WO2005056593A3 - Interactions between hsp90 and p50/cdc37 - Google Patents

Interactions between hsp90 and p50/cdc37 Download PDF

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Publication number
WO2005056593A3
WO2005056593A3 PCT/GB2004/005181 GB2004005181W WO2005056593A3 WO 2005056593 A3 WO2005056593 A3 WO 2005056593A3 GB 2004005181 W GB2004005181 W GB 2004005181W WO 2005056593 A3 WO2005056593 A3 WO 2005056593A3
Authority
WO
WIPO (PCT)
Prior art keywords
hsp90
terminal domain
p50cdc37
cdc37
interactions
Prior art date
Application number
PCT/GB2004/005181
Other languages
French (fr)
Other versions
WO2005056593A2 (en
Inventor
Laurence H Pearl
Chrisostomos Prodromou
S Mark Roe
Original Assignee
Pital The Inst Of Cancer Res R
Laurence H Pearl
Chrisostomos Prodromou
S Mark Roe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pital The Inst Of Cancer Res R, Laurence H Pearl, Chrisostomos Prodromou, S Mark Roe filed Critical Pital The Inst Of Cancer Res R
Publication of WO2005056593A2 publication Critical patent/WO2005056593A2/en
Publication of WO2005056593A3 publication Critical patent/WO2005056593A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Lubricants (AREA)

Abstract

The invention derives from the finding that the interaction between Hsp90 and p50cdc37 is mediated through the N-terminal domain of Hsp90, rather than the C-terminal domain as was previously thought. A crystal structure of a complex between the N-terminal domain of Hsp90 and the C-terminal domain of p50cdc37 is provided. The structure may be used for homology modelling and structure solution, as well as for identifying compounds which modulate the interaction between Hsp90 and p50cdc37.
PCT/GB2004/005181 2003-12-10 2004-12-10 Interactions between hsp90 and p50/cdc37 WO2005056593A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0328627.5 2003-12-10
GB0328627A GB0328627D0 (en) 2003-12-10 2003-12-10 Interaction between Hsp90 and p50 cdc37

Publications (2)

Publication Number Publication Date
WO2005056593A2 WO2005056593A2 (en) 2005-06-23
WO2005056593A3 true WO2005056593A3 (en) 2006-02-23

Family

ID=30129969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/005181 WO2005056593A2 (en) 2003-12-10 2004-12-10 Interactions between hsp90 and p50/cdc37

Country Status (2)

Country Link
GB (2) GB0328627D0 (en)
WO (1) WO2005056593A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106610424B (en) * 2015-10-25 2018-10-26 复旦大学 The screening technique of acetylation inhibitor of heat shock protein 90
CN112553231A (en) * 2020-12-25 2021-03-26 华南农业大学 Recombinant human heat shock protein HSP90-His and expression and purification method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1551957A4 (en) * 2001-10-01 2007-01-24 Univ Duke Isolated grp94 ligand binding domain polypeptide and nucleic acid encoding same, crystalline form of same, and screening methods employing same

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DATABASE PDB EBI; 22 October 1997 (1997-10-22), Database accession no. 1AH6 *
DATABASE PDB EBI; 22 October 1997 (1997-10-22), Database accession no. 1AH8 *
DATABASE PDB EBI; 24 June 1998 (1998-06-24), Database accession no. 1AM1 *
DATABASE PDB EBI; 24 June 1998 (1998-06-24), Database accession no. 1AMW *
DATABASE PDB EBI; 27 March 2003 (2003-03-27), Database accession no. 1OSF *
DATABASE PDB EBI; 6 August 1998 (1998-08-06), Database accession no. 1A4H *
DATABASE PDB EBI; 8 June 1999 (1999-06-08), Database accession no. 1BGQ *
JEZ JOSEPH M ET AL: "Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.", CHEMISTRY & BIOLOGY. APR 2003, vol. 10, no. 4, April 2003 (2003-04-01), pages 361 - 368, XP002333368, ISSN: 1074-5521 *
PRODROMOU C ET AL: "Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 90, 11 July 1997 (1997-07-11), pages 65 - 75, XP002211193, ISSN: 0092-8674 *
PRODROMOU C: "Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 18, no. 3, 1999, pages 754 - 762, XP002211194, ISSN: 0261-4189 *
PRODROMOU CHRISOSTOMOS ET AL: "A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone", NATURE STRUCTURAL BIOLOGY, vol. 4, no. 6, 1997, pages 477 - 482, XP009049758, ISSN: 1072-8368 *
ROE S MARK ET AL: "Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 2, 28 January 1999 (1999-01-28), pages 260 - 266, XP002333367, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
GB2408981A (en) 2005-06-15
WO2005056593A2 (en) 2005-06-23
GB0328627D0 (en) 2004-01-14
GB0427089D0 (en) 2005-01-12

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