WO2005081619A3 - Compounds and methods for increasing neurogenesis - Google Patents

Compounds and methods for increasing neurogenesis Download PDF

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Publication number
WO2005081619A3
WO2005081619A3 PCT/IB2004/004451 IB2004004451W WO2005081619A3 WO 2005081619 A3 WO2005081619 A3 WO 2005081619A3 IB 2004004451 W IB2004004451 W IB 2004004451W WO 2005081619 A3 WO2005081619 A3 WO 2005081619A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compounds
neurogenesis
increasing neurogenesis
modulating agents
Prior art date
Application number
PCT/IB2004/004451
Other languages
French (fr)
Other versions
WO2005081619A2 (en
Inventor
Goran Bertilsson
Rikard Erlandsson
Jonas Frisen
Anders Haegestrand
Jessica Heidrich
Nina Hellstrom
Johan Haggblad
Katarina Jansson
Jarkko Kortesmaa
Per Lindquist
Hanna Lundh
Jacqueline Mcguire
Alex Mercer
Karl Nyberg
Amina Ossoinak
Cesare Patrone
Harriet Ronnholm
Lilian Wirkstrom
Olof Zachrisson
Original Assignee
Neuronova Ab
Goran Bertilsson
Rikard Erlandsson
Jonas Frisen
Anders Haegestrand
Jessica Heidrich
Nina Hellstrom
Johan Haggblad
Katarina Jansson
Jarkko Kortesmaa
Per Lindquist
Hanna Lundh
Jacqueline Mcguire
Alex Mercer
Karl Nyberg
Amina Ossoinak
Cesare Patrone
Harriet Ronnholm
Lilian Wirkstrom
Olof Zachrisson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2003/005311 external-priority patent/WO2004045592A2/en
Priority claimed from US10/850,055 external-priority patent/US6969702B2/en
Application filed by Neuronova Ab, Goran Bertilsson, Rikard Erlandsson, Jonas Frisen, Anders Haegestrand, Jessica Heidrich, Nina Hellstrom, Johan Haggblad, Katarina Jansson, Jarkko Kortesmaa, Per Lindquist, Hanna Lundh, Jacqueline Mcguire, Alex Mercer, Karl Nyberg, Amina Ossoinak, Cesare Patrone, Harriet Ronnholm, Lilian Wirkstrom, Olof Zachrisson filed Critical Neuronova Ab
Priority to CA2546843A priority Critical patent/CA2546843C/en
Priority to EP04821493A priority patent/EP1750752A2/en
Publication of WO2005081619A2 publication Critical patent/WO2005081619A2/en
Publication of WO2005081619A3 publication Critical patent/WO2005081619A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.
PCT/IB2004/004451 2003-11-20 2004-11-19 Compounds and methods for increasing neurogenesis WO2005081619A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2546843A CA2546843C (en) 2003-11-20 2004-11-19 Compounds and methods for increasing neurogenesis
EP04821493A EP1750752A2 (en) 2003-11-20 2004-11-19 Compounds and methods for increasing neurogenesis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/IB2003/005311 WO2004045592A2 (en) 2002-11-20 2003-11-20 Compounds and methods for increasing neurogenesis
IBPCT/IB03/05311 2003-11-20
US10/718,071 2003-11-20
US10/718,071 US20050009847A1 (en) 2002-11-20 2003-11-20 Compounds and methods for increasing neurogenesis
US10/850,055 US6969702B2 (en) 2002-11-20 2004-05-19 Compounds and methods for increasing neurogenesis
US10/850,055 2004-05-19

Publications (2)

Publication Number Publication Date
WO2005081619A2 WO2005081619A2 (en) 2005-09-09
WO2005081619A3 true WO2005081619A3 (en) 2007-04-19

Family

ID=34915966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/004451 WO2005081619A2 (en) 2003-11-20 2004-11-19 Compounds and methods for increasing neurogenesis

Country Status (3)

Country Link
EP (1) EP1750752A2 (en)
CA (1) CA2546843C (en)
WO (1) WO2005081619A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2647568A1 (en) * 2006-03-31 2007-10-11 Amylin Pharmaceuticals, Inc. Amylin and amylin agonists for treating psychiatric diseases and disorders
CA2672524C (en) * 2006-12-14 2016-08-23 Neuronova Ab Treatment of disease or injury of the nervous system using agents that decrease the activity of the melanocortin 4 receptor
CA2699087A1 (en) * 2007-09-11 2009-04-16 Dorian Bevec Use of a peptide as a therapeutic agent
CA2698690A1 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Thyrotropin releasing hormone for therapeutic applications
WO2009033809A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US20110263642A1 (en) * 2008-08-26 2011-10-27 Fibrogen, Inc. Methods for treatment of multiple sclerosis
CN102924587B (en) * 2011-08-11 2016-08-24 中肽生化有限公司 Long-acting salmon calcitonin analogues and its production and use
UA116217C2 (en) 2012-10-09 2018-02-26 Санофі Exendin-4 derivatives as dual glp1/glucagon agonists
CN104870009B (en) 2012-12-21 2021-05-18 赛诺菲 Functionalized exendin-4 derivatives
TW201609795A (en) 2013-12-13 2016-03-16 賽諾菲公司 EXENDIN-4 peptide analogues as dual GLP-1/GIP receptor agonists
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
TW201625669A (en) 2014-04-07 2016-07-16 賽諾菲公司 Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4
TW201625670A (en) 2014-04-07 2016-07-16 賽諾菲公司 Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4
TW201625668A (en) 2014-04-07 2016-07-16 賽諾菲公司 Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
CN104888198A (en) * 2015-04-21 2015-09-09 徐志强 New application of calcitonin to preparing medicines for delaying brain aging
AR105319A1 (en) 2015-06-05 2017-09-27 Sanofi Sa PROPHARMS THAT INCLUDE A DUAL AGONIST GLU-1 / GLUCAGON CONJUGATE HIALURONIC ACID CONNECTOR
TW201706291A (en) 2015-07-10 2017-02-16 賽諾菲公司 New EXENDIN-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
US10883132B2 (en) * 2018-03-09 2021-01-05 Enzypep B.V. Chemo-enzymatic synthesis of Semaglutide, Liraglutide and GLP-1
CN115896029A (en) * 2023-01-09 2023-04-04 中国人民解放军军事科学院军事医学研究院 Application of calcitonin gene-related peptide in treating Parkinson's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012099A1 (en) * 1998-09-02 2000-03-09 The Regents Of The University Of California Promoters of neural regeneration
WO2004045592A2 (en) * 2002-11-20 2004-06-03 Neuronova Ab Compounds and methods for increasing neurogenesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012099A1 (en) * 1998-09-02 2000-03-09 The Regents Of The University Of California Promoters of neural regeneration
WO2004045592A2 (en) * 2002-11-20 2004-06-03 Neuronova Ab Compounds and methods for increasing neurogenesis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PERRY TRACYANN ET AL: "A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 300, no. 3, March 2002 (2002-03-01), pages 958 - 966, XP002402955, ISSN: 0022-3565 *
PERRY TRACYANN ET AL: "Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 302, no. 3, September 2002 (2002-09-01), pages 881 - 888, XP002402954, ISSN: 0022-3565 *
RYDEL R E ET AL: "CAMP ANALOGS PROMOTE SURVIVAL AND NEURITE OUTGROWTH IN CULTURES OF RAT SYMPATHETIC AND SENSORY NEURONS INDEPENDENTLY OF NERVE GROWTH FACTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 85, February 1988 (1988-02-01), pages 1257 - 1261, XP002923654, ISSN: 0027-8424 *
THORNE R G ET AL: "DELIVERY OF NEUROTROPHIC FACTORS TO THE CENTRAL NERVOUS SYSTEM - PHARMACOKINETIC CONSIDERATIONS", CLINICAL PHARMACOKINETICS, LEA & FEBIGER, PHILADELPHIA, PA, US, vol. 40, no. 12, 2001, pages 907 - 946, XP009071751 *

Also Published As

Publication number Publication date
CA2546843A1 (en) 2005-09-09
WO2005081619A2 (en) 2005-09-09
CA2546843C (en) 2015-01-06
EP1750752A2 (en) 2007-02-14

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