WO2005087311A1 - Improved apparatus for electrically mediated delivery of therapeutic agents - Google Patents
Improved apparatus for electrically mediated delivery of therapeutic agents Download PDFInfo
- Publication number
- WO2005087311A1 WO2005087311A1 PCT/US2005/007936 US2005007936W WO2005087311A1 WO 2005087311 A1 WO2005087311 A1 WO 2005087311A1 US 2005007936 W US2005007936 W US 2005007936W WO 2005087311 A1 WO2005087311 A1 WO 2005087311A1
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- Prior art keywords
- electrodes
- recited
- energy
- therapeutic agent
- reservoir
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0502—Skin piercing electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/14—Leading-off electric charges, e.g. by earthing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Definitions
- the present invention is directed to an apparatus for delivery of prophylactic and therapeutic agents to patients, and more particularly, to an apparatus utilizing electrical fields to deliver such agents intracellularly in a safe, reproducible, efficacious, and cost effective manner.
- Prophylactic and therapeutic agents have long been delivered to patients using various conventional routes of administration, such as topical, oral, intravenous, parenteral, and the like.
- routes of administration such as topical, oral, intravenous, parenteral, and the like.
- the delivery of the agent to the tissue of interest and its beneficial interaction with the tissue is largely dependent on its inherent physicochemical factors, but may have been facilitated by, for example, selected components of the delivery composition such as carriers, adjuvants, buffers and excipients, and the like.
- the application of electrical fields has been shown to enhance the movement and uptake of macromolecules in living tissue. Application of such electrical fields in tissue relative to the administration of a prophylactic or therapeutic agent can have desirable effects on the tissue and/or the agent to be delivered.
- agents include pharmaceuticals, proteins, antibodies, and nucleic acids.
- Potential clinical applications of such techniques include the delivery of chemotherapeutic drugs and/or therapeutic genes in tumors, the delivery of DNA vaccines for prophylactic and therapeutic immunization, and the delivery of nucleic acid sequences encoding therapeutic proteins.
- Many devices have been described for the application of electrical fields in tissue for the purpose of enhancing agent delivery. The vast majority of these have focused on a means for effective application of the electrical fields within a target region of tissue.
- a variety of surface and penetrating electrode systems have been developed for generating the desired electrophysiological effects.
- the present invention provides an integrated apparatus enabling Electrically Mediated Therapeutic Agent Delivery (EMTAD) to be accomplished in a safe, consistent, and cost effective manner.
- ETAD Electrically Mediated Therapeutic Agent Delivery
- the present invention allows effective intramuscular, intradermal, and/or subcutaneous administration of therapeutic or prophylactic agents such as nucleic acids, drugs, antibodies, and proteins.
- the present invention provides an apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient.
- the apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilograms per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes.
- the apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.
- Another aspect of the invention provides the apparatus with structural means configured to accept a fluid reservoir for containing a therapeutic agent, or with the fluid reservoir itself, where the reservoir is operatively connected to at least one injection orifice, and actuation means configured to transmit the therapeutic agent through the orifice to the predetermined site within the tissue of the patient.
- Other aspects of the invention include such apparatus configured to accept replaceable therapeutic agent fluid reservoir subassemblies, electrode subassemblies, and a combination thereof. Also included are include means for priming the automated mechanisms incorporated in the applicator upon insertion of the cartridge, identifying the model or type of cartridge that has been inserted, and protecting the user and patient from accidental injury associated with the usage of the apparatus.
- Additional aspects of the invention include such apparatus configured to improve the functionality and ergonomics of the Applicator (i.e. the user interface) in a number of ways.
- the inanimate source of energy can be positioned alongside the fluid reservoir, so as to reduce the overall length of the apparatus, and improve its ease of use.
- the deployment of the electrodes and administration of the therapeutic agent, as well as the creation of the electrical field, can be implemented with a single activation trigger.
- safety interlocks and shields can be included to reduce the risk of accidental discharge and inadvertent contact with the electrodes and fluid orifice.
- Further improvements can be included in the design of the fluid reservoir, such as the utilization of a vial, such as a glass, polycarbonate, polyethylene, etc.
- vial as a means of utilizing a dry, e.g. lyophilized, therapeutic agent and a fluid supply, and allowing the separate components to be mixed just prior to use.
- additional improvements can be included to render the apparatus more readily adaptable to a wide range of patients, e.g. patients with widely differing body mass indices indicating a range of the thickness of patients' subcutaneous adipose layers, or the need to adjust the depth of the predetermined site in the patient.
- Such improvements can include, for example, a depth gauge for adjusting the depth of the penetration of the electrodes and orifice, or the use of different length and/or diameter electrodes and orifice structures, e.g. different length and gauge of syringe needles.
- Figure 1 illustrates three components (Applicator, Cartridge and Syringe) of an embodiment of the integrated apparatus of the present invention in an exploded view;
- Figure 2 illustrates the Cartridge of the embodiment of Figure 1 assembled with the Applicator
- Figure 3 is a cross sectional view of the Applicator/Cartridge/Syringe assembly of the embodiment of Figure 1 with the insertion and injection spring mechanisms primed;
- Figure 4 is a cross sectional view of the Applicator of the embodiment of Figure 1 with the insertion and injection spring mechanisms not primed;
- FIG. 5 is a cross sectional view of the Cartridge of the embodiment of Figure 1 with the Syringe inserted.
- the present invention provides an integrated apparatus enabling Electrically Mediated Therapeutic Agent Delivery (EMTAD) to be accomplished in a safe, consistent, and cost effective manner.
- ETAD Electrically Mediated Therapeutic Agent Delivery
- the present invention allows effective intramuscular, intradermal, and/or subcutaneous administration of therapeutic or prophylactic agents such as nucleic acids, drugs, antibodies, and proteins.
- the present invention provides an apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient.
- the apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilograms per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes.
- the apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.
- Another aspect of the invention provides the apparatus with structural means configured to accept a fluid reservoir for containing a therapeutic agent, or with the fluid reservoir itself, where the reservoir is operatively connected to at least one injection orifice, and actuation means configured to transmit the therapeutic agent through the orifice to the predetermined site within the tissue of the patient.
- Other aspects of the invention include such apparatus configured to accept replaceable therapeutic agent fluid reservoir subassemblies, electrode subassemblies, and a combination thereof. Also included are include means for priming the automated mechanisms incorporated in the applicator upon insertion of the cartridge, identifying the model or type of cartridge that has been inserted, and protecting the user and patient from accidental injury associated with the usage of the apparatus.
- Additional aspects of the invention include such apparatus configured to improve the functionality and ergonomics of the Applicator (i.e. the user interface) in a number of ways.
- the inanimate source of energy can be positioned alongside the fluid reservoir, so as to reduce the overall length of the apparatus, and improve its ease of use.
- the deployment of the electrodes and administration of the therapeutic agent, as well as the creation of the electrical field, can be implemented with a single activation trigger.
- safety interlocks and shields can be included to reduce the risk of accidental discharge and inadvertent contact with the electrodes and fluid orifice.
- Further improvements can be included in the design of the fluid reservoir, such as the utilization of a vial, such as a glass, polycarbonate, polyethylene, etc.
- vial as a means of utilizing a dry, e.g. lyophilized, therapeutic agent and a fluid supply, and allowing the separate components to be mixed just prior to use.
- additional improvements can be included to render the apparatus more readily adaptable to a wide range of patients, e.g. patients with widely differing body mass indices indicating a range of the thickness of patients' subcutaneous adipose layers, or the need to adjust the depth of the predetermined site in the patient.
- Such improvements can include, for example, a depth gauge for adjusting the depth of the penetration of the electrodes and orifice, or the use of different length and/or diameter electrodes and orifice structures, e.g. different length and gauge of syringe needles.
- the present invention will preferably provide an apparatus for the delivery of a therapeutic agent and electrical fields to a predetermined site within the skin and/or skeletal muscle of a patient in a manner that is effective, reproducible, and safe for both the operator and the patient.
- One embodiment of the apparatus comprises a single use subassembly "cartridge” and a hand-held “applicator”.
- the single use sub-assembly integrates a reservoir for containing the agent of interest, at least one orifice through which the agent is delivered to the patient, and two or more electrodes capable of propagating electrical fields within the tissue.
- the hand-held applicator interfaces with the single use cartridge and incorporates automated mechanisms to (1) deploy the electrodes to the target tissue site, (2) position the orifice relative to the target tissue site, (3) transfer the agent from the reservoir through the orifice and into the target tissue site, and (4) relay electrical signals from a suitable pulse generator to the electrodes.
- agents which are administered to patients for prophylactic purposes and agents which are administered for therapeutic purposes, in the context of the present invention such agents are considered to be substantially equivalent and will be referred to herein as therapeutic agents, unless otherwise indicated.
- Apparatus Embodiments The present invention provides an improved apparatus for safe, efficacious and reproducible, transcutaneous intramuscular (IM) delivery of therapeutic agents with Electrically Mediated Therapeutic Agent Delivery (EMTAD).
- IM transcutaneous intramuscular
- ETAD Electrically Mediated Therapeutic Agent Delivery
- the apparatus consists of a main unit (applicator) 100 and a separable single use sub-assembly (cartridge) 200.
- the cartridge is configured to include a reservoir to contain the agent to be administered prior to delivery.
- the reservoir will be designed and constructed to maintain the agent in a stable environment and prevent contamination.
- the reservoir is operatively connected to an orifice through which the agent is administered into the patient.
- the reservoir and orifice are comprised of a syringe connected to a hollow injection needle 300.
- the cartridge encloses the electrode array and includes integral automatic protection against unwanted contact with the electrodes and/or the orifice/injection needle (i.e. "stick protection").
- the applicator 100 incorporates a spring mechanism for automatic insertion of the electrode array and the injection needle into the target tissue.
- the applicator also includes a separate spring mechanism for automated controlled therapeutic agent injection through the incorporated syringe.
- the applicator incorporates a means to allow electrical communication with a suitable pulse generation device capable of controlling the treatment application sequence. Most commonly electrical communication is achieved through a conductive cable and connector.
- a trigger 101 on the applicator is utilized to initiate the treatment.
- a system for identifying the inserted cartridge and setting the treatment parameters based on the cartridge is provided in the applicator.
- a means for administration of the therapeutic agent comprising a reservoir and at least one orifice through which the agent is administered have been described.
- the means for administration of the therapeutic agent (reservoir and orifice) with the cartridge. Integrating the administration means with the cartridge can simplify the procedure by reducing apparatus handling. Reducing apparatus handling can also improve operator and patient safety by eliminating needle stick hazards and dosage errors. Integration also improves the accuracy of the predetermined spatial relationship between the agent delivery orifice and the electrode array.
- the cartridge can be configured to accept a syringe and needle as the reservoir and orifice.
- the syringe can be an off-the-shelf syringe that is loaded with the agent prior to the agent administration procedure. Utilization of an off-the-shelf syringe allows one cartridge configuration to deliver numerous agent and dosage combinations. Additionally off-the-shelf syringes are readily available and cost effective.
- the syringe can alternatively be pre-filled with an agent and packaged with the cartridge. Utilization of a pre-filled syringe reduces the possibility for dosage errors.
- a pre-filled syringe does not require a plunger extending from the proximal end of the syringe' to manually load the agent. Elimination of the plunger extension allows for a smaller apparatus that uses less material and is more ergonomic.
- Another embodiment of integrating the reservoir and orifice with the cartridge is to incorporate the reservoir into the cartridge design thus eliminating the need for a separate syringe.
- the cartridge be constructed of an inert material to prevent reaction with the agent. Suitable materials include, but are not limited to, glass, polycarbonate and polyethylene. It is desirable to store certain agents in a lyophilized state to improve shelf life. Such agents are mixed with a diluent prior to administration.
- a dual chamber reservoir where the lyophilized agent and the diluent are stored in the separate chambers can also be utilized for s ⁇ ch agents. Prior to treatment the separation between the chambers is removed or broken to allow mixing of the agent and diluent.
- One suitable separation between the chambers is a stopcock valve that is manually opened.
- Another suitable separation is a thin film or a check valve that can be opened when adequate pressure is applied to the diluent chamber.
- Such a dual chamber reservoir can be incorporated into the cartridge.
- a specific embodiment for integrating the means for agent administration with the cartridge is herein described. The specific embodiment utilizes an off-the-shelf syringe and needle 300 for the administration reservoir and orifice.
- the cartridge 200 is configured to accept the syringe and locate the needle orifice in a predetermined spatial relationship with the electrode array. Furthermore the cartridge is configured with snap tabs 224 that lock the syringe in place once it is inserted into the cartridge. ⁇
- Electrode Drive Mechanisms There are several mechanisms that are suitable as inanimate sources of energy to insert the electrodes and injection needle through the skin and into the targeted treatment tissue and also to inject the agent through the needle.
- a compressed gas powered mechanism is one such apparatus.
- Electro/mechanical mechanisms such as solenoids, linear motors and lead screws are also acceptable.
- the preferred approach for transcutaneous electrode and injection needle insertion is the spring-based mechanism. Electrode insertion mechanisms require sufficient force to rapidly penetrate the skin and implant the electrodes into the muscle. Rapid insertion can reduce tenting of the skin at the insertion site and thereby reduce deflection of the electrode or needle. Electrode deflection may distort the electrode array and effect treatment efficacy and patient safety. Needle distortion may effect co-localization of the agent and electrical fields.
- Automatic/Passive Spring Priming Although their functional characteristics and cost effectiveness make them preferable overall, spring mechanisms require priming. Energy is be imparted to and stored in the spring prior to actuating the treatment sequence. Previously disclosed devices of this nature require that the user actively perform a separate step to prime the spring mechanism prior to the use of the device.
- the disclosed invention includes means to automatically or passively prime the spring mechanism upon insertion of the cartridge 200 into the applicator 100. It is desirable that the priming of the spring mechanism (“spring priming”) be accomplished in conjunction with the insertion of the cartridge 200 into the applicator 100.
- automated/passive spring priming also eliminates the problematic failure mode of not priming the spring. A variety of energized mechanisms can be employed in the apparatus to accomplish automated spring priming.
- These mechanisms comprise an energy source, a suitable trigger, and a means to transfer energy from the energy source to the spring(s). Insertion of the cartridge into the applicator activates the trigger leading to the transfer of energy from the energy source to the spring(s).
- Sources of energy/mechanisms to achieve this function include but are not limited to compressed gas, solenoids and electrical motor-based mechanisms.
- a preferred method and apparatus is to utilize the insertion and attachment of the cartridge 200 to the applicator 100 as a means to passively prime the spring mechanisms during cartridge insertion into the applicator - "cartridge priming". Utilizing the cartridge priming method provides the benefits of the described invention while eliminating the need for the additional priming mechanism required for automated spring priming.
- the cartridge is utilized to prime spring drive mechanisms
- the apparatus since the operator applies force to the cartridge to prime the spring mechanisms, it is desirable that the apparatus include means to prevent accidental deployment of electrodes and/or needles during the insertion of the cartridge into the applicator to prevent needle stick injuries.
- the means for stick prevention also prevent damage and/or contamination to the electrodes and needle during priming.
- At least one cantilevered extension 202 of the cartridge engages the injection drive mechanism 110 and imparts the priming force to the mechanism while preventing the mechanism from contacting the syringe plunger 302.
- This specific embodiment provides stick prevention and protects the electrodes/needle from damage/contamination during priming by maintaining the electrodes/needle safely retracted and locked within the cartridge.
- Snap tabs 222 incorporated into the cartridge prevent the electrode hub 220 from moving axially relative to the cartridge collar 210 and thereby maintain the electrodes/needle safely retracted within the cartridge.
- Further stick and contamination protection is provided by a cap 230 over the distal end of the cartridge. The cap 230 is removed prior to treatment application.
- the cap is constructed of puncture resistant material and the interface between the cap and the cartridge is designed to minimize the risk of contamination during handling.
- the electrode hub 220 engages the insertion drive mechanism 120 and transfers the priming force applied to the cartridge collar 210 to the insertion mechanism.
- this specific embodiment incorporates one-way leaf-spring latches 130 in the applicator that allow the cartridge to be inserted in the priming orientation but prevent it from being removed or ejected in that orientation.
- a ratchet mechanism is another suitable means to prevent accidental ejection of the cartridge.
- two spring-actuated latches 112, 122 capture the insertion and injection spring mechanisms and maintain them in their primed and energized state until they are actuated during treatment.
- a solenoid actuator 114, 124 is attached to each latch 112, 122 and when activated displaces the latch and releases the spring mechanism 110, 120.
- the cartridge Upon completion of the cartridge insertion and spring mechanism priming, the cartridge is twisted l ⁇ turn to complete attachment of the cartridge to the applicator. In this attached orientation the cantilevered extension 202 disengages from the injection drive mechanism 110 freeing the mechanism to act upon the syringe plunger 302 when the injection mechanism is released.
- the applicator depresses the tabs 222 and frees the electrode hub to move axially relative to the cartridge, so the insertion mechanism can advance the electrodes and needle when the mechanism is released.
- Designs Enabling Improved User Interface Factors In the practice of the invention, ergonomics and human factors play a significant role in consistently providing safe and effective agent administration.
- the size and shape of the apparatus used for agent administration can affect the operator's ability to effectively deliver the agent to the target tissue site. It is desirable that the design of the apparatus facilitate accurate positioning of the apparatus in the proper location and orientation. Improper positioning of the apparatus can affect both the safety and efficacy of the treatment.
- the size and shape of the device can also influence patient acceptance.
- a device can be threatening to patients, particularly if it is especially large, has a form suggestive of a weapon, or is otherwise intimidating. Therefore it is desirable that the device has a form factor that is both ergonomic and non-threatening.
- the drive mechanisms have been arranged co- linearly and in series with the cartridge. This results in a long and unwieldy device.
- the described invention utilizes one or more drive mechanisms arranged in parallel with the cartridge and the line of action of the electrodes and syringe.
- the parallel drive mechanisms can be arranged co-linearly or in an offset fashion. This parallel arrangement yields a more compact, ergonomic and non-threatening apparatus.
- the invention can be adapted to achieve a desirable form factor utilizing other spring and drive mechanisms.
- the spring may surround the electrode array or syringe.
- the mechanism may utilize mechanical advantage to increase linear motion or force.
- the insertion and injection spring mechanisms are positioned within the applicator parallel and offset from the cartridge. The Force and motion of the spring mechanisms is transferred to the cartridge through drive arms 116, 126 that extend through the applicator and interface with the cartridge.
- an EMTAD device should accommodate the range of doses that may be prescribed for a given agent.
- the "dose" of the agent is determined by the volume and concentration administered, the electrode array configuration and the electrical field parameters applied to the tissue (including waveform, voltage, duration, frequency, and number of pulses).
- the proper electrical parameters will be conveyed to the pulse generator.
- the electrical signal parameters partially determine dose are determined by the cartridge that includes the other two dose parameters (agent and electrode array). It is also desirable that the treatment sequence cannot be initiated until the electrical signal parameters are set. This assures safe and proper attachment of the cartridge to the applicator.
- programmable integrated circuits and other relatively expensive means have been described.
- the means for cartridge identification / electrical signal parameter recognition should be cost effective. In particular the components of the identification system and the associated manufacturing processes that are part of the single-use cartridge should be cost effective.
- Suitable means include optical bar code identification and wireless radio frequency identification.
- bar code identification the bar code would be affixed or imprinted onto the cartridge and the reader would be integrated into the applicator.
- radio frequency identification the transponder would be integrated into the cartridge and the receiver would be included in the applicator.
- the receiver would be tuned only to receive the radio frequency signal when the cartridge was properly attached to the applicator.
- Another suitable method is to utilize a series of discrete switches in the applicator that may be closed when the cartridge is inserted. The pattern of open and closed switches would determine the electrical signal parameters. The switches could be electro/mechanical, opto/electro or any other suitable switch.
- the described invention would also facilitate the use of a single application system for delivery of multiple classes of agents, which require different electrical conditions to achieve effective delivery.
- Adjustable Treatment Depth Efficacious, consistent, and safe application of EMTAD for intramuscular delivery relies in part on treating a consistent volume of muscle tissue.
- a range of deltoid fat pad thickness from 3.7mm to 35.6mm is reported. So for a given electrode array size, the volume of muscle tissue affected will vary depending on the fat pad thickness. Additionally the thickness of tissue between the skin and the bone also vary significantly between patients and between treatment sites.
- an electrode/needle length appropriate to treat a large patient may impact bone during insertion into a small patient. Electrode contact with bone could cause injury to the patient and/or it could distort the electrode array and effect safety and efficacy of the treatment. It is therefore desirable to provide a means for adjusting the depth of electrode/needle penetration based on the treatment site and patient anatomy.
- an adjustable ring 240 over the distal tip of the present invention modifies the electrode/needle penetration depth. The ring can be adjusted axially relative to the cartridge 200 tip so that the length of the ring that extends beyond the distal tip of the apparatus reduces the length of electrode/needle that penetrate into the patient.
- FIG. 1-5 utilizes a diamond shaped ring that snaps into discrete axial positions. To modify its position, the major axis of the diamond shaped ring is compressed causing the minor axis to expand and release the ring from the cartridge.
- Another suitable embodiment is a ring that is threaded onto the cartridge tip and can be adjusted by threading the ring back and forth on the cartridge. This embodiment allows for a continuous number of depth adjustment positions.
- the safety system is automatically and passively deactivated when the device is applied to the treatment site with adequate force.
- Automatic and passive disablement of the safety system does not require a separate operator step.
- automated/passive safety disablement also eliminates the possible failure mode of not deactivating the safety system.
- a typical electrode insertion force may be 2.5 pounds (11.1 Newtons), therefore, the minimum application force would be 2.5 pounds (11.1 Newtons).
- a margin of safety would be added to the insertion force so the application force would be between 3.5 and 5.0 pounds (15.6 - 22.2 Newtons).
- the required application force will not exceed a force that the operator can comfortably apply to the treatment site.
- a preferred embodiment of the disclosed safety system is herein described.
- the internal mechanisms of the applicator float axially within an outer housing 102 and are maintained in an extended position by a spring 144 acting between the internal applicator and the external housing.
- the spring is equal to the preferred application force.
- the internal applicator is repositioned within the outer housing 102. In this position the safety systems are disabled.
- the stop 140 is repositioned relative to the latches and no longer prevents the latches from disengaging from the insertion and injection spring mechanisms.
- the electronic switch 142 contacts the outer housing and is closed allowing the trigger to communicate with the pulse generator and initiate the treatment sequence.
- Electrode Array Insertion Spring Force/Rate Electrode insertion mechanisms require sufficient force to rapidly penetrate the skin and implant the electrodes into the muscle. Rapid insertion can reduce tenting of the skin at the insertion site and thereby reduce deflection of the electrode or needle. Electrode deflection may distort the electrode array and effect treatment efficacy and patient safety. Needle distortion may effect co-localization of the agent and electrical fields. So it is desirable to insert the electrodes and needle rapidly to minimize deflection. Additionally rapid electrode/needle insertion reduces patient discomfort. The energy storage and discharge characteristics of spring-based mechanisms are well suited to enable rapid deployment of electrodes and injection needles into tissue with minimal distortion.
- Electrode spacing is inversely proportional to the spacing between electrodes. Due to the interaction of tissue that is displaced as the electrode is inserted smaller electrode spacing result in higher insertion force.
- Typical EMTAD apparatus incorporating arrays of penetrating electrodes utilize an intra-electrode spacing at least 10 times greater than the diameter of the electrodes comprising the array and more commonly 15-20 times greater. Within this range there is little interaction of displaced tissue and therefore electrode spacing has minimal effect on the insertion force.
- Cutting electrode tip geometry is prefe ⁇ ed to minimize insertion force. Blunt and dilating tip geometry requires increased insertion force. Experiments are carried out to determine minimum spring force/rate necessary for rapid percutaneous intramuscular electrode implantation. A selection of electrode arrays appropriate for intramuscular application of EMTAD and with cutting tip electrodes is evaluated.
- Each electrode array is implanted into a porcine model and the minimum spring force necessary to rapidly penetrate the cutaneous tissue and implant the electrode array without significant distortion is determined. Because of the force exerted by a spring decreases as the energy is released from the spring two results are given. The first is the force at the beginning of the spring stroke and represents the minimum force necessary to penetrate the cutaneous tissue. The second is the force at the end of the spring stroke and represents the minimum force necessary to implant the electrode array through the sub cutaneous and muscle tissue. Because the forces are dependent upon the electrode diameter and the number of electrodes the results are given as a ratio of force to total cross-sectional area of the electrodes in the a ⁇ ay.
- an a ⁇ ay comprised of 4 electrodes, each with a diameter of 0.02 inches would have a total cross-sectional area of approximately 0.00125 square inches (0.8 square millimeters).
- a mechanism for deployment of the example array would require a minimum force of 1.25 pounds (5.5 Newtons) to achieve insertion and more preferably a force of at least 2.50 pounds (11 Newtons).
- the spring mechanisms are manually primed, it is preferable to limit the force of the springs so that the operator can comfortably prime the springs.
- a prefe ⁇ ed limit for spring priming is less than 15 pounds force (67 Newtons) .
- the maximum force for a spring is 15 pounds (67 Newtons).
- Agent Administration Spring Force/Rate Several variables affect the force necessary to administer the therapeutic agent. These variables include, agent viscosity, cross-sectional area of the syringe, needle gauge, cross- sectional area of orifice(s), and tissue density. For parameters typical of intramuscular EMTAD the minimum spring force necessary to administer the therapeutic agent is 0.25 pounds (1.1
- the injection spring force is between 1 and 10 pounds (4.5 - 45 Newtons).
- the functional characteristics and cost effectiveness of the injection spring mechanism makes it preferable overall, the impact of the drive mechanism onto the syringe plunger can create a "water hammer" effect.
- the force wave generated from the impact can travel through the agent within the syringe and result in damage to the syringe or needle.
- standard plastic needle hubs may crack or split causing the agent to leak before it is completely administered. It is therefore desirable to damp the impact energy of the drive mechanism without affecting the force/rate of agent injection. There are several means to damp the impact energy of the drive mechanism.
- One such means is to position an energy absorbing material 118 between the syringe plunger 302 and drive mechanism 116.
- energy absorbing materials include but are not limited to elastomers such as silicone and polyurethane and closed-cell foams.
- Another suitable means to absorb the impact is gas/fluid dampening to slow the rate of the drive mechanism.
- Such an apparatus requires that at least a portion of the injection drive mechanism displace a gas or fluid through a small bleed hole in order to move forward.
- the gas is air and the bleed hole is tuned so that the dampening or is less than the dampening produced from administering the agent through the injection needle. In such a case, the gas dampening will only affect the rate of the drive mechanism until it contacts the syringe at which point the dampening produced from administering the agent through the injection needle will be the limiting factor affecting agent administration.
- the apparatus includes integral stick protection.
- the stick protection is both automatic and passive. Automatic stick protection will eliminate possible injury when manually deploying the stick protection and it also eliminates the possible failure mode of not deploying the stick protection.
- the stick protection upon activation the stick protection includes a means for locking in place to prevent possible someone from defeating the stick protection once it has deployed.
- One prefe ⁇ ed embodiment of an integral automatic locking stick protection is presented. However one skilled in the art will appreciate that other embodiments that can achieve the same objective.
- the specific embodiment herein described utilizes a stick shield 250 integral to the cartridge that automatically extends over the electrodes/needle as they are removed from the patient.
- a compression spring 252 within the cartridge is positioned proximal to the stick shield between the stick shield and the electrode hub 220. As the electrode hub advances distally during electrode/needle insertion the spring is compressed. When the electrodes/needle are removed post treatment from the patient, the spring extends and extends the stick shield distally over the electrodes and needle. As the shield is completely extended over the electrodes and needle cantilevered tabs on the stick shield snap into co ⁇ esponding grooves in the collar 210 thereby locking the shield in the extended position.
- Single Use Users may attempt to reuse the single use cartridge to save costs or to apply an off label agent. Reusing the cartridge may affect the safety and efficacy of the treatment. For instance coatings on the electrodes that may be utilized to assure biocompatibility may not withstand multiple uses so the treatment may produce a toxic result in the patient. Additionally, sterility of a reused device cannot be assured. It is therefore desirable to include features in the apparatus that prevent reuse.
- the apparatus herein described includes three features that prevent reuse.
- the stick shield 250 locks in an extended position preventing the electrodes and needle from being inserted into the patient.
- the syringe is permanently attached to the cartridge when it is inserted, so the syringe cannot be detached to reload it with the agent.
- the cartridge hub/collar configuration is fixed with the hub inserted into the collar.
- the cartridge will not prime the insertion and injection spring mechanisms.
- the cartridge identification contacts in the applicator will not communicate with the cartridge so the control system will not recognize the cartridge and will prevent treatment.
- Those skilled in the art will recognize that there are other suitable means for preventing reuse.
- One such method is to incorporate a fuse into the cartridge and apply a signal from the pulse generator that blows the fuse at the end of the treatment.
- Another such means is to identify each cartridge with a unique serial number that is read by the applicator. The pulse generator would store the serial numbers and not apply treatments through cartridges whose serial numbers have already been read and stored.
- the manufacturing costs of a single- use cartridge should be as low as possible.
- multiple electrode a ⁇ ay configurations may be required to deliver a range of doses prescribed for a given agent.
- One method of reducing manufacturing costs while producing multiple a ⁇ ay configurations is to utilize many of the same components in the multiple cartridge configurations. This approach will reduce costs including but not limited to tooling costs, inventory costs, quality control costs and handling costs.
- the electrode a ⁇ ay configuration is modified by changing the geometry of only the electrodes 260.
- a bend 262 near the distal end of the electrode changes the relative position of the penetrating end of the electrodes within the cartridge and thus changes the a ⁇ ay configuration.
- the cartridge components are designed to accept multiple electrode geometries and therefore can be utilized in multiple electrode a ⁇ ay configurations. Additionally the cartridge components have been designed to snap together and utilize the bend in the electrode to securely capture the electrodes between the cartridge components. This approach further reduces fabrication costs by elimination more costly joining techniques such as adhesive joints, solvent bonding, insert molding and ultrasonic welding.
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Heart & Thoracic Surgery (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
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Abstract
Description
Claims
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
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EP18188950.2A EP3466483A1 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
AU2005221687A AU2005221687A1 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
EP05725237.1A EP1729848B1 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
DK05725237.1T DK1729848T3 (en) | 2004-03-08 | 2005-03-08 | IMPROVED APPARATUS FOR ELECTRICAL COMMUNICATED administration of therapeutic agents |
US10/591,806 US9364664B2 (en) | 2004-03-08 | 2005-03-08 | Apparatus for electrically mediated delivery of therapeutic agents |
KR1020067020757A KR101261642B1 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
SI200531982T SI1729848T1 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
NZ550342A NZ550342A (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
CN2005800145531A CN1997423B (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
JP2007503001A JP5221127B2 (en) | 2004-03-08 | 2005-03-08 | An improved device for the transfer of therapeutic agents using electricity |
PL05725237T PL1729848T3 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
CA2559083A CA2559083C (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
EP15165174.2A EP2929909B1 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
ES05725237.1T ES2542139T3 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for the supply, electrically mediated, of therapeutic agents |
IL177942A IL177942A (en) | 2004-03-08 | 2006-09-07 | Apparatus for electrically mediated delivery of therapeutic agents |
IL203766A IL203766A (en) | 2004-03-08 | 2010-02-07 | Apparatus for intracellular delivery of a therapeutic agent |
US15/153,558 US9802035B2 (en) | 2004-03-08 | 2016-05-12 | Apparatus for electrically mediated delivery of therapeutic agents |
US15/719,266 US10561834B2 (en) | 2004-03-08 | 2017-09-28 | Apparatus for electrically mediated delivery of therapeutic agents |
US16/737,701 US20200139107A1 (en) | 2004-03-08 | 2020-01-08 | Apparatus for electrically mediated delivery of therapeutic agents |
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EP (3) | EP3466483A1 (en) |
JP (2) | JP5221127B2 (en) |
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CN (2) | CN1997423B (en) |
AU (1) | AU2005221687A1 (en) |
CA (1) | CA2559083C (en) |
CY (1) | CY1116471T1 (en) |
DK (2) | DK1729848T3 (en) |
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HU (1) | HUE025052T2 (en) |
IL (2) | IL177942A (en) |
NZ (2) | NZ550342A (en) |
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US11845939B2 (en) | 2016-12-05 | 2023-12-19 | Janssen Pharmaceuticals, Inc. | Compositions and methods for enhancing gene expression |
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---|---|---|---|---|
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US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US9629251B2 (en) | 2013-12-11 | 2017-04-18 | The United States Of America, As Represented By The Secretary Of The Navy | Sub-micron laser patterning of graphene and 2D materials |
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US10413665B2 (en) | 2015-11-25 | 2019-09-17 | Insulet Corporation | Wearable medication delivery device |
US10275573B2 (en) | 2016-01-13 | 2019-04-30 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
EP3453414A1 (en) | 2016-01-14 | 2019-03-13 | Bigfoot Biomedical, Inc. | Adjusting insulin delivery rates |
WO2017136268A1 (en) | 2016-02-04 | 2017-08-10 | Insulet Corporation | Anti-inflammatory cannula |
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WO2018058041A1 (en) | 2016-09-23 | 2018-03-29 | Insulet Corporation | Fluid delivery device with sensor |
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US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
US10881792B2 (en) | 2017-01-13 | 2021-01-05 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
WO2018132765A1 (en) | 2017-01-13 | 2018-07-19 | Mazlish Bryan | Insulin delivery methods, systems and devices |
WO2018136699A1 (en) | 2017-01-19 | 2018-07-26 | Insulet Corporation | Cartridge hold-up volume reduction |
US11045603B2 (en) | 2017-02-22 | 2021-06-29 | Insulet Corporation | Needle insertion mechanisms for drug containers |
US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
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US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
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WO2023141627A2 (en) * | 2022-01-21 | 2023-07-27 | Rx Bandz, Inc. | Systems, devices, and methods for fluidic throttle control of the delivery of therapies in needle-based delivery systems |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5318514A (en) * | 1992-08-17 | 1994-06-07 | Btx, Inc. | Applicator for the electroporation of drugs and genes into surface cells |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6199766B1 (en) | 1909-03-29 | 2001-03-13 | University Of Southampton | Targeting of flying insects with insecticides and apparatus for charging liquids |
US2725877A (en) | 1950-12-22 | 1955-12-06 | Reiter David | Hypodermic syringe with feed control |
US2860439A (en) | 1955-08-10 | 1958-11-18 | Arvey Corp | Foldable display piece |
FR2348709A1 (en) * | 1976-04-23 | 1977-11-18 | Pistor Michel | MESOTHERAPIC TREATMENT PROCESS AND INJECTION DEVICE, FORMING AUTOMATIC MICRO-INJECTOR, INCLUDING APPLICATION |
US4198975A (en) | 1978-10-06 | 1980-04-22 | Haller J Gilbert | Self-injecting hypodermic syringe device |
US4394863A (en) | 1981-10-23 | 1983-07-26 | Survival Technology, Inc. | Automatic injector with cartridge having separate sequentially injectable medicaments |
US4832682A (en) | 1984-08-08 | 1989-05-23 | Survival Technology, Inc. | Injection method and apparatus with electrical blood absorbing stimulation |
US4636197A (en) | 1985-02-15 | 1987-01-13 | Ping Chu | Intravenous fluid infusion device |
FR2638359A1 (en) | 1988-11-03 | 1990-05-04 | Tino Dalto | SYRINGE GUIDE WITH ADJUSTMENT OF DEPTH DEPTH OF NEEDLE IN SKIN |
JPH04244172A (en) | 1991-01-30 | 1992-09-01 | Sony Corp | Analgenic method and apparatus with low frequency therapeutic apparatus |
JPH04362767A (en) | 1991-06-10 | 1992-12-15 | Agency Of Ind Science & Technol | Multiprocessor device |
US5215089A (en) | 1991-10-21 | 1993-06-01 | Cyberonics, Inc. | Electrode assembly for nerve stimulation |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
US5688233A (en) | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
US5306236A (en) | 1993-02-18 | 1994-04-26 | Vickers Plc | Needle electrode for use with hypodermic syringe attachment |
US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
US5425715A (en) * | 1993-08-05 | 1995-06-20 | Survival Technology, Inc. | Reloadable injector |
US5478316A (en) * | 1994-02-02 | 1995-12-26 | Becton, Dickinson And Company | Automatic self-injection device |
US5593429A (en) | 1994-06-28 | 1997-01-14 | Cadwell Industries, Inc. | Needle electrode with depth of penetration limiter |
US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
GB9612724D0 (en) | 1996-06-18 | 1996-08-21 | Owen Mumford Ltd | Improvements relating to injection devices |
US5846225A (en) | 1997-02-19 | 1998-12-08 | Cornell Research Foundation, Inc. | Gene transfer therapy delivery device and method |
US5851197A (en) * | 1997-02-05 | 1998-12-22 | Minimed Inc. | Injector for a subcutaneous infusion set |
ES2273408T3 (en) | 1997-04-03 | 2007-05-01 | Electrofect As. | METHOD FOR INTRODUCING MEDICATIONS AND NUCLEIC ACIDS IN THE SKELETIC MUSCLE. |
US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
US6558351B1 (en) | 1999-06-03 | 2003-05-06 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
EP1014790A4 (en) | 1997-09-18 | 2005-02-02 | Gene Therapy Systems Inc | Chemical modification of dna using peptide nucleic acid conjugates |
TW368420B (en) | 1997-11-04 | 1999-09-01 | Genetronics Inc | Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum |
US6356783B1 (en) | 1997-11-20 | 2002-03-12 | David R. Hubbard, Jr. | Multi-electrode and needle injection device for diagnosis and treatment of muscle injury and pain |
US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
US6208893B1 (en) | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
US6120493A (en) | 1998-01-27 | 2000-09-19 | Genetronics, Inc. | Method for the introduction of therapeutic agents utilizing an electroporation apparatus |
US6309370B1 (en) | 1998-02-05 | 2001-10-30 | Biosense, Inc. | Intracardiac drug delivery |
ATE254938T1 (en) | 1998-03-23 | 2003-12-15 | Elan Corp Plc | DEVICE FOR DRUG ADMINISTRATION |
GB9808408D0 (en) | 1998-04-18 | 1998-06-17 | Owen Mumford Ltd | Improvements relating to injection devices |
WO2000007453A1 (en) | 1998-08-03 | 2000-02-17 | North Carolina State University | Use of co2 cooling in treatment of poultry eggs |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
GB9817662D0 (en) | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
EP1183068A4 (en) | 1999-05-10 | 2008-12-17 | Gentronics Inc | Method of electroporation-enhanced delivery of active agents |
JP2000316991A (en) | 1999-05-13 | 2000-11-21 | Hisamitsu Pharmaceut Co Inc | Electrode structural body for iontophoresis device and its manufacture |
AU7064700A (en) | 1999-08-20 | 2001-03-19 | Bioject, Inc. | Intramuscular injection system for injecting dna-based injectables into humans |
US6319224B1 (en) | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
US20040054393A1 (en) | 2000-01-21 | 2004-03-18 | Goran Stemme | Medical electrode |
US7530964B2 (en) | 2000-06-30 | 2009-05-12 | Elan Pharma International Limited | Needle device and method thereof |
CN1345607A (en) * | 2000-09-30 | 2002-04-24 | 杭州泰士生物科技有限公司 | Muscle gene injection needle with electrode |
DE60138411D1 (en) * | 2000-10-13 | 2009-05-28 | Alza Corp | DEVICE AND METHOD FOR PURIFYING SKIN WITH MICRONED PINS |
US20020078161A1 (en) | 2000-12-19 | 2002-06-20 | Philips Electronics North America Corporation | UPnP enabling device for heterogeneous networks of slave devices |
US6899699B2 (en) | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
US6748266B2 (en) | 2001-04-06 | 2004-06-08 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US20050154434A1 (en) | 2002-03-07 | 2005-07-14 | Adam Simon | Clinical syringe with electrical stimulation aspects |
US6780171B2 (en) * | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
US7328064B2 (en) * | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
JP2004041434A (en) * | 2002-07-11 | 2004-02-12 | Kiyohito Ishida | Electroporation apparatus |
GB2421689B (en) * | 2002-08-05 | 2007-03-07 | Caretek Medical Ltd | Drug delivery system |
CN1997423B (en) | 2004-03-08 | 2012-10-03 | 艾科医疗系统公司 | Improved apparatus for electrically mediated delivery of therapeutic agents |
EP2117607A4 (en) | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | Imaging agents and methods of use thereof |
-
2005
- 2005-03-08 CN CN2005800145531A patent/CN1997423B/en not_active Expired - Fee Related
- 2005-03-08 HU HUE05725237A patent/HUE025052T2/en unknown
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- 2005-03-08 ES ES15165174T patent/ES2695235T3/en active Active
- 2005-03-08 EP EP18188950.2A patent/EP3466483A1/en not_active Withdrawn
- 2005-03-08 KR KR1020067020757A patent/KR101261642B1/en active IP Right Grant
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-
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- 2016-04-13 HK HK16104247.5A patent/HK1216239A1/en not_active IP Right Cessation
- 2016-05-12 US US15/153,558 patent/US9802035B2/en active Active
-
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- 2017-09-28 US US15/719,266 patent/US10561834B2/en active Active
-
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- 2020-01-08 US US16/737,701 patent/US20200139107A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5318514A (en) * | 1992-08-17 | 1994-06-07 | Btx, Inc. | Applicator for the electroporation of drugs and genes into surface cells |
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