WO2005094800A3 - A co-precipitated cefepime composition and process for preparation thereof - Google Patents

A co-precipitated cefepime composition and process for preparation thereof Download PDF

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Publication number
WO2005094800A3
WO2005094800A3 PCT/IN2005/000095 IN2005000095W WO2005094800A3 WO 2005094800 A3 WO2005094800 A3 WO 2005094800A3 IN 2005000095 W IN2005000095 W IN 2005000095W WO 2005094800 A3 WO2005094800 A3 WO 2005094800A3
Authority
WO
WIPO (PCT)
Prior art keywords
cefepime
sterile
pharmaceutically acceptable
composition
aqueous solution
Prior art date
Application number
PCT/IN2005/000095
Other languages
French (fr)
Other versions
WO2005094800B1 (en
WO2005094800A2 (en
Inventor
Om Dutt Tyagi
Yogendra Kumar Chauhan
Tushar Kumar Srivastava
Original Assignee
Lupin Ltd
Om Dutt Tyagi
Yogendra Kumar Chauhan
Tushar Kumar Srivastava
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd, Om Dutt Tyagi, Yogendra Kumar Chauhan, Tushar Kumar Srivastava filed Critical Lupin Ltd
Publication of WO2005094800A2 publication Critical patent/WO2005094800A2/en
Publication of WO2005094800A3 publication Critical patent/WO2005094800A3/en
Publication of WO2005094800B1 publication Critical patent/WO2005094800B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin

Abstract

The present invention provides a stable and sterile composition of Cefepime with a pharmaceutically acceptable non-toxic organic and inorganic base in high purity which exhibits good thermal stability which is obtained by co precipitation of composition containing non-sterile Cefepime and non-sterile pharmaceutically acceptable base. The method of preparing the co-precipitated composition of Cefepime with pharmaceutically acceptable non-toxic base comprises of, i) dissolving a composition containing mixture of non sterile Cefepime and a non sterile pharmaceutically acceptable non-toxic organic or inorganic base in water to obtain a clear aqueous solution having a pH in the range of 3.5-7 and ii) filtration of aqueous solution through 0.2 micron membrane filter and then adding the clear aqueous solution to a suitable an organic solvent followed by stirring, filtration and drying.
PCT/IN2005/000095 2004-03-31 2005-03-30 A co-precipitated cefepime composition and process for preparation thereof WO2005094800A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN393/MUM/2004 2004-03-31
IN393MU2004 2004-03-31

Publications (3)

Publication Number Publication Date
WO2005094800A2 WO2005094800A2 (en) 2005-10-13
WO2005094800A3 true WO2005094800A3 (en) 2005-11-24
WO2005094800B1 WO2005094800B1 (en) 2006-01-19

Family

ID=34973079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2005/000095 WO2005094800A2 (en) 2004-03-31 2005-03-30 A co-precipitated cefepime composition and process for preparation thereof

Country Status (1)

Country Link
WO (1) WO2005094800A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006106529A1 (en) * 2005-04-05 2006-10-12 Lupin Limited A co-spray dried composition of cefepime with base and process for preparation thereof
US20070038224A1 (en) * 2005-07-28 2007-02-15 Ethicon Endo-Surgery, Inc. Electroactive polymer-based flexing access port
TW200940552A (en) * 2008-03-04 2009-10-01 Elan Pharm Inc Stable liquid formulations of anti-infective agents and adjusted anti-infective agent dosing regimens
CN112094281B (en) * 2020-08-11 2021-07-30 华北制药河北华民药业有限责任公司 Preparation method of cefepime hydrochloride for injection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984403A (en) * 1972-06-30 1976-10-05 Takeda Chemical Industries, Ltd. Arginine and lysine salts of acid cephalosporins
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984403A (en) * 1972-06-30 1976-10-05 Takeda Chemical Industries, Ltd. Arginine and lysine salts of acid cephalosporins
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination

Also Published As

Publication number Publication date
WO2005094800A2 (en) 2005-10-13

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