WO2005090274A8 - Process for regioselective preparation of glycerol, derivative and intermediate therefor - Google Patents

Process for regioselective preparation of glycerol, derivative and intermediate therefor

Info

Publication number
WO2005090274A8
WO2005090274A8 PCT/KR2005/000824 KR2005000824W WO2005090274A8 WO 2005090274 A8 WO2005090274 A8 WO 2005090274A8 KR 2005000824 W KR2005000824 W KR 2005000824W WO 2005090274 A8 WO2005090274 A8 WO 2005090274A8
Authority
WO
WIPO (PCT)
Prior art keywords
palmitoyl
glycerol
reacting
obtaining
methyl
Prior art date
Application number
PCT/KR2005/000824
Other languages
French (fr)
Other versions
WO2005090274A1 (en
Inventor
Tae-Suk Lee
Jin-Soo Yook
Jong-Soo Lee
Chang-Hyun Yoo
Ju-Cheol Lee
Cheol-Min Lee
Wan-Hee Lee
Original Assignee
Enzychem Co Ltd
Tae-Suk Lee
Jin-Soo Yook
Jong-Soo Lee
Chang-Hyun Yoo
Ju-Cheol Lee
Cheol-Min Lee
Wan-Hee Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzychem Co Ltd, Tae-Suk Lee, Jin-Soo Yook, Jong-Soo Lee, Chang-Hyun Yoo, Ju-Cheol Lee, Cheol-Min Lee, Wan-Hee Lee filed Critical Enzychem Co Ltd
Publication of WO2005090274A1 publication Critical patent/WO2005090274A1/en
Publication of WO2005090274A8 publication Critical patent/WO2005090274A8/en

Links

Classifications

    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04G—SCAFFOLDING; FORMS; SHUTTERING; BUILDING IMPLEMENTS OR AIDS, OR THEIR USE; HANDLING BUILDING MATERIALS ON THE SITE; REPAIRING, BREAKING-UP OR OTHER WORK ON EXISTING BUILDINGS
    • E04G7/00—Connections between parts of the scaffold
    • E04G7/02—Connections between parts of the scaffold with separate coupling elements
    • E04G7/28—Clips or connections for securing boards
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Architecture (AREA)
  • Mechanical Engineering (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed is a process for regioselective preparation of l-palmitoyl-2-linoleoyl-3-acetylglycerol which is known as having activities for proliferation of hematopoietic stem cells and megakaryocytes, and an intermediate for the same. The process for preparation of l-palmitoyl-2-linoleoyl-3-acetylglycerol includes the steps of obtaining (2-alkoxy-2-methyl-[l,3]-dioxolane-4-yl)methanol by reacting glycerol and trialkylorthoacetate; obtaining 1-acetyl glycerol by hydrolyzing (2-alkoxy-2-methyl-[l,3]-dioxolane-4-yl)methanol; obtaining l-palmitoyl-3-acetyl glycerol by reacting 1-acetyl glycerol and palmitic acid derivative; and reacting l-palmitoyl-3-acetyl glycerol and linoleic acid derivative. l-palmitoyl-2-linoleoyl-3-acetylglycerol can also be prepared by the steps of obtaining l-palmitoyl-3-acetyl glycerol by hydrolyzing palmitic acid (2-alkoxy-2-methyl-[l,3] dioxolane- 4-yl)methyl ester; and reacting l-palmitoyl-3-acetyl glycerol and linoleic acid derivative.
PCT/KR2005/000824 2004-03-22 2005-03-22 Process for regioselective preparation of glycerol, derivative and intermediate therefor WO2005090274A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2004-0019484 2004-03-22
KR20040019484 2004-03-22

Publications (2)

Publication Number Publication Date
WO2005090274A1 WO2005090274A1 (en) 2005-09-29
WO2005090274A8 true WO2005090274A8 (en) 2006-02-02

Family

ID=34993607

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2005/000824 WO2005090274A1 (en) 2004-03-22 2005-03-22 Process for regioselective preparation of glycerol, derivative and intermediate therefor

Country Status (2)

Country Link
KR (1) KR100754888B1 (en)
WO (1) WO2005090274A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101278874B1 (en) * 2011-09-23 2013-06-26 주식회사 엔지켐생명과학 Method for preparing of 1-palmitoyl-3-acetylglycerol and Method for preparing of 1-palmitoyl-2-linoleoyl-3-acetyl glycerol using the same
EP3042651B1 (en) * 2013-09-03 2020-01-01 Enzychem Lifesciences Corporation Composition containing monoacetyldiacylglycerol compound as active ingredient for preventing or treating atopic dermatitis
CN109970606A (en) * 2019-04-22 2019-07-05 浙江海洲制药有限公司 A method of preparing methocarbamol
KR102333606B1 (en) * 2019-10-15 2021-12-01 주식회사 엔지켐생명과학 Method for producing 1-palmitoyl-2-linoleoyl-3-acetyl glycerol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231132A (en) 1991-06-17 1993-07-27 General Electric Company Polyphenylene ether-polyester blends compatibilized with ortho ester copolymers
JPH09249576A (en) * 1996-03-12 1997-09-22 Masahiro Tanaka Promoting solution for activating and culturing cell
DE69833333T2 (en) * 1997-11-20 2006-10-19 Jhon, Gil Ja PHARMACEUTICAL COMPOSITION CONTAINING CERVUS NIPPON GERMANIC ACIDS WITH GROWTH STIMULATING ACTIVITY ON HEMATOPOIETIC STEM CELLS AND MEGAKARYOCYTES

Also Published As

Publication number Publication date
KR100754888B1 (en) 2007-09-04
WO2005090274A1 (en) 2005-09-29
KR20060044536A (en) 2006-05-16

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