WO2005122699A3 - An improved process for the preparation of n-substituted hetero cyclic derivatives - Google Patents

An improved process for the preparation of n-substituted hetero cyclic derivatives Download PDF

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Publication number
WO2005122699A3
WO2005122699A3 PCT/IN2005/000183 IN2005000183W WO2005122699A3 WO 2005122699 A3 WO2005122699 A3 WO 2005122699A3 IN 2005000183 W IN2005000183 W IN 2005000183W WO 2005122699 A3 WO2005122699 A3 WO 2005122699A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
substituted hetero
solvent
cyclic derivatives
Prior art date
Application number
PCT/IN2005/000183
Other languages
French (fr)
Other versions
WO2005122699A2 (en
Inventor
Satyanarayana Chava
Mohan Bandari
Kumar Sethi Mathuresh
Original Assignee
Matrix Lab Ltd
Satyanarayana Chava
Mohan Bandari
Kumar Sethi Mathuresh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Lab Ltd, Satyanarayana Chava, Mohan Bandari, Kumar Sethi Mathuresh filed Critical Matrix Lab Ltd
Publication of WO2005122699A2 publication Critical patent/WO2005122699A2/en
Publication of WO2005122699A3 publication Critical patent/WO2005122699A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to a process for preparation of N-substituted 1-[(biphenyl-4­ yl)methyl-2-n-butyl-4-spirocylopentane-2-imidazolin-5-one by suspending 4'-(Bromo­methyl) [ 1,1'-biphenyl] derivative in aqueous solution of an in-organic base and adding the solution of 2-butyl-1, 3-diazaspiro [4,4] nonan-4-one in water-miscible organic solvent at temperature of 20°C to 55°C. Maintaining the reaction mixture at 25°C to about reflux temperature of the solvent followed by removing the solvent under reduced pressure, dissolving the residue in wafer-immiscible organic solvent, distilling under reduced pressure aid crystallizing the residue from acetonitrile.
PCT/IN2005/000183 2004-06-16 2005-06-06 An improved process for the preparation of n-substituted hetero cyclic derivatives WO2005122699A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN566CH2004 2004-06-16
IN566/CHE/2004 2004-06-16

Publications (2)

Publication Number Publication Date
WO2005122699A2 WO2005122699A2 (en) 2005-12-29
WO2005122699A3 true WO2005122699A3 (en) 2007-05-31

Family

ID=35510186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2005/000183 WO2005122699A2 (en) 2004-06-16 2005-06-06 An improved process for the preparation of n-substituted hetero cyclic derivatives

Country Status (1)

Country Link
WO (1) WO2005122699A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014679A1 (en) * 1990-03-20 1991-10-03 Sanofi Heterocyclic n-substituted derivatives, their preparation and thepharmaceutical compositions containing them
US5541209A (en) * 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
CN1415614A (en) * 2002-10-28 2003-05-07 南京长澳医药科技有限公司 Technique for synthesizing Irbesartan
WO2005051943A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Processes for the preparation of highly pure irbesartan

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014679A1 (en) * 1990-03-20 1991-10-03 Sanofi Heterocyclic n-substituted derivatives, their preparation and thepharmaceutical compositions containing them
US5541209A (en) * 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
CN1415614A (en) * 2002-10-28 2003-05-07 南京长澳医药科技有限公司 Technique for synthesizing Irbesartan
WO2005051943A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Processes for the preparation of highly pure irbesartan

Also Published As

Publication number Publication date
WO2005122699A2 (en) 2005-12-29

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