WO2005110212A1 - Dispositif pour determiner la duree d'une pulsation sanguine - Google Patents

Dispositif pour determiner la duree d'une pulsation sanguine Download PDF

Info

Publication number
WO2005110212A1
WO2005110212A1 PCT/DE2005/000929 DE2005000929W WO2005110212A1 WO 2005110212 A1 WO2005110212 A1 WO 2005110212A1 DE 2005000929 W DE2005000929 W DE 2005000929W WO 2005110212 A1 WO2005110212 A1 WO 2005110212A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
pulse
blood pulse
receiver
transmitters
Prior art date
Application number
PCT/DE2005/000929
Other languages
German (de)
English (en)
Inventor
Andreas Schönfeld
Original Assignee
Schoenfeld Andreas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schoenfeld Andreas filed Critical Schoenfeld Andreas
Priority to DE112005001783T priority Critical patent/DE112005001783A5/de
Publication of WO2005110212A1 publication Critical patent/WO2005110212A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0285—Measuring or recording phase velocity of blood waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A61B5/02427—Details of sensor
    • A61B5/02433—Details of sensor for infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346—Analysis of electrocardiograms
    • A61B5/349—Detecting specific parameters of the electrocardiograph cycle
    • A61B5/352—Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7228—Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal

Definitions

  • the invention relates to a device according to the preamble of claim 1, for determining the transit time of a blood pulse, with a first sensor, for detecting the blood pulse at a first point, and a second sensor for detecting a blood pulse at a second point, and with an evaluation unit for forming the time difference between the occurrence of the blood pulse at the first point and the occurrence of the blood pulse at the second point.
  • Such a device is known for example from EP 1 091 686 B1.
  • noises are recorded by means of a microphone, which are generated by the flow of a burst of blood through the arteries.
  • the sounds like the blood flow, are pulse-shaped.
  • the duration of the blood pulse is determined by measuring the noise pulse at a first location, such as the carotid artery, and at a second location, such as an artery in the area of the left foot, and between the occurrence of the blood pulse at the first location and the occurrence of the blood pulse at the second point forms the time difference.
  • the running time of the blood pulse allows a conclusion to be drawn about the elasticity of the arterial system.
  • the device used for this still has the disadvantage that it is very sensitive to environmental conditions.
  • ambient noise is extremely disruptive.
  • the body's own noises such as clearing the throat or noises caused by body movements, are also very disruptive.
  • the pulses received by means of the known device often have a very unspecific increase, as a result of which the start of the pulse often cannot be determined with sufficient accuracy.
  • a method for diagnosing arterial and venous vascular diseases is known from angiology, by means of which the blood filling of arteries or veins is determined.
  • a blood pressure measuring device is known from DE 35 33 912 A, which has a pulse wave sensor that responds to arterial pulse waves, an EKG signal sensor and a time measurement device.
  • the pulse wave sensor has a measurement signal transmitter which emits a measurement signal which changes blood pressure depending on and is detected by a measurement signal receiver.
  • the measurement signal transmitter is preferably an infrared luminescence diode, while the measurement signal receivers are each designed as infrared photodiodes.
  • two measurement signal receivers arranged at a distance from one another and from the measurement signal transmitter can be present.
  • a device for determining the transit time of a blood pulse with a first sensor, for recording the blood pulse at a first location, and a second sensor, for recording the blood pulse at a second location, and with an evaluation unit, for forming the temporal Difference between the occurrence of the blood pulse at the first point and the occurrence of the blood pulse at the second point, characterized in that at least the first sensor has at least two IR transmitters and at least one IR receiver, which is on the connecting line between the IR transmitters or is arranged perpendicular to the connecting line.
  • the first sensor has at least two IR transmitters and at least one IR receiver, which is arranged on the connection line between the IR transmitters or perpendicularly at a distance from the connection line, blood pulses can be determined very well with the first sensor .
  • an infrared transmitter and an infrared receiver the first sensor is completely insensitive to noise. Body movements also have almost no effects.
  • a sensor with an infrared transmitter can be used at a point where a microphone or another sensor can be used without any problems, and at a point where the use of a conventional sensor causes problems and an infrared receiver can be used.
  • the use of at least two IR transmitters ensures that the radiation introduced into the body tissue is relatively large and is distributed over a larger area, so that a larger area of the tissue is illuminated with infrared light. This ensures that a sufficiently large amount of light is reflected by a blood pulse flowing through an artery even if the sensor is not positioned exactly above the artery.
  • An embodiment of the invention has been found to be particularly advantageous in which at least three IR transmitters are present, it being very advantageous if the IR transmitters are arranged on the circumference of a circle, in the center of which the IR receiver is arranged.
  • the second sensor also has at least two IR transmitters and at least one IR receiver, which is arranged on the connection line between the IR transmitters or at a distance from the connection line. In this way, a very high reliability or immunity to interference of the device is achieved.
  • An embodiment of the invention has proven to be extremely advantageous in which the evaluation unit has a demodulator and the IR transmitter emits pulsed light and the corresponding signal emitted by the IR receiver is sent to the demodulator.
  • the device is thereby very insusceptible to movement artifacts and fluctuations in ambient light. Static reflections, as can be expected from different tissue structures, are easily averaged out by the amplitude modulation.
  • the demodulator emits a signal when the signal demodulated by it begins to rise.
  • the time difference between the signals emitted by the demodulators is measured in each case and that an arithmetic mean value is formed from a plurality of difference measurement values.
  • an arithmetic mean value is formed from a plurality of difference measurement values.
  • FIG. 1 shows a schematic illustration of a device according to the invention
  • FIG. 2a shows a first embodiment of a sensor designed according to the invention
  • FIG. 2b shows a second embodiment of a sensor designed according to the invention
  • FIG. 3 shows a signal output by an IR receiver
  • FIG. 4 shows a signal output by a demodulator relating to a sensor located at a first point
  • FIG. 5 shows a signal output by a demodulator relating to a sensor located at a second location
  • FIGS. 3 to 5 shows an EKG belonging to the signals shown in FIGS. 3 to 5.
  • a first sensor 1 is arranged in a human 7 at a first location 1a located in the area of the carotid artery. Furthermore, a second sensor 2 is located in the area of a Artery located second foot 2a located.
  • the first sensor 1 has a first infrared transmitter diode 11 and a first infrared receiver 14.
  • the second sensor 2 has a second infrared transmitter diode 21 and a second infrared receiver 24.
  • the first infrared transmitter diode 11 and the second infrared transmitter diode 21 are supplied by a generator 4 with a square-wave signal of approximately ten kilohertz.
  • the first infrared receiver 14 and the second infrared receiver 24 each receive the light reflected by the blood flowing through the corresponding arteries.
  • the signal emitted by the infrared receiver 14 of the first sensor 1 in accordance with the rectangular light signal emitted by the first infrared transmitter diode 11, the signal curve of which is shown in FIG. 3, is applied to a first demodulator 15.
  • the signal emitted by the second infrared receiver 24 of the second sensor 2 in accordance with the rectangular light signal emitted by the second infrared transmitter diode 21 is applied to a second demodulator 25.
  • the signal demodulated by the first demodulator 15, the waveform of which is shown in FIG. 4, is applied to a difference generator 5.
  • the signal demodulated by the second demodulator 25, the signal curve of which is shown in FIG. 5, is also applied to the difference generator 5.
  • the signals emitted by the demodulators 15, 25 are the envelope of the signals emitted by the infrared receivers 14, 24, which are then freed from an offset and are therefore easier to process.
  • the time difference ( ⁇ t) between the signal emitted by the first demodulator 15 and the signal emitted by the second demodulator 25 is formed in the difference generator 5.
  • the difference measurement value ( ⁇ t) formed in each case is given to an averager 6, which forms an arithmetic mean value from the difference measurement values ( ⁇ t) obtained.
  • the sum of the difference measurement values ( ⁇ t) is formed and divided by the number of difference measurement values (n).
  • the arithmetic mean is compared to a norm value, which depends on body size, gender, age and other factors, such as a region-specific diet. By comparing with the norm value one can make a statement about the elasticity of the arterial system of the person concerned.
  • An electrocardiogram (EKG) is recorded in a device 8, which records the heartbeats of the person 7, which are recorded by an electrode 8a.
  • the start of a heart action is given to the difference generator 5.
  • the signals emitted by the demodulators 15, 25 are checked for their plausibility and, if there is no plausibility, excluded from the evaluation.
  • the sensor 1 '(2') has two IR transmit diodes 11 ', 12' (21 ', 22'), between which an IR receive diode 14 '(24') is arranged.
  • the IR receive diode 14 '(24') is located on the connecting line 26 between the two IR transmit diodes 11 ', 12' (21 ', 22').
  • the infrared receiving diode 14 '(24') in the middle between the two IR transmitting diodes 11 ', 12' (21 ', 22') so that the arrangement is symmetrical, it can also be arranged asymmetrically between the two IR transmitter diodes 11 ', 12' (21 ', 22'). Furthermore, it can also be arranged at a distance perpendicular to the connecting line 26 between the two IR transmission diodes 11 ', 12' (21 ', 22').
  • Such a sensor is particularly well suited for detecting a blood pulse on an elongated extremity, such as a finger.
  • the sensor 1 (2) has three IR transmission diodes 11, 12, 13 (21, 22, 23) which are arranged on the circumference of a circle K.
  • An infrared receiver diode 14 (24) is arranged in the center M of the circle K. The light emitted by such an arrangement illuminates the tissue very well, so that an artery in question is illuminated with a relatively large light intensity. This brings a lot of that Blood flowing through the artery reflects light to the infrared receiver 14 (24).
  • the arrangement has the advantage that the sensor does not have to be positioned very precisely.
  • each blood pulse is the effect of a single heartbeat, it is particularly advantageous if the associated ECG is also recorded and the chronological assignment of the blood pulse curves is based on the start of a heart action.
  • the earliest start of a blood pulse curve can be determined from the determination of the R wave (R) in the EKG.
  • the R wave (R) in the ECG represents the beginning of the expulsion phase of the left ventricle, after which the blood pulse signal in the carotid can be detected after a very short period of time.
  • the time assignment of the blood pulse curves to the start of a heartbeat when determining the pulse duration between the carotid and, for example, the left foot can advantageously be used to determine whether no extrasystoles of the heart take place during the duration. Since this could lead to the individual signals being superimposed, the reference to the start of a heartbeat can ensure that only regular pulse transit times are taken into account in the evaluation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

L'invention concerne un dispositif pour déterminer la durée d'une pulsation sanguine, lequel dispositif comporte un premier capteur (1) destiné à détecter la pulsation sanguine en un premier point (1a), un second capteur (2) destiné à détecter la pulsation sanguine en un second point (2a) et une unité d'évaluation (3) prévue pour établir l'écart temporel entre l'apparition de la pulsation sanguine au premier point (1a) et l'apparition de cette pulsation sanguine au second point (2a). Ledit dispositif se caractérise en ce qu'au moins le premier capteur (1) présente au moins deux émetteurs IR (11', 12' ; 11, 12, 13) et au moins un récepteur IR (14' ; 14), placé sur la ligne de connexion (26) entre les émetteurs IR (11) ou à une certaine distance de ladite ligne de connexion (26) perpendiculairement à cette dernière.
PCT/DE2005/000929 2004-05-18 2005-05-18 Dispositif pour determiner la duree d'une pulsation sanguine WO2005110212A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112005001783T DE112005001783A5 (de) 2004-05-18 2005-05-18 Vorrichtung zur Bestimmung der Laufzeit eines Blutpulses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004025042A DE102004025042A1 (de) 2004-05-18 2004-05-18 Vorrichtung zur Bestimmung der Laufzeit eines Blutpulses
DE102004025042.1 2004-05-18

Publications (1)

Publication Number Publication Date
WO2005110212A1 true WO2005110212A1 (fr) 2005-11-24

Family

ID=34972413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2005/000929 WO2005110212A1 (fr) 2004-05-18 2005-05-18 Dispositif pour determiner la duree d'une pulsation sanguine

Country Status (2)

Country Link
DE (2) DE102004025042A1 (fr)
WO (1) WO2005110212A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3533912A1 (de) 1985-09-23 1987-04-02 Schmid Walter Blutdruckmessgeraet
EP1091686B1 (fr) 1998-09-09 2003-05-21 Helen Marcoyannopoulou Fojas Dispositif de determination de l'elasticite de la paroi arterielle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE132720T1 (de) * 1990-07-18 1996-01-15 Avl Medical Instr Ag Einrichtung und verfahren zur blutdruckmessung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3533912A1 (de) 1985-09-23 1987-04-02 Schmid Walter Blutdruckmessgeraet
EP1091686B1 (fr) 1998-09-09 2003-05-21 Helen Marcoyannopoulou Fojas Dispositif de determination de l'elasticite de la paroi arterielle

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NITZAN ET AL.: "The difference in pulse transit time to the toe and finger measured by photoplethysmography", PHYSIOLOGICAL MEASUREMENT, vol. 23, no. 1, February 2002 (2002-02-01), England, pages 85 - 93, XP002344867 *

Also Published As

Publication number Publication date
DE102004025042A1 (de) 2005-12-29
DE112005001783A5 (de) 2007-05-31

Similar Documents

Publication Publication Date Title
EP0892617B1 (fr) Detection de signaux parasites lors de mesures pulsoxymetriques
DE69829621T2 (de) Verfahren und Gerät zur Unterdrückung von Artefakten in physiologischen Signalen
DE69928569T2 (de) Rechner zur erkennung von plethysmographischen pulsen
EP0467853B1 (fr) Dispositif et procédé destinés à la mesure de la pression sanguine
US5226417A (en) Apparatus for the detection of motion transients
DE3807672C2 (fr)
DE3533912C2 (fr)
EP0027215B1 (fr) Cardiotachomètre
DE10311408B3 (de) Verfahren zur nichtinvasiven Messung der Konzentration von Blutbestandteilen
DE60215283T2 (de) Vorrichtung zur Festlegung der linksventrikulären Auswurfzeit in einem Herz
DE69432222T2 (de) Puls-oximeter mit virtuellem auslösesignal zum synchronisieren mit der herzfrequenz
DE602004010939T2 (de) Methode und Vorrichtung zur menschlichen Stressevaluierung durch Photoplethysmographie
DE69821775T2 (de) System und verfahren zur korrektur des gemessenen blutdrucks eines lebewesens
WO2008116838A2 (fr) Procédé de détermination de lésions microvasculaires
DE69725622T2 (de) Verfahren für das harmonische filtern von daten
DE3345739C2 (de) Am Handgelenk zu befestigende Einrichtung zum Erfassen und Anzeigen der Pulsfrequenz und anderer hiervon ableitbarer Kreislaufparameter
WO2005030050A1 (fr) Procede et appareil de mesure de la pression arterielle
DE69532610T2 (de) Automatisch aktivierte blutdruckmessvorrichtung
DE4238641C2 (de) Vorrichtung und Arbeitsverfahren zum Bestimmen und Auswerten des physiologischen Zustandes von Gefäßsystemen
EP3316768B1 (fr) Dispositif et procédé pour la surveillance et la mesure du mécanisme d'autorégulation de la pression sanguine chez un être vivant
EP3071098B1 (fr) Procédé et appareil pour déterminer au moins un paramètre physiologique au moyen d'un signal de mesure du pouls corrigé
WO2005110212A1 (fr) Dispositif pour determiner la duree d'une pulsation sanguine
DE10249863A1 (de) Verfahren und Vorrichtung zur nicht invasiven Blutdruckmessung
US6496723B1 (en) Method of obtaining information that corresponds to electrocardiogram of human body from pulse wave thereof
DE102018209198B3 (de) Verfahren und Gerät zur Bestimmung mindestens eines physiologischen Parameters

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1120050017834

Country of ref document: DE

REF Corresponds to

Ref document number: 112005001783

Country of ref document: DE

Date of ref document: 20070531

Kind code of ref document: P

122 Ep: pct application non-entry in european phase