WO2005049861A3 - Method for the analysis of gynaecological cell proliferative disorders - Google Patents

Method for the analysis of gynaecological cell proliferative disorders Download PDF

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Publication number
WO2005049861A3
WO2005049861A3 PCT/EP2004/012740 EP2004012740W WO2005049861A3 WO 2005049861 A3 WO2005049861 A3 WO 2005049861A3 EP 2004012740 W EP2004012740 W EP 2004012740W WO 2005049861 A3 WO2005049861 A3 WO 2005049861A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferative
analysis
proliferative disorders
gynaecological
gynaecological cell
Prior art date
Application number
PCT/EP2004/012740
Other languages
French (fr)
Other versions
WO2005049861A2 (en
Inventor
Martin Widschwendter
Original Assignee
Epigenomics Ag
Martin Widschwendter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag, Martin Widschwendter filed Critical Epigenomics Ag
Priority to JP2006538787A priority Critical patent/JP2007531512A/en
Priority to EP04797788A priority patent/EP1685260A2/en
Publication of WO2005049861A2 publication Critical patent/WO2005049861A2/en
Publication of WO2005049861A3 publication Critical patent/WO2005049861A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a method for the detection, differentiation and prognosis of a gynaecological cell proliferative disorder, comprising the following steps: a) obtaining a cervicovaginal secretion specimen from an individual b) determining the methylation status of a t least one or more CpG positions c) determining from said methylation status the presence, classification and/or prognosis of a gynaecological cell proliferative disorder in said individual. The present invention further relates to a kit for performing said method.
PCT/EP2004/012740 2003-11-10 2004-11-10 Method for the analysis of gynaecological cell proliferative disorders WO2005049861A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006538787A JP2007531512A (en) 2003-11-10 2004-11-10 Gynecological cell proliferation disorder analysis method
EP04797788A EP1685260A2 (en) 2003-11-10 2004-11-10 Method for the analysis of gynaecological cell proliferative disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025739.8 2003-11-10
EP03025739 2003-11-10

Publications (2)

Publication Number Publication Date
WO2005049861A2 WO2005049861A2 (en) 2005-06-02
WO2005049861A3 true WO2005049861A3 (en) 2005-11-24

Family

ID=34610045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/012740 WO2005049861A2 (en) 2003-11-10 2004-11-10 Method for the analysis of gynaecological cell proliferative disorders

Country Status (3)

Country Link
EP (1) EP1685260A2 (en)
JP (1) JP2007531512A (en)
WO (1) WO2005049861A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1701978T3 (en) * 2003-12-03 2009-07-31 Whitehead Inst Biomedical Res Use of soluble T-Cadherin for the treatment of metabolic disorders
ATE408032T1 (en) * 2004-07-16 2008-09-15 Oncomethylome Sciences Sa ESR1 AND CERVICAL CANCER
EP2271774B1 (en) * 2008-03-21 2018-03-07 MDxHealth Detection and prognosis of cervical cancer
US10597730B2 (en) 2012-05-25 2020-03-24 The Hospital For Sick Children Method of diagnosing cancer
CA2874528A1 (en) 2012-05-25 2013-11-28 Pedro CASTELO-BRANCO Method of diagnosing cancer comprising detection of the methylation signature in the htert promoter
WO2014046200A1 (en) * 2012-09-19 2014-03-27 シスメックス株式会社 Method for obtaining information about endometrial cancer, and marker and kit for obtaining information about endometrial cancer
CN106319053A (en) * 2016-08-23 2017-01-11 山东大学齐鲁医院 Method and kit for quantitative detection of effect of treating hepatic failure of glucocorticoid
CN109825581A (en) * 2019-02-28 2019-05-31 昆明理工大学 A kind of primer, detection method, kit and application detecting RASSF1A gene methylation
CN113278688A (en) * 2021-07-07 2021-08-20 武汉凯德维斯生物技术有限公司 Primer combination and kit for detecting HPV integration gene locus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024056A2 (en) * 2000-09-20 2002-03-28 Case Western Reserve University METHODS AND COMPOSITIONS FOR DETECTING CANCERS ASSOCIATED WITH METHYLATION OF hMLH1PROMOTER DNA
WO2004087957A2 (en) * 2003-04-03 2004-10-14 Oncomethylome Sciences S.A. Hypermethylated genes and cervical cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024056A2 (en) * 2000-09-20 2002-03-28 Case Western Reserve University METHODS AND COMPOSITIONS FOR DETECTING CANCERS ASSOCIATED WITH METHYLATION OF hMLH1PROMOTER DNA
WO2004087957A2 (en) * 2003-04-03 2004-10-14 Oncomethylome Sciences S.A. Hypermethylated genes and cervical cancer

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BADAL VINAY ET AL: "CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: Genomic hypomethylation correlates with carcinogenic progression.", JOURNAL OF VIROLOGY, vol. 77, no. 11, June 2003 (2003-06-01), pages 6227 - 6234, XP002330532, ISSN: 0022-538X *
DATABASE EMBL [online] 11 January 2000 (2000-01-11), "Homo sapiens BAC clone RP11-259G7 from 4, complete sequence.", XP002330537, retrieved from EBI accession no. EM_HUM:AC020703 Database accession no. AC020703 *
FIEGL HEIDI ET AL: "Methylated DNA collected by tampons--a new tool to detect endometrial cancer.", CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY. MAY 2004, vol. 13, no. 5, May 2004 (2004-05-01), pages 882 - 888, XP002330534, ISSN: 1055-9965 *
KUZMIN IGOR ET AL: "Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection.", CANCER RESEARCH, vol. 63, no. 8, 15 April 2003 (2003-04-15), pages 1888 - 1893, XP002330535, ISSN: 0008-5472 *
LIN W MICHAEL ET AL: "Molecular Papanicolaou tests in the twenty-first century: Molecular analyses with fluid-based Papanicolaou technology", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 183, no. 1, July 2000 (2000-07-01), pages 39 - 45, XP008048085, ISSN: 0002-9378 *
NARAYAN GOPESHWAR ET AL: "Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome.", MOLECULAR CANCER [ELECTRONIC RESOURCE]., vol. 2, no. 1, 13 May 2003 (2003-05-13), pages 24.1 - 24.12, XP002330533, ISSN: 1476-4598 *
VIRMANI A K ET AL: "Aberrant methylation during cervical carcinogenesis.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. MAR 2001, vol. 7, no. 3, March 2001 (2001-03-01), pages 584 - 589, XP002330531, ISSN: 1078-0432 *
ZOU HONGZHI ET AL: "Hypermethylation of Secreted-frizzled related protein genes occurs early during neoplastic progression in Barrett's esophagus.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 44, July 2003 (2003-07-01), & 94TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; WASHINGTON, DC, USA; JULY 11-14, 2003, pages 1357 - 1358, XP001206624, ISSN: 0197-016X *

Also Published As

Publication number Publication date
JP2007531512A (en) 2007-11-08
EP1685260A2 (en) 2006-08-02
WO2005049861A2 (en) 2005-06-02

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