WO2005082483A1 - A process for the purification of antibodies - Google Patents
A process for the purification of antibodiesInfo
- Publication number
- WO2005082483A1 WO2005082483A1 PCT/SE2005/000293 SE2005000293W WO2005082483A1 WO 2005082483 A1 WO2005082483 A1 WO 2005082483A1 SE 2005000293 W SE2005000293 W SE 2005000293W WO 2005082483 A1 WO2005082483 A1 WO 2005082483A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chromatography
- antibodies
- resin
- ligands
- modal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
- B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3847—Multimodal interactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
- B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05722175A EP1718386A1 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
US10/589,717 US7750129B2 (en) | 2004-02-27 | 2005-02-25 | Process for the purification of antibodies |
KR1020067017113A KR101150050B1 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
JP2007500725A JP4848356B2 (en) | 2004-02-27 | 2005-02-25 | Antibody purification method |
NZ548126A NZ548126A (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies involving addition of a second resin |
CA2552639A CA2552639C (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
AU2005216847A AU2005216847B2 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
CN200580006276XA CN1925898B (en) | 2004-02-27 | 2005-02-25 | Antibody purification technique |
IL176745A IL176745A (en) | 2004-02-27 | 2006-07-06 | Process for the purification of antibodies |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400501A SE0400501D0 (en) | 2004-02-27 | 2004-02-27 | Antibody purification |
SE0400501-3 | 2004-02-27 | ||
SE0402558A SE0402558D0 (en) | 2004-10-21 | 2004-10-21 | A process for the purification of antibodies |
SE0402558-1 | 2004-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005082483A1 true WO2005082483A1 (en) | 2005-09-09 |
Family
ID=34914633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2005/000293 WO2005082483A1 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
Country Status (9)
Country | Link |
---|---|
US (1) | US7750129B2 (en) |
EP (1) | EP1718386A1 (en) |
JP (1) | JP4848356B2 (en) |
KR (1) | KR101150050B1 (en) |
AU (1) | AU2005216847B2 (en) |
CA (1) | CA2552639C (en) |
IL (1) | IL176745A (en) |
NZ (1) | NZ548126A (en) |
WO (1) | WO2005082483A1 (en) |
Cited By (39)
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JP2008518885A (en) * | 2004-10-21 | 2008-06-05 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Chromatographic ligand |
CN100395001C (en) * | 2006-01-26 | 2008-06-18 | 合肥工业大学 | Semi fixed coordinate chromatograph for separating and purifying |
WO2008085116A1 (en) * | 2007-01-10 | 2008-07-17 | Ge Healthcare Bio-Sciences Ab | Mult i -modal ion exchange chromotography resins |
WO2009156430A1 (en) * | 2008-06-24 | 2009-12-30 | Octapharma Ag | A process of purifying coagulation factor viii |
EP2198954A2 (en) | 2008-12-18 | 2010-06-23 | Tosoh Corporation | Packing material for liquid chromatography and process for separation and purification of biopolymer by means of the packing material |
US20100210821A1 (en) * | 2007-08-23 | 2010-08-19 | Gustav Gilljam | Process for isolation and purification of a target protein free of prion protein (prpsc) |
EP2265129A1 (en) * | 2008-04-08 | 2010-12-29 | Bio-Rad Laboratories, Inc. | Chromatography purification of antibodies |
WO2011012302A1 (en) | 2009-07-28 | 2011-02-03 | Instraction Gmbh | Specific sorbent for binding proteins and peptides, and separation method using the same |
EP2326658A1 (en) * | 2008-09-12 | 2011-06-01 | GE Healthcare Bio-Sciences AB | Enhanced protein aggregate removal with multimodal anion exchangers in the presence of protein-excluded zwitterions |
WO2011121020A1 (en) | 2010-03-30 | 2011-10-06 | Octapharma Ag | A process for purifying vitamin k dependent proteins such as coagulation factor ix |
US8231876B2 (en) * | 2006-04-05 | 2012-07-31 | Abbott Biotechnology Ltd. | Purified antibody composition |
WO2012171853A1 (en) | 2011-06-16 | 2012-12-20 | Dsm Ip Assets B.V. | Single unit chromatography antibody purification |
US8802448B2 (en) | 2011-07-27 | 2014-08-12 | Pall Corporation | Mixed mode ligands |
US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015135884A1 (en) * | 2014-03-10 | 2015-09-17 | Richter Gedeon Nyrt. | Immunoglobulin purification using pre-cleaning steps |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9193787B2 (en) | 2012-04-20 | 2015-11-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9220997B2 (en) | 2007-03-28 | 2015-12-29 | Dpx Holdings B.V. | Expanded bed column and disposable chromatography |
US9234033B2 (en) | 2012-09-02 | 2016-01-12 | Abbvie, Inc. | Methods to control protein heterogeneity |
EP2894159A4 (en) * | 2012-09-03 | 2016-01-20 | Kaneka Corp | Mix-mode antibody affinity separation matrix and purification method using same, and target molecule |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9453045B2 (en) | 2010-03-30 | 2016-09-27 | Octapharma Ag | Process for the purification of a growth factor protein |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
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US9550826B2 (en) | 2013-11-15 | 2017-01-24 | Abbvie Inc. | Glycoengineered binding protein compositions |
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US9783570B2 (en) | 2011-07-01 | 2017-10-10 | Hoffmann-La Roche Inc. | Method for separation of monomeric polypeptides from aggregated polypeptides |
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US10519195B2 (en) | 2013-09-17 | 2019-12-31 | Kaneka Corporation | Antibody purification method, antibody obtained therefrom, novel antibody purification method using cation exchanger, and antibody obtained therefrom |
US10815269B2 (en) | 2012-11-13 | 2020-10-27 | Ge Healthcare Bioprocess R&D Ab | Multimodal anion exchange matrices |
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WO2011001963A1 (en) | 2009-07-03 | 2011-01-06 | 旭化成ケミカルズ株式会社 | Method for purification of antibody using porous membrane having amino group and alkyl group both bound to graft chain immobilized on porous base material |
EP2490780A4 (en) * | 2009-10-20 | 2014-04-09 | Merck Sharp & Dohme | Use of mixed mode chromatography for the capture and purification of basic antibody products |
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WO1997010887A1 (en) * | 1995-09-20 | 1997-03-27 | Novo Nordisk A/S | Novel affinity ligands and their use |
WO2002005959A2 (en) * | 2000-07-17 | 2002-01-24 | Amersham Biosciences Ab | Adsorption method and ligands |
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-
2005
- 2005-02-25 US US10/589,717 patent/US7750129B2/en active Active
- 2005-02-25 KR KR1020067017113A patent/KR101150050B1/en active IP Right Grant
- 2005-02-25 WO PCT/SE2005/000293 patent/WO2005082483A1/en active Application Filing
- 2005-02-25 NZ NZ548126A patent/NZ548126A/en not_active IP Right Cessation
- 2005-02-25 CA CA2552639A patent/CA2552639C/en active Active
- 2005-02-25 EP EP05722175A patent/EP1718386A1/en not_active Ceased
- 2005-02-25 JP JP2007500725A patent/JP4848356B2/en active Active
- 2005-02-25 AU AU2005216847A patent/AU2005216847B2/en active Active
-
2006
- 2006-07-06 IL IL176745A patent/IL176745A/en not_active IP Right Cessation
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Title |
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KASTNER M. ET AL.: "Protein liquid chromatography.", JOURNAL OF CHROMATOGRAPHY LIBRARY, vol. 61, no. 1, 2000, pages 60 - 61, XP002987337 * |
Cited By (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008518885A (en) * | 2004-10-21 | 2008-06-05 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Chromatographic ligand |
US10751645B2 (en) | 2004-10-21 | 2020-08-25 | Ge Healthcare Bioprocess R&D Ab | Chromatography ligand |
JP4831436B2 (en) * | 2004-10-21 | 2011-12-07 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Chromatographic ligand |
US9878266B2 (en) | 2004-10-21 | 2018-01-30 | Ge Healthcare Bioprocess R&D Ab | Chromatography ligand |
CN100395001C (en) * | 2006-01-26 | 2008-06-18 | 合肥工业大学 | Semi fixed coordinate chromatograph for separating and purifying |
US9913902B2 (en) | 2006-04-05 | 2018-03-13 | Abbvie Biotechnology Ltd. | Purified antibody composition |
US11083792B2 (en) | 2006-04-05 | 2021-08-10 | Abbvie Biotechnology Ltd | Purified antibody composition |
US8895009B2 (en) | 2006-04-05 | 2014-11-25 | Abbvie Biotechnology Ltd. | Purified antibody composition |
US9273132B2 (en) | 2006-04-05 | 2016-03-01 | Abbvie Biotechnology Ltd | Purified antibody composition |
AU2007235484B2 (en) * | 2006-04-05 | 2013-11-07 | Abbvie Biotechnology Ltd | Antibody purification |
US9328165B2 (en) | 2006-04-05 | 2016-05-03 | Abbvie Biotechnology Ltd. | Purified antibody composition |
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