WO2005060886A1

WO2005060886A1 - Body temperature controlling device

Info

Publication number: WO2005060886A1
Application number: PCT/JP2004/018959
Authority: WO
Inventors: Isao Shimosaki; Akira Takeuchi
Original assignee: Blast Co., Ltd.; Luke Hospital
Priority date: 2003-12-24
Filing date: 2004-12-13
Publication date: 2005-07-07
Also published as: CN100355409C; CN1897895A; JP2005185797A

Abstract

A body temperature controlling device mathematically, precisely, and constantly controlling a heat transmission condition of an animal or human body, to the center portion of which heat is less likely to be transferred and whose temperature autonomously varies, and optimally controlling heating efficiency, raising for a wide range the temperature of a deep portion of the body and maintaining temperature in a fixed range. Heat producing means (1a-e) are provided so as to cover the entire portion from the neck of a human body downward, and fans (2a-f) are arranged at various places to ventilate the inside. Body temperature is FFT-analyzed to obtain a heating cycle at which the surface and deep portion of the human body resonate, and the heat producing means are set to ON-OFF at the same cycle and also at the same or reversed phase as the heating cycle to vary a heating value cyclically. This causes the temperature of the deep portion of the human body to be raised or controlled.

Description

Description Body temperature control device Technical field

According to the present invention, an object to be heated is a living body such as an animal or a human body, and the entire inside of the living body, such as an animal or a human body, in which the thermal conductivity changes by adjusting the temperature autonomously, The present invention relates to a body temperature control device that performs heating or temperature control well. Background art

[02] Conventionally, since cancer is considered to be vulnerable to heat, hyperthermia has been used to treat cancer by applying high fever to the human body and heating the cancer cells. Types include local hyperthermia, which irradiates microwaves directly to cancer cells, and whole-body hyperthermia, which raises the entire body's body temperature. Because local hyperthermia has little effect on advanced metastases, systemic hyperthermia is being studied for advanced cancers. The goal is to increase the rectal temperature to about 42 ° C, which is a measure of overall body temperature.

[03] Systemic hyperthermia has a therapeutic effect even on advanced metastases with remarkable metastases, and is one of the treatments expected for many cancer patients. In addition, it has been known in recent studies that the systemic response caused by increased body temperature expresses various cell growth factors 増殖 heat shock proteins, not only in cancer treatment but also in viral diseases such as hepatitis C and AIDS. Therapeutic applications are also being studied.

[04] A heating device that raises the entire body temperature was used to put a human body in a bathtub filled with warm water. There is a warm water warming device that heats the human body by raising the temperature of warm water, and an extracorporeal circulation warming device that circulates blood outside the body to heat it and returns it to the body. In addition, there is an infrared heating method apparatus in which the whole body is laid on the bed and the surrounding area is the largest in the chamber, and a heating element that emits infrared rays such as black carbon, ceramic heaters, halogen heaters, etc. is adhered inside and heated. Was. Among the infrared heaters, a far-infrared whole-body heater, which uses a far-infrared heater as a heating element and raises the entire body temperature by radiating far-infrared rays, is used in clinical or research for cancer treatment. Has been used. Disclosure of the invention

Problems to be solved by the invention

[05] However, the human body autonomously releases or accumulates heat to the external environmental temperature by maintaining body temperature regulation such as sweating, breathing promotion, and vasodilatory exercise to maintain a constant core temperature. As a result, the temperature of the skin, which is the surface, can be easily increased, but it has been extremely difficult to raise the temperature of the entire human body, particularly in the deep part, to 42 ° C.

[06] Among several types of heating equipment, research and development of hot water heating equipment was started in Germany in the 1970s. However, hot water has a very high heat transfer efficiency, and the amount of heat transfer tends to increase too much. Because of this, the burden on the human body is large, and deep general anesthesia is required to suppress the rise in heart rate and the feeling of heat. In recent years, it has been known that the damage to leukocytes is large, and it is not currently used in cancer clinical practice.

[07] The extracorporeal circulation heating device, which circulates blood outside the body and warms it, returns it to the body and raises the body temperature, was used more than ten years ago in Japan for the treatment of early whole body hyperthermia at Tokyo Women's Medical University. Was used in science. According to a survey conducted in 1990, out of 1667 cases, Mild improvement was about 40% and exacerbation was 21%. While it certainly raises body temperature and is effective in treating cancer, it involves a very large invasion of perfusing blood outside the body, which poses a significant physical burden on patients and the risk of infectious diseases, making it impossible to continue treatment. is there. There is a limit to its spread as a general therapy device.

[08] In recent years, infrared heating devices have been studied. The bedding on which the human body lies is covered with a resin or metal housing, and a heating element such as a ceramic heater or a planar far-infrared heater is provided inside to heat the whole body. Since it is performed non-invasively, there is little risk of infection, and heat energy adjustment is easier and relatively safe than heating with hot water or extracorporeal circulation, so it is used in current clinical practice. In recent years, therapeutic effects have been obtained even at temperatures above 40 ° C in combination with anticancer drugs, and treatment with relatively mild heating has been attempted.

[09] In the actual treatment using this infrared heating device, the body's thermoregulatory function is suppressed by anesthesia, and the physician monitors the body temperature, heart rate, blood pressure, and other biological information at each site while responding to physical conditions at that time. The calorific value of the heating element is manually adjusted to increase the core body temperature. However, controlling and managing hyperthermia under anesthesia requires skilled medical techniques. Although mild, it applies so much heat energy that it raises the depth to 40 ° C, which can cause burns under the skin if used improperly. Although infrared heating devices are expected to be useful for dissemination of whole-body hyperthermia, they depend largely on the skills of physicians, and safer and easier methods of use have not yet been standardized. Means for solving the problem

[10] Provide a bed to lie down on the human body or animals, seal the periphery with a resin material such as FRP so that only the head is exposed, and the entire area below the neck is covered. A fan to blow air to the head and the head is provided. A plurality of heating means such as planar far-infrared heaters and ceramic heaters are provided inside, and temperature sensors such as thermistors detect the skin temperature of the chest, abdomen, and groin and the deep temperature of the human body such as the rectum, esophagus, and eardrum. Then, the surface temperature of the heating means and the air temperature near the body surface are detected. At the same time, it detects biological information such as heart rate, blood pressure, blood oxygen concentration, and respiratory rate.

[11] Before heating, the skin temperature and the deep temperature are determined by FFT processing of the analysis means to determine the frequency in the change of the skin temperature and the deep temperature, that is, the time required for one cycle, and the function of maintaining the homeostasis of the human body Define a specific cycle of autonomous thermoregulation. Next, the temperature of the heating means is turned ON-OFF with the same cycle and phase as the skin temperature to create periodic fluctuations, and heating is started with the deep temperature as the target temperature. Heat generation means In the OFF phase, the internal heat is exhausted by a fan to lower the temperature aggressively to create more cycles.

[12] If warming is continued for a while, a significant sweating or vasodilation acts on the human body to prevent a rise in body temperature. At this time, in order to grasp the state of heat transfer of the human body, the heating cycle of the heating means is arbitrarily changed, and the FFT processing of the analysis means is used to transfer the cycle of skin temperature change and the cycle of deep temperature change. Determine the function, determine the cycle in which the absolute value of the amplitude or gain in the transfer function is the maximum as the cycle in which the skin temperature and the deep temperature resonate, and generate heat so that it has the same cycle and the same or opposite phase as the resonance cycle Adjust the cycle of

[13] When the target temperature is reached, the amplitude of the period of the heating means, that is, the surface temperature or phase is shifted or overlapped, and adjusted to be constant. If you want to reduce the amount of energy so that the body temperature does not rise too much, you can reduce the maximum temperature of the heating element, but on the contrary, the body temperature may drop too much. In that case, the period of the heat generating means is adjusted to a phase opposite to the resonance cycle in the transfer function or the cycle of skin temperature change. Or skin temperature cycle The heating cycle of the heating means is adjusted so that the phase is opposite to the above. If biological information such as heart rate, blood dissolved oxygen concentration, blood pressure, etc. is likely to deviate from a predetermined allowable value on the way, the amplitude of the heating cycle of the heating means, that is, the maximum temperature in the cycle, may be reduced. Rotates the exhaust fan to the maximum to remove hot air and blows air to the head to lower the permissible value of biological information. The invention's effect

[14] The most efficient thermal energy transfer conditions from the surface to the deep part of the human body can be identified by quantitatively evaluating the periodic changes by FFT analysis. Although the body's thermal conductivity varies greatly due to the autonomous body temperature maintenance function during heating as well as individual differences, it follows minute changes in body temperature that are adjusted once a thousandths, so accurate and accurate body temperature Can be raised or adjusted. Therefore, the amount of anesthesia used to suppress the heat sensation and the function of maintaining body temperature can be reduced or unnecessary, and heating can be performed, and optimal heating can be performed while reducing the burden on the cardiopulmonary function and the risk of burns. Brief Description of Drawings

[15] FIG. 1 is a diagram showing a connection according to the present invention.

FIG. 2 is a diagram showing data when the present invention is not used.

FIG. 3 is a diagram showing a flowchart of the present invention.

FIG. 4 is a diagram showing an effect when the present invention is used.

FIG. 5 is a diagram showing an effect when the present invention is used.

Explanation of symbols

[16] 1 a-d heating means 2 a ~ e fan

2 f Head fan +

3 Control port

4a Biological information measurement means

4 b Temperature measurement means

5 a to e temperature sensor

6a heart rate sensor

6 b Blood pressure measurement means

7 Channo

8 Power supply Best mode for carrying out the invention

Hereinafter, examples of the present invention will be described. Heating means 1 a to lb are provided on the bed that lays down the human body, and heat generating means 1 c to ld are provided on the lower side, and the surrounding area is surrounded by a chamber 7 made of a resin material such as FRP. If the bed is made of a fine mesh such as a lip, it is easy to transmit infrared rays from below. The heating means uses four far-infrared heaters with a rating of about 50,000 W made of carbon fiber in the form of a sheet, and the power is supplied through the control board 3 that supplies power and adjusts the amount of power to increase or decrease the heat energy. Connect to 8. Provide a guard on the heater surface to prevent direct contact. Fans 2a to 2e are provided on the outer wall of chamber 17, and a door through which the human body can enter and exit is provided. In addition, a fan 2 f that blows wind to the human head is provided, and fans 2 a to f are connected to a power source 8 through a control port 3. The number of fans and heating means may be increased or decreased. [18] The skin temperature corresponding to the surface layer to be heated is the chest, abdomen, groin, and the deep part of the rectum, esophagus, and eardrum corresponding to the deep part of the human body. A temperature sensor 5a to 5e such as a thermistor is provided on the surface, and the temperature is measured by a temperature measuring device 4b which converts an electric signal of the sensor into temperature information. The fingertip is equipped with a heart rate sensor 6a for use with a pulse oximeter, etc., and the arm is equipped with a blood pressure measuring means 6b such as an air pressure sensor to detect heart rate, blood oxygen concentration, blood pressure, etc. Measure these values with measuring means 4a. The temperature measurement device 4b and the biological information measurement device 4a are connected to the control port 3 equipped with a function capable of FFT (Fast Fourier Transform) analysis processing, and send the measured values. When the present invention is used in the above structure, the following is performed. Example

[19] Let the human body rest in the chamber and rest, and measure the body temperature when it is not heated by the temperature measuring means 4b. Normally, body temperature is maintained at 36 to 37 ° C by the homeostasis function, but its autonomous regulation is maintained at regular intervals. When the environmental temperature changes, the body temperature cycle, that is, the time required for one cycle also changes, which is indicated as a state of thermoregulation.

[20] The measured body temperature is taken into the control board 3 and subjected to FFT analysis to specify the cycle. Although it differs greatly depending on the individual and the environment, one standard is a period of several minutes on the surface and about ten minutes on the deep part. The FFT is a fast Fourier transform, a method that performs high-speed extraction of which frequency components are contained in a signal and was devised in 1965. The reciprocal of the frequency expressed in Hz is the time required for one cycle of a sine wave.

[21] In the Stokes second problem of hydrodynamics, it is known that the phase of thermal energy is similar to that of fluid energy, and the transmission of oscillating energy depends on its period and amplitude. With When the period of the applied vibration energy is matched to the natural frequency of the object, its transmission capacity increases due to the resonance phenomenon. Therefore, the heating value of the heating means 1a to 1d is turned on and off at the same cycle and in the same phase as the skin temperature, and heating is performed. Rectal temperature begins to rise rapidly following skin temperature.

[22] In general, heat transfer conditions in the body vary greatly depending on various environmental factors. The skin surface reacts sensitively to changes in the temperature of the environment, that is, the heat generating means, and radiates or accumulates heat inside the human body by vasomotion or perspiration, thereby keeping the temperature of the probe constant. Since the temperature of the core is slower than the skin temperature and is less likely to be dissipated, the autonomous body temperature control cycle tends to increase.

[23] At this time, the human body is regarded as one system, the cycle of skin temperature change is used as the input waveform, and the cycle of deep temperature change is used as the output waveform, and the transfer function for heat conduction in the body is determined. The transfer function is a function that indicates the relationship between the input and output of the signal transmission system, and expresses changes in amplitude and phase between input and output signals of the target transmission system with respect to frequency. .

[24] The magnitude of the transfer function amplitude or gain is shown on the vertical axis, and the values are negative because rectal temperature is attenuated relative to the skin. At this time, the resonance frequency of the skin temperature change and the deep temperature change, that is, the thermal energy vibratingly applied to the skin, has a period in which the absolute value of the amplitude or the gain in the transfer function becomes maximum, It can be regarded as a well-transmitted cycle.

[25] In synchronization with this cycle, the surface temperature of the heating means is changed to heat. If multiple peaks of the absolute value of the amplitude or gain, that is, resonance peaks, appear in the transfer function, select a portion near the skin temperature change period and heat it. If the resonance frequency changes as heating is performed, the heating cycle is also changed following the cycle. When selecting the resonance peak, The temperature cycle is arbitrarily changed, and the response time when the change of the cycle is shown in the cycle change of the skin temperature and when the change in the cycle is shown in the cycle change of the deep temperature are determined. You may choose something close to the time it takes.

[26] When the core temperature reaches a predetermined temperature, adjust the cycle, amplitude and phase of the heating means to keep the temperature constant, taking into account the cycle and amplitude of each body temperature change. To suppress the rise in the deep part temperature, the heat of the heat generating means may be turned off.However, in some cases, the temperature may drop too much.In such a case, the heat of the heat generating means is maintained, and the period is controlled by the resonance of the transfer function. The phase is opposite to that of the frequency or skin temperature change. In order to raise the deep portion temperature in a short time, the amplitude of the heating cycle, that is, the temperature of the heating means is increased.

[27] While heating or maintaining a constant temperature, define a safe range where no strain is imposed on the human body, and if it exceeds the range, adjust by lowering the amplitude or blowing air to the head. The safe range is heated based on the standard that the heart rate is less than 150 beats per minute, the skin temperature is less than 43 ° C, and the blood pressure and blood oxygen saturation do not change from normal. Make detailed settings according to your physical condition.

[28] Fig. 2 shows actual data obtained by heating the human body without using the present invention with the target of the deep temperature set at 40 ° C. FIG. 3 is a flowchart of the present invention, and FIGS. 4 and 5 show data obtained by heating a human body using the present invention. Note that none of the anesthesia was used during the heating shown in Figs. 2, 4 and 5. The eardrum and rectum indicate the core temperature, the chest indicates the skin temperature, the set temperature in Fig. 2 indicates the surface temperature of the heating means, and the inside of the compartment indicates the inside temperature, that is, the air temperature near the human body.

[29] In FIG. 2, which was heated without using the present invention, in the early stage of heating, an autonomous function of suppressing an increase in core body temperature by sweating and promotion of respiration works, and at the same time, blood flow increases by vasodilation. As a result, the ability to radiate heat to the outside of the body is increased, and the thermal conductivity inside the human body is reduced, and the rectal temperature corresponding to the core temperature does not increase. At this time, if the heating value or the surface temperature of the heating element is too high, the skin temperature becomes too high, which may cause burns. Therefore, the temperature of the heating element cannot be raised too rapidly.

[30] After about an hour, it only begins to rise, but at this time the heart rate is about 200 beats per minute, which may be a burden on cardiopulmonary function. After more than 2 hours, the rectal temperature had finally risen to around 40 ° C, the temperature range where the effects of cancer treatment began to be seen, but after the heating was completed, the subjects to be heated had severe heat He fell ill and complained of considerable fatigue two days later.

[31] In Fig. 4 showing the data using the present invention, there is no temporary decrease in the core temperature due to the maintenance of the core body homeostasis seen in the early stage of the heating in Fig. 2; The heating means starts heating while arbitrarily and periodically fluctuating in accordance with the appropriate control cycle, and the skin temperature is maintained at 43 ° C or less, which is safe even though it is periodically fluctuated. Rectal temperature reached 39 ° C. The heart rate was less than 130 beats per minute with little burden on the cardiopulmonary function. After the heating was completed, the subject quickly recovered to a normal state.

[32] FIG. 5 shows data when the amplitude, that is, the surface temperature of the heating means in the heating cycle is further increased by using the present invention. For about 30 minutes after the start of heating, the heating cycle of the heating means ON-OFF is adjusted at about 5 minutes, that is, about 3.3 mHz, and a temporary increase in heart rate is seen 30 minutes later. Therefore, the fan exhausts the hot air in the champ for 30 seconds, and then the heating cycle is about 2 minutes, that is, about 8.3 mHz until about 80 minutes later, and finally the rectal temperature is about The temperature reached 40 ° C.

[33] At this time, the heart rate, blood pressure, and skin temperature remain in safe areas, and even after the heating is completed. No heatstroke symptoms were seen at the time of Fig. 2, and no fatigue or malaise was felt the next day. With the index of the cycle or amplitude of the temperature change, it was shown that the body temperature in the deep part of the human body can be safely and quantitatively performed without anesthesia. Industrial potential

[34] While systemic hyperthermia is expected to be effective against advanced metastases such as advanced cancer, hepatitis C, and AIDS and other viral diseases, physicians are now considering systemic anesthesia and safety management under hyperthermia. However, the use of the present invention makes it possible to provide a standard, safer and more convenient system for performing whole body hyperthermia treatment for cancer.

Claims

Claims The object to be heated is a human body or an animal, and the object to be heated is heated directly or indirectly via a medium by a heating means, and the surface or inside of the object to be heated is brought to a predetermined temperature. In a device for heating or maintaining a constant temperature, a heating means for heating, a temperature measuring means for detecting the temperature, an analyzing means for processing the measured temperature by FFT (Fast Fourier Transform), and a calorific value of the heating means. Or a body temperature control device consisting of control means for adjusting the temperature and a fan for exhausting the area around the object to be heated.

2. The body temperature control device according to claim 1, wherein the control means adjusts the temperature of the heat generating means while changing the temperature at an arbitrary amplitude and at an arbitrary cycle.

In Claim 2, the control for adjusting the heating cycle of the heating means and the temperature, which is the amplitude thereof, to an arbitrary phase in comparison with the cycle and amplitude of the temperature change of the heating target obtained by the analysis means. Body temperature control device with means.

In claim 3, when the temperature of the object to be heated is raised, the heating cycle of the heating means is adjusted to have the same cycle and the same phase as the cycle of the temperature change of the object to be heated. A body temperature control device comprising control means for adjusting a heating cycle of a heating means so that when the temperature of the heating target is decreased, the heating cycle becomes the same cycle as the cycle of the temperature change of the object to be heated and has the opposite phase.

In claim 4, the heating cycle of the heating means is arbitrarily changed, and the cycle of the heating means when the cycle of the temperature change of the heating target obtained by the analyzing means resonates is determined. A body temperature control device comprising control means for adjusting a heating cycle of a heating means so as to have the same or opposite phases.

In claim 5, the object to be heated is a whole or a part of a living body or a human body, The temperature measurement means measures the skin temperature corresponding to the surface layer to be heated, such as the chest, abdomen, and groin, or the deep part temperature corresponding to the inside of the heating target, such as the rectum, esophagus, and tympanic membrane.The analysis means changes the skin temperature. The transfer function between the cycle of the deep temperature and the cycle of the change in the deep temperature is determined.The cycle in which the absolute value of the amplitude or gain in the transfer function is maximized is defined as the cycle in which the skin temperature and the deep temperature resonate. A body temperature control device that adjusts the cycle of the heating means so that they have the same cycle and the same or opposite phases.

Claim 6 includes a biological information measuring means for detecting a heart rate, a dissolved oxygen concentration in blood, a blood pressure, an electrocardiogram, etc., and adding a heating means when the biological information is likely to deviate from a predetermined allowable value. A body temperature control device that reduces the amplitude of the temperature cycle, that is, the maximum temperature in one cycle, or adjusts the heating cycle of the heating means in a phase opposite to the cycle of resonance in the transfer function or the cycle of the skin temperature.

In claim 7, when a region having a low temperature in the period of the heat generation amount is provided, the heat generation amount of the heat generating means is reduced or made zero, or the air heated by the fan provided around the human body is discharged. A body temperature control device for lowering the value of biological information by blowing air when the biological information deviates from a predetermined allowable value by a fan provided around a human head.