WO2005112963A3 - Phytomedicinal compositions for the control of lipid accumulation and metabolism in mammals - Google Patents

Phytomedicinal compositions for the control of lipid accumulation and metabolism in mammals Download PDF

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Publication number
WO2005112963A3
WO2005112963A3 PCT/US2005/016169 US2005016169W WO2005112963A3 WO 2005112963 A3 WO2005112963 A3 WO 2005112963A3 US 2005016169 W US2005016169 W US 2005016169W WO 2005112963 A3 WO2005112963 A3 WO 2005112963A3
Authority
WO
WIPO (PCT)
Prior art keywords
phytomedicinal
group
lipase
compositions
esculetin
Prior art date
Application number
PCT/US2005/016169
Other languages
French (fr)
Other versions
WO2005112963A2 (en
Inventor
Ilya Raskin
Diego A Moreno-Fernandez
Original Assignee
Phytomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytomedics Inc filed Critical Phytomedics Inc
Publication of WO2005112963A2 publication Critical patent/WO2005112963A2/en
Publication of WO2005112963A3 publication Critical patent/WO2005112963A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of producing a phytomedicinal therapeutic for the prevention and control of a disease selected from the group consisting of obesity, cardiovascular disease, and diabetes, and conditions related thereto is provided which comprises extracting peanut shells with a solvent, removing a substantial portion of the solvent to produce a concentrated extract. Phytomedicinal compositions are provided that comprise an effective amount of at least one coumarin compound or one coumarin derivative derived from plant material that modulates a biological activity of at least one enzyme selected from the group consisting of Pancreatic Lipase (PL), Lipoprotein Lipase (LPL), and Hormone-Sensitive Lipase (HSL). Phytomedicinal compositions are provided that comprise at least an effective amount of coumarin derivatives (6,7-dihydroxycoumarin-esculetin, and esculetin-like compounds). A method for the prevention and/or treatment of treatment of a condition selected from the group consisting of obesity, cardiovascular disease, and diabetes, is provided which comprises administering a composition comprising an effective amount of at least one coumarin derivative, including 6,7-dihydroxycoumarin (esculetin), derived from plant material that modulates a biological activity of at least one enzyme selected from the group consisting of Pancreatic Lipase (PL), Lipoprotein Lipase (LPL), and Hormone-Sensitive Lipase (HSL).
PCT/US2005/016169 2004-05-12 2005-05-10 Phytomedicinal compositions for the control of lipid accumulation and metabolism in mammals WO2005112963A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57042204P 2004-05-12 2004-05-12
US60/570,422 2004-05-12
US94336205A 2005-05-09 2005-05-09
US11/124,691 2005-05-09

Publications (2)

Publication Number Publication Date
WO2005112963A2 WO2005112963A2 (en) 2005-12-01
WO2005112963A3 true WO2005112963A3 (en) 2006-03-09

Family

ID=35428841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/016169 WO2005112963A2 (en) 2004-05-12 2005-05-10 Phytomedicinal compositions for the control of lipid accumulation and metabolism in mammals

Country Status (1)

Country Link
WO (1) WO2005112963A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102631902B (en) * 2012-04-13 2014-03-26 宁波市疾病预防控制中心 Method for preparing molecular imprinting solid-phase extraction column of coumarin rodenticide
CN108244644A (en) * 2018-01-08 2018-07-06 南京中医药大学 A kind of Salvia miltiorrhiza stem extract with conditioning function of intestinal canal and preparation method and application
CN112645922B (en) * 2020-12-24 2022-01-07 中国人民解放军空军军医大学 Coumarin compound, preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0952891A (en) * 1995-06-08 1997-02-25 Otsuka Pharmaceut Factory Inc Coumarin derivative

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0952891A (en) * 1995-06-08 1997-02-25 Otsuka Pharmaceut Factory Inc Coumarin derivative

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BILBIS L.S. ET AL: "Hypoglycemic and Hypolipidemic Effects of Aqueous Extract of Arachis Hypogaea in Normal and Alloxan-induced Diabetic Rats", vol. 9, no. 6, September 2002 (2002-09-01), pages 553 - 555, XP004957097 *
OKADA Y. ET AL: "Search for Naturally Occurring Substances for Prevention against the Complications of Diabetes Inhibitory Effect on Aldose Reductase and Platelet Aggregation", TOWARDS NATURAL MEDICINE RESEARCH IN THE 21ST CENTURY. PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON NATURAL MEDICINES, 28 October 1997 (1997-10-28) - 30 October 1997 (1997-10-30), KYOTO, JAPAN, pages 295 - 303, XP002964341 *

Also Published As

Publication number Publication date
WO2005112963A2 (en) 2005-12-01

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