WO2005076939A3 - Assay and method for diagnosing and treating alzheimer’s disease - Google Patents

Assay and method for diagnosing and treating alzheimer’s disease Download PDF

Info

Publication number
WO2005076939A3
WO2005076939A3 PCT/US2005/003668 US2005003668W WO2005076939A3 WO 2005076939 A3 WO2005076939 A3 WO 2005076939A3 US 2005003668 W US2005003668 W US 2005003668W WO 2005076939 A3 WO2005076939 A3 WO 2005076939A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
diagnosing
assay
treating alzheimer
alzheimer
Prior art date
Application number
PCT/US2005/003668
Other languages
French (fr)
Other versions
WO2005076939A2 (en
Inventor
Philip W Landfield
Nada M Porter
Kuey Chu Chen
James Geddes
Eric Blalock
Original Assignee
Univ Kentucky Res Found
Philip W Landfield
Nada M Porter
Kuey Chu Chen
James Geddes
Eric Blalock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky Res Found, Philip W Landfield, Nada M Porter, Kuey Chu Chen, James Geddes, Eric Blalock filed Critical Univ Kentucky Res Found
Publication of WO2005076939A2 publication Critical patent/WO2005076939A2/en
Publication of WO2005076939A3 publication Critical patent/WO2005076939A3/en
Priority to US11/501,226 priority Critical patent/US20070082350A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods and kits for diagnosing Alzheimer’s disease and/or incipient Alzheimer’s disease are disclosed. The methods and kits of the invention utilize a set of genes and their encoded proteins that are shown to be correlated with incipient Alzeimer’s disease.
PCT/US2005/003668 2004-02-09 2005-02-09 Assay and method for diagnosing and treating alzheimer’s disease WO2005076939A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/501,226 US20070082350A1 (en) 2005-02-09 2006-08-09 Assay and method for diagnosing and treating alzheimer's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54228104P 2004-02-09 2004-02-09
US60/542,281 2004-02-09

Publications (2)

Publication Number Publication Date
WO2005076939A2 WO2005076939A2 (en) 2005-08-25
WO2005076939A3 true WO2005076939A3 (en) 2006-07-06

Family

ID=34860279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/003668 WO2005076939A2 (en) 2004-02-09 2005-02-09 Assay and method for diagnosing and treating alzheimer’s disease

Country Status (1)

Country Link
WO (1) WO2005076939A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10254601A1 (en) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Gene products differentially expressed in tumors and their use
DE102004024617A1 (en) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentially expressed in tumors gene products and their use
WO2006093138A1 (en) * 2005-03-04 2006-09-08 Nagoya Industrial Science Research Institute Method for determination of tendency to progress to apoptosis and use of the same
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
WO2008048466A2 (en) * 2006-10-10 2008-04-24 President And Fellows Of Harvard College Bone resorption disorders
EP2123303A1 (en) * 2007-02-20 2009-11-25 Takeda Pharmaceutical Company Limited Ameliorating agent for insulin resistance
FR2929292A1 (en) 2008-03-28 2009-10-02 Exonhit Therapeutics S A Sa In vitro or ex vivo process, useful e.g. for detecting the presence of Alzheimer's disease or the risk of developing Alzheimer's disease in a mammal, comprises determination of the presence of alteration in one or more genes or RNA
US20140255301A1 (en) * 2010-11-29 2014-09-11 Mark Chen Methods for detecting neurodegenerative diseases or disorders
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720138B2 (en) * 1997-04-30 2004-04-13 Diagenic As Method of preparing a standard diagnostic gene transcript pattern

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720138B2 (en) * 1997-04-30 2004-04-13 Diagenic As Method of preparing a standard diagnostic gene transcript pattern

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"GeneChip Human Genome arrays. U133 A array", AFFYMETRIX DATA SHEET, 20 April 2001 (2001-04-20), pages 1 - 4 *
BLALOCK ET AL.: "Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses", PNAS, vol. 101, no. 7, 9 February 2004 (2004-02-09), pages 2173 - 2178, XP055073328, DOI: doi:10.1073/pnas.0308512100 *
CHEE ET AL.: "Accessing genetic Information with High-density DNA arrays", SCIENCE, vol. 274, 25 October 1996 (1996-10-25), XP002022508, DOI: doi:10.1126/science.274.5287.610 *

Also Published As

Publication number Publication date
WO2005076939A2 (en) 2005-08-25

Similar Documents

Publication Publication Date Title
WO2005076939A3 (en) Assay and method for diagnosing and treating alzheimer’s disease
WO2003071927A3 (en) Diagnostics and therapeutics for macular degeneration-related disorders
WO2006020269A3 (en) Biomarkers of neurodegenerative disease
WO2007022529A3 (en) Method of treating inflammatory diseases
WO2007065025A3 (en) Method of dna analysis using micro/nanochannel
WO2005106038A3 (en) Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2006138659A3 (en) Intranasal red light probe for treating alzheimers disease
WO2005092038A3 (en) Methods for the detection of nucleic acid differences
WO2005087951A3 (en) Reagents, methods and kits for use in deactivating nucleic acids
EP2420838A3 (en) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
WO2004050707A3 (en) Tumor-specific recognition molecules
WO2007092640A3 (en) Antibodies that bind par-2
WO2007086980A3 (en) Methods of determining the risk of developing coronary artery disease
WO2006116016A3 (en) Molecular determinants of egfr kinase inhibitor response in glioblastoma
WO2007019312A3 (en) Methods for characterizing and treating cognitive impairment in aging and disease
WO2004106495A3 (en) Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
WO2005034732A3 (en) Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
WO2006042137A3 (en) Methods for identifying parkinson's disease therapeutics
WO2006081553A3 (en) ANTI-MUC1 α/ß ANTIBODIES
WO2008103202A3 (en) Hypoxia related genes and proteins for the treatment and diagnosis of pregnancy related complications
WO2009138499A3 (en) Biomarkers for depression
WO2005026392A3 (en) Compositions, reagents and kits for and methods of diagnosing, monitoring and treating obesity and/or diabetes
WO2006079334A3 (en) Protein identifying and quantifying method
WO2004022769A3 (en) Means of detecting neurodegenerative processes and applications of same
WO2007113685A8 (en) USE OF THE α CHAIN OF BRAIN SPECTRIN AND FRAGMENTS THEREOF, FOR DIAGNOSING CEREBRAL DISEASES

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase