WO2005097208A3 - Tissue oxygenation measurements - Google Patents

Tissue oxygenation measurements Download PDF

Info

Publication number
WO2005097208A3
WO2005097208A3 PCT/US2005/010112 US2005010112W WO2005097208A3 WO 2005097208 A3 WO2005097208 A3 WO 2005097208A3 US 2005010112 W US2005010112 W US 2005010112W WO 2005097208 A3 WO2005097208 A3 WO 2005097208A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue oxygenation
contrast agent
mri
methods
peg
Prior art date
Application number
PCT/US2005/010112
Other languages
French (fr)
Other versions
WO2005097208A2 (en
Inventor
Edward Allan Ross
Christopher David Batich
Original Assignee
Univ Florida
Edward Allan Ross
Christopher David Batich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Edward Allan Ross, Christopher David Batich filed Critical Univ Florida
Publication of WO2005097208A2 publication Critical patent/WO2005097208A2/en
Publication of WO2005097208A3 publication Critical patent/WO2005097208A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG

Abstract

An effective contrast agent for use in MRI-based methods for directly determining tissue oxygenation in a subject using MRI equipment as well as methods for assessing tissue oxygenation were discovered. Methods employ a blood substitute bound to a water soluble polymer as an MRI contrast agent. In the experiments described herein, polyethylene glycol (PEG) derivatives of bovine hemoglobin (pegylated Hb or PEG-Hb) were used as the contrast agent.
PCT/US2005/010112 2004-03-26 2005-03-25 Tissue oxygenation measurements WO2005097208A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55693204P 2004-03-26 2004-03-26
US60/556,932 2004-03-26

Publications (2)

Publication Number Publication Date
WO2005097208A2 WO2005097208A2 (en) 2005-10-20
WO2005097208A3 true WO2005097208A3 (en) 2006-01-26

Family

ID=35125629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/010112 WO2005097208A2 (en) 2004-03-26 2005-03-25 Tissue oxygenation measurements

Country Status (1)

Country Link
WO (1) WO2005097208A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9339559B2 (en) 2005-09-09 2016-05-17 Georgia State University Research Foundation, Inc. Targeted contrast agents and methods for targeting contrast agents
WO2009146099A2 (en) 2008-04-02 2009-12-03 Georgia State University Research Foundation, Inc. Contrast agents, methods for preparing contrast agents, and methods of imaging
GB0812191D0 (en) * 2008-07-03 2008-08-13 Greater Glasgow Health Board Modified cells and methods of monitoring their viability
AU2009271530B2 (en) 2008-07-18 2016-01-07 Oxygen Biotherapeutics, Inc. Method of treating traumatic brain injury
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
CA2770695A1 (en) * 2009-08-25 2011-03-03 Hiroshi Mizukami Synthesis of oxygen carrying, turbulence resistant, high density submicron particulates
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
WO2011140193A1 (en) * 2010-05-04 2011-11-10 Massachusetts Institute Of Technology Implantable dissolved oxygen sensor and methods of use
US8513309B2 (en) 2010-10-01 2013-08-20 Oxygen Biotherapeutics, Inc. Perfluorocarbons for use in treating pruritus
CN105854034B (en) * 2016-06-23 2018-08-24 吉林大学 The poly- amino-pyrroles composite nanoparticle diagnosis and treatment reagent of metal ion Copper-cladding Aluminum Bar, preparation method and applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498421A (en) * 1993-02-22 1996-03-12 Vivorx Pharmaceuticals, Inc. Composition useful for in vivo delivery of biologics and methods employing same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498421A (en) * 1993-02-22 1996-03-12 Vivorx Pharmaceuticals, Inc. Composition useful for in vivo delivery of biologics and methods employing same

Also Published As

Publication number Publication date
WO2005097208A2 (en) 2005-10-20

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