WO2005085286A3 - Peptides with antiangiogenic and antitumor activities - Google Patents

Peptides with antiangiogenic and antitumor activities Download PDF

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Publication number
WO2005085286A3
WO2005085286A3 PCT/EP2005/001945 EP2005001945W WO2005085286A3 WO 2005085286 A3 WO2005085286 A3 WO 2005085286A3 EP 2005001945 W EP2005001945 W EP 2005001945W WO 2005085286 A3 WO2005085286 A3 WO 2005085286A3
Authority
WO
WIPO (PCT)
Prior art keywords
arg
ala
gly
leu
ser
Prior art date
Application number
PCT/EP2005/001945
Other languages
French (fr)
Other versions
WO2005085286A2 (en
Inventor
Francesco Chillemi
Original Assignee
Francesco Chillemi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Francesco Chillemi filed Critical Francesco Chillemi
Publication of WO2005085286A2 publication Critical patent/WO2005085286A2/en
Publication of WO2005085286A3 publication Critical patent/WO2005085286A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Abstract

The peptide with the following sequence: Asn-Ser-Pro-Leu-Ser-Gly-Gly-Met-Arg-Gly-Ile-Arg-Gly-Ala-Asp-Phe-­Gln-Cys(Acm)-Phe-Gln-Gln-Ala-Arg-Ala-Val-Gly-Leu-Ala-Gly-Thr-Phe­-Arg-Ala-Phe-Leu-Ser-Ser-Arg-Leu-Gln-Asp-Leu-Tyr-Ser-Ile-Val-Arg-Arg­-Ala-Asp-Arg-Ala, its analogues and derivatives, are useful for the preparation of medicaments with antiangiogenic and antitumor activities
PCT/EP2005/001945 2004-02-27 2005-02-24 Peptides with antiangiogenic and antitumor activities WO2005085286A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20040364 ITMI20040364A1 (en) 2004-02-27 2004-02-27 PEPTIDES WITH ANTIANGIOGENIC AND ANTI-TUMOR ACTIVITY
ITMI2004A000364 2004-02-27

Publications (2)

Publication Number Publication Date
WO2005085286A2 WO2005085286A2 (en) 2005-09-15
WO2005085286A3 true WO2005085286A3 (en) 2006-03-02

Family

ID=34917541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/001945 WO2005085286A2 (en) 2004-02-27 2005-02-24 Peptides with antiangiogenic and antitumor activities

Country Status (2)

Country Link
IT (1) ITMI20040364A1 (en)
WO (1) WO2005085286A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048924A1 (en) * 1998-03-24 1999-09-30 The Children's Medical Center Corporation Endostatin derived peptides with anti-angiogenic and anti-cancer activity
WO2000063249A1 (en) * 1999-04-15 2000-10-26 Universita' Degli Studi Di Milano Polypeptides derived from endostatin exhibiting antiangiogenic activity
WO2000067771A1 (en) * 1999-05-06 2000-11-16 The Burnham Institute Antiangiogenic endostatin peptides, endostatin variants and methods of use
WO2002068457A2 (en) * 2001-02-27 2002-09-06 Universita' Degli Studi Di Milano Antiangiogenic peptides derived from endostatin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048924A1 (en) * 1998-03-24 1999-09-30 The Children's Medical Center Corporation Endostatin derived peptides with anti-angiogenic and anti-cancer activity
WO2000063249A1 (en) * 1999-04-15 2000-10-26 Universita' Degli Studi Di Milano Polypeptides derived from endostatin exhibiting antiangiogenic activity
WO2000067771A1 (en) * 1999-05-06 2000-11-16 The Burnham Institute Antiangiogenic endostatin peptides, endostatin variants and methods of use
WO2002068457A2 (en) * 2001-02-27 2002-09-06 Universita' Degli Studi Di Milano Antiangiogenic peptides derived from endostatin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHILLEMI FRANCESCO ET AL: "Studies on the structure-activity relationship of endostatin: Synthesis of human endostatin peptides exhibiting potent antiangiogenic activities.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 19, 11 September 2003 (2003-09-11), pages 4165 - 4172, XP002350488, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2005085286A2 (en) 2005-09-15
ITMI20040364A1 (en) 2004-05-27

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