WO2005049209A1 - Pipette with a tip removing mechanism - Google Patents

Pipette with a tip removing mechanism Download PDF

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Publication number
WO2005049209A1
WO2005049209A1 PCT/FI2004/000694 FI2004000694W WO2005049209A1 WO 2005049209 A1 WO2005049209 A1 WO 2005049209A1 FI 2004000694 W FI2004000694 W FI 2004000694W WO 2005049209 A1 WO2005049209 A1 WO 2005049209A1
Authority
WO
WIPO (PCT)
Prior art keywords
tip
pipette
ramp
ramp surface
removing mechanism
Prior art date
Application number
PCT/FI2004/000694
Other languages
French (fr)
Inventor
Juha Telimaa
Vesa Salo
Mikael Lind
Original Assignee
Thermo Electron Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Electron Oy filed Critical Thermo Electron Oy
Priority to US10/579,875 priority Critical patent/US7690274B2/en
Priority to DE602004011980T priority patent/DE602004011980T2/en
Priority to EP04798303A priority patent/EP1689528B1/en
Priority to JP2006540484A priority patent/JP4883298B2/en
Publication of WO2005049209A1 publication Critical patent/WO2005049209A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices

Definitions

  • the invention relates to a plunger-operated pipette for use in dispensing liquids and provided with a tip remover.
  • the invention relates explicitly to this tip remover.
  • the tip element is usually provided with a replaceable tip container or a tip used for drawing therein a liquid to be subsequently dispensed.
  • pipettes also include a tip remover, comprising a collar slidable along the tip element, and a spring against whose force the collar is pressable downwards.
  • Electrically operated pipettes have also been available, in which the plunger is operated by means of an electric motor. Even in such pipettes, the tip remover has usually been manually operated.
  • Publication US 4 399 712 discloses an electrically operated pipette, in which the tip remover is powered by the same motor as the plunger.
  • the plunger is provided with two nuts, which are non-rotatable relative to the housing and fitted on motor-driven lead screws.
  • the plunger is driven to its bottom position, the nuts pressing a spring-loaded tip removing collar downwards.
  • the motor is driven respectively in reverse.
  • a pipette as defined in claim 1 , a tip removing mechanism as defined in claim 9, and a tip removing method as defined in claim 10 have now been invented.
  • Other claims disclose some embodiments of the invention.
  • the tip removing mechanism comprises a rotatable ramp member, having a circle-forming ramp surface with one or more segments, each of said segments having a top position and a bottom position on the ramp surface.
  • the remover element In a basic condition, the remover element is in the top position.
  • the ramp member In re- sponse to its rotation, the ramp member forces the remover element towards the tip. A segment is followed by stopping the ramp member at the commencement of a next segment and a new tip can be attached to the pipette.
  • the mechanism can be provided with a spring for returning the remover element.
  • the ramp member can be rotated by means of a motor, such as an electric motor. Stopping of the motor after a segment is most preferably performed automatically.
  • a removal function of the tip can be effected by means of a one-way rotating action. This enables a simpler control. Neither does the return require motorized power. The function will also be more reliable in operation, since the mechanism does not become jammed as easily as in the case that the mechanism is driven by a motor in two directions.
  • the ramp member can be located particularly above the top end of a remover element.
  • the ramp surface can be against a similar surface in contact with the remover element.
  • the ramp member can be rotated especially about an axis parallel to the moving direction of the remover element.
  • the axis can be for example perpendicular or inclined relative to the moving direction.
  • the ramp surface may have for example one segment per circle. Between the bottom and top positions can be provided a substantially vertical section.
  • the segment profile between the top position and the bottom position can be for example flat or wave shaped.
  • the segment may also have a length en excess of a circle.
  • the removing mechanism control includes preferably a feature to turn off the motor automatically once the remover has returned to its top position. This can be implemented for example by means of an angular sensor capable of identifying a rotational position of the ramp member. It is optional to use a linear sensor capable of identifying a position of the plunger. Drawings
  • Fig. 1 shows a pipette, wherein a plunger is operated manually
  • Fig. 1a shows in an exploded axonometric view a portion of the tip removing mechanism for the pipette of fig. 1
  • FIG. 2 shows another pipette, wherein a plunger is operated manually
  • FIG. 3 shows portions of a pipette, wherein a plunger is operated by a motor.
  • a pipette 1.1 comprises a housing 2.1 and a tip element 3.1 at its bottom end, a tip container or a tip being attached to said bottom end for a liquid.
  • the housing has its top end provided with an actuating button 4 for operating the pipette's plunger.
  • the design can be, for example, similar to what is disclosed in publication FI 64752 (corresponds to publication EP 112887).
  • the pipette 1.1 is provided with a tip removing mechanism 5.1. It comprises a tip removing collar 6.1 slidable along the tip element 3.1. Secured to its top end is an operating rod 7.1 slidable alongside the housing 2.1. Near the operating rod's top end is an inward extension 8 and the housing has therebelow an outward support 9. Interposed between the extension and the support is a return spring 10, pressing the operating rod to its top position.
  • the operating rod's top end is provided with a crosswise bracket 11.
  • the bracket is fitted with a ramp abutment 12.1. Its top surface comprises a response surface, extending spirally around the surface for a single circle and descending clockwise as viewed from above.
  • the housing has its upper section above the rod fitted with an electric motor 13 (e.g. a DC motor), its drive shaft extending downwards.
  • an electric motor 13 e.g. a DC motor
  • the drive shaft is provided with a ramp member 15.1 , which is rotatable on top of the ramp abutment and has its bottom surface comprising a ramp surface complementary to and fitting against the response surface of the ramp abutment.
  • the ramp surface forces the ramp abutment 12.1 , and therealong the operating rod 7.1 and the tip removing collar 6.1 , to move downwards.
  • the ramp member and the ramp abutment are dimensioned in such a way that the tip removing collar effects a movement sufficient to disengage a tip attached to the pipette's tip element.
  • the ramp surface and the response surface have their vertical points again in register with each other, whereby the ramp abutment, the operating rod, and the tip removing collar return to their top position in response to the return spring 10.
  • the tip removing operation only requires the motor 13 to be driven in one direction.
  • the pipette has the upper part of its hand-gripping portion designed to be wider, the pipette providing a good fit for the hand.
  • the motor 13 the gear system 14
  • the ramp member 15.1 the ramp abutment 12.1.
  • the axis for these is located further out relative to the operating rod and the bracket 11 is also wider outward than inward in lateral direction.
  • the cover 16 has its top surface provided with an operating switch 17 for the tip removing mechanism.
  • a pipette 1.2 is otherwise similar to the pipette 1.1 except that a tip removing mechanism 5.2, a ramp abutment 12.2, and a ramp member 15.2 are provided with a peripheral wave shaped surface. This includes four waves, whereby the removal of a tip only requires one quarter of a circle. In order to return the mechanism to a top position, the ramp member must be rotated further (or allowed to rotate) from its removing position.
  • a pipette 1.3 comprises a housing 2.3 with a tip element 3.3 at its bottom end.
  • the plunger is operated by means of an electric motor 18 and a lead screw.
  • the design can be similar to what is disclosed for example in publication EP 576967.
  • the pipette 1.3 is provided with a tip removing mechanism 5.3. It comprises a tip removing collar 6.3 slidable along a tip element 3.3. To its top end is mounted an operating rod 7.3 slidable alongside the housing 2.3. Above the rod there is mounted an electric motor 13 (e.g. a DC motor), having its shaft provided, by way of a gear system 14, with a ramp member 15.3 rotatable on top of the rod's upper end.
  • a tip removing mechanism 5.3 comprises a tip removing collar 6.3 slidable along a tip element 3.3.
  • an operating rod 7.3 slidable alongside the housing 2.3.
  • an electric motor 13 e.g. a DC motor
  • the ramp member 15.3 has its bottom end provided with an encircling ramp surface lying against a top end 12.3 of the operating rod 7.3.
  • the ramp surface lies at different levels in various parts of a circle.
  • the ramp surface has its highest point against the rod's top end.
  • the motor 13 is started to commence rotation of the ramp member and sliding of the ramp surface on the rod's top end surface with the result that the ramp surface will have its lowest point in alignment with the rod's top end. This results in the ramp surface forcing the operating rod, and hence also the tip removing collar, downwards.
  • the ramp surface consists of one segment, wherein the surface level descends from a high point to a low point and then returns as a return section up to the highest point.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention relates to a pipette, comprising a tip remover element (6.1) which, upon moving it against a tip, disengages the tip. The remover element is operated with a mechanism, comprising a rotatable ramp member (15.1) which is provided with a circle-forming ramp surface, including one or more segments within which the ramp surface has a high point and a low point, whereby the ramp surface, upon rotating through a single segment, forces the remover element (6.1) first to move against the tip and then allows it to return.

Description

PIPETTE WITH A TIP REMOVING MECHANISM
Description
Technical field
The invention relates to a plunger-operated pipette for use in dispensing liquids and provided with a tip remover. The invention relates explicitly to this tip remover.
Background art
In plunger-operated pipettes, the tip element is usually provided with a replaceable tip container or a tip used for drawing therein a liquid to be subsequently dispensed. Usually, pipettes also include a tip remover, comprising a collar slidable along the tip element, and a spring against whose force the collar is pressable downwards. Electrically operated pipettes have also been available, in which the plunger is operated by means of an electric motor. Even in such pipettes, the tip remover has usually been manually operated.
Publication US 4 399 712 discloses an electrically operated pipette, in which the tip remover is powered by the same motor as the plunger. In that configuration, the plunger is provided with two nuts, which are non-rotatable relative to the housing and fitted on motor-driven lead screws. When it is time to remove the tip, the plunger is driven to its bottom position, the nuts pressing a spring-loaded tip removing collar downwards. When the tip is removed, the motor is driven respectively in reverse.
Summary of the invention
A pipette as defined in claim 1 , a tip removing mechanism as defined in claim 9, and a tip removing method as defined in claim 10 have now been invented. Other claims disclose some embodiments of the invention.
According to the invention, the tip removing mechanism comprises a rotatable ramp member, having a circle-forming ramp surface with one or more segments, each of said segments having a top position and a bottom position on the ramp surface. In a basic condition, the remover element is in the top position. In re- sponse to its rotation, the ramp member forces the remover element towards the tip. A segment is followed by stopping the ramp member at the commencement of a next segment and a new tip can be attached to the pipette. The mechanism can be provided with a spring for returning the remover element. The ramp member can be rotated by means of a motor, such as an electric motor. Stopping of the motor after a segment is most preferably performed automatically.
According to the invention, a removal function of the tip can be effected by means of a one-way rotating action. This enables a simpler control. Neither does the return require motorized power. The function will also be more reliable in operation, since the mechanism does not become jammed as easily as in the case that the mechanism is driven by a motor in two directions.
The ramp member can be located particularly above the top end of a remover element. The ramp surface can be against a similar surface in contact with the remover element.
The ramp member can be rotated especially about an axis parallel to the moving direction of the remover element. However, the axis can be for example perpendicular or inclined relative to the moving direction.
The ramp surface may have for example one segment per circle. Between the bottom and top positions can be provided a substantially vertical section. The segment profile between the top position and the bottom position can be for example flat or wave shaped. There may also be several segments per circle, usually identical segments. The segment may also have a length en excess of a circle.
The removing mechanism control includes preferably a feature to turn off the motor automatically once the remover has returned to its top position. This can be implemented for example by means of an angular sensor capable of identifying a rotational position of the ramp member. It is optional to use a linear sensor capable of identifying a position of the plunger. Drawings
The attached drawings constitute a part of the written description of the invention and relate to the subsequent detailed specification dealing with a few embodiments of the invention. Therein
- Fig. 1 shows a pipette, wherein a plunger is operated manually
- Fig. 1a shows in an exploded axonometric view a portion of the tip removing mechanism for the pipette of fig. 1
- Fig. 2 shows another pipette, wherein a plunger is operated manually
- Fig. 3 shows portions of a pipette, wherein a plunger is operated by a motor.
Detailed description of some embodiments of the invention
Some pipettes of the invention will now be further described in more detail.
A pipette 1.1 comprises a housing 2.1 and a tip element 3.1 at its bottom end, a tip container or a tip being attached to said bottom end for a liquid. The housing has its top end provided with an actuating button 4 for operating the pipette's plunger. The design can be, for example, similar to what is disclosed in publication FI 64752 (corresponds to publication EP 112887).
The pipette 1.1 is provided with a tip removing mechanism 5.1. It comprises a tip removing collar 6.1 slidable along the tip element 3.1. Secured to its top end is an operating rod 7.1 slidable alongside the housing 2.1. Near the operating rod's top end is an inward extension 8 and the housing has therebelow an outward support 9. Interposed between the extension and the support is a return spring 10, pressing the operating rod to its top position. The operating rod's top end is provided with a crosswise bracket 11. The bracket is fitted with a ramp abutment 12.1. Its top surface comprises a response surface, extending spirally around the surface for a single circle and descending clockwise as viewed from above. At the commencement (and thus, likewise, at the completion) of a circle there is a vertical step. The housing has its upper section above the rod fitted with an electric motor 13 (e.g. a DC motor), its drive shaft extending downwards. By way of a gear system 14 the drive shaft is provided with a ramp member 15.1 , which is rotatable on top of the ramp abutment and has its bottom surface comprising a ramp surface complementary to and fitting against the response surface of the ramp abutment. In the process of rotating the ramp member 15.1 counter-clockwise as viewed from above, the ramp surface forces the ramp abutment 12.1 , and therealong the operating rod 7.1 and the tip removing collar 6.1 , to move downwards. The ramp member and the ramp abutment are dimensioned in such a way that the tip removing collar effects a movement sufficient to disengage a tip attached to the pipette's tip element. After one circle, the ramp surface and the response surface have their vertical points again in register with each other, whereby the ramp abutment, the operating rod, and the tip removing collar return to their top position in response to the return spring 10. Thus, the tip removing operation only requires the motor 13 to be driven in one direction.
Alongside the housing there is a cover 16 for concealing components of the tip removing mechanism present alongside the housing. By means of the cover, the pipette has the upper part of its hand-gripping portion designed to be wider, the pipette providing a good fit for the hand. Provided thereby is also space in lateral direction for the motor 13, the gear system 14, the ramp member 15.1 and the ramp abutment 12.1. The axis for these is located further out relative to the operating rod and the bracket 11 is also wider outward than inward in lateral direction.
The cover 16 has its top surface provided with an operating switch 17 for the tip removing mechanism.
A pipette 1.2 is otherwise similar to the pipette 1.1 except that a tip removing mechanism 5.2, a ramp abutment 12.2, and a ramp member 15.2 are provided with a peripheral wave shaped surface. This includes four waves, whereby the removal of a tip only requires one quarter of a circle. In order to return the mechanism to a top position, the ramp member must be rotated further (or allowed to rotate) from its removing position.
A pipette 1.3 comprises a housing 2.3 with a tip element 3.3 at its bottom end. The plunger is operated by means of an electric motor 18 and a lead screw. The design can be similar to what is disclosed for example in publication EP 576967.
The pipette 1.3 is provided with a tip removing mechanism 5.3. It comprises a tip removing collar 6.3 slidable along a tip element 3.3. To its top end is mounted an operating rod 7.3 slidable alongside the housing 2.3. Above the rod there is mounted an electric motor 13 (e.g. a DC motor), having its shaft provided, by way of a gear system 14, with a ramp member 15.3 rotatable on top of the rod's upper end.
The ramp member 15.3 has its bottom end provided with an encircling ramp surface lying against a top end 12.3 of the operating rod 7.3. The ramp surface lies at different levels in various parts of a circle. When the operating rod, and hence also the tip removing collar 6.3, is in a top position, the ramp surface has its highest point against the rod's top end. When it is time to remove the tip, the motor 13 is started to commence rotation of the ramp member and sliding of the ramp surface on the rod's top end surface with the result that the ramp surface will have its lowest point in alignment with the rod's top end. This results in the ramp surface forcing the operating rod, and hence also the tip removing collar, downwards. The ramp surface consists of one segment, wherein the surface level descends from a high point to a low point and then returns as a return section up to the highest point.

Claims

Claims
1. A pipette, which is fitted with a tip for a liquid to be drawn therein by means of a plunger and which has a tip removing mechanism for disengaging the tip, said tip removing mechanism comprising a remover element (6.1 , 7.1 ; 6.3, 7.3) which, upon moving it against the tip, disengages the tip, characterized in that the tip removing mechanism further comprises a ramp member (15.1 ; 15.2; 15.3), which is rotatable and which has a circle-forming ramp surface, including one or more segments within which the ramp surface has a high point and a low point, whereby the ramp surface, upon rotating through a single segment, forces the remover element (6.1 , 7.1 ; 6.3, 7.3) first to move against the tip and then allows it to return.
2. A pipette as set forth in claim 1 , wherein the ramp member (15.1 ; 15.3) has a ramp surface with a single segment.
3. A pipette as set forth in claim 1 or 2, wherein the ramp member (15.1 ) has between its low point and high point a substantially vertical section.
4. A pipette as set forth in claim 3, wherein the ramp member (15.1) has its ramp surface responded by a complementary surface (12.1 ) integral with the remover element (7.1 ).
5. A pipette as set forth in any of the preceding claims, which has a motor (13) for rotating the ramp member.
6. A pipette as set forth in any of the preceding claims, wherein the ramp member (15.1 ; 15.2; 15.3) has its ramp surface above the top end of the remover element (7.1 ; 7.3).
7. A pipette as set forth in any of the preceding claims, wherein the ramp member is rotatable about an axis substantially parallel to the moving direction of the remover element (7.1 ; 7.2).
8. A pipette as set forth in any of the preceding claims, which is provided with a manually operated element (4) or a motor (18) for operating the plunger.
9. A pipette tip removing mechanism for disengaging a tip from a pipette, said tip removing mechanism comprising a remover element (6.1 , 7.1 ; 6.3, 7.3) which, upon moving it against the tip, disengages the tip, characterized in that the tip removing mechanism is provided with a ramp member (15.1 ; 15.2; 15.3), which is rotatable by a motor and which has a circle-forming ramp surface, including one or more segments within which the ramp surface has a high point and a low point, whereby the ramp surface, upon rotating through a single segment, forces the remover element (6.1 , 7.1 ; 6.3, 7.3) first to move against the tip and then allows it to return.
10. A method for removing a tip from a pipette, in which method the tip is pressed off by means of a remover element (6.1 , 7.1 ; 6.3, 7.3) included in a tip removing mechanism, characterized in that the tip removing mechanism is operated by using a ramp member (15.1 ; 15.2; 15.3), which is rotatable by a motor about an axis parallel to the moving direction of the remover element and which has a circle-forming ramp surface, including one or more segments within which the ramp surface has a high point and a low point, whereby the ramp surface, upon rotating through a single segment, forces the remover element (6.1 , 7.1 ; 6.3, 7.3) first to move against the tip and then allows it to return.
PCT/FI2004/000694 2003-11-19 2004-11-18 Pipette with a tip removing mechanism WO2005049209A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/579,875 US7690274B2 (en) 2003-11-19 2004-11-18 Pipette with a tip removing mechanism
DE602004011980T DE602004011980T2 (en) 2003-11-19 2004-11-18 PIPETTE WITH A TOP REMOVAL MECHANISM
EP04798303A EP1689528B1 (en) 2003-11-19 2004-11-18 Pipette with a tip removing mechanism
JP2006540484A JP4883298B2 (en) 2003-11-19 2004-11-18 Pipette with tip removal mechanism

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20031683A FI20031683A0 (en) 2003-11-19 2003-11-19 Pipette with tip removal mechanism
FI20031683 2003-11-19

Publications (1)

Publication Number Publication Date
WO2005049209A1 true WO2005049209A1 (en) 2005-06-02

Family

ID=29558652

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2004/000694 WO2005049209A1 (en) 2003-11-19 2004-11-18 Pipette with a tip removing mechanism

Country Status (9)

Country Link
US (1) US7690274B2 (en)
EP (1) EP1689528B1 (en)
JP (1) JP4883298B2 (en)
CN (1) CN100421801C (en)
AT (1) ATE386592T1 (en)
DE (1) DE602004011980T2 (en)
ES (1) ES2303112T3 (en)
FI (1) FI20031683A0 (en)
WO (1) WO2005049209A1 (en)

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USD805651S1 (en) 2013-12-12 2017-12-19 Eppendorf Ag Flange for a pipette adapter
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EP3112026B1 (en) * 2015-06-30 2018-03-14 Sartorius Biohit Liquid Handling Oy Pipette with a tip removal mechanism, a method for removing a tip, and a method for pipetting
CN110465342B (en) * 2016-06-15 2022-10-04 汉密尔顿公司 Pipetting device, pipette tip coupler and pipette tip: apparatus and method
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USD875964S1 (en) * 2018-04-26 2020-02-18 IKA—Werke Gmbh & Co. KG Pipette
EP3680017B1 (en) 2019-01-08 2021-07-21 Eppendorf AG Pipette for use with a pipette tip
EP3680016B1 (en) 2019-01-08 2021-08-11 Eppendorf AG Pipette for use with a pipette tip
EP3693745B1 (en) * 2019-02-07 2023-05-17 Sartorius Biohit Liquid Handling Oy Tip removal in automated pipette module
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Publication number Publication date
CN1905942A (en) 2007-01-31
CN100421801C (en) 2008-10-01
US7690274B2 (en) 2010-04-06
DE602004011980T2 (en) 2009-02-19
ATE386592T1 (en) 2008-03-15
JP2007512945A (en) 2007-05-24
DE602004011980D1 (en) 2008-04-03
ES2303112T3 (en) 2008-08-01
EP1689528B1 (en) 2008-02-20
EP1689528A1 (en) 2006-08-16
JP4883298B2 (en) 2012-02-22
US20070272037A1 (en) 2007-11-29
FI20031683A0 (en) 2003-11-19

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