced by the conformation and orientation of molecules in the unit cell, which defines a particular polymorphic form of a substance. These conformational and orientation factors in turn result in particular intramolecular interactions such that different polymorphic forms may give rise to distinct spectroscopic properties that may be detectable by powder X-ray diffraction, solid state 13C NMR spectrometry and infrared spectrometry. A particular polymorphic form may also give rise to thermal behavior different from that of the amorphous material or another polymorphic form. Thermal behavior is measured in the laboratory by such techniques as capillary melting point, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) and can be used to distinguish some polymorphic forms from others.
The discovery of new polymorphic forms of a pharmaceutically useful compound provides a new opportunity to improve the performance characteristics of a pharmaceutical product. It enlarges the repertoire of materials that a formulation scientist has available for designing, for example, a pharmaceutical dosage form of a drug with a targeted release profile or other desired characteristic. There is a need in the art for additional polymorphic forms of Linezolid.
Summary of the Invention
The present invention provides linezolid crystalline Form IV. Form IV is characterized by a powder X-ray diffraction (PXRD) pattern with peaks at about 13.5, 18.0, 21.1, 22.2 and 25.4 ±0.2 degrees 2 theta. Form IV may be further characterized by PXRD peaks at about 7.5, 18.7, 19.9, 27.7 and 28.4 ±0.2 degrees 2 theta. Form TV may be further characterized by a PXRD pattern substantially as depicted in Figure 1.
The crystalline linezolid Form IV of the present invention is polymorphically pure, i.e., contains less than about 10% Form II, preferably less than about 5% Form II, and even more preferably less than about 1% Form π, and most preferably, less than about 0.5% Form II (by weight).
The crystalline linezolid Form IV of the present invention is anhydrous, and is stable against transformation into Form II upon storage at a relative humidity of about 0% to about 100% at room temperature for at least 10 days.
The present invention also provides crystalline linezolid Form IV that is enantiomerically pure with respect to its R-enantiomer, i.e., containing less than about 0.1% area by HPLC of the R-enantiomer, preferably less than about 0.02% area by HPLC of the R-enantiomer.
In one embodiment, the novel crystalline linezolid Form IV is in the form of irregular plate crystals when observed under the microscope.
Another embodiment of the present invention is a novel method of making crystalline linezolid Form IV that comprises spray-drying a solution of linezolid at a temperature of at least 5O0C.
Also described in the present invention is another process for preparing crystalline linezolid Form IV comprising the step of heating crystalline linezolid Form II.
Form IV may also be prepared comprising the step of heating a slurry of form II in an aromatic solvent.
Another aspect of the present invention is the preparation of Form II from a slurry of Form IV in water or an organic solvent.
hi another embodiment, the crystalline linezolid Form IV provided by the present invention has a preferred maximum particle size of 500 μm.
Another embodiment of the present invention is a pharmaceutical formulation comprising a therapeutically effective amount of crystalline linezolid Form IV, combined with a pharmaceutically acceptable excipient or carrier. A further embodiment of the present invention is a method for treating a patient suffering from a gram positive bacterial infection, using a formulation containing a therapeutically effective amount of crystalline linezolid Form IV.
Figures
Figure 1 is a powder X-Ray diffractogram of crystalline linezolid Form IV.
Figure 2a-2c is an FTIR spectrum of crystalline linezolid Form IV obtained with the mineral oil mull technique.
Figure 2d-2f is an FTIR spectrum of crystalline Linezolid Form IV obtaind with the DRIFT technique.
Figure 3 is a DSC thermogram of crystalline linezolid Form IV.
Figure 4a-4d is an FTRaman spectrum of crystalline linezolid Form IV.
Figure 5 shows the needle shape of crystals of crystalline linezolid Form II as seen through a microscope.
Figure 6 shows the plate shape of crystals of crystalline linezolid Form IV as seen through a microscope.
Figure 7 also shows the plate shape of crystals of crystalline linezolid Form IV as seen through a microscope.
Figure 8 is a DSC thermogram of crystalline linezolid Form II.
Detailed Description of the Invention The term "spray drying" broadly refers to processes involving breaking up liquid mixtures into small droplets (atomization) and rapidly removing solvent from the mixture. In a typical spray-drying apparatus, there is a strong driving force for evaporation of solvent from the droplets, which maybe provided by a heated drying gas. Spray-drying processes and equipment are described in Perry's Chemical Engineer's Handbook, pgs. 20-54 to 20-57 (Sixth Edition 1984).
By way of non-limiting example only, the typical spray-drying apparatus comprises a drying chamber, atomizing means for atomizing a solvent-containing feed into the drying chamber, a source of heated drying gas that flows into the drying chamber to remove solvent from the atomized-solvent-containing feed, an outlet for the products of drying, and product collection means located downstream of the drying chamber. Examples of such apparatuses include Niro Models PSD-I, PSD-2 and PSD-4 (Niro A/S, Soeborg, Denmark). Typically, the product collection means includes a cyclone connected to the drying apparatus. In the cyclone, the particles produced during spray-drying are separated from the drying gas and evaporated solvent, allowing the particles to be collected. A filter may also be used to separate and collect the particles produced by spray-drying. The process of the invention is not limited to the use of such drying apparatuses as described above.
"Therapeutically effective amount" means the amount of a crystalline form that, when administered to a patient for treating a disease or other undesirable medical condition, is sufficient to have a beneficial effect with respect to that disease or condition. The "therapeutically effective amount" will vary depending on the crystalline form, the disease or condition and its severity, and the age, weight, etc., of the patient to be treated. Determining the therapeutically effective amount of a given crystalline form is within the ordinary skill of the art and requires no more than routine experimentation.
The present invention provides crystalline linezolid Form IV, characterized by a powder X-ray diffraction (PXRD) pattern with peaks at about 13.5, 18.0, 21.1, 22.2, and 25.4 ±0.2 degrees 2 theta. Form IV may be further characterized by PXRD peaks at about 7.5, 18.7, 19.9, 27.7, and 28.4 ±0.2 degrees 2 theta. Form IV may be further characterized by a PXRD pattern substantially as depicted in Figure 1. Crystalline linezolid Form IV may be further characterized by an FTIR spectrum with peaks at about 3333, 2817, 1732, 1661, 1540, 1515, 1335, 1256, 1229, 1200, 1213, 1148, 1080, 1059, 1050, 903, 825, 755, and 662 cm"1. Crystalline linezolid Form IV may be further characterized by an FTIR spectrum substantially as depicted in Figure 2a-2c or in Figure 2d-2f. The most characteristic FTIR peaks are 2817, 1335, 1229, 1200, and 662 cm"1.
Crystalline linezolid Form IV may also be characterized by a differential scanning calorimetry (DSC) thermogram substantially as depicted in Figure 3. Form IV has a characteristic DSC thermogram compared to the DSC thermogram of Form II (Figure 8). Form II has a sharp endothermic peak around 1550C, followed by a sharp exothermic peak at around 16O0C, and another sharp endothermic peak at around 18O0C, which corresponds to the final melting of linezolid. Form IV has only one sharp endothermic peak, which corresponds to the final melting of linezolid.
Crystalline linezolid Form IV may be further characterized by an FTRaman spectrum having peaks at about 2975, 2930, 2865, 1083, and 750 cm"1. Crystalline linezolid Form IV may be further characterized by an FTRaman spectrum substantially as depicted in Figure 4a-4d.
The invention also provides crystalline linezolid Form TV, which has about 0.1% water by weight. Form IV may also be characterized by a weight loss measured by thermal gravimetric analysis (TGA) of about 0.1% by weight. This embodiment of Form IV is anhydrous. Thus, the present invention includes crystalline linezolid Form IV which has about 0.1 % or less water by weight.
The crystalline linezolid Form IV of the present invention can be made in the form of irregular plate crystals. The previously known crystalline linezolid Form II forms needle shaped crystals. The flowability of crystals with an irregular plate shape of the present invention is much better than the flowability of crystals with needle shape. Another advantage of the irregular plate crystals is that they are easier to work with than needle shaped linezolid of the prior art. The bulk properties of the crystalline linezolid Form IV of the present invention are advantageous compared to those of the prior art linezolid. The difference between the needle-shaped crystals of Form II and the plate-shaped crystals of Form IV can be appreciated by a comparison of Figure 5 (Form II) with Figure 6 (Form IV) or Figure 7 (also Form IV).
The crystalline linezolid Form IV provided in the present invention is enantiomerically pure. Enantiomerically pure linezolid Form IV contains the unwanted R-enantiomer at a level of less than about 0.1% area by HPLC. Preferably, the enantiomerically pure linezolid Form IV of the present invention contains less than about 0.02% area by HPLC of the R-enantiomer.
The crystalline linezolid Form IV of the present invention is also polymorphically pure. Thus, it contains less than about 10% Form II, preferably less than about 5% Form II, and even more preferably less than about 1% Form II, and most preferably, less than about 0.5% Form II (by weight).
The present invention provides a novel method of making crystalline linezolid Form IV by spray-drying a solution of linezolid at a temperature of at least 5O0C. This method comprises dissolving linezolid in a polar organic solvent at about room temperature, pumping the obtained solution into a spray dryer and contacting it with a nitrogen gas at a temperature of at least 5O0C until Form IV is obtained. Preferably, the polar organic solvent is methanol.
The present invention provides another process for preparing crystalline linezolid Form IV comprising the step of heating crystalline linezolid Form II to a temperature of at least 85°C, preferably for at least one hour.
Form IV may also be prepared by heating a slurry of Form II in an organic solvent. The slurry is produced by combining Form II with an aromatic solvent at room temperature, followed by heating for one hour to induce partial dissolution. The partially clear slurry is then filtered and the obtained solid is dried, providing crystals that were analyzed by PXRD and shown to be linezolid Form IV.
Preferred organic solvents are aromatic solvents and more preferably, xylene and toluene. Another preferred solvent is a silicon fluid. Enantiomerically pure Form IV is prepared by slurrying Form II in an organic solvent, as described above, and using Form II that contains a maximum of 0.1% of the R- enantiomer. Preferably, the Form II contains less than about 0.02% of the R- enantiomer.
Form II and the solvents used in the slurrying processes are preferably combined at 250C, providing a slurry that is heated, preferably to reflux, when an aromatic solvent is used, and more preferably, to 14O0C, when a silicon fluid is used. The isolated linezolid Form IV is dried, preferably in an oven, preferably by heating to a temperature of 500C.
The invention encompasses a process for the transformation of Form IV into Form II comprising combining Form IV at room temperature with water or with an organic solvent selected from the group consisting of a ketone, a straight or branched C1-C4 alcohol, an ester, an aromatic solvent, and a nitrile, to obtain a slurry, and maintaining the slurry for at least about one hour. The slurry is then filtered, providing crystals of Form II, which are then dried and analyzed by PXRD.
The temperature of the reaction is preferably room temperature. The slurry is maintained for at least about one hour, preferably for about one hour to about 24 hours.
The stability of linezolid Form IV was tested by storing it for 10 days at a relative humidity of between 0 and 100% at room temperature. The results are summarized in Table 1.
TABLE l
Figure imgf000011_0001
Form rV has proven to be stable and non-hygroscopic between 0-100 % RH.
The long term stability of linezolid Form IV was tested by storing it at room temperature and under accelerated conditions at 40° C and 55 °C. The results are summarized in Table 2.
Table 2
Figure imgf000011_0002
Form IV has proven to be stable at 25°C, 400C, and 55°C for a minimum of 3 months.
The particle size distribution (PSD) of the active ingredient is one of the key parameters of a formulation. For measuring particle size, the following main methods may be employed: sieves, sedimentation, electrozone sensing (coulter counter), microscopy, Low Angle Laser Light Scattering (LALLS). The crystalline linezolid Form rV of the present invention has a preferred maximum particle size of 500 μm. Preferably, the particle size is less than 300 μm, less than 200 μm, less than 100 μm, or even less than 50 μm. Another embodiment of the present invention is a pharmaceutical formulation comprising a therapeutically effective amount of crystalline linezolid Form IV, combined with a pharmaceutically acceptable excipient or carrier.
Another embodiment of the present invention is a method for treating a patient suffering from a gram positive bacterial infection, comprising the step of administering to the patient the pharmaceutical formulation comprising a therapeutically effective amount of crystalline linezolid Form IV.
The crystalline linezolid Form IV of the present invention used to prepare pharmaceutical formulations may be substantially pure with respect to other crystalline forms, i.e., the pharmaceutical formulations may contain less than about 10%, preferably less than about 5%, and even more preferably less than about 1% (by weight) of other crystalline forms of linezolid. hi particular, the pharmaceutical formulations may contain less than about 10%, preferably less than about 5%, and more preferably less than about 1%, and even more preferably less than 0.5% (by weight) of crystalline linezolid Form II. Li certain embodiments, the pharmaceutical formulations may contain less than about 10%, preferably less than about 5%, and even more preferably less than about 1% (by weight) of amorphous linezolid.
hi other embodiments, pharmaceutical formulations of the present invention may contain crystalline linezolid Form IV in a mixture with other forms of linezolid.
hi addition to the active ingredient(s), the pharmaceutical formulations of the present invention may contain one or more excipients. Excipients are added to the formulation for a variety of purposes.
Diluents may be added to the formulations of the present invention. Diluents increase the bulk of a solid pharmaceutical composition, and may make a pharmaceutical dosage form containing the composition easier for the patient and care giver to handle. Diluents for solid compositions include, for example, microcrystalline cellulose (e.g., AVICEL®), rnicrofine cellulose, lactose, starch, pregelatinized starch, calcium carbonate, calcium sulfate, sugar, dextrates, dextrin, dextrose, dibasic calcium phosphate dihydrate, tribasic calcium phosphate, kaolin, magnesium carbonate, magnesium oxide, maltodextrin, mannitol, polymethacrylates (e.g., EUDRAGIT®), potassium chloride, powdered cellulose, sodium chloride, sorbitol, and talc.
Solid pharmaceutical compositions that are compacted into a dosage form, such as a tablet, may include excipients whose functions include helping to bind the active ingredient and other excipients together after compression. Binders for solid pharmaceutical compositions include acacia, alginic acid, carbomer (e.g., carbopol), carboxymethylcellulose sodium, dextrin, ethyl cellulose, gelatin, guar gum, hydrogenated vegetable oil, hydroxyethyl cellulose, hydroxypropyl cellulose (e.g., KLUCEL®), hydroxypropyl methyl cellulose (e.g., METHOCEL®), liquid glucose, magnesium aluminum silicate, maltodextrin, methylcellulose, polymethacrylates, povidone (e.g., KOLLIDON®, PLASDONE®), pregelatinized starch, sodium alginate, and starch.
The dissolution rate of a compacted solid pharmaceutical composition in the patient's stomach may be increased by the addition of a disintegrant to the composition. Disintegrants include alginic acid, carboxymethylcellulose calcium, carboxymethylcellulose sodium (e.g., AC-DI-SOL®, PRIMELLOSE®), colloidal silicon dioxide, croscarmellose sodium, crospovidone (e.g., KOLLIDON®,
POLYPLASDONE®), guar gum, magnesium aluminum silicate, methyl cellulose, microcrystalline cellulose, polacrilin potassium, powdered cellulose, pregelatinized starch, sodium alginate, sodium starch glycolate (e.g., EXPLOTAB®), and starch.
Glidants can be added to improve the flowability of a non-compacted solid composition and to improve the accuracy of dosing. Excipients that may function as glidants include colloidal silicon dioxide, magnesium trisilicate, powdered cellulose, starch, talc, and tribasic calcium phosphate.
When a dosage form such as a tablet is made by the compaction of a powdered composition, the composition is subjected to pressure from a punch and dye. Some excipients and active ingredients have a tendency to adhere to the surfaces of the punch and dye, which can cause the product to have pitting and other surface irregularities. A lubricant can be added to the composition to reduce adhesion and ease the release of the product from the dye. Lubricants include magnesium stearate, calcium stearate, glyceryl monostearate, glyceryl palmitostearate, hydrogenated castor oil, hydrogenated vegetable oil, mineral oil, polyethylene glycol, sodium benzoate, sodium lauryl sulfate, sodium stearyl fumarate, stearic acid, talc, and zinc stearate.
Flavoring agents and flavor enhancers make the dosage form more palatable to the patient. Common flavoring agents and flavor enhancers for pharmaceutical products that may be included in the composition of the present invention include maltol, vanillin, ethyl vanillin, menthol, citric acid, fumaric acid, ethyl maltol, and tartaric acid.
Solid and liquid compositions may also be dyed using any pharmaceutically acceptable colorant to improve their appearance and/or facilitate patient identification of the product and unit dosage level.
The present invention is not intended to encompass true solutions of crystalline linezolid Form IV whereupon the crystal structure of the novel Form IV and the properties that characterize the novel crystalline form of the present invention are lost. However, the use of the novel form to prepare such solutions (e.g., so as to deliver linezolid in a liquid pharmaceutical formulation) is considered to be within the contemplation of the invention.
hi liquid pharmaceutical compositions prepared using Form IV of the present invention, Form IV and any other solid excipients are dissolved or suspended in a liquid carrier such as water, vegetable oil, alcohol, polyethylene glycol, propylene glycol, or glycerin.
Liquid pharmaceutical compositions may contain emulsifying agents to disperse uniformly throughout the composition an active ingredient or other excipient that is not soluble in the liquid carrier. Emulsifying agents that may be useful in liquid compositions of the present invention include, for example, gelatin, egg yolk, casein, cholesterol, acacia, tragacanth, chondrus, pectin, methyl cellulose, carbomer, cetostearyl alcohol, and cetyl alcohol. Liquid pharmaceutical compositions may also contain a viscosity enhancing agent to improve the mouth-feel of the product and/or coat the lining of the gastrointestinal tract. Such agents include acacia, alginic acid bentonite, carbomer, carboxymethylcellulose calcium or sodium, cetostearyl alcohol, methyl cellulose, ethylcellulose, gelatin guar gum, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, maltodextrin, polyvinyl alcohol, povidone, propylene carbonate, propylene glycol alginate, sodium alginate, sodium starch glycolate, starch tragacanth, and xanthan gum.
Sweetening agents such as sorbitol, saccharin, sodium saccharin, sucrose, aspartame, fructose, mannitol, and invert sugar may be added to improve the taste.
Preservatives and chelating agents such as alcohol, sodium benzoate, butylated hydroxyl toluene, butylated hydroxyanisole, and ethylenediamine tetraacetic acid may be added at levels safe for ingestion to improve storage stability.
A liquid composition may also contain a buffer such as guconic acid, lactic acid, citric acid or acetic acid, sodium guconate, sodium lactate, sodium citrate, or sodium acetate. Selection of excipients and the amounts used may be readily determined by the formulation scientist based upon experience and consideration of standard procedures and reference works in the field.
The solid compositions of the present invention include powders, granulates, aggregates and compacted compositions. The dosages include dosages suitable for oral, buccal, rectal, parenteral (including subcutaneous, intramuscular, and intravenous), inhalant, and ophthalmic administration. Although the most suitable administration in any given case will depend on the nature and severity of the condition being treated, the most preferred route of the present invention is oral. The dosages may be conveniently presented in unit dosage form and prepared by any of the methods well-known in the pharmaceutical arts.
Dosage forms include solid dosage forms like tablets, powders, capsules, suppositories, sachets, troches and lozenges, as well as liquid syrups, suspensions and elixirs. The dosage of GEODON may be used as guidance. The oral dosage form of the present invention is preferably in the form of an oral capsule having a dosage of about 10 mg to about 160 mg, more preferably from about 20 mg to about 80 mg, and most preferably capsules of 20, 40, 60 and 80 mg. Daily dosages may include 1, 2, or more capsules per day.
The dosage form of the present invention may be a capsule containing the composition, preferably a powdered or granulated solid composition of the invention, within either a hard or soft shell. The shell may be made from gelatin and optionally contain a plasticizer such as glycerin and sorbitol, and an opacifying agent or colorant.
A composition for tableting or capsule filling may be prepared by wet granulation. In wet granulation, some or all of the active ingredients and excipients in powder form are blended and then further mixed in the presence of a liquid, typically water, that causes the powders to clump into granules. The granulate is screened and/or milled, dried and then screened and/or milled to the desired particle size. The granulate may then be tableted, or other excipients may be added prior to tableting, such as a glidant and/or a lubricant.
A tableting composition may be prepared conventionally by dry blending. For example, the blended composition of the actives and excipients may be compacted into a slug or a sheet and then comminuted into compacted granules. The compacted granules may subsequently be compressed into a tablet.
As an alternative to dry granulation, a blended composition may be compressed directly into a compacted dosage form using direct compression techniques. Direct compression produces a more uniform tablet without granules. Excipients that are particularly well suited for direct compression tableting include microcrystalline cellulose, spray dried lactose, dicalcium phosphate dihydrate and colloidal silica. The proper use of these and other excipients in direct compression tableting is known to those in the art with experience and skill in particular formulation challenges of direct compression tableting. A capsule filling of the present invention may comprise any of the aforementioned blends and granulates that were described with reference to tableting, however, they are not subjected to a final tableting step.
The active ingredient and excipients may be formulated into compositions and dosage forms according to methods known in the art.
The crystalline linezolid Form IV of the present invention may be used in pharmaceutical formulations or compositions as a single active ingredient or as a mixture together with other crystalline forms of linezolid or with amorphous linezolid.
However, it is preferred that the pharmaceutical formulations or compositions of the present invention contain 25-100% by weight, especially 50-100% by weight, of crystalline linezolid Form IV, based on the total amount of linezolid in the formulation or composition. Preferably, such an amount of crystalline linezolid Form
IV is 75-100% by weight, especially 90-100% by weight. Highly preferred is an amount of 95-100% by weight.
Having described the invention with reference to certain preferred embodiments, other embodiments will become apparent to one skilled in the art from consideration of the specification. The invention is further defined by reference to the following examples describing in detail the preparation of the composition and methods of use of the invention. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the invention.
Examples
Microscopic samples were prepared in mineral oil suspension and placed between slides.
Powder X-ray diffraction
Powder X-ray diffraction data were obtained by methods known in the art using a
SCINTAG® powder X-ray diffractometer model X'TRA® equipped with a solid state detector. Copper radiation of 1.5418 A was used. A round aluminum sample holder with round zero background quartz plate was used, with cavity of 25(diameter)* 0.5(depth) mm. The obtained characteristic peaks were in the range of 2-40 degrees two theta.
DSC analysis was done using a Mettler 821 Star0. The weight of the samples was about 5 mg; the samples were scanned at a rate of 10°C/min from 3O0C to 25O0C. The oven was constantly purged with nitrogen gas at a flow rate of 40 ml/min. Standard 70 μl alumina crucibles covered by lids with 1 hole were used.
IR analysis was done using a Perkin Elmer SPECTRUM ONE FT-IR spectrometer in DRIFT mode or using mineral oil mull technique. The samples in the 4000-400 cm"1 interval were scanned 16 times with 4.0 cm'1 resolution.
The FTRaman analysis was performed by Bruker RFS-100/S Raman spectrometer. The scanning parameters were:
Range: 3500 to 50 cm"1;
Aperture Setting: 10.0mm;
Low Pass Filter 16: IkHz; Source Setting Laser: 9394.0 cm"1, 1600 mW;
Raman Laser Power: 500 mW;
Scanner: Velocity 5.0 at 4 kHz;
Sample Scans: 100; and
Resolution: 4.0 cm"1.
Example 1 - preparation of crystalline linezolid Form IV
A flask containing 5.5 g of (S)-N-(4-moφholinyl-3-fluorophenyl)-2-oxo-5- oxazolidinyl-methyl amine and 20 ml ammonium hydroxide in 200 ml toluene was mixed at 25°C. Triethyl amine (2 equivalents) was added. The mixture was cooled to 30C and acetic anhydride (2.5 equivalents) was added dropwise. The reaction mixture was brought to RT. Linezolid that precipitated from the reaction mixture was filtered. The wet crystals were analyzed by PXRD and shown to be crystalline linezolid Form IV.
Example 2 - Procedure for the preparation of crystalline linezolid Form IV
This example was carried out on a Buchi Mini Spray Dryer B-290. 5 g of linezolid was dissolved in methanol (300 ml) at room temperature. The obtained solution was pumped into the spray dryer. The nitrogen was at an inlet temperature of 5O0C. The evaporated solvent and nitrogen exited the spray dryer at 35°C. The obtained sample was analyzed by PXRD and shown to be linezolid Form IV.
Example 3 - preparation of crystalline linezolid Form IV by heating crystalline linezolid Form II
Crystalline linezolid Form IV may be prepared by heating crystalline linezolid Form II to a temperature higher than 85°C. Crystalline linezolid Form IV is obtained by keeping crystalline linezolid Form II at a temperature of between 85-1750C. As an example, crystalline linezolid Form π was kept at a temperature of 17O0C during one hour. The polymorphic form of crystalline linezolid Form II was changed to crystalline linezolid Form IV. The crystalline linezolid Form IV obtained at 17O0C was chemically stable.
Example 4 - preparation of crystalline linezolid Form IV by reslurrying Form II in xylene
Crystalline (S)-N-(4-morpholinyl-3 -fluorophenyl)-2-oxo-5 -oxazolidiny 1-methyl acetamide (Form II having an (R)-Linezolid content of 0.02%) (2.2 g) was mixed with xylene (20 ml) at 250C. The mixture was heated to reflux and stirred for one hour to induce partial dissolution. The clearer slurry was then filtered and the obtained crystals were dried at 50 C in an oven overnight. The crystals obtained were analyzed by PXRD and shown to be Linezolid Form IV, with the same enantiomeric content.
Example 5 - preparation of crystalline linezolid Form IV by reslurrying Form II in toluene
Crystalline (S)-N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl acetamide (Form II having an (R)-Linezolid content of 0.02%) (2.2 g) was mixed with toluene (20 ml) at 250C. The mixture was heated to reflux and stirred for one hour to induce partial dissolution. The clearer slurry was then filtered and the obtained crystals were dried at 500C in an oven overnight. The crystals obtained were analyzed by PXRD and shown to be Linezolid Form IV, with the same enantiomeric content. Example 6 - preparation of crystalline linezolid Form IV by reslurrying Form II in a silicon fluid
Crystalline (S)-N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl acetamide (Form II having an (R)-Linezolid content of 0.02%) (2.2 g) was mixed with a silicon fluid (20 ml) at 250C. The mixture was heated to 14O0C and stirred for one hour to induce partial dissolution. The clearer slurry was then filtered and the obtained crystals were dried at 50 C in an oven overnight. The crystals obtained were analyzed by PXRD and shown to be Linezolid Form IV, with the same enantiomeric content
Example 7 - preparation of crystalline linezolid Form II from a slurry of Form IV
A slurry of linezolid Form IV was produced by combining linezolid Form IV (2.0 g) with one of the solvents listed below, at room temperature. The slurry was then stirred for 1 to 24 hours, followed by filtering and drying the obtained crystals. The crystals were analyzed by PXRD and shown to be Form II of Linezolid, as summarized in the following Table 3:
Table 3
Figure imgf000020_0001
Figure imgf000021_0001

Claims

What is claimed is:
1. Crystalline linezolid characterized by data selected from the group consisting of: a) a powder X-ray diffraction pattern with peaks at about 13.5, 18.0, 21.1,
22.2, and 25.4 ±0.2 degrees 2 theta; b) an FTIR spectrum with peaks at about 2817, 1335, 1229, 1200, and 662 cm"1; and c) an FTRaman spectrum with peaks at about 2975, 2930, 2865, 1083, and 750 cm"1.
2. The crystalline linezolid of claim 1 characterized by an FTIR spectrum with peaks at about 3333, 2817, 1732, 1661, 1540, 1515, 1335, 1256, 1229, 1200, 1213, 1148, 1080, 1059, 1050, 903, 825, 755, and 662 cm"1.
3. The crystalline linezolid of claim 1 characterized by a powder X-ray diffraction pattern with peaks at about 7.5, 13.5, 18.0, 18.7, 19.9, 21.1, 22.2, 25.4, 27.7, and 28.4 ±0.2 degrees 2 theta.
4. The crystalline linezolid of claim 1 which has a powder X-ray diffraction pattern substantially as depicted in Figure 1 or an FTIR spectrum substantially as depicted in Figure 2a-2c or in Figure 2d-2f.
5. The crystalline linezolid of claim 1 which has a DSC thermogram substantially as depicted in Figure 3 or an FTRaman spectrum substantially as depicted in
Figure 4a-4d.
6. The crystalline linezolid of claim 1, having a plate-shaped morphology.
7. The crystalline linezolid of claim 1 which has about 0.5 % or less water by weight.
8. The crystalline linezolid of claim 1 having a content of less than 0.5% (w/w) of the R-enantiomer of linezolid.
9. The crystalline linezolid of claim 1, containing less than about 10% of crystalline Form II.
10. The crystalline linezolid of claim 9, containing less than about 5% of crystalline Form II.
11. The crystalline linezolid of claim 10, containing less than about 0.5% of crystalline Form II.
12. The crystalline linezolid of claim 1 which is stable against transformation into Form II upon storage at a relative humidity of about 0% to about 100% at room temperature for at least 10 days.
13. A method of preparing the crystalline linezolid of claim 1, comprising: a) dissolving linezolid in a polar organic solvent to form a linezolid solution; b) spray-drying the linezolid solution at a temperature of at least 50°C
14. The method of claim 13 where the dissolving is carried out at room temperature
15. The method of claim 13 where the polar organic solvent is methanol.
16. The method of claim 13 where the spray-drying is carried out with nitrogen gas.
17. A process for preparing the crystalline linezolid of claim 1, comprising heating crystalline Linezolid Form II to a temperature of at least 850C for at least one hour.
18. A process for preparing crystalline linezolid Form II comprising: a) combining crystalline linezolid Form IV with a solvent at room temperature to form a slurry; b) stirring the slurry for 1 to 24 hours to obtain crystalline material; c) filtering and drying the crystalline material to obtain crystalline linezolid Form π.
19. The process of claim 18 where the solvent is selected from the group consisting of: acetone, EtOH 95%, EtOAc, toluene, CAN, IPA, and H2O.
20. A process for preparing crystalline linezolid Form IV comprising: a) combining crystalline linezolid Form II with a solvent at room temperature to form a slurry; b) heating the slurry; c) filtering the heated slurry to obtain crystalline linezolid Form IV.
21. The process of claim 20 where the solvent is selected from the group consisting of: xylene, toluene, and a silicon fluid.
22. A pharmaceutical composition comprising a therapeutically effective amount of the crystalline linezolid of claim 1 and a pharmaceutically acceptable excipient or carrier.
23. A method of treating a patient with a gram-positive bacterial infection comprising administering to the patient the pharmaceutical composition of claim 22.
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