WO2005079410A3 - Biological profiles and methods of use - Google Patents

Biological profiles and methods of use Download PDF

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Publication number
WO2005079410A3
WO2005079410A3 PCT/US2005/004817 US2005004817W WO2005079410A3 WO 2005079410 A3 WO2005079410 A3 WO 2005079410A3 US 2005004817 W US2005004817 W US 2005004817W WO 2005079410 A3 WO2005079410 A3 WO 2005079410A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
samples
biological profiles
apolipoproteins
prognosing
Prior art date
Application number
PCT/US2005/004817
Other languages
French (fr)
Other versions
WO2005079410A2 (en
Inventor
Gary L Nelsestuen
Original Assignee
Gary L Nelsestuen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gary L Nelsestuen filed Critical Gary L Nelsestuen
Publication of WO2005079410A2 publication Critical patent/WO2005079410A2/en
Publication of WO2005079410A3 publication Critical patent/WO2005079410A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method for diagnosing, prognosing or monitoring the health of a subject based on mass spectrometric analysis of specific proteins in fractionated blood samples is provided. Preferable embodiment utilized MALDI-TOF technique, which is applied to monitor apolipoproteins in the samples, see Figure 1. The major biological markers include apolipoprotein CI and its modification with m/z 6631 +/- 3 and 6433 +/- 3. The ratio of intensities or integral of these peaks can be used as a reference for diagnosis specific diseases, such as diabetes.
PCT/US2005/004817 2004-02-16 2005-02-16 Biological profiles and methods of use WO2005079410A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54445004P 2004-02-16 2004-02-16
US60/544,450 2004-02-16
US57368004P 2004-05-21 2004-05-21
US60/573,680 2004-05-21

Publications (2)

Publication Number Publication Date
WO2005079410A2 WO2005079410A2 (en) 2005-09-01
WO2005079410A3 true WO2005079410A3 (en) 2007-05-24

Family

ID=34890467

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004817 WO2005079410A2 (en) 2004-02-16 2005-02-16 Biological profiles and methods of use

Country Status (1)

Country Link
WO (1) WO2005079410A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10534005B2 (en) 2015-05-04 2020-01-14 Universita'delgi Studi Di Milano-Bicocca Method for the in vitro diagnosis of thyroid diseases
CN106885837B (en) * 2015-12-15 2019-04-09 中国科学院大连化学物理研究所 A kind of method of the highly sensitive detection pesticide sample of fast and stable
CN105758696B (en) * 2016-01-21 2018-11-13 谱尼测试集团股份有限公司 Method for extracting whole egg liquid fat at low temperature
CN108318573B (en) * 2016-08-16 2020-11-13 北京毅新博创生物科技有限公司 Preparation method of mass spectrum model for detecting insulin resistance
CN106198812B (en) * 2016-08-23 2018-12-25 国家烟草质量监督检验中心 A kind of measurement screening technique of the laryngocarcinoma urine difference metabolin based on hydrophilic Interaction Chromatography flight time mass spectrum
WO2023240089A1 (en) * 2022-06-07 2023-12-14 The Board Of Regents Of The University Of Texas System Neurological condition characterization and diagnosis systems, devices, and methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BONDARENKO ET AL.: "Mass spectral study of polymorphisms of the apolipoproteins of very low density lipoprotein", LIPID RES., vol. 40, March 1999 (1999-03-01), pages 543 - 555, XP003012855 *
KIERNAN ET AL.: "Detection of novel truncated forms of human serum amyloid A protein in human plasma", FEBS LETTERS, vol. 537, February 2003 (2003-02-01), pages 166 - 170, XP004411998 *
LIM ET AL.: "In vitro and in Vivo interactions of homocysteine with human plasma transthyretin", J. BIOL. CHEMISTRY, vol. 278, no. 50, 2003, pages 49707 - 49713, XP003012856 *
NELSESTUEN ET AL.: "Plasma protein profiling: unique and stable features of individuals", PROTEOMICS, October 2005 (2005-10-01), pages 4012 - 4024, XP003012854 *

Also Published As

Publication number Publication date
WO2005079410A2 (en) 2005-09-01

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