WO2005094797A3 - Nouveaux antagonistes de recepteur ampa - Google Patents

Nouveaux antagonistes de recepteur ampa Download PDF

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Publication number
WO2005094797A3
WO2005094797A3 PCT/EP2005/002305 EP2005002305W WO2005094797A3 WO 2005094797 A3 WO2005094797 A3 WO 2005094797A3 EP 2005002305 W EP2005002305 W EP 2005002305W WO 2005094797 A3 WO2005094797 A3 WO 2005094797A3
Authority
WO
WIPO (PCT)
Prior art keywords
ampa
receptor antagonists
treating dementia
dementia
nootropics
Prior art date
Application number
PCT/EP2005/002305
Other languages
English (en)
Other versions
WO2005094797A2 (fr
Inventor
Kurt Lingenhoehl
Ferenc Martenyi
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Kurt Lingenhoehl
Ferenc Martenyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Kurt Lingenhoehl, Ferenc Martenyi filed Critical Novartis Ag
Publication of WO2005094797A2 publication Critical patent/WO2005094797A2/fr
Publication of WO2005094797A3 publication Critical patent/WO2005094797A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un procédé destiné au traitement et/ou à la prévention de la démence qui comprend les étapes consistant à administrer à un animal à sang chaud, notamment un être humain, le nécessitant une quantité efficace d'un antagoniste récepteur AMPA seul ou en combinaison avec des nootropes.
PCT/EP2005/002305 2004-03-05 2005-03-04 Nouveaux antagonistes de recepteur ampa WO2005094797A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0405034.0 2004-03-05
GBGB0405034.0A GB0405034D0 (en) 2004-03-05 2004-03-05 Organic compounds

Publications (2)

Publication Number Publication Date
WO2005094797A2 WO2005094797A2 (fr) 2005-10-13
WO2005094797A3 true WO2005094797A3 (fr) 2005-12-01

Family

ID=32088811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/002305 WO2005094797A2 (fr) 2004-03-05 2005-03-04 Nouveaux antagonistes de recepteur ampa

Country Status (2)

Country Link
GB (1) GB0405034D0 (fr)
WO (1) WO2005094797A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4403185A1 (fr) * 2021-09-15 2024-07-24 University of The Ryukyus Composition pharmaceutique destinée à être mise en oeuvre dans le traitement soit du déclin des fonctions cognitives, soit de la surcharge pondérale ou de l'obésité

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0784054A1 (fr) * 1994-09-27 1997-07-16 Yamanouchi Pharmaceutical Co. Ltd. Derive de 1,2,3,4-tetrahydroquinoxalindione
US5756495A (en) * 1994-08-01 1998-05-26 Schering Aktiengesellschaft 3-substituted 3H-2, 3-benzodiazepine derivatives, the production and use as pharmaceutical agents
EP0884316A1 (fr) * 1997-06-09 1998-12-16 Pfizer Products Inc. Quinazoline-4-ones antagonistes d'AMPA
WO2000027851A1 (fr) * 1998-11-09 2000-05-18 Gyógyszerkutató Intézet Kft. Nouveaux types de composes de pyridazinone condenses
US6117873A (en) * 1996-10-24 2000-09-12 Novartis Ag Substituted aminoalkane phosphonic acids
WO2003020289A1 (fr) * 2001-08-30 2003-03-13 Ortho-Mcneil Pharmaceutical, Inc. Traitement de la demence et des troubles de la memoire par le biais d'anticonvulsifs et d'inhibiteurs de l'acetylcholinesterase
WO2003092701A2 (fr) * 2002-04-30 2003-11-13 Novartis Ag Utilisation d'acides amino-alcane-phosphoniques substitués

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756495A (en) * 1994-08-01 1998-05-26 Schering Aktiengesellschaft 3-substituted 3H-2, 3-benzodiazepine derivatives, the production and use as pharmaceutical agents
EP0784054A1 (fr) * 1994-09-27 1997-07-16 Yamanouchi Pharmaceutical Co. Ltd. Derive de 1,2,3,4-tetrahydroquinoxalindione
US6117873A (en) * 1996-10-24 2000-09-12 Novartis Ag Substituted aminoalkane phosphonic acids
EP0884316A1 (fr) * 1997-06-09 1998-12-16 Pfizer Products Inc. Quinazoline-4-ones antagonistes d'AMPA
WO2000027851A1 (fr) * 1998-11-09 2000-05-18 Gyógyszerkutató Intézet Kft. Nouveaux types de composes de pyridazinone condenses
WO2003020289A1 (fr) * 2001-08-30 2003-03-13 Ortho-Mcneil Pharmaceutical, Inc. Traitement de la demence et des troubles de la memoire par le biais d'anticonvulsifs et d'inhibiteurs de l'acetylcholinesterase
WO2003092701A2 (fr) * 2002-04-30 2003-11-13 Novartis Ag Utilisation d'acides amino-alcane-phosphoniques substitués

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CACABELOS R ET AL: "THE GLUTAMATERGIC SYSTEM AND NEURODEGENERATION IN DEMENTIA: PREVENTIVE STRATEGIES IN ALZHEIMER'S DISEASE", INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, JOHN WILEY AND SONS, CHICHESTER, GB, vol. 14, no. 1, 1999, pages 3 - 47, XP000924811, ISSN: 0885-6230 *
KHAN S A ET AL: "TOPIRAMATE ATTENUATES EXAGGERATED ACOUSTIC STARTLE IN AN ANIMAL MODEL OF PTSD", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, vol. 2003, 8 November 2003 (2003-11-08), pages ABSTRNO41605, XP008048316, ISSN: 0190-5295 *

Also Published As

Publication number Publication date
GB0405034D0 (en) 2004-04-07
WO2005094797A2 (fr) 2005-10-13

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