WO2005085838A3 - Computational analysis of mass spectroscopic lipid data - Google Patents

Computational analysis of mass spectroscopic lipid data Download PDF

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Publication number
WO2005085838A3
WO2005085838A3 PCT/US2005/006843 US2005006843W WO2005085838A3 WO 2005085838 A3 WO2005085838 A3 WO 2005085838A3 US 2005006843 W US2005006843 W US 2005006843W WO 2005085838 A3 WO2005085838 A3 WO 2005085838A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
computational analysis
mass spectroscopic
lipid data
methods
Prior art date
Application number
PCT/US2005/006843
Other languages
French (fr)
Other versions
WO2005085838A2 (en
Inventor
H Alex Brown
Jeffrey Forrester
Original Assignee
Univ Vanderbilt
H Alex Brown
Jeffrey Forrester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt, H Alex Brown, Jeffrey Forrester filed Critical Univ Vanderbilt
Publication of WO2005085838A2 publication Critical patent/WO2005085838A2/en
Publication of WO2005085838A3 publication Critical patent/WO2005085838A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

The present invention provides methods for developing a lipid profile from cells using a computational statistical analysis of a lipid data array derived from mass spectroscopy. The methods have particular utility in diagnosing disease, screening drugs, and identifying new lipids and lipid-linked pathways.
PCT/US2005/006843 2004-03-02 2005-03-02 Computational analysis of mass spectroscopic lipid data WO2005085838A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54948304P 2004-03-02 2004-03-02
US60/549,483 2004-03-02

Publications (2)

Publication Number Publication Date
WO2005085838A2 WO2005085838A2 (en) 2005-09-15
WO2005085838A3 true WO2005085838A3 (en) 2006-01-19

Family

ID=34919497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006843 WO2005085838A2 (en) 2004-03-02 2005-03-02 Computational analysis of mass spectroscopic lipid data

Country Status (1)

Country Link
WO (1) WO2005085838A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007066216A2 (en) * 2005-12-09 2007-06-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Fatty acids profile correlated to the propensity or risk of breast cancer
WO2007098585A1 (en) * 2006-02-28 2007-09-07 Phenomenome Discoveries Inc. Methods for the diagnosis of dementia and other neurological disorders
JP5470050B2 (en) 2007-02-08 2014-04-16 フェノメノーム ディスカバリーズ インク Treatment for Alzheimer-type senile dementia
CN101675337A (en) 2007-04-13 2010-03-17 菲诺梅诺米发现公司 Methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging
WO2013173642A1 (en) * 2012-05-18 2013-11-21 Sanford-Burnham Medical Research Institute High-throughput lipidomics
JP2016537964A (en) * 2013-10-09 2016-12-08 ユニバーシティ オブ メリーランド，ボルチモア How to identify fungi
WO2019140257A1 (en) * 2018-01-11 2019-07-18 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for characterizing and treating prostate cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004957A2 (en) * 2000-07-10 2002-01-17 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004957A2 (en) * 2000-07-10 2002-01-17 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAN X, GROSS RW: "Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics", JOURNAL OF LIPID RESEARCH, vol. 44, 2003, pages 1071 - 1079, XP002354052, Retrieved from the Internet <URL:http://www.jlr.org/cgi/reprint/44/6/1071.pdf> [retrieved on 20051115] *
MILNE SB, FORRESTER JS, IVANOVA PT, ARMSTRONG MD, BROWN HA: "Multiplexed Lipid Arrays of Anti-Immunoglobulin M-Induced Changes in the Glycerophospholipid Composition of WEHI-231 Cells", ALLIANCE FOR CELLULAR SIGNALLING RESEARCH REPORTS, vol. 1, no. 11, 24 October 2003 (2003-10-24), pages 1 - 11, XP002354051, Retrieved from the Internet <URL:http://www.signaling-gateway.org/reports/v1/DA0011/DA0011.pdf> [retrieved on 20051115] *

Also Published As

Publication number Publication date
WO2005085838A2 (en) 2005-09-15

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