WO2005099763A3 - Composition for intracellular transfer of a nucleic acid - Google Patents

Composition for intracellular transfer of a nucleic acid Download PDF

Info

Publication number
WO2005099763A3
WO2005099763A3 PCT/FR2005/050252 FR2005050252W WO2005099763A3 WO 2005099763 A3 WO2005099763 A3 WO 2005099763A3 FR 2005050252 W FR2005050252 W FR 2005050252W WO 2005099763 A3 WO2005099763 A3 WO 2005099763A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
composition
intracellular transfer
efficient amount
intracellular
Prior art date
Application number
PCT/FR2005/050252
Other languages
French (fr)
Other versions
WO2005099763A2 (en
Inventor
Bruno Pitard
Original Assignee
Inst Nat Sante Rech Med
Bruno Pitard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Bruno Pitard filed Critical Inst Nat Sante Rech Med
Publication of WO2005099763A2 publication Critical patent/WO2005099763A2/en
Publication of WO2005099763A3 publication Critical patent/WO2005099763A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

The invention concerns a composition useful for the intracellular transfer of at least one nucleic acid, said composition comprising: an efficient amount of at least one nucleic acid; an efficient amount of at least one polyoxyethylene/polyoxypropylene copolymer; and an efficient amount of at least one inorganic divalent cation salt.
PCT/FR2005/050252 2004-04-16 2005-04-15 Composition for intracellular transfer of a nucleic acid WO2005099763A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0404010 2004-04-16
FR0404010A FR2868953B1 (en) 2004-04-16 2004-04-16 COMPOSITION FOR THE INTRACELLULAR TRANSFER OF A NUCLEIC ACID.

Publications (2)

Publication Number Publication Date
WO2005099763A2 WO2005099763A2 (en) 2005-10-27
WO2005099763A3 true WO2005099763A3 (en) 2006-04-13

Family

ID=34946275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/050252 WO2005099763A2 (en) 2004-04-16 2005-04-15 Composition for intracellular transfer of a nucleic acid

Country Status (2)

Country Link
FR (1) FR2868953B1 (en)
WO (1) WO2005099763A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021265103A1 (en) 2020-04-29 2023-01-19 Bristol-Myers Squibb Company Miniaturized dystrophins having spectrin fusion domains and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051645A1 (en) * 1999-03-02 2000-09-08 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Polymer compositions for polynucleotide delivery
US6353055B1 (en) * 1994-11-18 2002-03-05 Supratek Pharma Inc. Polynucleotide compositions
WO2002067990A1 (en) * 2001-02-19 2002-09-06 Aventis Pasteur Polynucleotide formulation for enhanced intracellular transfer
WO2003066104A2 (en) * 2002-02-08 2003-08-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Pharmaceutical composition which improves in vivo gene transfer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6353055B1 (en) * 1994-11-18 2002-03-05 Supratek Pharma Inc. Polynucleotide compositions
WO2000051645A1 (en) * 1999-03-02 2000-09-08 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Polymer compositions for polynucleotide delivery
WO2002067990A1 (en) * 2001-02-19 2002-09-06 Aventis Pasteur Polynucleotide formulation for enhanced intracellular transfer
WO2003066104A2 (en) * 2002-02-08 2003-08-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Pharmaceutical composition which improves in vivo gene transfer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Dulbecco's Modification of Eagle's Medium (DMEM)", pages 1 - 3, XP002366782, Retrieved from the Internet <URL:http://www.mpbio.com/ecom/docs/proddata.nsf/(webtds)/1642354> [retrieved on 20060208] *

Also Published As

Publication number Publication date
FR2868953B1 (en) 2006-06-30
FR2868953A1 (en) 2005-10-21
WO2005099763A2 (en) 2005-10-27

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