WO2005117942A3 - Methods for encapsulation of biomacromolecules in polymers - Google Patents

Methods for encapsulation of biomacromolecules in polymers Download PDF

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Publication number
WO2005117942A3
WO2005117942A3 PCT/US2005/017140 US2005017140W WO2005117942A3 WO 2005117942 A3 WO2005117942 A3 WO 2005117942A3 US 2005017140 W US2005017140 W US 2005017140W WO 2005117942 A3 WO2005117942 A3 WO 2005117942A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomacromolecule
pore
biomacromolecules
encapsulation
polymers
Prior art date
Application number
PCT/US2005/017140
Other languages
French (fr)
Other versions
WO2005117942A2 (en
Inventor
Steven P Schwendeman
Original Assignee
Univ Michigan
Steven P Schwendeman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, Steven P Schwendeman filed Critical Univ Michigan
Priority to US11/596,524 priority Critical patent/US8017155B2/en
Publication of WO2005117942A2 publication Critical patent/WO2005117942A2/en
Publication of WO2005117942A3 publication Critical patent/WO2005117942A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method for encapsulating a biomacromolecule in a pore-containing polymer comprising the steps of providing an encapsulating solution containing the biomacromolecule and the pore-containing polymer; contacting the biomacromolecule with the pore-containing polymer for a time sufficient for the biomacromolecule to enter the pores of the pore-containing polymer; and rearranging the polymer such that the surface pores of the polymer are closed thus encapsulating the biomacromolecule in the pore-containing polymer.
PCT/US2005/017140 2004-05-14 2005-05-16 Methods for encapsulation of biomacromolecules in polymers WO2005117942A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/596,524 US8017155B2 (en) 2004-05-14 2005-05-16 Methods for encapsulation of biomacromolecules in polymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57102904P 2004-05-14 2004-05-14
US60/571,029 2004-05-14

Publications (2)

Publication Number Publication Date
WO2005117942A2 WO2005117942A2 (en) 2005-12-15
WO2005117942A3 true WO2005117942A3 (en) 2006-07-06

Family

ID=35463347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/017140 WO2005117942A2 (en) 2004-05-14 2005-05-16 Methods for encapsulation of biomacromolecules in polymers

Country Status (1)

Country Link
WO (1) WO2005117942A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
JP5756588B2 (en) 2005-07-15 2015-07-29 ミセル テクノロジーズ、インコーポレイテッド Polymer coating containing controlled morphological drug powder
CA2650590C (en) 2006-04-26 2018-04-03 Micell Technologies, Inc. Coatings containing multiple drugs
US8636767B2 (en) 2006-10-02 2014-01-28 Micell Technologies, Inc. Surgical sutures having increased strength
CA2667228C (en) 2006-10-23 2015-07-14 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
CN101711137B (en) 2007-01-08 2014-10-22 米歇尔技术公司 Stents having biodegradable layers
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
AU2008256684B2 (en) 2007-05-25 2012-06-14 Micell Technologies, Inc. Polymer films for medical device coating
SG192523A1 (en) 2008-04-17 2013-08-30 Micell Technologies Inc Stents having bioabsorbable layers
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
JP2011528275A (en) 2008-07-17 2011-11-17 ミセル テクノロジーズ，インク． Drug delivery medical device
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
WO2010111238A2 (en) * 2009-03-23 2010-09-30 Micell Technologies, Inc. Improved biodegradable polymers
WO2010120552A2 (en) 2009-04-01 2010-10-21 Micell Technologies, Inc. Coated stents
WO2010121187A2 (en) 2009-04-17 2010-10-21 Micell Techologies, Inc. Stents having controlled elution
EP2531140B1 (en) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
EP2560576B1 (en) 2010-04-22 2018-07-18 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
WO2012009684A2 (en) 2010-07-16 2012-01-19 Micell Technologies, Inc. Drug delivery medical device
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
WO2013012689A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
EP2967803B1 (en) 2013-03-12 2023-12-27 Micell Technologies, Inc. Bioabsorbable biomedical implants
EP2996629B1 (en) 2013-05-15 2021-09-22 Micell Technologies, Inc. Bioabsorbable biomedical implants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470582A (en) * 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
US6962716B1 (en) * 2000-09-27 2005-11-08 Board Of Regents, The University Of Texas System Compositions and methods for biodegradable microspheres as carriers of bioactive substances

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470582A (en) * 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
US6962716B1 (en) * 2000-09-27 2005-11-08 Board Of Regents, The University Of Texas System Compositions and methods for biodegradable microspheres as carriers of bioactive substances

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LAM X. ET AL.: "Encapsulation and stabilization of nerve growth factor into poly(lactic-co-glycolic) acid microspheres", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 9, no. 9, 2001, pages 1356 - 1365 *

Also Published As

Publication number Publication date
WO2005117942A2 (en) 2005-12-15

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