WO2005078090A3 - Antisense-oligonukleotide zur behandlung von unerwünschter pigmentierung der haut und der haare - Google Patents

Antisense-oligonukleotide zur behandlung von unerwünschter pigmentierung der haut und der haare Download PDF

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Publication number
WO2005078090A3
WO2005078090A3 PCT/EP2005/050549 EP2005050549W WO2005078090A3 WO 2005078090 A3 WO2005078090 A3 WO 2005078090A3 EP 2005050549 W EP2005050549 W EP 2005050549W WO 2005078090 A3 WO2005078090 A3 WO 2005078090A3
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WO
WIPO (PCT)
Prior art keywords
hair
skin
antisense oligonucleotides
structures
treating unwanted
Prior art date
Application number
PCT/EP2005/050549
Other languages
English (en)
French (fr)
Other versions
WO2005078090A2 (de
Inventor
Claudia Mundt
Stefan Gallinat
Ute Breitenbach
Thomas Blatt
Rainer Wolber
Werner Berens
Original Assignee
Beiersdorf Ag
Claudia Mundt
Stefan Gallinat
Ute Breitenbach
Thomas Blatt
Rainer Wolber
Werner Berens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag, Claudia Mundt, Stefan Gallinat, Ute Breitenbach, Thomas Blatt, Rainer Wolber, Werner Berens filed Critical Beiersdorf Ag
Priority to EP05707971A priority Critical patent/EP1716236A2/de
Publication of WO2005078090A2 publication Critical patent/WO2005078090A2/de
Publication of WO2005078090A3 publication Critical patent/WO2005078090A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oligonukleotid oder ein physiologisch verträgliches Salz davon, das in der Lage ist, mit einer mRNA oder einer Gensequenz zu hybridisieren, die ein oder mehrere an der Pig­mentierung der Haut und/oder der Haare beteiligten Strukturen kodieren, wobei diese an der Pigmentierung der Haut und/oder der Haare beteiligten Strukturen an: I) der eigentlichen Melanin-Synthese (Melanosomenstrukturen) und/oder an der II) Expression dieser Melanosomen-Strukturen und/oder am III) Transfer der Melanosomen (in die Keratinozyten) beteiligt sind.
PCT/EP2005/050549 2004-02-12 2005-02-08 Antisense-oligonukleotide zur behandlung von unerwünschter pigmentierung der haut und der haare WO2005078090A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05707971A EP1716236A2 (de) 2004-02-12 2005-02-08 Antisense-oligonukleotide zur behandlung von unerwünschter pigmentierung der haut und der haare

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004007032.6 2004-02-12
DE200410007032 DE102004007032A1 (de) 2004-02-12 2004-02-12 Antisense-Oligonukleotide zur Behandlung von unerwünschter Pigmentierung der Haut und der Haare

Publications (2)

Publication Number Publication Date
WO2005078090A2 WO2005078090A2 (de) 2005-08-25
WO2005078090A3 true WO2005078090A3 (de) 2005-12-01

Family

ID=34801894

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/050549 WO2005078090A2 (de) 2004-02-12 2005-02-08 Antisense-oligonukleotide zur behandlung von unerwünschter pigmentierung der haut und der haare

Country Status (3)

Country Link
EP (1) EP1716236A2 (de)
DE (1) DE102004007032A1 (de)
WO (1) WO2005078090A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014529628A (ja) * 2011-09-01 2014-11-13 ザ ジェネラル ホスピタル コーポレイション 皮膚色素沈着を調節するための方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014700A1 (en) * 2000-02-11 2004-01-22 Robin Kurfurst Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379887B1 (en) * 1998-09-10 2002-04-30 The General Hospital Corporation Gene for inhibiting melanin biosynthesis
TW200718944A (en) * 1999-06-29 2007-05-16 Univ New York Screening methods for compounds that affect melanogenesis
US20020064876A1 (en) * 1999-12-28 2002-05-30 Kyonggeun Yoon Novel gene therapy methods for the treatment of skin disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014700A1 (en) * 2000-02-11 2004-01-22 Robin Kurfurst Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AOKI HIROFUMI ET AL: "Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)", LIFE SCIENCES, vol. 71, no. 18, 20 September 2002 (2002-09-20), pages 2171 - 2179, XP002327571, ISSN: 0024-3205 *
SHIBAHARA SHIGEKI ET AL: "Microphthalmia-associated transcription factor (MITF): Multiplicity in structure, function, and regulation.", JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, vol. 6, no. 1, November 2001 (2001-11-01), pages 99 - 104, XP002327573, ISSN: 1087-0024 *
UDONO TETSUO ET AL: "Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1491, no. 1-3, 25 April 2000 (2000-04-25), pages 205 - 219, XP002327572, ISSN: 0006-3002 *

Also Published As

Publication number Publication date
WO2005078090A2 (de) 2005-08-25
DE102004007032A1 (de) 2005-08-25
EP1716236A2 (de) 2006-11-02

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