WO2005118580A3 - Composes tricycliques utiles comme inhibiteurs du mecanisme de signalisation hypoxique - Google Patents
Composes tricycliques utiles comme inhibiteurs du mecanisme de signalisation hypoxique Download PDFInfo
- Publication number
- WO2005118580A3 WO2005118580A3 PCT/US2005/016569 US2005016569W WO2005118580A3 WO 2005118580 A3 WO2005118580 A3 WO 2005118580A3 US 2005016569 W US2005016569 W US 2005016569W WO 2005118580 A3 WO2005118580 A3 WO 2005118580A3
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- WO
- WIPO (PCT)
- Prior art keywords
- tricyclic compounds
- inhibitors
- signaling pathway
- activity
- hypoxic signaling
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/24—[b,e]-condensed with two six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/46—Phenazines
- C07D241/48—Phenazines with hydrocarbon radicals, substituted by nitrogen atoms, directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/36—[b, e]-condensed, at least one with a further condensed benzene ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C07D327/08—[b,e]-condensed with two six-membered carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57061504P | 2004-05-12 | 2004-05-12 | |
US60/570,615 | 2004-05-12 | ||
US61827904P | 2004-10-12 | 2004-10-12 | |
US60/618,279 | 2004-10-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005118580A2 WO2005118580A2 (fr) | 2005-12-15 |
WO2005118580A3 true WO2005118580A3 (fr) | 2006-08-03 |
Family
ID=35447501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/016569 WO2005118580A2 (fr) | 2004-05-12 | 2005-05-11 | Composes tricycliques utiles comme inhibiteurs du mecanisme de signalisation hypoxique |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2005118580A2 (fr) |
Families Citing this family (19)
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---|---|---|---|---|
FR2904317A1 (fr) | 2006-07-27 | 2008-02-01 | Inst Nat Sante Rech Med | Analogues d'halogenobenzamides marques a titre de radiopharmaceutiques |
WO2009043093A1 (fr) * | 2007-10-04 | 2009-04-09 | Newsouth Innovations Pty Limited | Inhibition de hif |
EP2085390A1 (fr) | 2008-01-31 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Analogues d'halobenzamide marqués en tant que produits radiopharmaceutiques multimodaux et leurs précurseurs |
WO2010018458A2 (fr) * | 2008-08-12 | 2010-02-18 | Crystalgenomics, Inc. | Dérivés de phénol et leurs procédés d'utilisation |
WO2010075869A1 (fr) * | 2008-12-30 | 2010-07-08 | European Molecular Biology Laboratory (Embl) | Toluidine sulfonamides et leur utilisation |
EP2440048B8 (fr) | 2009-06-09 | 2015-12-16 | NantBioScience, Inc. | Dérivés de l'isoquinoléine, de la quinoléine et de la quinazoléine servant d'inhibiteurs de signal hedgehog |
BRPI1011319A2 (pt) | 2009-06-09 | 2016-06-21 | California Capital Equity Llc | derivados de triazina benzil-substituídos e suas aplicações terapêuticas |
BRPI1011318A2 (pt) | 2009-06-09 | 2019-09-24 | California Capital Equity Llc | derivados de triazina e suas aplicações terapêuticas |
EP2977050A1 (fr) | 2010-10-08 | 2016-01-27 | Nivalis Therapeutics, Inc. | Nouveaux composés quinoléine substitués comme inhibiteurs de la s-nitrosoglutathione réductase |
US8785643B2 (en) | 2010-12-16 | 2014-07-22 | N30 Pharmaceuticals, Inc. | Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors |
US9586949B2 (en) | 2015-02-09 | 2017-03-07 | Incyte Corporation | Aza-heteroaryl compounds as PI3K-gamma inhibitors |
US10399946B2 (en) | 2015-09-10 | 2019-09-03 | Laurel Therapeutics Ltd. | Solid forms of an S-Nitrosoglutathione reductase inhibitor |
HUE059324T2 (hu) | 2015-11-06 | 2022-11-28 | Incyte Corp | Heterociklusos vegyületek, mint PI3K-gamma inhibitorok |
AR107293A1 (es) | 2016-01-05 | 2018-04-18 | Incyte Corp | COMPUESTOS DE PIRIDINA Y PIRIDIMINA COMO INHIBIDORES DE PI3K-g |
AR108875A1 (es) | 2016-06-24 | 2018-10-03 | Incyte Corp | COMPUESTOS HETEROCÍCLICOS COMO INHIBIDORES DE PI3K-g |
IL295978B1 (en) | 2017-10-18 | 2023-09-01 | Incyte Corp | Concentrated imidazole derivatives substituted by tertiary hydroxy groups as P13K-gamma inhibitors |
US11186580B2 (en) | 2018-09-05 | 2021-11-30 | Incyte Corporation | Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor |
EP4364798A2 (fr) | 2018-10-05 | 2024-05-08 | Annapurna Bio Inc. | Composés et compositions pour le traitement d'états associés à l'activité du récepteur apj |
WO2021158495A1 (fr) * | 2020-02-03 | 2021-08-12 | Bristol-Myers Squibb Company | Composés de benzo[5,6] [1,4]dioxino[2,3-b]pyridine utiles en tant qu'inhibiteurs de l'irak4 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0098098A2 (fr) * | 1982-06-25 | 1984-01-11 | Development Finance Corporation Of New Zealand | Composés acridinecarboxamidiques |
EP0172744A2 (fr) * | 1984-08-16 | 1986-02-26 | Development Finance Corporation Of New Zealand | Composés de phénazinecarboxamide |
EP0206802A2 (fr) * | 1985-06-24 | 1986-12-30 | Cancer Research Campaign Technology Limited | Dérivés de quinoléine substitués |
WO2002100843A1 (fr) * | 2001-06-13 | 2002-12-19 | Jianqing Lu | Composes phenoxazines, preparations les contenant et leurs utilisations medicinales |
-
2005
- 2005-05-11 WO PCT/US2005/016569 patent/WO2005118580A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0098098A2 (fr) * | 1982-06-25 | 1984-01-11 | Development Finance Corporation Of New Zealand | Composés acridinecarboxamidiques |
EP0172744A2 (fr) * | 1984-08-16 | 1986-02-26 | Development Finance Corporation Of New Zealand | Composés de phénazinecarboxamide |
EP0206802A2 (fr) * | 1985-06-24 | 1986-12-30 | Cancer Research Campaign Technology Limited | Dérivés de quinoléine substitués |
WO2002100843A1 (fr) * | 2001-06-13 | 2002-12-19 | Jianqing Lu | Composes phenoxazines, preparations les contenant et leurs utilisations medicinales |
Non-Patent Citations (11)
Title |
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ATWELL G J ET AL: "POTENTIAL ANTITUMOR AGENTS. 57. 2-PHENYLQUINOLINE-8-CARBOXAMIDES AS MINIMAL DNA-INTERCALATING ANTITUMOR AGENTS WITH IN VIVO SOLID TUMOR ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 32, no. 2, 1989, pages 396 - 401, XP001071285, ISSN: 0022-2623 * |
DATABASE WPI Section Ch Week 200318, Derwent World Patents Index; Class B02, AN 2003-183933, XP002379936 * |
DENNY W A ET AL: "POTENTIAL ANTITUMOR AGENTS 59. STRUCTURE-ACTIVITY RELATIONSHIPS FOR 2-PHENYLBENZIMIDAZOLE-4-CARB OXAMIDES, A NEW CLASS OF MINIMAL DNA-INTERCALATING AGENTS WHICH MAY NOT ACT VIA TOPOISOMERASE II", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 2, 1 February 1990 (1990-02-01), pages 814 - 819, XP002007402, ISSN: 0022-2623 * |
DENNY W A ET AL: "POTENTIAL ANTITUMOR AGENTS. 49. 5-SUBSTITUTED DERIVATIVES OF N-2-(DIMETHYLAMINO)ETHYL-9-AMINOACRIDINE-4-CARBOXAMIDE WITH IN VIVO SOLID-TUMOR ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 30, no. 4, 1986, pages 658 - 663, XP001024208, ISSN: 0022-2623 * |
HO H. LEE ET AL: "Potentail Antitumor Agents. 64. Synthesis and Antitumor Evaluation of Dibenzo[1,4]dioxin-1-carboxamides: A New Class of Weakly Binding DNA-Intercalating Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, 1992, pages 258 - 266, XP002379888 * |
KRISHNAMACHARY B ET AL: "Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 63, no. 5, 1 March 2003 (2003-03-01), pages 1138 - 1143, XP002341115, ISSN: 0008-5472 * |
KUNG A L ET AL: "Suppression of tumor growth through disruption of hypoxia-inducible transcription", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 6, no. 12, December 2000 (2000-12-01), pages 1335 - 1340, XP002328150, ISSN: 1078-8956 * |
MAXWELL P H ET AL: "Hypoxia -inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 94, July 1997 (1997-07-01), pages 8104 - 8109, XP002124649, ISSN: 0027-8424 * |
PALMER B D ET AL: "POTENTIAL ANTITUMOR AGENTS. 54. CHROMOPHORE REQUIREMENTS FOR IN VIVO ANTITUMOR ACTIVITY AMONG THE GENERAL CLASS OF LINEAR TRICYCLICCARBOXAMIDES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 31, no. 4, 1988, pages 707 - 712, XP002059942, ISSN: 0022-2623 * |
PAWLAK K ET AL: "CYTOTOXIC AND ANTITUMOR ACTIVITY OF 1-NITROACRIDINES AS AN AFTEREFFECT OF THEIR INTERSTRAND DNA CROSS-LINKING", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 44, no. 10, October 1984 (1984-10-01), pages 4289 - 4296, XP001008685, ISSN: 0008-5472 * |
REWCASTLE G W ET AL: "POTENTIAL ANTITUMOR AGENTS. 51. SYNTHESIS AND ANITITUMOR ACITIVITY OF SUBSTITUTED PHENAZINE-1-CARBOXAMIDES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 30, no. 5, 1987, pages 843 - 851, XP002051604, ISSN: 0022-2623 * |
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WO2005118580A2 (fr) | 2005-12-15 |
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