WO2005119263A3 - Diagnostic et traitement des maladies associees au recepteur couple aux proteines g 92 (gpr92) - Google Patents

Diagnostic et traitement des maladies associees au recepteur couple aux proteines g 92 (gpr92) Download PDF

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Publication number
WO2005119263A3
WO2005119263A3 PCT/EP2005/005788 EP2005005788W WO2005119263A3 WO 2005119263 A3 WO2005119263 A3 WO 2005119263A3 EP 2005005788 W EP2005005788 W EP 2005005788W WO 2005119263 A3 WO2005119263 A3 WO 2005119263A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
gpr92
therapeutics
diagnostics
protein
Prior art date
Application number
PCT/EP2005/005788
Other languages
English (en)
Other versions
WO2005119263A2 (fr
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2005119263A2 publication Critical patent/WO2005119263A2/fr
Publication of WO2005119263A3 publication Critical patent/WO2005119263A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention porte sur un récepteur GPR92 humain, lequel est associé aux maladies cardio-vasculaires, aux affections dermatologiques, aux maladies endocrinologiques, aux maladies métaboliques, aux cancers, aux maladies gastro-entérologiques, aux inflammations, aux maladies hématologiques, aux affections respiratoires, aux affections musculo-squelettales, aux maladies neurologiques, et aux maladies urologiques. L'invention concerne également des méthodes permettant l'identification de composés efficaces pour le traitement ou la prévention des maladies cardio-vasculaires, des affections dermatologiques, des maladies endocrinologiques, des maladies métaboliques, des cancers, des maladies gastro-entérologiques, des inflammations, des maladies hématologiques, des affections respiratoires, des affections musculo-squelettales, des maladies neurologiques, et des maladies urologiques. L'invention concerne également des composés qui se lient au récepteur GPR92 et/ou inhibent son activité, ainsi que des compositions pharmaceutiques contenant de tels composés.
PCT/EP2005/005788 2004-06-03 2005-05-30 Diagnostic et traitement des maladies associees au recepteur couple aux proteines g 92 (gpr92) WO2005119263A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04013106.2 2004-06-03
EP04013106 2004-06-03

Publications (2)

Publication Number Publication Date
WO2005119263A2 WO2005119263A2 (fr) 2005-12-15
WO2005119263A3 true WO2005119263A3 (fr) 2006-02-16

Family

ID=34969026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/005788 WO2005119263A2 (fr) 2004-06-03 2005-05-30 Diagnostic et traitement des maladies associees au recepteur couple aux proteines g 92 (gpr92)

Country Status (1)

Country Link
WO (1) WO2005119263A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7039483B2 (ja) 2016-04-14 2022-03-22 マース インコーポレーテッド Ｇｐｒ９２の調節因子の同定方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087937A2 (fr) * 2000-05-18 2001-11-22 Incyte Genomics, Inc. Recepteurs couples aux proteines g

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087937A2 (fr) * 2000-05-18 2001-11-22 Incyte Genomics, Inc. Recepteurs couples aux proteines g

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEE D K ET AL: "Discovery and mapping of ten novel G protein-coupled receptor genes", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 275, no. 1, 5 September 2001 (2001-09-05), pages 83 - 91, XP004307114, ISSN: 0378-1119 *
TAO YA-XIONG ET AL: "Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor.", 13 February 2004, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 13 FEB 2004, VOL. 279, NR. 7, PAGE(S) 5904 - 5914, ISSN: 0021-9258, XP009054365 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7039483B2 (ja) 2016-04-14 2022-03-22 マース インコーポレーテッド Ｇｐｒ９２の調節因子の同定方法

Also Published As

Publication number Publication date
WO2005119263A2 (fr) 2005-12-15

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