WO2005123162A1 - Device for the filling of a plurality of syringes - Google Patents

Device for the filling of a plurality of syringes Download PDF

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Publication number
WO2005123162A1
WO2005123162A1 PCT/CH2004/000380 CH2004000380W WO2005123162A1 WO 2005123162 A1 WO2005123162 A1 WO 2005123162A1 CH 2004000380 W CH2004000380 W CH 2004000380W WO 2005123162 A1 WO2005123162 A1 WO 2005123162A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringes
dispensing member
filling
opening
cement
Prior art date
Application number
PCT/CH2004/000380
Other languages
French (fr)
Inventor
Thierry Stoll
Roman Egger
Ilka Boecken
Original Assignee
Synthes Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthes Gmbh filed Critical Synthes Gmbh
Priority to PCT/CH2004/000380 priority Critical patent/WO2005123162A1/en
Priority to TW094113417A priority patent/TW200600072A/en
Publication of WO2005123162A1 publication Critical patent/WO2005123162A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B65B3/10—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material
    • B65B3/12—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material mechanically, e.g. by pistons or pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8833—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A61J1/2062—Connecting means having multiple connecting ports with directional valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/223—Multiway valves

Definitions

  • the invention relates to a device for the filling of a plurality of syringes according to the preamble of claim 1 and a method for the filling of a plurality of syringes according to the preamble of claim 6.
  • Vertebroplasty is an effective treatment option for osteoporotic v@rte.bxal fractures and vertebral body augmentation.
  • Various injectable bi ⁇ rnaterials like Polymethylmethacrylate (PMMA) - a autopolymerising two-component system - or Calcium Phosphate (CaP) cements - a hydraulic cement hardening by the action of water as known e.g. from WO2004/000374 - are currently used as reinforcement materials together with appropriate cement injection instrumentations.
  • PMMA Polymethylmethacrylate
  • CaP Calcium Phosphate
  • the device according to the invention is related to the instrumentation used for vertebroplasty.
  • a cement mixing device is needed to mix the cement components and an application device to inject the cement through a cannula over the pedicles into the vertebral body.
  • An adequate mixing device for a surgical cement is described in PCT/WO03/084445.
  • a possible injection syringe to be attached on a cannula is the subject International Patent Application PCT/CH04/00067, not yet published.
  • An adequate cannula for injection of bone cements into vertebral bodies is described in WO0202033.
  • Two procedures are currently used to transfer a mixed cement into the vertebra: (1 ) the mixing device containing the mixed cement (e.g. cartridge, syringe) is connected directly to a cannula over an injection system (injection gun, tubing system, screw-in device); (2) the mixed cement contained in a mixing device (e.g. cartridge, syringe) is manually transferred to single portion syringes that are one after the other filled and connected to the cannula for cement injection.
  • injection gun injection gun, tubing system, screw-in device
  • the mixed cement contained in a mixing device e.g. cartridge, syringe
  • the last mentioned procedure (2) is preferred by the surgeon because it allows to apply the cement in small doses and to better control the injection force needed to augment the vertebra.
  • the invention intends to provide remedial measures.
  • the invention is based on the objective of providing a device allowing the use of single syringes for the application of cement into the vertebral body having the advantages of better feeling of the injection and of step by step injection.
  • the aim of the invention is the increase of the handling properties of cement portioning after the mixing procedure.
  • the invention solves the posed problem with a device for the filling of a plurality of syringes that displays the features of claim 1 , as well as with a method for the filling of a plurality of syringes that displays the features of claim 6.
  • the present invention allows to simplify the last mentioned procedure (2) of mixed cement transfer into single syringes.
  • the device according to the invention is used for the dispensing of freshly mixed surgical cement into cement syringes.
  • a varying number of little injection syringes is mounted on the device according o the invention by Luer lock or similar connection systems.
  • the mixing device containing the freshly mixed cement is then connected to the dispensing device according to the invention by Luer lock or similar connection systems and by one shut the cement can be transferred into all syringes simultaneously.
  • Luer lock or similar connection systems by Luer lock or similar connection systems
  • the injectable substance is a hardenable cement, particularly a surgical cement, e.g. a hydraulic cement or a two-component autopolymerising cement.
  • the discharge of the syringes may be effected sequentially. Therewith it is possible to prepare exact doses of surgical cement in the syringes.
  • the surgical cement may be prepared in one mixing device
  • each adapting means is configured as male or female Luer-lock adapter.
  • the dispensing member is realized as a longitudinal tube having a peripheral wall, a first end and a second end with a feed opening at the first end while the outlet openings are arranged axially spaced apart from each other and penetrating the peripheral wall transversely to the longitudinal axis.
  • the cavity within the dispensing member is provided with a discharge opening allowing prepared doses of injectable substances in each syringe to be discharged sequentially through the discharge opening.
  • the dispensing member is provided with a separate valve for each outlet opening.
  • the device comprises a filling device, e.g. a mixing apparatus with a mixing chamber of a volume V or a large syringe with an injection volume V.
  • a filling device e.g. a mixing apparatus with a mixing chamber of a volume V or a large syringe with an injection volume V.
  • the device additionally comprises a plurality of syringes being provided with an injection volume v whereby the ratio of v : V ranges between 0.2 and 0.5, preferably between 0.1 and 0.2.
  • V cement volume
  • the filling device has a cement volume V of 20ml, resp. 15-20ml.
  • this volume V may be divided in sub- volumes (e.g. V/2 & V/2) in order to use 2 syringes according to claim 8.
  • the small volume v allows good feeling of the injection process and better control of the injected total volume by the surgeon.
  • valves are configures as three-way valves.
  • the dispensing member offers the advantage that the syringes may be simultaneously or sequentially filled by feeding the injectable substance through the feed opening.
  • Fig. 1 a lateral view on one embodiment of the device according to the invention.
  • Fig. 2 a lateral view on the embodiment of Fig. 1 during filling one of the syringes.
  • Fig. 1 and 2 show an embodiment of the device 1 where a tube like dispensing member 2 is provided with a longitudinal axis 9 and a coaxial cavity 3.
  • the dispensing member 2 is realized through a longitudinal tube with a peripheral wall 12, whereby the cavity 3 is provided with a feed opening 4 at the first end 10 of the dispensing member 2 and a discharge opening 13 at the second end 11 of the dispensing member 2 as well as five outlet openings 5 being arranged sequentially and transversely to the longitudinal axis 9.
  • the outlet openings 5 are arranged axially spaced apart from each other and penetrate the peripheral wall 12 transversely to the longitudinal axis.
  • the feed openings are arranged axially spaced apart from each other and penetrate the peripheral wall 12 transversely to the longitudinal axis.
  • first adapting means 6 for being joined e.g. with a mixing apparatus or another filling device 16.
  • the first adapting means 6 are here configured as a female Luer-lock adapter.
  • Another female Luer-lock adapter is situated at the second end 11 of the dispensing member 2.
  • a second adapting means 7 is attached which is here configured as female Luer-lock adapter being engageable with a complementary third adapting means 7, e.g. a male Luer-lock adapter at the outlet of the syringes 14.
  • the dispensing member 2 is provided with a valve 8 at each outlet opening
  • Fig. 1 depicts all valves 8 at the outlet openings 5 in an open position and the syringes 14 with their pistons in their forward positions such allowing a simultaneous filling of the syringes 14 with a freshly mixed, injectable substance.
  • the substance may be filled into the cavity 3 from filling device 16, e.g. another syringe which is connected to the first adapting means 6 at the first end 10 of the dispensing member 2.
  • the discharge opening 13 is sealed by means of a sealing cap 17.
  • An exemplary positioning of the valves for sequential filling of the syringes 14 is shown in Fig. 2.
  • the two syringes 14 next to the feed opening 4 are already filled so that their corresponding valve 8a; 8b are in their open position allowing the substance being fed through the feed opening 4 to flow into the cavity 3 until the third valve 8c which is in a position allowing the substance only to flow through the third outlet opening 5 and subsequently into the connected third syringe 14.
  • Preferred materials for the dispensing member 2 are medical grade transparent polymers. The flow of the cements through the dispensing member 2 should be visible.
  • the discharge opening 13 has no specific meaning for this invention. A possible meaning could be used as a connection for a 6 th syringe or as outlet for superfluous cement.
  • the dispensing member 2 shown on the picture is already available on the market for haematological use, it can be imagined e.g. that the blood flow is given between opening 4 and opening 13.
  • the side openings 5 could be used for drug delivery or to take blood samples. But this is not the intended use of this invention.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Prostheses (AREA)

Abstract

Device (1) for the filling one or more syringes (14) with freshly mixed, injectable substances comprising A) a dispensing member (2) being provided with a cavity (3) which has a feed opening (4) for feeding an injectable mixture into the cavity (3) and a plurality of outlet openings (5) for filling syringes (14) being connectable to the dispensing member (2); whereby B) the dispensing member (2) is provided with a first adapting means (6) at the feed opening (4) for being connected to a filling device (16) and second adapting means (7) at the outlet openings (5) configured to engage with a complementary third adapting means (7) at the outlet of the syringes (14); and C) the dispensing member (2) is provided with at least one valve (8) allowing each outlet opening (5) to be opened or closed separately.

Description

Device for the filling of a plurality of syringes
The invention relates to a device for the filling of a plurality of syringes according to the preamble of claim 1 and a method for the filling of a plurality of syringes according to the preamble of claim 6.
Vertebroplasty is an effective treatment option for osteoporotic v@rte.bxal fractures and vertebral body augmentation. Various injectable biαrnaterials like Polymethylmethacrylate (PMMA) - a autopolymerising two-component system - or Calcium Phosphate (CaP) cements - a hydraulic cement hardening by the action of water as known e.g. from WO2004/000374 - are currently used as reinforcement materials together with appropriate cement injection instrumentations.
The device according to the invention is related to the instrumentation used for vertebroplasty. In order to perform vertebroplasty, a cement mixing device is needed to mix the cement components and an application device to inject the cement through a cannula over the pedicles into the vertebral body. An adequate mixing device for a surgical cement is described in PCT/WO03/084445. A possible injection syringe to be attached on a cannula is the subject International Patent Application PCT/CH04/00067, not yet published. An adequate cannula for injection of bone cements into vertebral bodies is described in WO0202033.
The success of the whole clinical procedure is time-dependent and handling steps by the surgical teams should be reduced to the minimum. After mixing of a cement, various working times including injection are available according to the chemical consistency of the used material before hardening of the cements. Due to hardening properties of the cements over time, injection-dependent handling steps (filling of injection syringes with mixed cement, injection of cement through cannula) are directly effected by the cement behavior and may alter the surgical procedure.
Two procedures are currently used to transfer a mixed cement into the vertebra: (1 ) the mixing device containing the mixed cement (e.g. cartridge, syringe) is connected directly to a cannula over an injection system (injection gun, tubing system, screw-in device); (2) the mixed cement contained in a mixing device (e.g. cartridge, syringe) is manually transferred to single portion syringes that are one after the other filled and connected to the cannula for cement injection. The last mentioned procedure (2) is preferred by the surgeon because it allows to apply the cement in small doses and to better control the injection force needed to augment the vertebra.
Besides the more difficult handling of these two procedures, they exhibit the following further drawbacks: a) with the current injection systems (injection gun, tubing system, screw-in device) it is very difficult to feel directly the pressure that is applied to the injection system and therefore to feel how the cement is injected into the bony structure of the vertebra. This may lead to an overpressure in the vertebral body followed by cement leakage out the vertebral body or to fat embolism due to over-displacement of the bone marrow inside the vertebral bone structure; and b) the mixing of the cement in a bowl and transfer to single syringes with a spatula is a "primitive" and messy procedure. Furthermore, PMMA cements are very odorous and therefore a closed system of cement mixing and dispensing is preferred.
On this point, the invention intends to provide remedial measures. The invention is based on the objective of providing a device allowing the use of single syringes for the application of cement into the vertebral body having the advantages of better feeling of the injection and of step by step injection. The aim of the invention is the increase of the handling properties of cement portioning after the mixing procedure.
The invention solves the posed problem with a device for the filling of a plurality of syringes that displays the features of claim 1 , as well as with a method for the filling of a plurality of syringes that displays the features of claim 6.
The main advantage of the device according to the invention is the time gain of the syringe filling (one shot = all syringes filled) instead of filling one by one with a spatula. Furthermore, the system is a closed system and does not expose the surgeon to evaporation of the odorous PMMA cement.
The present invention allows to simplify the last mentioned procedure (2) of mixed cement transfer into single syringes. In order to fill a cement into all single syringes at the same time and reduce the manual steps thereof, the device according to the invention is used for the dispensing of freshly mixed surgical cement into cement syringes. A varying number of little injection syringes is mounted on the device according o the invention by Luer lock or similar connection systems. The mixing device containing the freshly mixed cement is then connected to the dispensing device according to the invention by Luer lock or similar connection systems and by one shut the cement can be transferred into all syringes simultaneously. During this straightforward procedure there is almost no time loss where the cement properties can alter and lead to intermediate hardening of the surgical cement.
Preferably, the injectable substance is a hardenable cement, particularly a surgical cement, e.g. a hydraulic cement or a two-component autopolymerising cement.
Furthermore, the discharge of the syringes may be effected sequentially. Therewith it is possible to prepare exact doses of surgical cement in the syringes.
The advantages achieved by the invention are essentially to be seen in the fact that, thanks to the device according to the invention:
- the surgical cement may be prepared in one mixing device;
- exact doses of surgical cement may be prepared;
- easy handling of the device;
- the cleanness of the cement application may be improved; and
- a rapid preparation of exact doses and application of surgical cement is possible.
In the preferred embodiment each adapting means is configured as male or female Luer-lock adapter. Therewith, common syringes with Luer-lock connectors may be used. Preferably, the dispensing member is realized as a longitudinal tube having a peripheral wall, a first end and a second end with a feed opening at the first end while the outlet openings are arranged axially spaced apart from each other and penetrating the peripheral wall transversely to the longitudinal axis.
In another embodiment the cavity within the dispensing member is provided with a discharge opening allowing prepared doses of injectable substances in each syringe to be discharged sequentially through the discharge opening.
In a further embodiment the dispensing member is provided with a separate valve for each outlet opening.
In yet another embodiment the device comprises a filling device, e.g. a mixing apparatus with a mixing chamber of a volume V or a large syringe with an injection volume V.
In a further embodiment the device additionally comprises a plurality of syringes being provided with an injection volume v whereby the ratio of v : V ranges between 0.2 and 0.5, preferably between 0.1 and 0.2. It is intended that the filling device has a cement volume V of 20ml, resp. 15-20ml. However, this volume V may be divided in sub- volumes (e.g. V/2 & V/2) in order to use 2 syringes according to claim 8. It is intended to use small syringes with a cement volume v of 2ml each. The small volume v allows good feeling of the injection process and better control of the injected total volume by the surgeon.
In another embodiment the valves are configures as three-way valves. Therewith, the dispensing member offers the advantage that the syringes may be simultaneously or sequentially filled by feeding the injectable substance through the feed opening.
Additional advantageous embodiments of the invention are characterized in the subclaims.
The invention and additional configurations of the invention are explained in even more detail with reference to the partially schematic illustration of several embodiments. Shown are:
Fig. 1 a lateral view on one embodiment of the device according to the invention; and
Fig. 2 a lateral view on the embodiment of Fig. 1 during filling one of the syringes.
Fig. 1 and 2 show an embodiment of the device 1 where a tube like dispensing member 2 is provided with a longitudinal axis 9 and a coaxial cavity 3. The dispensing member 2 is realized through a longitudinal tube with a peripheral wall 12, whereby the cavity 3 is provided with a feed opening 4 at the first end 10 of the dispensing member 2 and a discharge opening 13 at the second end 11 of the dispensing member 2 as well as five outlet openings 5 being arranged sequentially and transversely to the longitudinal axis 9. The outlet openings 5 are arranged axially spaced apart from each other and penetrate the peripheral wall 12 transversely to the longitudinal axis. The feed opening
4 and the discharge opening 13 are arranged parallel to the longitudinal axis 9. Furthermore, the first end 10 of the dispensing member 2 is provided with first adapting means 6 for being joined e.g. with a mixing apparatus or another filling device 16. The first adapting means 6 are here configured as a female Luer-lock adapter. Another female Luer-lock adapter is situated at the second end 11 of the dispensing member 2. At each outlet opening 5 a second adapting means 7 is attached which is here configured as female Luer-lock adapter being engageable with a complementary third adapting means 7, e.g. a male Luer-lock adapter at the outlet of the syringes 14. Furthermore, the dispensing member 2 is provided with a valve 8 at each outlet opening
5 allowing each outlet opening 5 to be opened or closed separately.
Fig. 1 depicts all valves 8 at the outlet openings 5 in an open position and the syringes 14 with their pistons in their forward positions such allowing a simultaneous filling of the syringes 14 with a freshly mixed, injectable substance. The substance may be filled into the cavity 3 from filling device 16, e.g. another syringe which is connected to the first adapting means 6 at the first end 10 of the dispensing member 2. The discharge opening 13 is sealed by means of a sealing cap 17. An exemplary positioning of the valves for sequential filling of the syringes 14 is shown in Fig. 2. The two syringes 14 next to the feed opening 4 are already filled so that their corresponding valve 8a; 8b are in their open position allowing the substance being fed through the feed opening 4 to flow into the cavity 3 until the third valve 8c which is in a position allowing the substance only to flow through the third outlet opening 5 and subsequently into the connected third syringe 14.
Preferred materials for the dispensing member 2 are medical grade transparent polymers. The flow of the cements through the dispensing member 2 should be visible.
There is no cleaning of the dispensing member 2 required because it is a disposable part. After cement hardening it is not possible to reuse the device.
The discharge opening 13 has no specific meaning for this invention. A possible meaning could be used as a connection for a 6th syringe or as outlet for superfluous cement.
As the dispensing member 2 shown on the picture is already available on the market for haematological use, it can be imagined e.g. that the blood flow is given between opening 4 and opening 13. The side openings 5 could be used for drug delivery or to take blood samples. But this is not the intended use of this invention.

Claims

Claims
1. Device (1 ) for the filling of one or more syringes (14) with freshly mixed, injectable substances characterized in that
A) it comprises a dispensing member (2) being provided with a cavity (3) which has a feed opening (4) for feeding an injectable mixture into the cavity (3) and one or more outlet openings (5) for filling syringes (14) being connectable to the dispensing member (2); whereby B) the dispensing member (2) is provided with a first adapting means (6) at the feed opening (4) for being connected to a filling device (16) and at least one second adapting means (7) at the at least one outlet opening (5) for being connected to a syringe (14); and
C) the dispensing member (2) is provided with at least one valve (8) allowing at least one outlet opening (5) to be opened or closed separately.
2. Device (1) according to claim 1 , characterized in that each adapting means (6;7) is configured as male or female Luer-lock adapter.
3. Device (1) according to claim 1 or 2, characterized in that the dispensing member (2) is realized as a longitudinal tube with a longitudinal axis (9), a peripheral wall (12), a first end (10) and a second end (11) and that the feed opening (4) is situated at the first end (10) and the outlet openings (5) are arranged axially spaced apart from each other and penetrating the peripheral wall (12) transversely to the longitudinal axis (9).
4. Device (1) according to one of the claims 1 to 3, characterized in that the cavity (3) is provided with a discharge opening (13).
5. Device (1) according to one of the claims 1 to 4, characterized in that the dispensing member (2) is provided with one valve (8) for each outlet opening (5).
6. Device (1) according to one of the claims 1 to 5, characterized in that it comprises a filling device (16).
7. Device (1) according to claim 6, characterized in that the filling device (16) is a mixing apparatus (16) with a mixing chamber of a volume V.
8. Device (1) according to claim 6, characterized in that the filling device (16) is a large syringe with an injection volume V.
9. Device (1) according to one of the claims 1 to 8, characterized in that it comprises a plurality of syringes (14) being provided with an injection volume v.
10. Device (1) according to claim 9, characterized in that the ratio of v : V ranges between 0.2 and 0.5, preferably between 0.1 and 0.2.
11. Device (1) according to one of the claims 1 to 10, characterized in that the valves (8) are three-way valves.
12. Method for filling one or more syringes with freshly mixed, injectable substances characterized in that it comprises the steps of a) mixing of a surgical cement in a mixing apparatus; b) connection of the mixing apparatus to the dispensing member (2) by means of joining the adapting means of the mixing apparatus to the adapting means (7) at the first end (10) of the dispensing member (2); c) opening of at least one valve (8) such that the chamber of the syringe (14) is connected with the cavity (3) in the dispensing member (2); and d) pressing the injectable substance from the mixing apparatus into the cavity (3) and the chamber of the at least one syringe (14).
13. Method according to claim 12, characterized in that step c) comprises the opening of all valves (8) such that the injectable substance may be filled simultaneously in all syringes (14).
14. Method according to claim 12, characterized in that step c) is repeated with sequentially opening the valves (8) such that the injectable substance may be filled one after the other into the syringes (14).
PCT/CH2004/000380 2004-06-18 2004-06-18 Device for the filling of a plurality of syringes WO2005123162A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CH2004/000380 WO2005123162A1 (en) 2004-06-18 2004-06-18 Device for the filling of a plurality of syringes
TW094113417A TW200600072A (en) 2004-06-18 2005-04-27 Device for the filling of a plurality of syringes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2004/000380 WO2005123162A1 (en) 2004-06-18 2004-06-18 Device for the filling of a plurality of syringes

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WO2005123162A1 true WO2005123162A1 (en) 2005-12-29

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Cited By (25)

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FR2903594A1 (en) * 2006-07-13 2008-01-18 I2M Sarl Device for producing an injectable foam, comprises a blister having a first syringe with a gas, a second syringe with a liquid and a foaming substance, a three way faucet and a third syringe, and a machine
FR2934173A1 (en) * 2008-07-22 2010-01-29 Genia Pumpable mixture i.e. vaccine, preparation assisting device for veterinary field, has imposition units operated in such manner that one of units is in discharge configuration when other unit is in aspiration configuration and vise-versa
WO2011014525A3 (en) * 2009-07-29 2012-01-19 Icu Medical, Inc. Fluid transfer devices and methods of use
WO2012135423A1 (en) * 2011-03-31 2012-10-04 Fishman Corporation System and method for accurately delivering controlled amounts of viscous fluid to a fluid delivery device
WO2013013081A1 (en) * 2011-07-20 2013-01-24 Stryker Corporaton Manifold for filling plural cannulae
CN103845101A (en) * 2014-03-14 2014-06-11 深圳市爱杰特医药科技有限公司 Injection liquid transferring device
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DE102015204951A1 (en) * 2015-03-19 2016-09-22 Robert Bosch Gmbh filling
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WO2017112513A1 (en) * 2015-12-22 2017-06-29 Ethicon, Inc. Syringes with mixing chamber in a removable cap
US9849236B2 (en) 2013-11-25 2017-12-26 Icu Medical, Inc. Methods and systems for filling IV bags with therapeutic fluid
US9883987B2 (en) 2011-12-22 2018-02-06 Icu Medical, Inc. Fluid transfer devices and methods of use
USD837983S1 (en) 2015-12-04 2019-01-08 Icu Medical, Inc. Fluid transfer device
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WO2022213101A1 (en) * 2021-04-01 2022-10-06 Vitrean Inc. Methods for manufacturing of highly concentrated hydrogels
US11554215B2 (en) 2017-06-08 2023-01-17 Novartis Ag Injection device and injection solution transferring system
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
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FR2934173A1 (en) * 2008-07-22 2010-01-29 Genia Pumpable mixture i.e. vaccine, preparation assisting device for veterinary field, has imposition units operated in such manner that one of units is in discharge configuration when other unit is in aspiration configuration and vise-versa
US9827163B2 (en) 2009-07-29 2017-11-28 Icu Medical, Inc. Fluid transfer devices and methods of use
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US8950442B2 (en) 2011-03-31 2015-02-10 Fishman Corporation System and method for accurately delivering controlled amounts of viscous fluid to a fluid delivery device
US9532823B2 (en) 2011-07-20 2017-01-03 Stryker Corporation Manifold for filling plural cannulae, the manifold including a quick release mechanism for simultaneously holding and releasing the cannulae to/from the manifold
WO2013013081A1 (en) * 2011-07-20 2013-01-24 Stryker Corporaton Manifold for filling plural cannulae
US11439570B2 (en) 2011-12-22 2022-09-13 Icu Medical, Inc. Fluid transfer devices and methods of use
US9883987B2 (en) 2011-12-22 2018-02-06 Icu Medical, Inc. Fluid transfer devices and methods of use
US11439571B2 (en) 2011-12-22 2022-09-13 Icu Medical, Inc. Fluid transfer devices and methods of use
US10314764B2 (en) 2011-12-22 2019-06-11 Icu Medical, Inc. Fluid transfer devices and methods of use
CN105307621A (en) * 2013-09-19 2016-02-03 株式会社汤山制作所 Coinjection device and coinjection method
CN105307621B (en) * 2013-09-19 2020-01-10 株式会社汤山制作所 Mixed injection device and mixed injection method
DE202013010100U1 (en) 2013-11-07 2015-02-09 Mathys Ag Bettlach Dosing device for filling Appliziervorrichtungen with bone cement or bone replacement pastes
US9849236B2 (en) 2013-11-25 2017-12-26 Icu Medical, Inc. Methods and systems for filling IV bags with therapeutic fluid
US11541171B2 (en) 2013-11-25 2023-01-03 Icu Medical, Inc. Methods and systems for filling IV bags with therapeutic fluid
CN103845101A (en) * 2014-03-14 2014-06-11 深圳市爱杰特医药科技有限公司 Injection liquid transferring device
WO2016010909A3 (en) * 2014-07-14 2016-04-07 Icu Medical, Inc. Fluid transfer devices and methods of use
DE202014008486U1 (en) 2014-10-27 2016-01-28 Mathys Ag Bettlach Device for applying bone replacement pastes
WO2016065490A1 (en) 2014-10-27 2016-05-06 Mathys Ag Bettlach Device for applying bone replacement pastes
DE102015204951A1 (en) * 2015-03-19 2016-09-22 Robert Bosch Gmbh filling
USD837983S1 (en) 2015-12-04 2019-01-08 Icu Medical, Inc. Fluid transfer device
US11865295B2 (en) 2015-12-04 2024-01-09 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US10188849B2 (en) 2015-12-04 2019-01-29 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US10420927B2 (en) 2015-12-04 2019-09-24 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US11135416B2 (en) 2015-12-04 2021-10-05 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
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US10596069B2 (en) 2015-12-22 2020-03-24 Ethicon, Inc. Syringes with mixing chamber in a removable cap
WO2017112513A1 (en) * 2015-12-22 2017-06-29 Ethicon, Inc. Syringes with mixing chamber in a removable cap
CN106137749A (en) * 2016-07-16 2016-11-23 苏州富实吉医疗科技发展有限公司 A kind of high efficient mixed multi-wad join pipe
USD905228S1 (en) 2016-07-19 2020-12-15 Icu Medical, Inc. Medical fluid transfer system
USD874644S1 (en) 2016-07-19 2020-02-04 Icu Medical, Inc. Medical fluid transfer system
USD943732S1 (en) 2016-07-19 2022-02-15 Icu Medical, Inc. Medical fluid transfer system
USD851745S1 (en) 2016-07-19 2019-06-18 Icu Medical, Inc. Medical fluid transfer system
US11951293B2 (en) 2016-07-25 2024-04-09 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
US11020541B2 (en) 2016-07-25 2021-06-01 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
US11583637B2 (en) 2016-07-25 2023-02-21 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
US11554215B2 (en) 2017-06-08 2023-01-17 Novartis Ag Injection device and injection solution transferring system
US10575887B2 (en) 2017-08-04 2020-03-03 Medtronic Holding Company Sàrl Dispensing system and methods of use
US11653963B2 (en) 2017-08-04 2023-05-23 Medtronic Holding Company Sarl Dispensing system and methods of use
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US20220193341A1 (en) * 2020-12-22 2022-06-23 University Of Kansas Syringe splitting device
WO2022213101A1 (en) * 2021-04-01 2022-10-06 Vitrean Inc. Methods for manufacturing of highly concentrated hydrogels
EP4169608A1 (en) * 2021-10-25 2023-04-26 Heraeus Medical GmbH Device for providing a fluid component of a bone cement mass, system and method for providing a bone cement mass
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