WO2005076827A3 - Fbsa compositions for use in promoting fibrinogen aggregation and potentiating fibrin polymerization - Google Patents

Fbsa compositions for use in promoting fibrinogen aggregation and potentiating fibrin polymerization Download PDF

Info

Publication number
WO2005076827A3
WO2005076827A3 PCT/US2005/002647 US2005002647W WO2005076827A3 WO 2005076827 A3 WO2005076827 A3 WO 2005076827A3 US 2005002647 W US2005002647 W US 2005002647W WO 2005076827 A3 WO2005076827 A3 WO 2005076827A3
Authority
WO
WIPO (PCT)
Prior art keywords
fibrin
fbsa
potentiating
promoting
fibrinogen
Prior art date
Application number
PCT/US2005/002647
Other languages
French (fr)
Other versions
WO2005076827A2 (en
Inventor
Pietro Speziale
Original Assignee
Univ Pavia
Bates Sarah E
Pietro Speziale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pavia, Bates Sarah E, Pietro Speziale filed Critical Univ Pavia
Publication of WO2005076827A2 publication Critical patent/WO2005076827A2/en
Publication of WO2005076827A3 publication Critical patent/WO2005076827A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A composition containing the FbsA protein from Streptococcus agalactiae is provided which is effective in potentiating the polymerization of fibrin or in promoting fibrinogen aggregates so as to be useful as a wound sealant, and a pharmaceutically acceptable vehicle, carrier or excipient. Methods of treating patients by administering an amount of FbsA effective to promote aggregation of fibrinogen so as to promote blood clotting and wound sealing, or an amount effective to potentiate polymerization of fibrin so as to be useful as a fibrin wound sealant or an adjuvant for a fibrin wound sealant are also provided, and said methods are particularly advantageous in treating wounds without the need for sutures or staples in a variety of medical applications.
PCT/US2005/002647 2004-02-04 2005-02-02 Fbsa compositions for use in promoting fibrinogen aggregation and potentiating fibrin polymerization WO2005076827A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54126404P 2004-02-04 2004-02-04
US60/541,264 2004-02-04

Publications (2)

Publication Number Publication Date
WO2005076827A2 WO2005076827A2 (en) 2005-08-25
WO2005076827A3 true WO2005076827A3 (en) 2005-10-20

Family

ID=34860190

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/002647 WO2005076827A2 (en) 2004-02-04 2005-02-02 Fbsa compositions for use in promoting fibrinogen aggregation and potentiating fibrin polymerization

Country Status (1)

Country Link
WO (1) WO2005076827A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035618A2 (en) * 2002-10-15 2004-04-29 Intercell Ag Nucleic acids coding for adhesion factor of group b streptococcus, adhesion factors of group b streptococcus and further uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035618A2 (en) * 2002-10-15 2004-04-29 Intercell Ag Nucleic acids coding for adhesion factor of group b streptococcus, adhesion factors of group b streptococcus and further uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PIETROCOLA G. ET AL: "FbsA, a fibrinogen-binding protein from Streptococcus agalactiae mediates platelet aggregation.", BLOOD., vol. 105, no. 3, 1 February 2005 (2005-02-01), pages 1052 - 1059, XP002988994 *
SCHUBERT A. ET AL: "A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sites.", MOLECULAR MICROBIOLOGY., vol. 46, no. 2, 24 October 2002 (2002-10-24), pages 557 - 569, XP002268224 *
SCHUBERT A. ET AL: "The Fibrinigen Receptor FbsA Promotes Adherence of Streptococcus agalactiae to Human Epithelial Cells.", INFECTION AND IMMUNITY., vol. 72, no. 11, November 2004 (2004-11-01), pages 6197 - 6205, XP002988995 *

Also Published As

Publication number Publication date
WO2005076827A2 (en) 2005-08-25

Similar Documents

Publication Publication Date Title
Frachon et al. Management options for dental extraction in hemophiliacs: a study of 55 extractions (2000–2002)
Seo et al. The comparative efficacies of intra-articular and IV tranexamic acid for reducing blood loss during total knee arthroplasty
JP7146712B2 (en) One-component fibrin glue containing zymogen
Sterling et al. Hemostasis in burn surgery—a review
BR112012016633A2 (en) dry powder pharmaceutical composition and wound treatment method.
WO2007098114A3 (en) Clotting and healing compositions containing keratin biomaterials
WO2006037116A3 (en) Semi-solid delivery vehicle and pharmaceutical compositions
HK1090843A1 (en) Pharmaceutical compositions for healing wounds
Notarnicola et al. Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty
Baik et al. Development and analysis of a collagen-based hemostatic adhesive
WO2008019128A3 (en) Solid dressing for treating wounded tissue
ATE361084T1 (en) TOPICAL PHARMACEUTICAL COMPOSITIONS CONTAINING PROANTHOCYANIDINS, GLYCYRRHETINIC ACID AND TELMESTEINS FOR THE TREATMENT OF DERMATITIS
WO2012006516A3 (en) Protein kinase c activators and anticoagulant for the treatment of stroke
GB2462228A (en) Providing hemostasis in anticoagulated blood by using zeolites
US20030040692A1 (en) Fibrinogen bandages and arterial bleeding models and methods of making and using thereof
Kamoh et al. Hemostasis in oral surgery
ATE553772T1 (en) USE OF LVV HEMORPHIN-6 AND OPTIONAL AF12198 AS THERAPEUTIC AGENT(S).
WO2010002435A3 (en) Hemostatic pouch and method to stabilize hemostatic components
KR20080091440A (en) Thrombin-free biological adhesive and use thereof as a medicament
WO2008130607A3 (en) Wound healing compositions containing keratin biomaterials
WO2009016629A3 (en) Pharmaceutical composition for treating wounds and related methods
WO2006135493A3 (en) A composition for wound healing and use thereof
WO2009134054A3 (en) Heparin-conjugated fibrin gel and method and kit for preparing the same
Banerjee et al. Intraoperative pharmacotherapeutic blood management strategies in total knee arthroplasty
WO2006042478A8 (en) Small-molecule inhibitors of coronaviral main protease, their preparation and use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase