WO2005049532A3 - A process for purification - Google Patents

A process for purification Download PDF

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Publication number
WO2005049532A3
WO2005049532A3 PCT/IN2004/000298 IN2004000298W WO2005049532A3 WO 2005049532 A3 WO2005049532 A3 WO 2005049532A3 IN 2004000298 W IN2004000298 W IN 2004000298W WO 2005049532 A3 WO2005049532 A3 WO 2005049532A3
Authority
WO
WIPO (PCT)
Prior art keywords
purification
ethyl
amino
methylcyclohexyl
alkanol
Prior art date
Application number
PCT/IN2004/000298
Other languages
French (fr)
Other versions
WO2005049532A2 (en
Inventor
Rashminkumar Rameshchan Pandya
Vijay Chhangamal Chhabada
Rajeev Budhdev Rehani
Rajamannar Thennati
Original Assignee
Sun Pharmaceutical Ind Ltd
Rashminkumar Rameshchan Pandya
Vijay Chhangamal Chhabada
Rajeev Budhdev Rehani
Rajamannar Thennati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Ind Ltd, Rashminkumar Rameshchan Pandya, Vijay Chhangamal Chhabada, Rajeev Budhdev Rehani, Rajamannar Thennati filed Critical Sun Pharmaceutical Ind Ltd
Publication of WO2005049532A2 publication Critical patent/WO2005049532A2/en
Publication of WO2005049532A3 publication Critical patent/WO2005049532A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Abstract

The present invention provides a process for purification of pharmaceutically active compounds selected from the group consisting of thiazolidinedione derivatives and trans-3-Ethyl-2,5-dihydro-4-methyl-N- [2-[4-[[[[(4-methylcyclohexyl)amino] carbonyl] amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide comprising extraction in a solvent comprising an alkanol (C1-C4) and ammonia.
PCT/IN2004/000298 2003-09-30 2004-09-22 A process for purification WO2005049532A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1026/MUM/2003 2003-09-30
IN1026MU2003 2003-09-30

Publications (2)

Publication Number Publication Date
WO2005049532A2 WO2005049532A2 (en) 2005-06-02
WO2005049532A3 true WO2005049532A3 (en) 2006-04-06

Family

ID=34611198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000298 WO2005049532A2 (en) 2003-09-30 2004-09-22 A process for purification

Country Status (1)

Country Link
WO (1) WO2005049532A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2004844A3 (en) * 2004-07-27 2006-03-15 Zentiva, A. S Salt of oxalic acid with 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, process for its preparation and its use
JP2008534576A (en) * 2005-04-01 2008-08-28 ユーエスヴィー リミテッド A novel process for the preparation of substantially pure glimepiride
EP1903042A3 (en) * 2006-09-22 2008-05-28 Cadila Pharmaceuticals Limited An improved process for hydrogenation of 5-(substituted Benzylidene) 2,4- Thiazolidine Dione compounds to give corresponding ( +/- ) 5- (substituted Benzyl ) 2,4-Thiazolidine Dione
CN106699631A (en) * 2017-02-08 2017-05-24 深圳市新阳唯康科技有限公司 Glimepiride gamma crystal form and preparation method thereof
CN106866487A (en) * 2017-02-08 2017-06-20 深圳市新阳唯康科技有限公司 A kind of Glimepiride ε crystal formations and preparation method thereof
CN106866485A (en) * 2017-02-08 2017-06-20 深圳市新阳唯康科技有限公司 A kind of Glimepiride δ crystal formations and preparation method thereof
CN106883161A (en) * 2017-02-08 2017-06-23 深圳市新阳唯康科技有限公司 A kind of Glimepiride beta crystal and preparation method thereof
CN108383768A (en) * 2018-04-13 2018-08-10 江西博雅欣和制药有限公司 A kind of Glimepiride bulk drug synthesis technology
CN114264765B (en) * 2020-09-16 2023-10-03 徐州万邦金桥制药有限公司 Analytical method for determining related substances in glimepiride intermediate by utilizing HPLC

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057131A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Novel process for the preparation of trans-3- ethyl-2,5- dihydro-4- methyl-n-[2-[ 4-[[[[(4-methyl cyclohexyl) amino]carbonyl] amino]sulfonyl] phenyl]ethyl] -2-oxo-1h-pyrrole -1-carboxamide
WO2004108721A1 (en) * 2003-04-01 2004-12-16 Sun Pharmaceutical Industries Limited Process for the preparation of 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl] methyl]-2,4-thiazolidinedione

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057131A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Novel process for the preparation of trans-3- ethyl-2,5- dihydro-4- methyl-n-[2-[ 4-[[[[(4-methyl cyclohexyl) amino]carbonyl] amino]sulfonyl] phenyl]ethyl] -2-oxo-1h-pyrrole -1-carboxamide
WO2004108721A1 (en) * 2003-04-01 2004-12-16 Sun Pharmaceutical Industries Limited Process for the preparation of 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl] methyl]-2,4-thiazolidinedione

Also Published As

Publication number Publication date
WO2005049532A2 (en) 2005-06-02

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