WO2005069741A3 - Process for producing simvastatin using novel hydrazide intermediates - Google Patents

Process for producing simvastatin using novel hydrazide intermediates Download PDF

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Publication number
WO2005069741A3
WO2005069741A3 PCT/IN2004/000302 IN2004000302W WO2005069741A3 WO 2005069741 A3 WO2005069741 A3 WO 2005069741A3 IN 2004000302 W IN2004000302 W IN 2004000302W WO 2005069741 A3 WO2005069741 A3 WO 2005069741A3
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WO
WIPO (PCT)
Prior art keywords
lovastatin
simvastatin
producing
hydrazide
producing simvastatin
Prior art date
Application number
PCT/IN2004/000302
Other languages
French (fr)
Other versions
WO2005069741A2 (en
Inventor
Dinesh R Panchasara
Sanjay Jaiswal
Govind Singh
Paramvir Bhadwal
Rajesh Kumar Thaper
Sushil Kumar Dubey
Jag Mohan Khanna
Original Assignee
Jubilant Organosys Ltd
Dinesh R Panchasara
Sanjay Jaiswal
Govind Singh
Paramvir Bhadwal
Rajesh Kumar Thaper
Sushil Kumar Dubey
Jag Mohan Khanna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Organosys Ltd, Dinesh R Panchasara, Sanjay Jaiswal, Govind Singh, Paramvir Bhadwal, Rajesh Kumar Thaper, Sushil Kumar Dubey, Jag Mohan Khanna filed Critical Jubilant Organosys Ltd
Publication of WO2005069741A2 publication Critical patent/WO2005069741A2/en
Publication of WO2005069741A3 publication Critical patent/WO2005069741A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention relates to an industrially feasible process for producing HMG-CoA reductase inhibitor, simvastatin via novel intermediates, wherein the process comprises treating lovastatin [2] or lovastatin ammonium salt [2’] with hydrazine or hydrazine derivatives to obtain lovastatin hydrazide [3], optionally protecting the hydroxyl groups of hydrazide intermediate [3] to obtain protected lovastatin hydrazide intermediate [4] which is further used in the process for producing simvastatin [1].
PCT/IN2004/000302 2004-01-21 2004-09-28 Process for producing simvastatin using novel hydrazide intermediates WO2005069741A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN108DE2004 2004-01-21
IN108/DEL/2004 2004-01-21

Publications (2)

Publication Number Publication Date
WO2005069741A2 WO2005069741A2 (en) 2005-08-04
WO2005069741A3 true WO2005069741A3 (en) 2005-12-22

Family

ID=34803680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000302 WO2005069741A2 (en) 2004-01-21 2004-09-28 Process for producing simvastatin using novel hydrazide intermediates

Country Status (1)

Country Link
WO (1) WO2005069741A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102532184B (en) * 2010-12-21 2015-04-29 北大方正集团有限公司 Dihydroxyl protection method of lovaamide and preparation method of simvastatin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630492B1 (en) * 1997-08-28 2003-10-07 Novartis Ag Lymphocyte function antigen-1 antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630492B1 (en) * 1997-08-28 2003-10-07 Novartis Ag Lymphocyte function antigen-1 antagonists

Also Published As

Publication number Publication date
WO2005069741A2 (en) 2005-08-04

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