WO2005121376A3 - Hiv variants showing a novel resistance mechanism against protease inhibitors, diagnostic assays for detecting the variant, and methods for identifying drugs effective against the resistant variant - Google Patents
Hiv variants showing a novel resistance mechanism against protease inhibitors, diagnostic assays for detecting the variant, and methods for identifying drugs effective against the resistant variant Download PDFInfo
- Publication number
- WO2005121376A3 WO2005121376A3 PCT/EP2005/006262 EP2005006262W WO2005121376A3 WO 2005121376 A3 WO2005121376 A3 WO 2005121376A3 EP 2005006262 W EP2005006262 W EP 2005006262W WO 2005121376 A3 WO2005121376 A3 WO 2005121376A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- variant
- diagnostic assays
- protease inhibitors
- resistance mechanism
- detecting
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04076669A EP1605064A1 (en) | 2004-06-07 | 2004-06-07 | HIV Variant showing a novel resistance mechanism against protease inhibitors, diagnostic assays for detecting the variant, and methods for identifying drugs effective against the resistant virus |
EP04076669.3 | 2004-06-07 | ||
EP04078431.6 | 2004-12-20 | ||
EP04078431 | 2004-12-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005121376A2 WO2005121376A2 (en) | 2005-12-22 |
WO2005121376A3 true WO2005121376A3 (en) | 2006-08-10 |
Family
ID=35079127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/006262 WO2005121376A2 (en) | 2004-06-07 | 2005-06-07 | Hiv variants showing a novel resistance mechanism against protease inhibitors, diagnostic assays for detecting the variant, and methods for identifying drugs effective against the resistant variant |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2005121376A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10738365B2 (en) | 2013-05-31 | 2020-08-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs |
EP3290412A1 (en) | 2016-08-31 | 2018-03-07 | Università degli Studi di Siena | Hiv-1 nucleocapsid inhibitors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073511A1 (en) * | 1999-05-28 | 2000-12-07 | Virco Nv | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
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2005
- 2005-06-07 WO PCT/EP2005/006262 patent/WO2005121376A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073511A1 (en) * | 1999-05-28 | 2000-12-07 | Virco Nv | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
Non-Patent Citations (5)
Title |
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BALLY FRANK ET AL: "Polymorphism of HIV type 1 Gag p7/p1 and p1/p6 cleavage sites: Clinical significance and implications for resistance to protease inhibitors", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 16, no. 13, 1 September 2000 (2000-09-01), pages 1209 - 1213, XP002352919, ISSN: 0889-2229 * |
DESAI S M ET AL: "MOLECULAR CLONING AND PRIMARY NUCLEOTIDE SEQUENCE ANALYSIS OF A DISTINCT HUMAN IMMUNODEFICIENCY VIRUS ISOLATE REVEAL SIGNIFICANT DIVERGENCE IN ITS GENOMIC SEQUENCES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 83, no. 21, 1986, pages 8380 - 8384, XP002352918, ISSN: 0027-8424 * |
GATANAGA HIROYUKI ET AL: "Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 8, 22 February 2002 (2002-02-22), pages 5952 - 5961, XP001121729, ISSN: 0021-9258 * |
RATNER L ET AL: "COMPLETE NUCLEOTIDE SEQUENCE OF THE AIDS VIRUS, HTLV-III", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 313, 24 January 1985 (1985-01-24), pages 277 - 284, XP000572709, ISSN: 0028-0836 * |
ZHANG Y-M ET AL: "Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 9, 1997, pages 6662 - 6670, XP002316390, ISSN: 0022-538X * |
Also Published As
Publication number | Publication date |
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WO2005121376A2 (en) | 2005-12-22 |
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