WO2005123964A3 - Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement - Google Patents

Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement Download PDF

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Publication number
WO2005123964A3
WO2005123964A3 PCT/US2005/021211 US2005021211W WO2005123964A3 WO 2005123964 A3 WO2005123964 A3 WO 2005123964A3 US 2005021211 W US2005021211 W US 2005021211W WO 2005123964 A3 WO2005123964 A3 WO 2005123964A3
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WIPO (PCT)
Prior art keywords
treatment
methods
susceptibility gene
human stroke
stroke
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PCT/US2005/021211
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English (en)
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WO2005123964A2 (fr
Inventor
Solveig Gretarsdottir
Gudmar Thorleifsson
Jeffrey R Gulcher
Original Assignee
Decode Genetics Ehf
Solveig Gretarsdottir
Gudmar Thorleifsson
Jeffrey R Gulcher
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Publication date
Priority claimed from US10/067,514 external-priority patent/US20030054531A1/en
Priority claimed from US10/419,723 external-priority patent/US20040014099A1/en
Priority claimed from PCT/US2003/029906 external-priority patent/WO2004028341A2/fr
Priority claimed from US10/868,397 external-priority patent/US20050164220A1/en
Application filed by Decode Genetics Ehf, Solveig Gretarsdottir, Gudmar Thorleifsson, Jeffrey R Gulcher filed Critical Decode Genetics Ehf
Publication of WO2005123964A2 publication Critical patent/WO2005123964A2/fr
Publication of WO2005123964A3 publication Critical patent/WO2005123964A3/fr

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un rôle du gène PDE4D humain ainsi que des procédés de diagnostic, de prévision de l'évolution clinique et de traitement des accidents vasculaires cérébraux au moyen de polymorphismes du gène PDE4D.
PCT/US2005/021211 2001-03-19 2005-06-14 Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement WO2005123964A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US81135201A 2001-03-19 2001-03-19
US10/067,514 US20030054531A1 (en) 2001-03-19 2002-02-04 Human stroke gene
US10/255,120 US20040091865A1 (en) 2001-03-19 2002-09-25 Human stroke gene
US10/419,723 US20040014099A1 (en) 2001-03-19 2003-04-18 Susceptibility gene for human stroke; methods of treatment
US65012003A 2003-08-27 2003-08-27
PCT/US2003/029906 WO2004028341A2 (fr) 2001-03-19 2003-09-25 Gene de predisposition pour l'attaque chez l'homme, et procedes de traitement
US10/868,397 2004-06-14
US10/868,397 US20050164220A1 (en) 2001-03-19 2004-06-14 Susceptibility gene for human stroke: method of treatment

Publications (2)

Publication Number Publication Date
WO2005123964A2 WO2005123964A2 (fr) 2005-12-29
WO2005123964A3 true WO2005123964A3 (fr) 2006-05-26

Family

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Application Number Title Priority Date Filing Date
PCT/US2005/021211 WO2005123964A2 (fr) 2001-03-19 2005-06-14 Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement

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WO (1) WO2005123964A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2723590A1 (fr) * 1994-08-09 1996-02-16 Inst Nat Sante Rech Med Procede de detection et trousse de diagnostic in vitro d'une predisposition a l'infarctus du myocarde
WO2004028341A2 (fr) * 2001-03-19 2004-04-08 Decode Genetics Ehf. Gene de predisposition pour l'attaque chez l'homme, et procedes de traitement

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2723590A1 (fr) * 1994-08-09 1996-02-16 Inst Nat Sante Rech Med Procede de detection et trousse de diagnostic in vitro d'une predisposition a l'infarctus du myocarde
WO2004028341A2 (fr) * 2001-03-19 2004-04-08 Decode Genetics Ehf. Gene de predisposition pour l'attaque chez l'homme, et procedes de traitement

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOMINICZAK ANNA F ET AL: "Genetics of common polygenic stroke.", NATURE GENETICS. OCT 2003, vol. 35, no. 2, October 2003 (2003-10-01), pages 116 - 117, XP002354559, ISSN: 1061-4036 *
GRETARSDOTTIR SOLVEIG ET AL: "The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.", NATURE GENETICS, vol. 35, no. 2, October 2003 (2003-10-01), pages 131 - 138, XP002354558, ISSN: 1061-4036 *

Also Published As

Publication number Publication date
WO2005123964A2 (fr) 2005-12-29

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