WO2005054211A8 - A method of purification of lorazepam - Google Patents

A method of purification of lorazepam

Info

Publication number
WO2005054211A8
WO2005054211A8 PCT/SK2004/000015 SK2004000015W WO2005054211A8 WO 2005054211 A8 WO2005054211 A8 WO 2005054211A8 SK 2004000015 W SK2004000015 W SK 2004000015W WO 2005054211 A8 WO2005054211 A8 WO 2005054211A8
Authority
WO
WIPO (PCT)
Prior art keywords
lorazepam
purification
solvent
products
solvate
Prior art date
Application number
PCT/SK2004/000015
Other languages
French (fr)
Other versions
WO2005054211A1 (en
Inventor
Jozef Lopuch
Bohumil Proksa
Dusan Vandak
Original Assignee
Zentiva As
Jozef Lopuch
Bohumil Proksa
Dusan Vandak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva As, Jozef Lopuch, Bohumil Proksa, Dusan Vandak filed Critical Zentiva As
Publication of WO2005054211A1 publication Critical patent/WO2005054211A1/en
Publication of WO2005054211A8 publication Critical patent/WO2005054211A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Abstract

A new method of purification of Lorazepam is disclosed that consists in removing products of synthesis, decomposition products, water or other solvent that forms a solvate with Lorazepam, by crystallization or stirring in an organic solvent of the ether, ester or ketone type. Lorazepam prepared via this method can be utilized in the pharmaceutical industry for the manufacture of pharmaceuticals.
PCT/SK2004/000015 2003-12-03 2004-11-30 A method of purification of lorazepam WO2005054211A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SKPP1483-2003 2003-12-03
SK1483-2003A SK286118B6 (en) 2003-12-03 2003-12-03 Method of purifying lorazepam

Publications (2)

Publication Number Publication Date
WO2005054211A1 WO2005054211A1 (en) 2005-06-16
WO2005054211A8 true WO2005054211A8 (en) 2005-10-13

Family

ID=34651619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SK2004/000015 WO2005054211A1 (en) 2003-12-03 2004-11-30 A method of purification of lorazepam

Country Status (3)

Country Link
CZ (1) CZ298518B6 (en)
SK (1) SK286118B6 (en)
WO (1) WO2005054211A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110683994B (en) * 2019-11-19 2022-10-11 湖南洞庭药业股份有限公司 Novel crystal form of lorazepam, preparation method and pharmaceutical application thereof
CN110776473B (en) * 2019-11-19 2023-09-15 湖南洞庭药业股份有限公司 Process for preparing lorazepam
CN110840898B (en) * 2019-11-19 2022-05-13 湖南洞庭药业股份有限公司 Light-stabilized pharmaceutical composition, preparation method and pharmaceutical application thereof
CN110804023A (en) * 2019-12-09 2020-02-18 华中药业股份有限公司 Lorazepam purification method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL151632A0 (en) * 2000-03-06 2003-04-10 Teva Pharma Process for preparing pure crystalline lorazepam

Also Published As

Publication number Publication date
WO2005054211A1 (en) 2005-06-16
SK14832003A3 (en) 2005-07-01
CZ20041138A3 (en) 2006-12-13
SK286118B6 (en) 2008-04-07
CZ298518B6 (en) 2007-10-24

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121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 24/2005 UNDER (72,75) THE ADDRESS OF LOPUCH, JOZEF, SHOULD READ "920 25 HORNé ZELENICE 25"

122 Ep: pct application non-entry in european phase