WO2005105093A3 - METHOD OF ARRESTING THE SIDE EFFECTS OF µ-OPIOID RECEPTOR AGONISTS DURING THEIR ADMINISTRATION - Google Patents

METHOD OF ARRESTING THE SIDE EFFECTS OF µ-OPIOID RECEPTOR AGONISTS DURING THEIR ADMINISTRATION Download PDF

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Publication number
WO2005105093A3
WO2005105093A3 PCT/US2004/027669 US2004027669W WO2005105093A3 WO 2005105093 A3 WO2005105093 A3 WO 2005105093A3 US 2004027669 W US2004027669 W US 2004027669W WO 2005105093 A3 WO2005105093 A3 WO 2005105093A3
Authority
WO
WIPO (PCT)
Prior art keywords
side effects
receptor agonists
opioid receptor
arresting
administration
Prior art date
Application number
PCT/US2004/027669
Other languages
French (fr)
Other versions
WO2005105093A2 (en
Inventor
Laura M Bohn
Julia K L Walker
Robert J Lefkowitz
Marc G Caron
Original Assignee
Univ Duke
Laura M Bohn
Julia K L Walker
Robert J Lefkowitz
Marc G Caron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Laura M Bohn, Julia K L Walker, Robert J Lefkowitz, Marc G Caron filed Critical Univ Duke
Publication of WO2005105093A2 publication Critical patent/WO2005105093A2/en
Publication of WO2005105093A3 publication Critical patent/WO2005105093A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9486—Analgesics, e.g. opiates, aspirine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides methods for decreasing the side effects of µ opioid receptor agonists and methods for screening compounds for activity in reducing the side effects of µ opioid receptor agonists.
PCT/US2004/027669 2003-08-26 2004-08-25 METHOD OF ARRESTING THE SIDE EFFECTS OF µ-OPIOID RECEPTOR AGONISTS DURING THEIR ADMINISTRATION WO2005105093A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49783803P 2003-08-26 2003-08-26
US60/497,838 2003-08-26

Publications (2)

Publication Number Publication Date
WO2005105093A2 WO2005105093A2 (en) 2005-11-10
WO2005105093A3 true WO2005105093A3 (en) 2006-09-14

Family

ID=35242219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/027669 WO2005105093A2 (en) 2003-08-26 2004-08-25 METHOD OF ARRESTING THE SIDE EFFECTS OF µ-OPIOID RECEPTOR AGONISTS DURING THEIR ADMINISTRATION

Country Status (1)

Country Link
WO (1) WO2005105093A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126529A1 (en) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. 6,7-unsaturated-7-carbamoyl substituted morphinan derivative
EP2785874B1 (en) 2011-11-30 2018-09-26 Children's Hospital Medical Center Personalized pain management and anesthesia: preemptive risk identification and therapeutic decision support
JP6581117B2 (en) 2014-02-24 2019-09-25 チルドレンズ ホスピタル メディカル センター Methods and compositions for personalized pain management
WO2018136728A1 (en) 2017-01-20 2018-07-26 Children's Hospital Medical Center Methods and compositions relating to oprm1 dna methylation for personalized pain management

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BOHN L.M. ET AL.: "mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence", NATURE, vol. 408, no. 6813, 7 December 2000 (2000-12-07), pages 720 - 723, XP003001769 *

Also Published As

Publication number Publication date
WO2005105093A2 (en) 2005-11-10

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