WO2005098038A3 - Use of rna polymerase as an information-dependent molecular motor - Google Patents

Use of rna polymerase as an information-dependent molecular motor Download PDF

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Publication number
WO2005098038A3
WO2005098038A3 PCT/US2004/006896 US2004006896W WO2005098038A3 WO 2005098038 A3 WO2005098038 A3 WO 2005098038A3 US 2004006896 W US2004006896 W US 2004006896W WO 2005098038 A3 WO2005098038 A3 WO 2005098038A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna polymerase
information
molecular motor
dependent molecular
dependent
Prior art date
Application number
PCT/US2004/006896
Other languages
French (fr)
Other versions
WO2005098038A2 (en
Inventor
William T Mcallister
Richard Pomerantz
Michael Anikin
Original Assignee
Univ New York State Res Found
William T Mcallister
Richard Pomerantz
Michael Anikin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, William T Mcallister, Richard Pomerantz, Michael Anikin filed Critical Univ New York State Res Found
Priority to JP2007501757A priority Critical patent/JP2008507952A/en
Priority to PCT/US2004/006896 priority patent/WO2005098038A2/en
Priority to EP04718069A priority patent/EP1721000A4/en
Publication of WO2005098038A2 publication Critical patent/WO2005098038A2/en
Priority to US11/469,957 priority patent/US20070077575A1/en
Publication of WO2005098038A3 publication Critical patent/WO2005098038A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07006—DNA-directed RNA polymerase (2.7.7.6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Materials and methods are described in which the information dependence of RNA polymerase is employed to enable its use as a molecular motor adaptable for movement within DNA grid arrays and to actuate, move, position or alter cargo such as physical structures and normally inanimate substances and objects.
PCT/US2004/006896 2004-03-05 2004-03-05 Use of rna polymerase as an information-dependent molecular motor WO2005098038A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2007501757A JP2008507952A (en) 2004-03-05 2004-03-05 Use of RNA polymerase as an information-dependent molecular motor
PCT/US2004/006896 WO2005098038A2 (en) 2004-03-05 2004-03-05 Use of rna polymerase as an information-dependent molecular motor
EP04718069A EP1721000A4 (en) 2004-03-05 2004-03-05 Use of rna polymerase as an information-dependent molecular motor
US11/469,957 US20070077575A1 (en) 2004-03-05 2006-09-05 Use of rna polymerase as an information-dependent molecular motor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/006896 WO2005098038A2 (en) 2004-03-05 2004-03-05 Use of rna polymerase as an information-dependent molecular motor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/469,957 Continuation US20070077575A1 (en) 2004-03-05 2006-09-05 Use of rna polymerase as an information-dependent molecular motor

Publications (2)

Publication Number Publication Date
WO2005098038A2 WO2005098038A2 (en) 2005-10-20
WO2005098038A3 true WO2005098038A3 (en) 2008-01-24

Family

ID=35125681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/006896 WO2005098038A2 (en) 2004-03-05 2004-03-05 Use of rna polymerase as an information-dependent molecular motor

Country Status (3)

Country Link
EP (1) EP1721000A4 (en)
JP (1) JP2008507952A (en)
WO (1) WO2005098038A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012220546B2 (en) * 2011-02-23 2017-02-23 Eve Biomedical, Inc. Rotation-dependent transcriptional sequencing systems and methods of using
CA2859913C (en) * 2011-12-22 2021-02-23 Centre National De La Recherche Scientifique (Cnrs) Method of dna detection and quantification by single-molecule hybridization and manipulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355464B1 (en) * 1996-12-03 2002-03-12 Anadys Pharmaceuticals, Inc. M. tuberculosis RNA polymerase alpha subunit
US6524828B1 (en) * 1998-12-11 2003-02-25 Akzo Nobel N.V. Mutant of RNA polymerases with increased stability

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207403B1 (en) * 1998-01-08 2001-03-27 The Regents Of The University Of California Kinesin motor modulators derived from the marine sponge Adocia
US6210896B1 (en) * 1998-08-13 2001-04-03 Us Genomics Molecular motors
AU2003233310A1 (en) * 2002-05-08 2003-11-11 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Agent and method for transporting biologically active molecules in cells
JP2003334070A (en) * 2002-05-22 2003-11-25 Japan Science & Technology Corp Modified type f0f1-atp synthase molecule and use thereof
JP4367825B2 (en) * 2002-07-31 2009-11-18 国立大学法人群馬大学 Recombinant myosin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355464B1 (en) * 1996-12-03 2002-03-12 Anadys Pharmaceuticals, Inc. M. tuberculosis RNA polymerase alpha subunit
US6524828B1 (en) * 1998-12-11 2003-02-25 Akzo Nobel N.V. Mutant of RNA polymerases with increased stability

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1721000A4 *

Also Published As

Publication number Publication date
EP1721000A2 (en) 2006-11-15
WO2005098038A2 (en) 2005-10-20
EP1721000A4 (en) 2008-08-20
JP2008507952A (en) 2008-03-21

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