WO2005051321A3 - Treatment of inflammatory bowel disease through induction of indoleamine 2,3-dioxygenase - Google Patents

Treatment of inflammatory bowel disease through induction of indoleamine 2,3-dioxygenase Download PDF

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Publication number
WO2005051321A3
WO2005051321A3 PCT/US2004/039611 US2004039611W WO2005051321A3 WO 2005051321 A3 WO2005051321 A3 WO 2005051321A3 US 2004039611 W US2004039611 W US 2004039611W WO 2005051321 A3 WO2005051321 A3 WO 2005051321A3
Authority
WO
WIPO (PCT)
Prior art keywords
indoleamine
dioxygenase
inflammatory bowel
bowel disease
induction
Prior art date
Application number
PCT/US2004/039611
Other languages
French (fr)
Other versions
WO2005051321A2 (en
Inventor
Gregory J Di Gurtner
William F Stenson
Original Assignee
Univ Washington
William F Stenson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, William F Stenson filed Critical Univ Washington
Publication of WO2005051321A2 publication Critical patent/WO2005051321A2/en
Publication of WO2005051321A3 publication Critical patent/WO2005051321A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Methods and compositions for treating inflammatory bowel disease based upon increasing activity of indoleamine 2,3-dioxygenase in antigen presenting cells are disclosed.
PCT/US2004/039611 2003-11-25 2004-11-24 Treatment of inflammatory bowel disease through induction of indoleamine 2,3-dioxygenase WO2005051321A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52475303P 2003-11-25 2003-11-25
US60/524,753 2003-11-25
US53158703P 2003-12-19 2003-12-19
US60/531,587 2003-12-19

Publications (2)

Publication Number Publication Date
WO2005051321A2 WO2005051321A2 (en) 2005-06-09
WO2005051321A3 true WO2005051321A3 (en) 2005-12-22

Family

ID=34636524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/039611 WO2005051321A2 (en) 2003-11-25 2004-11-24 Treatment of inflammatory bowel disease through induction of indoleamine 2,3-dioxygenase

Country Status (2)

Country Link
US (1) US20050191276A1 (en)
WO (1) WO2005051321A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260155A1 (en) * 2004-05-18 2005-11-24 Gopala Kovvali Compositions and methods for treatment of ulcerative colitis
WO2009073620A2 (en) * 2007-11-30 2009-06-11 Newlink Genetics Ido inhibitors
US20090253706A1 (en) * 2008-04-03 2009-10-08 Muller Alexander J Methods and Compositions for the Treatment of Rheumatoid Arthritis and Other Inflammatory Diseases
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921697A (en) * 1985-05-30 1990-05-01 Boehringer Ingelheim International Gmbh IFN-gamma as an active substance for inhibiting and preventing degradation processes in bone
US6833451B2 (en) * 2000-03-20 2004-12-21 Pharma-Zentrale Gmbh Lipopolysaccharides (LPS) extracted from Escherichia coli

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US6750334B1 (en) * 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
US20040022787A1 (en) * 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921697A (en) * 1985-05-30 1990-05-01 Boehringer Ingelheim International Gmbh IFN-gamma as an active substance for inhibiting and preventing degradation processes in bone
US6833451B2 (en) * 2000-03-20 2004-12-21 Pharma-Zentrale Gmbh Lipopolysaccharides (LPS) extracted from Escherichia coli

Also Published As

Publication number Publication date
US20050191276A1 (en) 2005-09-01
WO2005051321A2 (en) 2005-06-09

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