WO2005092297A3 - A stable pharmaceutical composition comprising an acid labile drug - Google Patents
A stable pharmaceutical composition comprising an acid labile drug Download PDFInfo
- Publication number
- WO2005092297A3 WO2005092297A3 PCT/US2005/006589 US2005006589W WO2005092297A3 WO 2005092297 A3 WO2005092297 A3 WO 2005092297A3 US 2005006589 W US2005006589 W US 2005006589W WO 2005092297 A3 WO2005092297 A3 WO 2005092297A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid labile
- pharmaceutical composition
- labile drug
- stable pharmaceutical
- provides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007501900A JP2007526319A (en) | 2004-03-03 | 2005-03-02 | Stable pharmaceutical composition comprising an acid labile drug |
MXPA06009991A MXPA06009991A (en) | 2004-03-03 | 2005-03-02 | A stable pharmaceutical composition comprising an acid labile drug. |
EP05724184A EP1720527A2 (en) | 2004-03-03 | 2005-03-02 | A stable pharmaceutical composition comprising an acid labile drug |
CA002558535A CA2558535A1 (en) | 2004-03-03 | 2005-03-02 | A stable pharmaceutical composition comprising an acid labile drug |
IL177869A IL177869A0 (en) | 2004-03-03 | 2006-09-03 | A stable pharmaceutical composition comprising an acid labile drug |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54965304P | 2004-03-03 | 2004-03-03 | |
US60/549,653 | 2004-03-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005092297A2 WO2005092297A2 (en) | 2005-10-06 |
WO2005092297A3 true WO2005092297A3 (en) | 2006-10-12 |
Family
ID=34961526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/006589 WO2005092297A2 (en) | 2004-03-03 | 2005-03-02 | A stable pharmaceutical composition comprising an acid labile drug |
Country Status (8)
Country | Link |
---|---|
US (2) | US20050214372A1 (en) |
EP (1) | EP1720527A2 (en) |
JP (1) | JP2007526319A (en) |
CN (1) | CN1964704A (en) |
CA (1) | CA2558535A1 (en) |
IL (1) | IL177869A0 (en) |
MX (1) | MXPA06009991A (en) |
WO (1) | WO2005092297A2 (en) |
Families Citing this family (63)
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US20050163846A1 (en) * | 2001-11-21 | 2005-07-28 | Eisai Co., Ltd. | Preparation composition containing acid-unstable physiologically active compound, and process for producing same |
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US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
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WO2007100984A2 (en) * | 2006-02-24 | 2007-09-07 | Allergan, Inc. | Beads containing pyridin-sulfinyl benzoimidazole sulfonyl phenoxy acetate derivatives |
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US8703191B2 (en) | 2006-07-25 | 2014-04-22 | Intelgenx Corp. | Controlled-release pharmaceutical tablets |
US7674479B2 (en) * | 2006-07-25 | 2010-03-09 | Intelgenx Corp. | Sustained-release bupropion and bupropion/mecamylamine tablets |
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US20100105738A1 (en) * | 2006-10-06 | 2010-04-29 | Mitsuru Mizuno | Extended release formulations of a proton pump inhibitor |
KR20190042766A (en) | 2006-11-09 | 2019-04-24 | 오렉시젠 세러퓨틱스 인크. | Layered pharmaceutical formulations comprising an intermediate rapidly dissolving layer |
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CN101219118B (en) * | 2007-01-08 | 2011-05-25 | 天津药物研究院 | Impulse released oral medication preparation |
WO2008094877A2 (en) * | 2007-01-30 | 2008-08-07 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
WO2009113090A2 (en) * | 2008-01-17 | 2009-09-17 | Alkem Laboratories Ltd. | Process for preparing an oral formulation of an acid-sensitive benzimidazole drug |
CN104127368A (en) | 2008-03-11 | 2014-11-05 | 武田药品工业株式会社 | Orally-disintergrating solid preparation |
TWI519322B (en) * | 2008-04-15 | 2016-02-01 | 愛戴爾製藥股份有限公司 | Compositions comprising weakly basic drugs and controlled-release dosage forms |
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SI22806A (en) * | 2008-06-23 | 2009-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New crystalline forms of sodium rabeprazole |
BRPI0915411A2 (en) * | 2008-06-26 | 2015-11-03 | Mcneil Ppc Inc | coated particles containing pharmaceutically active agents |
US20110150945A1 (en) * | 2008-08-11 | 2011-06-23 | Mepha Gmbh | Oral pharmaceutical formulation for omeprazole comprising a specific separation layer |
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US10154964B2 (en) * | 2011-09-07 | 2018-12-18 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
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KR102006777B1 (en) * | 2018-01-29 | 2019-10-08 | 주식회사 종근당 | Pharmaceutical formulation comprising esomeprazole and sodium bicarbonate |
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WO2021115648A1 (en) | 2019-12-11 | 2021-06-17 | Evonik Operations Gmbh | Dosage form comprising an alkaline agent and an enteric coating layer |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
WO1994002140A1 (en) * | 1992-07-17 | 1994-02-03 | Astra Aktiebolag | Pharmaceutical composition containing antiulcer agent |
WO1998019668A1 (en) * | 1996-11-06 | 1998-05-14 | Sharmatek, Inc. | Delayed delivery system for acid-sensitive drugs |
WO1999048498A1 (en) * | 1998-03-20 | 1999-09-30 | A/S Gea Farmaceutisk Fabrik | Pharmaceutical formulation comprising a 2- [[(2- pyridinyl) methyl] sulfinyl] benzimidazole having anti-ulcer activity and a process for the preparation of such formulation |
WO2000012064A1 (en) * | 1998-08-28 | 2000-03-09 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
WO2001041734A2 (en) * | 1999-12-09 | 2001-06-14 | Ratiopharm Gmbh | Stable galenic preparations comprising a benzimidazol and method for the production thereof |
US6346269B1 (en) * | 2000-05-08 | 2002-02-12 | Standard Chem. & Pharm. Co., Ltd. | Method for preparing an oral formulation containing acid-sensitive drugs and oral formulation made thereby |
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IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
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US5433959A (en) * | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
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-
2005
- 2005-03-02 JP JP2007501900A patent/JP2007526319A/en active Pending
- 2005-03-02 WO PCT/US2005/006589 patent/WO2005092297A2/en active Application Filing
- 2005-03-02 CN CNA2005800134170A patent/CN1964704A/en active Pending
- 2005-03-02 CA CA002558535A patent/CA2558535A1/en not_active Abandoned
- 2005-03-02 US US11/068,889 patent/US20050214372A1/en not_active Abandoned
- 2005-03-02 MX MXPA06009991A patent/MXPA06009991A/en active IP Right Grant
- 2005-03-02 EP EP05724184A patent/EP1720527A2/en not_active Withdrawn
- 2005-03-02 US US11/068,881 patent/US20050214371A1/en not_active Abandoned
-
2006
- 2006-09-03 IL IL177869A patent/IL177869A0/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
WO1994002140A1 (en) * | 1992-07-17 | 1994-02-03 | Astra Aktiebolag | Pharmaceutical composition containing antiulcer agent |
WO1998019668A1 (en) * | 1996-11-06 | 1998-05-14 | Sharmatek, Inc. | Delayed delivery system for acid-sensitive drugs |
WO1999048498A1 (en) * | 1998-03-20 | 1999-09-30 | A/S Gea Farmaceutisk Fabrik | Pharmaceutical formulation comprising a 2- [[(2- pyridinyl) methyl] sulfinyl] benzimidazole having anti-ulcer activity and a process for the preparation of such formulation |
WO2000012064A1 (en) * | 1998-08-28 | 2000-03-09 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
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US6346269B1 (en) * | 2000-05-08 | 2002-02-12 | Standard Chem. & Pharm. Co., Ltd. | Method for preparing an oral formulation containing acid-sensitive drugs and oral formulation made thereby |
Non-Patent Citations (1)
Title |
---|
ANONYMOUS: "Stabilized pharmaceutical composition", IP.COM, 17 September 2002 (2002-09-17), pages 1 - 2, XP002374253, Retrieved from the Internet <URL:https://priorart.ip.com/download/IPCOM000009757D/IPCOM000009757D.pdf> [retrieved on 20060325] * |
Also Published As
Publication number | Publication date |
---|---|
WO2005092297A2 (en) | 2005-10-06 |
MXPA06009991A (en) | 2007-04-10 |
CN1964704A (en) | 2007-05-16 |
JP2007526319A (en) | 2007-09-13 |
IL177869A0 (en) | 2006-12-31 |
US20050214371A1 (en) | 2005-09-29 |
EP1720527A2 (en) | 2006-11-15 |
US20050214372A1 (en) | 2005-09-29 |
CA2558535A1 (en) | 2005-10-06 |
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