WO2005068657A3 - Genetically profiled cell lines (gpcl) and methods of utilizing same for genetic dissection of cellular phenotypes - Google Patents

Genetically profiled cell lines (gpcl) and methods of utilizing same for genetic dissection of cellular phenotypes Download PDF

Info

Publication number
WO2005068657A3
WO2005068657A3 PCT/IL2005/000077 IL2005000077W WO2005068657A3 WO 2005068657 A3 WO2005068657 A3 WO 2005068657A3 IL 2005000077 W IL2005000077 W IL 2005000077W WO 2005068657 A3 WO2005068657 A3 WO 2005068657A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
gpcl
cell lines
utilizing same
cellular phenotypes
Prior art date
Application number
PCT/IL2005/000077
Other languages
French (fr)
Other versions
WO2005068657A2 (en
Inventor
Ariel Darvasi
Sagiv Shifman
Original Assignee
Yissum Res Dev Co
Ariel Darvasi
Sagiv Shifman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Ariel Darvasi, Sagiv Shifman filed Critical Yissum Res Dev Co
Publication of WO2005068657A2 publication Critical patent/WO2005068657A2/en
Publication of WO2005068657A3 publication Critical patent/WO2005068657A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Genetically profiled cell cultures are provided along with a dataset representing the genetic profile of the cells. Also provided are methods and kits using same for the identification of the genetic basis of a trait, a disease or a state which can be directly or indirectly measured in a cell-based assay. In addition, the methods provided by the present invention can be used to: (i) identify novel drugs for the treatment and/or prevention of diseases (ii) determine population variation to drug responsiveness, efficacy, toxicity and adverse effects, and (iii) to optimize the drug lead process.
PCT/IL2005/000077 2004-01-20 2005-01-20 Genetically profiled cell lines (gpcl) and methods of utilizing same for genetic dissection of cellular phenotypes WO2005068657A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53700304P 2004-01-20 2004-01-20
US60/537,003 2004-01-20
US57043804P 2004-05-13 2004-05-13
US60/570,438 2004-05-13

Publications (2)

Publication Number Publication Date
WO2005068657A2 WO2005068657A2 (en) 2005-07-28
WO2005068657A3 true WO2005068657A3 (en) 2005-09-22

Family

ID=34798872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000077 WO2005068657A2 (en) 2004-01-20 2005-01-20 Genetically profiled cell lines (gpcl) and methods of utilizing same for genetic dissection of cellular phenotypes

Country Status (1)

Country Link
WO (1) WO2005068657A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108504722A (en) * 2018-04-09 2018-09-07 殷东敏 A method of tandem repetitive sequence is quickly detected based on lock probe isothermal duplication

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032927A2 (en) * 1999-11-04 2001-05-10 Incyte Genomics, Inc. Tissue specific genes of diagnostic import

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032927A2 (en) * 1999-11-04 2001-05-10 Incyte Genomics, Inc. Tissue specific genes of diagnostic import

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALTARESCU G ET AL: "The interleukin-6 promoter polymorphism in Gaucher disease: A new modifier gene?", QJM, vol. 96, no. 8, August 2003 (2003-08-01), pages 575 - 578, XP008050346, ISSN: 1460-2725 *
HELLMANN GARY M ET AL: "Gene expression profiling of cultured human bronchial epithelial and lung carcinoma cells", TOXICOLOGICAL SCIENCES, vol. 61, no. 1, May 2001 (2001-05-01), pages 154 - 163, XP008050344, ISSN: 1096-6080 *
LASH LAWRENCE H ET AL: "Genetics and susceptibility to toxic chemicals: Do you (or should you) know your genetic profile?", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 305, no. 2, May 2003 (2003-05-01), pages 403 - 409, XP002338160, ISSN: 0022-3565 *
MOORE PATRICK S ET AL: "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4", VIRCHOWS ARCHIV, vol. 439, no. 6, December 2001 (2001-12-01), pages 798 - 802, XP002338159, ISSN: 0945-6317 *
NEBERT D W: "Pharmacogenetics and pharmacogenomics: Why is this relevant to the clinical geneticist?", CLINICAL GENETICS, COPENHAGEN, DK, vol. 56, no. 4, October 1999 (1999-10-01), pages 247 - 258, XP002277872 *
ROSES ALLEN D: "Pharmacogenetics", HUMAN MOLECULAR GENETICS, vol. 10, no. 20, 1 October 2001 (2001-10-01), pages 2261 - 2267, XP002338161, ISSN: 0964-6906 *

Also Published As

Publication number Publication date
WO2005068657A2 (en) 2005-07-28

Similar Documents

Publication Publication Date Title
Pavelka et al. Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer
WO2006058014A3 (en) Harnessing network biology to improve drug discovery
WO2007039319A8 (en) Dna microarray for rapid identification of candida albicans in blood cultures
WO2005068664A3 (en) Cell-type-specific patterns of gene expression
WO2006076025A3 (en) Immune cell biosensors and methods of using same
WO2008108803A3 (en) Immune cell biosensors and methods of using same
WO2010039627A3 (en) Biodetection articles
CL2007002060A1 (en) PROCESS TO CULTIVATE CELLS IN A REACTOR, IN SUSPENSION IN A CROP MEANS; AND CELL CULTURE.
WO2006018836A3 (en) Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
WO2007012811A9 (en) Prostate stem cell markers
WO2006015209A3 (en) Differentiation of stem cells
WO2005005601A8 (en) Compositions and methods for treating and diagnosing cancer
WO2005042703A3 (en) Placental stem cells and uses thereof
WO2006047412A3 (en) Methods and kits for detecting germ cell genomic instability
WO2006138275A3 (en) Compositions and methods for treating and diagnosing cancer
WO2006089091A3 (en) Methods for detecting minimum residual disease
WO2008118392A3 (en) Synthetic cell platforms and methods of use thereof
WO2009152484A3 (en) Methods and platforms for drug discovery
WO2006055338A3 (en) Methods and systems for identifying and isolating stem cells and for observing mitochondrial structure and distribution in living cells
WO2008033427A3 (en) Compositions and methods for detection of lysosomal storage disease
WO2008044032A3 (en) T cell epitope databases
WO2004087965A3 (en) Statistical analysis of regulatory factor binding sites of differentially expressed genes
BRPI0710637A2 (en) analysis of differential expression profile of cell culture phenotypes and their uses
IL190706A0 (en) Isolated nucleic acid which encodes a sucrose fluorescent indicator, sucrose biosensors and methods of using the same
WO2008029290A3 (en) Identification of cancer stem cells using genetic markers

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase