WO2005054280A3 - Procede - Google Patents

Procede Download PDF

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Publication number
WO2005054280A3
WO2005054280A3 PCT/GB2004/005108 GB2004005108W WO2005054280A3 WO 2005054280 A3 WO2005054280 A3 WO 2005054280A3 GB 2004005108 W GB2004005108 W GB 2004005108W WO 2005054280 A3 WO2005054280 A3 WO 2005054280A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
producing
methods
cell
resistant animals
Prior art date
Application number
PCT/GB2004/005108
Other languages
English (en)
Other versions
WO2005054280A2 (fr
Inventor
Miles Carroll
James Kaufman
Kyriacos Mitrophanous
Original Assignee
Oxford Biomedica Ltd
Animal Health Inst
Miles Carroll
James Kaufman
Kyriacos Mitrophanous
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biomedica Ltd, Animal Health Inst, Miles Carroll, James Kaufman, Kyriacos Mitrophanous filed Critical Oxford Biomedica Ltd
Priority to EP04805936A priority Critical patent/EP1727899A2/fr
Publication of WO2005054280A2 publication Critical patent/WO2005054280A2/fr
Priority to US11/447,508 priority patent/US20060265773A1/en
Publication of WO2005054280A3 publication Critical patent/WO2005054280A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé de production d'animal transgénique à résistance modifiée vis-à-vis d'une maladie, qui consiste à introduire un rétrovirus dans une cellule de l'animal ou une cellule capable de produire l'animal. Le rétrovirus comprend une séquence polynucléotidique aui code une protéine et qui est capable de l'exprimer, cette protéine modifiant la résistance de l'animal vis-à-vis de la maladie. Lorsque la cellule est une cellule capable de produire l'animal, le procédé consiste à produire cet animal à partir de la cellule.
PCT/GB2004/005108 2003-12-05 2004-12-03 Procede WO2005054280A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04805936A EP1727899A2 (fr) 2003-12-05 2004-12-03 Procede
US11/447,508 US20060265773A1 (en) 2003-12-05 2006-06-05 Methods for producing transgenic animals with modified disease resistance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0328248.0 2003-12-05
GBGB0328248.0A GB0328248D0 (en) 2003-12-05 2003-12-05 Method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/447,508 Continuation-In-Part US20060265773A1 (en) 2003-12-05 2006-06-05 Methods for producing transgenic animals with modified disease resistance

Publications (2)

Publication Number Publication Date
WO2005054280A2 WO2005054280A2 (fr) 2005-06-16
WO2005054280A3 true WO2005054280A3 (fr) 2006-09-28

Family

ID=29764658

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/005108 WO2005054280A2 (fr) 2003-12-05 2004-12-03 Procede

Country Status (4)

Country Link
US (1) US20060265773A1 (fr)
EP (1) EP1727899A2 (fr)
GB (1) GB0328248D0 (fr)
WO (1) WO2005054280A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110117137A1 (en) * 2008-01-28 2011-05-19 Tapimmune, Inc. Tapasin augmentation for enhanced immune response
WO2014196931A1 (fr) * 2013-06-06 2014-12-11 Agency For Science, Technology And Research Transposon pour la manipulation du génome
WO2020146886A1 (fr) * 2019-01-11 2020-07-16 GlycoScience Research, Inc. Traitement d'une maladie neurodégénérative par le ganglioside gm1 de gangliosidose à gm1 d'ovin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001972A1 (fr) * 1987-09-03 1989-03-09 The Edison Animal Biotechnology Center Animaux transgeniques resistants aux virus
WO1996003034A1 (fr) * 1994-07-27 1996-02-08 Massachusetts Institute Of Technology Procede d'insertion de vecteur retroviral chez les poissons
WO2003056022A2 (fr) * 2001-12-21 2003-07-10 Oxford Biomedica (Uk) Limited Organisme transgenique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001972A1 (fr) * 1987-09-03 1989-03-09 The Edison Animal Biotechnology Center Animaux transgeniques resistants aux virus
WO1996003034A1 (fr) * 1994-07-27 1996-02-08 Massachusetts Institute Of Technology Procede d'insertion de vecteur retroviral chez les poissons
WO2003056022A2 (fr) * 2001-12-21 2003-07-10 Oxford Biomedica (Uk) Limited Organisme transgenique

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HILTON LOUISE S ET AL: "The emerging role of avian cytokines as immunotherapeutics and vaccine adjuvants", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, AMSTERDAM, NL, vol. 85, no. 3-4, March 2002 (2002-03-01), pages 119 - 128, XP002295789, ISSN: 0165-2427 *
LOIS CARLOS ET AL: "Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 295, no. 5556, 1 February 2002 (2002-02-01), pages 868 - 872, XP002288582, ISSN: 0036-8075 *
LOWENTHAL J W ET AL: "Avian cytokines: The natural approach to therapeutics", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, PERGAMON PRESS, US, vol. 24, no. 2-3, March 2000 (2000-03-01), pages 355 - 365, XP002259863, ISSN: 0145-305X *
MCGREW MICHAEL J ET AL: "Efficient production of germline transgenic chickens using lentiviral vectors", EMBO REPORTS, XX, XX, vol. 5, no. 7, July 2004 (2004-07-01), pages 728 - 733, XP002341505 *
PLACHY J ET AL: "Biology of the chicken MHC (B complex)", CRITICAL REVIEWS IN IMMUNOLOGY, vol. 12, no. 1-2, 1992, pages 47 - 79, XP009053572, ISSN: 1040-8401 *

Also Published As

Publication number Publication date
US20060265773A1 (en) 2006-11-23
WO2005054280A2 (fr) 2005-06-16
EP1727899A2 (fr) 2006-12-06
GB0328248D0 (en) 2004-01-07

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