WO2005079164A3 - 5α-REDUCTASE INHIBITORS - Google Patents

5α-REDUCTASE INHIBITORS Download PDF

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Publication number
WO2005079164A3
WO2005079164A3 PCT/JP2005/002013 JP2005002013W WO2005079164A3 WO 2005079164 A3 WO2005079164 A3 WO 2005079164A3 JP 2005002013 W JP2005002013 W JP 2005002013W WO 2005079164 A3 WO2005079164 A3 WO 2005079164A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid
reductase inhibitors
lanosta
trien
efficacious
Prior art date
Application number
PCT/JP2005/002013
Other languages
French (fr)
Japanese (ja)
Other versions
WO2005079164A2 (en
WO2005079164A1 (en
Inventor
Ryuichirou Kondou
Kuniyoshi Shimizu
Jie Lui
Shoichiro Kumamoto
Fumiko Konishi
Shuhei Kaneko
Yoshitarou Suimi
Original Assignee
Kyushu Tlo Co Ltd
Chlorella Industry Company Ltd
Ryuichirou Kondou
Kuniyoshi Shimizu
Jie Lui
Shoichiro Kumamoto
Fumiko Konishi
Shuhei Kaneko
Yoshitarou Suimi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyushu Tlo Co Ltd, Chlorella Industry Company Ltd, Ryuichirou Kondou, Kuniyoshi Shimizu, Jie Lui, Shoichiro Kumamoto, Fumiko Konishi, Shuhei Kaneko, Yoshitarou Suimi filed Critical Kyushu Tlo Co Ltd
Priority to JP2006510188A priority Critical patent/JP5008973B2/en
Publication of WO2005079164A2 publication Critical patent/WO2005079164A2/en
Publication of WO2005079164A1 publication Critical patent/WO2005079164A1/en
Publication of WO2005079164A3 publication Critical patent/WO2005079164A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Abstract

It is intended to provide 5α-reductase inhibitors efficacious in preventing and treating diseases in which androgen participates, for example, prostatic cancer, prostatic hypertrophy, male pattern alopecia, simple acne, seborrhea and so on. Because of having a high 5α-reductase inhibitory activity, lanosta type triterpenes (in particular, ganoderic acid DM, 15α-hydroxy-3-oxolanosta-7,9(11),24-trien-26-oic acid), 5-lanosta-7,9(11),24-trien-15α,26-dihydroxy-3-one) or tyromycic acid) are efficacious as preventives/remedies for prostatic hypertrophy.
PCT/JP2005/002013 2004-02-10 2005-02-10 5α-REDUCTASE INHIBITORS WO2005079164A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006510188A JP5008973B2 (en) 2004-02-10 2005-02-10 5α-reductase inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004033283 2004-02-10
JP2004-033283 2004-02-10

Publications (3)

Publication Number Publication Date
WO2005079164A2 WO2005079164A2 (en) 2005-09-01
WO2005079164A1 WO2005079164A1 (en) 2005-09-01
WO2005079164A3 true WO2005079164A3 (en) 2005-10-27

Family

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62270595A (en) * 1986-03-03 1987-11-24 Advance Co Ltd Novel compound and liver enhancing agent
JPH10245393A (en) * 1997-02-28 1998-09-14 Shiseido Co Ltd Composition containing triterpenes
JPH10245394A (en) * 1997-02-28 1998-09-14 Shiseido Co Ltd New triterpenes and composition containing the same
JPH11246413A (en) * 1998-03-04 1999-09-14 Shiseido Co Ltd Steroid 5-alpha-reductase ii-type-specific inhibitor
JPH11246414A (en) * 1998-03-04 1999-09-14 Shiseido Co Ltd Steroid 5-alpha-reductase ii-type-specific inhibitor
JP2000169497A (en) * 1998-03-04 2000-06-20 Shiseido Co Ltd New triterpene and composition including the same
JP2004043440A (en) * 2002-05-14 2004-02-12 Sangaku Renkei Kiko Kyushu:Kk 5alpha-REDUCTASE INHIBITOR

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62270595A (en) * 1986-03-03 1987-11-24 Advance Co Ltd Novel compound and liver enhancing agent
JPH10245393A (en) * 1997-02-28 1998-09-14 Shiseido Co Ltd Composition containing triterpenes
JPH10245394A (en) * 1997-02-28 1998-09-14 Shiseido Co Ltd New triterpenes and composition containing the same
JPH11246413A (en) * 1998-03-04 1999-09-14 Shiseido Co Ltd Steroid 5-alpha-reductase ii-type-specific inhibitor
JPH11246414A (en) * 1998-03-04 1999-09-14 Shiseido Co Ltd Steroid 5-alpha-reductase ii-type-specific inhibitor
JP2000169497A (en) * 1998-03-04 2000-06-20 Shiseido Co Ltd New triterpene and composition including the same
JP2004043440A (en) * 2002-05-14 2004-02-12 Sangaku Renkei Kiko Kyushu:Kk 5alpha-REDUCTASE INHIBITOR

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
FUJITA R. ET AL.: "Mannentake no Ko-Dansei Hormone Koka.", THE PHARMACEUTICAL SOCIETY OF JAPAN DAI 123 NENKAI YOSHISHU, vol. 27, 2003, pages 112, XP002998419 *
GONZALEZ A. ET AL.: "Lanostanoid Triterpenes from Ganoderma lucidum", J.NAT.PROD., vol. 62, 1992, pages 1700 - 1701, XP002998420 *
HIROTANI M. ET AL.: "Ganoderic acid derivatives and ergosta-4, 7,22-triene-3,6-dione from ganoderma lucidum", PHYTOCHEMISTRY, vol. 26, no. 10, 1987, pages 2797 - 2803, XP002998423 *
KIKUCHI T. ET AL.: "Reishi no Seiri Kassei Seibun no Kenkyu.", PHARMA MEDICA, vol. 6, 1988, pages 110 - 126, XP002998422 *
KONDO R. ET AL.: "Shokuyo Yakuyo Kinoko no Ko-Dansei Hormone Koka.", NIPPON NOGEI KAGAKUKAI, 2003, pages 58, XP002998418 *
LIN L. ET AL.: "Triterpenes from Ganoderma Lucidum", PHYTOCHEMISTRY, vol. 27, no. 7, 1988, pages 2269 - 2271, XP002998426 *
RYU K. ET AL.: "Mannentake kara no-alpha- Reductase Sogai Seibun", NIPPON NOGEI KAGAKUKAI, 2004, pages 120, XP002998427 *
TOTH J. ET AL.: "Les Acides Ganoderiques T a Z: Triterpenes Cytotoxiques de Ganoderma lucidum (Polyporacee)", TETRAHEDRON LETT, vol. 24, no. 10, 1983, pages 1081 - 1084, XP002998425 *
WANG F. ET AL.: "Studies on the Ganoderic acid, a new constituents from the fruiting body of ganoderma lucidum (FR) karst.Yaoxue Xuebao", ACTA PHARMACEUTICA SINICA, vol. 32, no. 6, 1997, pages 447 - 450, XP002998421 *
YANG F. ET AL.: "Ganoderic acid Derivatives, 3-oxo-lanoszane-type triterpenoids,from ganoderma lucidum", REPT. TAIWAN SUGER RES.INST., 2002, pages 21 - 31, XP002998424 *

Also Published As

Publication number Publication date
JP5008973B2 (en) 2012-08-22
WO2005079164A2 (en) 2005-09-01
JPWO2005079164A1 (en) 2007-10-25

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