WO2005093413A3 - Diagnosis and treatment of preeclampsia - Google Patents

Diagnosis and treatment of preeclampsia Download PDF

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Publication number
WO2005093413A3
WO2005093413A3 PCT/US2005/009329 US2005009329W WO2005093413A3 WO 2005093413 A3 WO2005093413 A3 WO 2005093413A3 US 2005009329 W US2005009329 W US 2005009329W WO 2005093413 A3 WO2005093413 A3 WO 2005093413A3
Authority
WO
WIPO (PCT)
Prior art keywords
preeclampsia
diagnosis
treatment
present
provides methods
Prior art date
Application number
PCT/US2005/009329
Other languages
French (fr)
Other versions
WO2005093413A2 (en
Inventor
Irina Buhimschi
Errol Norwitz
Catalin Buhimschi
Lawerence Tsen
Original Assignee
Univ Yale
Brigham & Womens Hospital
Irina Buhimschi
Errol Norwitz
Catalin Buhimschi
Lawerence Tsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Brigham & Womens Hospital, Irina Buhimschi, Errol Norwitz, Catalin Buhimschi, Lawerence Tsen filed Critical Univ Yale
Publication of WO2005093413A2 publication Critical patent/WO2005093413A2/en
Publication of WO2005093413A3 publication Critical patent/WO2005093413A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

In certain embodiments, the present invention provides methods and kits for diagnosing or aiding in the diagnosis of preeclampsia in a female. In other embodiments, the present invention provides methods of identifying a compound that ameliorates or treats preeclampsia as well as methods of identifying biomarkers for preeclampsia in a bodily fluid such as cerebrospinal fluid (CSF).
PCT/US2005/009329 2004-03-22 2005-03-22 Diagnosis and treatment of preeclampsia WO2005093413A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55534904P 2004-03-22 2004-03-22
US60/555,349 2004-03-22
US63794404P 2004-12-21 2004-12-21
US60/637,944 2004-12-21

Publications (2)

Publication Number Publication Date
WO2005093413A2 WO2005093413A2 (en) 2005-10-06
WO2005093413A3 true WO2005093413A3 (en) 2006-01-05

Family

ID=34966398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/009329 WO2005093413A2 (en) 2004-03-22 2005-03-22 Diagnosis and treatment of preeclampsia

Country Status (1)

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WO (1) WO2005093413A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9488655B2 (en) 2004-07-14 2016-11-08 The Regents Of The University Of California Biomarkers for detection of early- and late-stage endometrial cancer
US7670792B2 (en) 2004-07-14 2010-03-02 The Regents Of The University Of California Biomarkers for early detection of ovarian cancer
EP3203241A1 (en) 2004-07-14 2017-08-09 The Regents of The University of California Biomarkers for early detection of ovarian cancer
WO2012047930A2 (en) 2010-10-04 2012-04-12 The Regents Of The University Of California Compositions and methods for treatment of gynecologic cancers
EA022609B1 (en) 2007-02-12 2016-02-29 А1М Фарма Аб Use of free fetal haemoglobin as a marker for preeclampsia
US20100113286A1 (en) * 2007-05-05 2010-05-06 Gilles Andre Lajoie Methods for detection of preeclampsia
CN110187119B (en) * 2008-10-31 2022-07-29 耶鲁大学 Methods and compositions for the detection and treatment of preeclampsia
ES2617755T3 (en) 2009-04-24 2017-06-19 Inserm - Institut National De La Santé Et De La Recherche Médicale Method to diagnose a hemoglobin-related disorder
CN102906568B (en) 2010-03-24 2014-11-12 普利鲁米那诊断公司 Hbf And A1m As Early Stage Markers For Preeclampsia
WO2013033260A1 (en) 2011-08-29 2013-03-07 The Regents Of The University Of California Use of hdl-related molecules to treat and prevent proinflammatory conditions

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198366A (en) * 1986-03-23 1993-03-30 Technion Research & Development Foundation Ltd. Method for the detection of pregnancy disorders
US5238819A (en) * 1988-12-14 1993-08-24 The Regents Of The University Of California Diagnostic assay for the detection of preeclampsia
US5849474A (en) * 1995-12-06 1998-12-15 Olson; Camilla M. Diagnosis of preeclampsia in mammals
US20010055781A1 (en) * 1996-07-11 2001-12-27 Groome Nigel Patrick Diagnosis of pre-eclampsia
US20030068653A1 (en) * 2000-06-01 2003-04-10 Parrott Jeff A. Determining existence of complications in pregnancies by measuring levels of bioactive lipids
US6642055B1 (en) * 2000-03-31 2003-11-04 Arbogast Pharmaceuticals, Inc. Method for the prediction of preeclampsia and other diseases
WO2004088324A2 (en) * 2003-03-25 2004-10-14 Proteogenix, Inc. Proteomic analysis of biological fluids
WO2004113926A2 (en) * 2003-06-16 2004-12-29 Brian David Owen Owen-Smith Diagnosis of pre-eclampsia

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198366A (en) * 1986-03-23 1993-03-30 Technion Research & Development Foundation Ltd. Method for the detection of pregnancy disorders
US5238819A (en) * 1988-12-14 1993-08-24 The Regents Of The University Of California Diagnostic assay for the detection of preeclampsia
US5849474A (en) * 1995-12-06 1998-12-15 Olson; Camilla M. Diagnosis of preeclampsia in mammals
US20010055781A1 (en) * 1996-07-11 2001-12-27 Groome Nigel Patrick Diagnosis of pre-eclampsia
US6642055B1 (en) * 2000-03-31 2003-11-04 Arbogast Pharmaceuticals, Inc. Method for the prediction of preeclampsia and other diseases
US20030068653A1 (en) * 2000-06-01 2003-04-10 Parrott Jeff A. Determining existence of complications in pregnancies by measuring levels of bioactive lipids
WO2004088324A2 (en) * 2003-03-25 2004-10-14 Proteogenix, Inc. Proteomic analysis of biological fluids
WO2004113926A2 (en) * 2003-06-16 2004-12-29 Brian David Owen Owen-Smith Diagnosis of pre-eclampsia

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BUHIMSCHI IRINA ET AL: "Proteomic profiling of cerebrospinal fluid (CSF) in patients with severe preeclampsia (SPE) suggests subclinical microhemorrhage with functional consequences", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 191, no. 6, December 2004 (2004-12-01), & 25TH ANNUAL MEETING OF THE SOCIETY-FOR-MATERNAL-FETAL-MEDICINE; RENO, NV, USA; FEBRUARY 09 -12, 2005, pages S32, XP002346271, ISSN: 0002-9378 *
CHAPPELL L C ET AL: "A LONGITUDINAL STUDY OF BIOCHEMICAL VARIABLES IN WOMEN AT RISK OF PREECLAMPSIA", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 187, no. 1, July 2002 (2002-07-01), pages 127 - 136, XP001205032, ISSN: 0002-9378 *
LEVINE RICHARD J ET AL: "Circulating angiogenic factors and the risk of preeclampsia", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 350, no. 7, 12 February 2004 (2004-02-12), pages 672 - 683, XP002314828, ISSN: 1533-4406 *
LIBERATORI S ET AL: "A TWO-DIMENSIONAL PROTEIN MAP OF HUMAN AMNIOTIC FLUID AT 17 WEEK'S GESTATION", ELECTROPHORESIS, WEINHEIM, DE, vol. 18, no. 15, December 1997 (1997-12-01), pages 2816 - 2822, XP008038127, ISSN: 0173-0835 *
NORWITZ ERROL ET AL: "Validation and quantitation of proteomic biomarkers for severe preeclampsia in cerebrospinal fluid", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 191, no. 6, December 2004 (2004-12-01), & 25TH ANNUAL MEETING OF THE SOCIETY-FOR-MATERNAL-FETAL-MEDICINE; RENO, NV, USA; FEBRUARY 09 -12, 2005, pages S40, XP002346272, ISSN: 0002-9378 *
NORWITZ ERROL R ET AL: "Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia.", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. SEP 2005, vol. 193, no. 3 Suppl, September 2005 (2005-09-01), pages 957 - 964, XP002346224, ISSN: 0002-9378 *
PUCHADES MAJA ET AL: "Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease.", MOLECULAR BRAIN RESEARCH, vol. 118, no. 1-2, 21 October 2003 (2003-10-21), pages 140 - 146, XP002346222, ISSN: 0169-328X *
UOTILA J T ET AL: "The total peroxyl radical-trapping ability of plasma and cerebrospinal fluid in normal and preeclamptic parturients.", FREE RADICAL BIOLOGY & MEDICINE. MAY 1994, vol. 16, no. 5, May 1994 (1994-05-01), pages 581 - 590, XP002346220, ISSN: 0891-5849 *
WINKLER U ET AL: "URINARY PROTEIN PATTERNS FOR EARLY DETECTION OF PREECLAMPSIA", CONTRIBUTIONS TO NEPHROLOGY, KARGER, BASEL, CH, vol. 68, 1988, pages 227 - 229, XP008038176, ISSN: 0302-5144 *

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