WO2005107807A3 - Methode de transplantation intraventriculaire cerebrale utilisee pour traiter la sclerose laterale amyotrophique - Google Patents

Methode de transplantation intraventriculaire cerebrale utilisee pour traiter la sclerose laterale amyotrophique Download PDF

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Publication number
WO2005107807A3
WO2005107807A3 PCT/US2005/016033 US2005016033W WO2005107807A3 WO 2005107807 A3 WO2005107807 A3 WO 2005107807A3 US 2005016033 W US2005016033 W US 2005016033W WO 2005107807 A3 WO2005107807 A3 WO 2005107807A3
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WO
WIPO (PCT)
Prior art keywords
lateral sclerosis
amyotrophic lateral
treating amyotrophic
transplantation
cerebral intraventricular
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Application number
PCT/US2005/016033
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English (en)
Other versions
WO2005107807A2 (fr
Inventor
Svitlana Garbuzova-Davis
Andrew Balber
Cyndy Davis-Sanberg
Tracy Gentry
Nicole Kuzmin-Nichols
Paul R Sanberg
Alison Willing
Original Assignee
Univ South Florida
Svitlana Garbuzova-Davis
Andrew Balber
Cyndy Davis-Sanberg
Tracy Gentry
Nicole Kuzmin-Nichols
Paul R Sanberg
Alison Willing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Univ South Florida, Svitlana Garbuzova-Davis, Andrew Balber, Cyndy Davis-Sanberg, Tracy Gentry, Nicole Kuzmin-Nichols, Paul R Sanberg, Alison Willing filed Critical Univ South Florida
Publication of WO2005107807A2 publication Critical patent/WO2005107807A2/fr
Publication of WO2005107807A3 publication Critical patent/WO2005107807A3/fr

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources

Abstract

L'invention concerne une méthode destinée à traiter un patient présentant une maladie neurodégénérative, telle que la sclérose latérale amyotrophique, au moyen de cellules progénitrices isolées à partir du sang d'un cordon ombilical humain. La transplantation non invasive d'une aldéhyde déshydrogénase (ALDH+) exprimant les cellules progénitrices permet de réaliser un remplacement cellulaire et de protéger les neurones moteurs.
PCT/US2005/016033 2004-05-06 2005-05-06 Methode de transplantation intraventriculaire cerebrale utilisee pour traiter la sclerose laterale amyotrophique WO2005107807A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52149304P 2004-05-06 2004-05-06
US60/521,493 2004-05-06

Publications (2)

Publication Number Publication Date
WO2005107807A2 WO2005107807A2 (fr) 2005-11-17
WO2005107807A3 true WO2005107807A3 (fr) 2006-01-19

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PCT/US2005/016033 WO2005107807A2 (fr) 2004-05-06 2005-05-06 Methode de transplantation intraventriculaire cerebrale utilisee pour traiter la sclerose laterale amyotrophique

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US (1) US8765119B2 (fr)
WO (1) WO2005107807A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309070B2 (en) * 2004-05-17 2012-11-13 Regents Of The University Of Minnesota Use of umbilical cord blood stem cells to treat ischemic event
US20080027031A1 (en) * 2006-03-08 2008-01-31 Kinemed, Inc. Retinoids and Related Compounds for the Treatment of Neuroinflammatory Conditions, Diseases and Disorders
JP2010509360A (ja) * 2006-11-08 2010-03-25 アルダジェン， インコーポレイテッド 幹細胞移植を補助するためにＡＬＤＨｂｒ細胞を使用する方法
CN102186338B (zh) 2008-08-20 2016-03-16 人类起源公司 改进的细胞组合物及制备所述组合物的方法
US9795652B2 (en) 2010-02-25 2017-10-24 University Of South Florida Use of endogenous antioxidant proteins in the treatment of stroke

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028510A1 (en) * 2000-03-09 2002-03-07 Paul Sanberg Human cord blood as a source of neural tissue for repair of the brain and spinal cord
US20050032209A1 (en) * 2003-06-27 2005-02-10 Messina Darin J. Regeneration and repair of neural tissue using postpartum-derived cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031233A1 (fr) * 1995-04-07 1996-10-10 Rijksuniversiteit Leiden Emploi de la gelatinase b et d'enzymes apparentees pour mobiliser les cellules souches hematopoietiques en vue de transplanter des cellules souches sanguines
JP2002513545A (ja) * 1998-05-07 2002-05-14 ザ ユニヴァーシティー オブ サウス フロリダ 脳および脊髄修復のためのニューロン源としての骨髄細胞
ATE462014T1 (de) * 1998-12-07 2010-04-15 Univ Duke Bodipy aminoacetaldehyd diethyl acetal
US20020132343A1 (en) * 2001-03-19 2002-09-19 Clark Lum System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028510A1 (en) * 2000-03-09 2002-03-07 Paul Sanberg Human cord blood as a source of neural tissue for repair of the brain and spinal cord
US20050032209A1 (en) * 2003-06-27 2005-02-10 Messina Darin J. Regeneration and repair of neural tissue using postpartum-derived cells

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Publication number Publication date
US20050249708A1 (en) 2005-11-10
US8765119B2 (en) 2014-07-01
WO2005107807A2 (fr) 2005-11-17

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