WO2005082423A3 - Materiaux et procedes d'imagerie - Google Patents

Materiaux et procedes d'imagerie Download PDF

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Publication number
WO2005082423A3
WO2005082423A3 PCT/US2004/038682 US2004038682W WO2005082423A3 WO 2005082423 A3 WO2005082423 A3 WO 2005082423A3 US 2004038682 W US2004038682 W US 2004038682W WO 2005082423 A3 WO2005082423 A3 WO 2005082423A3
Authority
WO
WIPO (PCT)
Prior art keywords
serum albumin
imaging
fluorescent substances
albumin conjugated
near infrared
Prior art date
Application number
PCT/US2004/038682
Other languages
English (en)
Other versions
WO2005082423A2 (fr
Inventor
John V Frangioni
Shunsuke Onishi
Original Assignee
Beth Israel Hospital
John V Frangioni
Shunsuke Onishi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital, John V Frangioni, Shunsuke Onishi filed Critical Beth Israel Hospital
Priority to US10/579,613 priority Critical patent/US20080308744A1/en
Publication of WO2005082423A2 publication Critical patent/WO2005082423A2/fr
Publication of WO2005082423A3 publication Critical patent/WO2005082423A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen

Abstract

L'invention concerne des compositions et des procédés d'imagerie de tissus ou d'un système lymphatique ou circulatoire, par exemple, dans le proche infrarouge. Des colorants qui émettent des longueurs d'onde dans les régions infrarouge ou proche infrarouge du spectre peuvent être utilisés seuls, en combinaison ou en complexe avec de la sérumalbumine, ou en tant que partie d'un conjugué covalent avec de la sérumalbumine.
PCT/US2004/038682 2003-11-18 2004-11-17 Materiaux et procedes d'imagerie WO2005082423A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/579,613 US20080308744A1 (en) 2003-11-18 2004-11-17 Serum Albumin Conjugated to Fluorescent Substances for Imaging

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52305903P 2003-11-18 2003-11-18
US60/523059 2003-11-18
US60826704P 2004-09-09 2004-09-09
US60/608267 2004-09-09

Publications (2)

Publication Number Publication Date
WO2005082423A2 WO2005082423A2 (fr) 2005-09-09
WO2005082423A3 true WO2005082423A3 (fr) 2006-02-16

Family

ID=34915518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/038682 WO2005082423A2 (fr) 2003-11-18 2004-11-17 Materiaux et procedes d'imagerie

Country Status (2)

Country Link
US (1) US20080308744A1 (fr)
WO (1) WO2005082423A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1743658A1 (fr) * 2005-07-14 2007-01-17 Schering Aktiengesellschaft Imagerie optique de l'arhtrite rhumatoïde
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
WO2007070680A2 (fr) * 2005-12-16 2007-06-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Sondes detectables optiquement pour l’identification et le traitement de tumeurs
WO2008025000A2 (fr) * 2006-08-24 2008-02-28 Baylor College Of Medicine Agents d'imagerie pour l'imagerie fonctionnelle de structures lymphatiques
GB0724412D0 (en) * 2007-12-14 2008-02-06 Ucl Business Plc Marker
EP2396347B1 (fr) 2009-02-11 2017-04-12 Albumedix A/S Variants et conjugés de l'albumine
CN102741280B (zh) 2009-10-30 2015-12-02 诺维信生物制药丹麦公司 白蛋白变体
CA2793698C (fr) 2010-03-19 2016-11-29 The University Of Melbourne Kit et procede de detection d'hydroxylapatite dentaire poreuse
US10233228B2 (en) 2010-04-09 2019-03-19 Albumedix Ltd Albumin derivatives and variants
EP2571529A2 (fr) 2010-05-14 2013-03-27 Mallinckrodt LLC Nanostructures réticulées fonctionnelles pour le tandem imagerie optique et thérapie
EP2780364A2 (fr) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Protéines ayant une demi-vie et d'autres propriétés améliorées
AU2013234299B2 (en) 2012-03-16 2017-06-22 Albumedix Ltd. Albumin variants
JP6177036B2 (ja) * 2012-07-20 2017-08-09 キヤノン株式会社 光音響イメージング用造影剤
CN104487098B (zh) * 2012-07-20 2017-12-15 佳能株式会社 光声成像用造影剂
GB2512156A (en) 2012-11-08 2014-09-24 Novozymes Biopharma Dk As Albumin variants
EP3062825B1 (fr) * 2013-10-31 2022-08-24 Beth Israel Deaconess Medical Center Agents de contraste pour la bioimagerie dans le proche infrarouge et leurs méthodes d'utilisation
WO2015066296A1 (fr) 2013-10-31 2015-05-07 Beth Israel Deaconess Medical Center Agents de contraste pour les nerfs fluorescents dans le proche infrarouge et procédés d'utilisation de ceux-ci
JP7007261B2 (ja) 2015-08-20 2022-01-24 アルブミディクス リミティド アルブミン変異体及びコンジュゲート

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS557245A (en) * 1978-06-30 1980-01-19 Dai Ichi Seiyaku Co Ltd Colorant for lymph system
WO1996017628A1 (fr) * 1994-12-07 1996-06-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Procede de diagnostic in vivo par rayons infrarouges proches
WO2000035490A2 (fr) * 1998-12-15 2000-06-22 Christer Busch Agent de contraste destine a faciliter l'identification oculaire et l'examen des ganglions lymphatiques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
US5453505A (en) * 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
US5607764A (en) * 1994-10-27 1997-03-04 Fuji Photo Film Co., Ltd. Optical diffuser
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS557245A (en) * 1978-06-30 1980-01-19 Dai Ichi Seiyaku Co Ltd Colorant for lymph system
WO1996017628A1 (fr) * 1994-12-07 1996-06-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Procede de diagnostic in vivo par rayons infrarouges proches
WO2000035490A2 (fr) * 1998-12-15 2000-06-22 Christer Busch Agent de contraste destine a faciliter l'identification oculaire et l'examen des ganglions lymphatiques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GANDORFER A ET AL: "Retinal damage from indocyanine green in experimental macular surgery", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND, US, vol. 44, no. 1, January 2003 (2003-01-01), pages 316 - 323, XP002989964, ISSN: 0146-0404 *
PARUNGO C. P. ET AL: "In vivo optical imaging of pleural space drainage to lymph nodes of prognostic significance", ANNALS OF SURGICAL ONCOLOGY, vol. 11, no. 12, 2004, pages 1085 - 1092, XP008053242 *
PATENT ABSTRACTS OF JAPAN vol. 004, no. 034 (C - 003) 22 March 1980 (1980-03-22) *
ZAHEER A ET AL: "IRDYE78 CONJUGATES FOR NEAR-INFRARED FLUORESCENCE IMAGING", MOLECULAR IMAGING, MIT PRESS,, US, vol. 1, no. 4, October 2002 (2002-10-01), pages 354 - 364, XP008029547, ISSN: 1535-3508 *

Also Published As

Publication number Publication date
US20080308744A1 (en) 2008-12-18
WO2005082423A2 (fr) 2005-09-09

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