WO2005082329A3 - Process for the preparation of solid dosage forms of valsartan and hydrochlorthiazide - Google Patents

Process for the preparation of solid dosage forms of valsartan and hydrochlorthiazide Download PDF

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Publication number
WO2005082329A3
WO2005082329A3 PCT/IB2005/000340 IB2005000340W WO2005082329A3 WO 2005082329 A3 WO2005082329 A3 WO 2005082329A3 IB 2005000340 W IB2005000340 W IB 2005000340W WO 2005082329 A3 WO2005082329 A3 WO 2005082329A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrochlorthiazide
valsartan
preparation
dosage forms
solid dosage
Prior art date
Application number
PCT/IB2005/000340
Other languages
French (fr)
Other versions
WO2005082329B1 (en
WO2005082329A2 (en
Inventor
Romi Barat Singh
Girish Karanth
Vishnubhotla Nagaprasad
Original Assignee
Ranbaxy Lab Ltd
Romi Barat Singh
Girish Karanth
Vishnubhotla Nagaprasad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Romi Barat Singh, Girish Karanth, Vishnubhotla Nagaprasad filed Critical Ranbaxy Lab Ltd
Publication of WO2005082329A2 publication Critical patent/WO2005082329A2/en
Publication of WO2005082329A3 publication Critical patent/WO2005082329A3/en
Publication of WO2005082329B1 publication Critical patent/WO2005082329B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to solid dosage forms comprising valsartan in a core and hydrochlorthiazide (HCTZ) in a coating layer; and process of preparation thereof.
PCT/IB2005/000340 2004-02-19 2005-02-10 Process for the preparation of solid dosage forms of valsartan and hydrochlorthiazide WO2005082329A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN238DE2004 2004-02-19
IN238/DEL/2004 2004-02-19

Publications (3)

Publication Number Publication Date
WO2005082329A2 WO2005082329A2 (en) 2005-09-09
WO2005082329A3 true WO2005082329A3 (en) 2006-04-13
WO2005082329B1 WO2005082329B1 (en) 2006-06-08

Family

ID=34897730

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000340 WO2005082329A2 (en) 2004-02-19 2005-02-10 Process for the preparation of solid dosage forms of valsartan and hydrochlorthiazide

Country Status (1)

Country Link
WO (1) WO2005082329A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007049291A1 (en) * 2005-10-27 2007-05-03 Lupin Limited Novel solid dosage forms of valsartan and rochlorothiazide
ATE499090T1 (en) * 2006-06-16 2011-03-15 Lek Pharmaceuticals PHARMACEUTICAL COMPOSITION CONTAINING HYDROCHLOROTHIAZIDE AND TELMISARTAN
WO2008056375A2 (en) * 2006-11-09 2008-05-15 Lupin Limited Pharmaceutical formulations comprising valsartan
GB0715628D0 (en) * 2007-08-10 2007-09-19 Generics Uk Ltd Solid valsartan composition
CA2715350C (en) 2008-03-19 2017-02-14 Ratiopharm Gmbh Solid pharmaceutical composition comprising a non-peptide angiotensin ii receptor antagonist and a diuretic
DE102008051783A1 (en) * 2008-10-17 2010-04-22 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Valsartan-containing tablet
EP4295839A1 (en) 2022-06-20 2023-12-27 KRKA, d.d., Novo mesto Combination of valsartan and indapamide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294197B1 (en) * 1996-06-27 2001-09-25 Novartis Ag Solid oral dosage forms of valsartan
WO2003059327A1 (en) * 2002-01-16 2003-07-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bilayer pharmaceutical tablet comprising telmisartan and a diuretic and preparation thereof
WO2003097045A1 (en) * 2002-05-17 2003-11-27 Novartis Ag Combination of organic compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294197B1 (en) * 1996-06-27 2001-09-25 Novartis Ag Solid oral dosage forms of valsartan
WO2003059327A1 (en) * 2002-01-16 2003-07-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bilayer pharmaceutical tablet comprising telmisartan and a diuretic and preparation thereof
WO2003097045A1 (en) * 2002-05-17 2003-11-27 Novartis Ag Combination of organic compounds

Also Published As

Publication number Publication date
WO2005082329B1 (en) 2006-06-08
WO2005082329A2 (en) 2005-09-09

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