WO2005092873A3 - Thiadiazoles for treatment of cancer or neurological disease - Google Patents

Thiadiazoles for treatment of cancer or neurological disease Download PDF

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Publication number
WO2005092873A3
WO2005092873A3 PCT/PL2005/000019 PL2005000019W WO2005092873A3 WO 2005092873 A3 WO2005092873 A3 WO 2005092873A3 PL 2005000019 W PL2005000019 W PL 2005000019W WO 2005092873 A3 WO2005092873 A3 WO 2005092873A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
thiadiazoles
cancer
neurological disease
new compounds
Prior art date
Application number
PCT/PL2005/000019
Other languages
French (fr)
Other versions
WO2005092873A2 (en
Inventor
Joanna Matysiak
Andrzej Niewiadomy
Wojciech Rzeski
Original Assignee
Univ M Curie Sklodowskiej
Akad Rolnicza
Joanna Matysiak
Andrzej Niewiadomy
Wojciech Rzeski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ M Curie Sklodowskiej, Akad Rolnicza, Joanna Matysiak, Andrzej Niewiadomy, Wojciech Rzeski filed Critical Univ M Curie Sklodowskiej
Publication of WO2005092873A2 publication Critical patent/WO2005092873A2/en
Publication of WO2005092873A3 publication Critical patent/WO2005092873A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

The invention discloses a new compounds as per general formula (I): where -R stands for: alkyl, alkenyl, aryl, substituted aryl (with chlorine, alkyl, alkoxyl, -CF3, CN, -NO2), phenoxyphenyl, or morpholinoalkyl. The new compounds are applicable as antineoplastic agents, and additionally, one of them is particularly applicable in treatment of neurological diseases. The method of obtaining the new compounds was also disclosed.
PCT/PL2005/000019 2004-03-26 2005-03-25 Thiadiazoles for treatment of cancer or neurological disease WO2005092873A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL366644A PL204750B1 (en) 2004-03-26 2004-03-26 New compound, application of the new compound for therapy of neurological diseases as well as method for obtaining the new compound
PLP.366644 2004-03-26

Publications (2)

Publication Number Publication Date
WO2005092873A2 WO2005092873A2 (en) 2005-10-06
WO2005092873A3 true WO2005092873A3 (en) 2006-03-16

Family

ID=35056781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2005/000019 WO2005092873A2 (en) 2004-03-26 2005-03-25 Thiadiazoles for treatment of cancer or neurological disease

Country Status (2)

Country Link
PL (1) PL204750B1 (en)
WO (1) WO2005092873A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2771069A4 (en) 2011-10-27 2015-08-26 Mayo Foundation Inhibiting g protein coupled receptor 6 kinase polypeptides
US9902739B2 (en) 2014-04-21 2018-02-27 Mayo Foundation For Medical Education And Research Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides
EP3134390B1 (en) * 2014-04-21 2020-02-26 Mayo Foundation for Medical Education and Research Small molecule inhibitors of g protein coupled receptor 6 kinase polypeptides
CN109251188A (en) * 2018-09-26 2019-01-22 河北工业大学 A kind of preparation method of 2- methylamino -5- tert-butyl -1,3,4- thiadiazoles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999028309A1 (en) * 1997-11-26 1999-06-10 Pharmacia & Upjohn S.P.A. 1,3,4-thiadiazoles derivatives as kyn-oh inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999028309A1 (en) * 1997-11-26 1999-06-10 Pharmacia & Upjohn S.P.A. 1,3,4-thiadiazoles derivatives as kyn-oh inhibitors

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ACTA CIENCIA INDICA, CHEMISTRY , 13(2), 109-11 CODEN: ACICDV; ISSN: 0253-7338, 1987 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CIUGUREANU, C. ET AL: "Study of biological effect of some new thiosemicarbazides and their derivatives with triazole and thiadiazole nucleus. IV. Testing of cytostatic effect", XP002354826, retrieved from STN Database accession no. 1983:11117 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GAGIU, F. ET AL: "Synthesis of new C-5 substituted 2-allylamino-1,3,4-thiadiazoles with possible cytostatic activity", XP002354825, retrieved from STN Database accession no. 1967:482169 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GAWANDE, N. G. ET AL: "Synthesis of some thiosemicarbazides and related compounds", XP002354824, retrieved from STN Database accession no. 1989:8130 *
FARMACIA (BUCHAREST, ROMANIA) , 30(2), 101-10 CODEN: FRMBAZ; ISSN: 0014-8237, 1982 *
JOURNAL FUER PRAKTISCHE CHEMIE (LEIPZIG) , 36(1-2), 108-12 CODEN: JPCEAO; ISSN: 0021-8383, 1967 *
LEGOCKI JAN ET AL: "Synthesis and fungistatic activity of new groups of 2,4-dihydroxythiobenzoyl derivatives against phytopathogenic fungi.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 51, no. 2, 15 January 2003 (2003-01-15), pages 362 - 368, XP002351870, ISSN: 0021-8561 *

Also Published As

Publication number Publication date
PL204750B1 (en) 2010-02-26
WO2005092873A2 (en) 2005-10-06
PL366644A1 (en) 2005-10-03

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