WO2005048973A1 - Oral application of extract of stevia rebaudiana or its active substances for the elimination of cellulite - Google Patents
Oral application of extract of stevia rebaudiana or its active substances for the elimination of cellulite Download PDFInfo
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- WO2005048973A1 WO2005048973A1 PCT/YU2003/000033 YU0300033W WO2005048973A1 WO 2005048973 A1 WO2005048973 A1 WO 2005048973A1 YU 0300033 W YU0300033 W YU 0300033W WO 2005048973 A1 WO2005048973 A1 WO 2005048973A1
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- cellulite
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- active substances
- stevia rebaudiana
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- Stevia rebaudiana is perennial shrub plant, growing wild at highlands of Paraguay, Brasill and Argentina.
- Stevia is a member of Compositacae family. It is also called «honney leaf» or «sweet herb».
- the herb has a lot of branches that rises above the ground with pairs of meaty leaves (one herb can give 500g of fresh leaf).
- the root system consists of thin little roots, which are spreading right below ground surface, while just a few thicker roots reaches deeper in the ground. Leaf is collected by the begining of flowering when the leaf mass is the biggest and the sweetest.
- the most suitable temperature for stevia before harvesting is 15-38°C (night-day). Also, longer sunny days are suitable for accumulation of sweet substances in leaf. Under cultivation, the stevioside content in dry leaf is in range 6-12%.
- This herb contain over a hundred different natural substances of which the most significant are glycosides from which the highest sweetenes of leaf comes.
- the leaf of this herb is used for production of extract. Extraction of stevia leaf is performed by water.
- Quality and quantity determination of stevioside and rebaudioside A is performed by highpressure liquid chromatography (HPLC) at 210 nm. Chromatograpy is obtained at ambiental temperature so before each determination of sample it is necessary to make chromatographising some of standard samples at least three times to make correction of retention time. The sample is prepared for chromatography without pre conditioning. Stevioside is characterised with retention time of 9,5 min., and rebaudioside A of 12,9 min. Wavelenght at which the recording is performed is 210 nm.
- Stevia is mainly used as a sweetener. There is very wide application of stevia in food industry of Japan. The most commonly in products marked as a healthy food such as: fruit and vegetable products, sauces, sea fruit, soft drinks, lowenergy drinks and products of dairy industry (cream, yogurt, fruit yogurt).
- Dosed quantities of stevia extract and steviosides lowers blood pressure, reduces the number of hearth beets and acts as a diuretic. It is also used as supplement to the mixtures for loosing body weight for its lowcallory values.
- Cellulite appearance is usually localized at upper and back parts of thighs, but it can also appear on the other parts of body such as: knees, stomach, behind, lower part of back, inner and back part of brachium, anklebone, upper part of back below shoulder blade. It can appear in any life age, independently of body weight, even at very skinny people.
- Procedure according to invention enables partial or total (depending on type) cellulite elimination, by using dosed quantity of stevia extract in form of capsule in 30 days period, for the first time till now, without physical acitivity . During terapy it must be taken 1500ml to 2000ml of water.
- cellulite type 3 and type 2 is totaly eliminated, and with cellulite type 1 and type 0 stevia extract returnes lost tonicity and livelines of the skin.
- stevia extract can be used in form of pills in appropriate dose in period of 30 days to acheive the same effect in cellulite elimination as in usage in form of capsules. Pills are suitable pharmaceutical form of product for persons with problems when taking capsules.
- stevia extract when applied in form of undivided powder, more times during day, and in period of 30 days, dissolved in water immediately before usage, accheives the same effect as applied in form of two above mentioned pharmaceutical forms.
- Stevia extract can be used in form of capsule and/or pill two times during day with necessary consumption of mineral still water and lower consumption of kitchen salt. Mineral water rich with iodium is recomended as it effects at total combustion of food carried in organism.
- Preparation is applied everyday, without break in period of 30 days.
- stevia extract can also be used in form of undivided powder and the effect of it's influence on cellulite is completely the same as with earlier mentioned forms (capsules and pills).
- Preparing stevia extract in this way enables individuals to, ritually preparing beverages with stevia develop feeling of contribution in eliminating cellulite. In that way, their satisfaction with achieved results, which are evident within this experiment, is complete.
- stevia can be used as a supplement to tea, juices, water with slice of lemon, but to avoid consuming coffee, alcohol and refreshing beverages with artificial flavor, which contributes in making cellulite.
- Stevia extract in form of powder ought to be taken 6 to 8 times during the day, everyday, without break, during one month period.
- Stevia extract can be used in form of liquid (concentrated solution), in that form it is added to beverages or groceries. Consumption in this form do not influence the efficiency of stevia in eliminating cellulite, id est. gained results mach the effects made by consuming capsules, pills or powder.
- Stevia can be used in combination with other extracts, but it's efficiency remains the same.
- Stevia extract gives the possibility of combining with vitamins which make whole state of the organism better, rising of immunity and resistance to stress which often contributes to gaining cellulite.
- Stevia extract is dosed in hard galatinous white capsules.
- the quantity of capsules included in testing is 60 pieces.
- capsules are to be taken two times during the day. First capsule is to be taken half an hour before breakfast with 250 ml of still mineral water. Second capsule is to be taken half an hour before lunch with 250 ml of water. Left over quantity of water to 1500 ml or
- Paramethers that are monitored during the testing are: volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 30 years ⁇ Height: 160 cm ⁇ Body weight: 51,30 kg ⁇ Volume of thighs: 54,00cm ⁇ Volume of hips: 94,00cm ⁇ Volume of waist: 69,00cm ⁇ Test by squeezing: type 3
- Placebo is an inert substance which is dosed in hard gelatinous white capsules.
- the quantity of capsules included in testing is 60 pieces.
- Method of consumption capsules are to be taken two times during the day. First capsule is to be taken half an hour before breakfast with 250 ml of still mineral water. Second capsule is to be taken half an hour before lunch with 250 ml of water. Left over quantity of water to 1500 ml or 2000 ml is to be taken into the organism according to own needs. Eating habbits and other usual activities are not to be changed.
- Paramethers that are monitored during the testing are: A ' volume of thighs, volume of hips, volume of waist( cm) A ⁇ body weight (kg) and A test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 29 years ⁇ Height: 161 cm ⁇ Body weight: 50,50 kg ⁇ Volume of thighs: 53,50cm ⁇ Volume of hips: 95,00cm ⁇ Volume of waist: 69,00cm ⁇ Test by squeezing: type 3
- the quantity of pills included in testing is 60 pieces.
- Pills are to be taken two times during the day. First pill is to be taken half an hour before breakfast with 250 ml of still mineral water. Second pill is to be taken half an hour before lunch with 250 ml of water.Left over quantity of water to 1500 ml or 2000 ml is to be taken into the organism according to own needs. Eating habbits and other usual activities are not to be changed.
- Paramethers that are monitored during the testing are: A volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and A test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 33 years ⁇ Height: 165 cm ⁇ Body weight: 53,00 kg ⁇ Volume of thighs: 57,00cm ⁇ Volume of hips: 96,00cm ⁇ Volume of waist: 71 ,00cm ⁇ Test by squeezing: type 3
- Placebo is pill formulated without stevia extract.
- the quantity of pills included in testing is 60 pieces.
- Method of consumption pills are to be taken two times during the day. First pill is to be taken half an hour before breakfast with 250 ml of still mineral water. Second pill is to be taken half an hour before lunch with 250 ml of water. Left over quantity of water to 1500 ml or 2000 ml is to be taken into the organism according to own needs. Eating habbits and other usual activities are not to be changed.
- Paramethers that are monitored during the testing are: A volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and A test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 31 godina ⁇ Height: 161,0 cm ⁇ Body weight: 52,00 kg ⁇ Volume of thighs: 54,00cm ⁇ Volume of hips: 93,00cm ⁇ Volume of waist: 69,00cm ⁇ Test by sqeezing: type 3
- Example 3 Application of stevia extract in form of undevided powder. Stevia extract is packed in 100 gram jars with little spoon which enables control of taken quantities of stevia (individual and overall dosage). Methods of consumtion: Stevia extract is taken 6 times during the day (at every two hours) by soluting the content of little spoon in 250 ml to 300 ml of any kind of beverage. Eating habbits and other usual activities are not to be changed.
- Paramethers that are monitored during the testing are: A volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 37 godina ⁇ Height: 160 cm ⁇ Body weight: 50,50 kg ⁇ Volume of thighs: 53,00cm ⁇ Volume of hips: 91,00cm ⁇ Volume of waist: 67,00cm ⁇ Test by sqeezing: type 3
- Paramethers that are monitored during the testing are: A ' volume of thighs, volume of hips, volume of waist( cm) " body weight (kg) and " test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 29 years ⁇ Height: 161 cm ⁇ Body weight: 50,50 kg ⁇ Volume of thighs: 53,50cm ⁇ Volume of hips: 95,00cm ⁇ Volume of waist: 69,00cm ⁇ Test by sqeezing: type 3
- Example 4 Application of stevia extract in form of solutio.
- Stevia extract is packed in 100 ml small botle with droper which enables control of taken quantities of stevia (individual and overall dosage).
- Paramethers that are monitored during the testing are: A volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and A test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 33 godina ⁇ Height: 172,00 cm ⁇ Body weight: 55,60 kg ⁇ Volume of thighs: 51,00cm ⁇ Volume of hips: 92,00cm ⁇ Volume of waist: 69,00cm ⁇ Test by sqeezing: type 3
- Comparative example - monitoring changes with person who uses placebo Placebo is transparent, uncolored solution (solution of sorbitol). Placebo is packed in 100 ml smoll botle with droper which enables control of taken quantity of powder (individual or overall dosage)
- Method of consumption Placebo is taken 6 times during the day (at every two hour) by soluting the 6-8 drops in 250 ml to 300 ml of any kind of beverage. Eating habbits and other usual activities are not to be changed.
- Paramethers that are monitored during the testing are: ⁇ A " volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and ⁇ test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ⁇ Age: 31 years ⁇ Height: 167,00 cm ⁇ Body weight: 54,30 kg ⁇ Volume of thighs: 55,50cm ⁇ Volume of hips: 97,00cm ⁇ Volume of waist: 74,00cm ⁇ Test by sqeezing: type 3
Abstract
Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, in form that is suitable for oral usage leads to eliminating or reducing cellulite.
Description
ORAL APPLICATION OF EXTRACT OF STEVIA REBAUDIANA OR ITS ACTIVE SUBSTANCES FOR THE ELIMINATION OF CELLULITE
Field of technique to which the invention is refered to : cosmetics
Specific problem for which solution protection is required: Cellulite elimination The state of technique: Stevia rebaudiana is perennial shrub plant, growing wild at highlands of Paraguay, Brasill and Argentina. Stevia is a member of Compositacae family. It is also called «honney leaf» or «sweet herb». Growing wild, it grows to 60 cm height, while under cultivation it achives 90 cm. The herb has a lot of branches that rises above the ground with pairs of meaty leaves (one herb can give 500g of fresh leaf). The root system consists of thin little roots, which are spreading right below ground surface, while just a few thicker roots reaches deeper in the ground. Leaf is collected by the begining of flowering when the leaf mass is the biggest and the sweetest. The most suitable temperature for stevia before harvesting is 15-38°C (night-day). Also, longer sunny days are suitable for accumulation of sweet substances in leaf. Under cultivation, the stevioside content in dry leaf is in range 6-12%. This herb contain over a hundred different natural substances of which the most significant are glycosides from which the highest sweetenes of leaf comes. There are eight sweet glycosides of stevia known: stevioside, rebaudioside A, rebaudioside B, rebaudioside C (dulcoside B), rebaudioside D, rebaudioside E, dulcoside A and steviolbioside. The leaf of this herb is used for production of extract. Extraction of stevia leaf is performed by water. From the obtained extract, the color and bitter substance are removed in the refining proces. Refined extract is steamed to dry and white cristall mass, 300 times sweeter then sugar is obtained. The obtained Stevia rebaudiana folii extractum siccum standardisatum extract is standardized to the stevioside content with following structure:
and rebaudioside A with following structure:
Quality and quantity determination of stevioside and rebaudioside A is performed by highpressure liquid chromatography (HPLC) at 210 nm. Chromatograpy is obtained at ambiental temperature so before each determination of sample it is necessary to make chromatographising some of standard samples at least three times to make correction of retention time. The sample is prepared for chromatography without pre conditioning. Stevioside is caracterised with retention time of 9,5 min., and rebaudioside A of 12,9 min. Wavelenght at which the recording is performed is 210 nm.
Stevia is mainly used as a sweetener. There is very wide application of stevia in food industry of Japan. The most commonly in products marked as a healthy food such as: fruit and vegetable products, sauces, sea fruit, soft drinks, lowenergy drinks and products of dairy industry (cream, yogurt, fruit yogurt).
Research of group of scientists in Copenhageen at the endocrinology department, on the hypoglicemichal effect of stevia extract, shows that it directly affects to betta cells of pancreas which causes insulin press out. These results justifies application of this herb for centuries in
treatment of diabetes mellitus-a type2. It is confirmed that water extract of stevia leaf lowers the level of glucose in blood for 35%. Stevia rebaudiana folii extractum siccum standardisatum prevents growth of bacteria Streptococcus mutans and Lactobacillus plantarum, and it totally stops growth of Lactobacillus Casei and prevents formation of cavity which enables its application in products for mouth cavity care. Dosed quantities of stevia extract and steviosides lowers blood pressure, reduces the number of hearth beets and acts as a diuretic. It is also used as supplement to the mixtures for loosing body weight for its lowcallory values.
During research of stevia extract (Stevia rebaudiana folii extractum siccum standardisatum), it is concluded that if it is consumed oraly, in form of pills or capsules or solution or powder; alone or in combination with extracts of other herbal species and vitamins, eliminates cellulite equaly at all points of its localisation.
Cellulite appearance is usually localized at upper and back parts of thighs, but it can also appear on the other parts of body such as: knees, stomach, behind, lower part of back, inner and back part of brachium, anklebone, upper part of back below shoulder blade. It can appear in any life age, independently of body weight, even at very skinny people. It comese in four types classified by Nurnberger-Muller scalle: > type 3 - Wrinkled skin (»orange peek) and swellings appears when person lies or sits type 2 - Wrinkled skin (»orange peel«) appears spontaneously when person stands, but not in laying position type 1 - No wrinkled skin (»orange peel«) when person stands or lies, but test by squeezing with thumb and index finger shows loose skin type 0 - No wrinkled skin (»orange peek) when person stands or lies, test by squeezing with thumb and index finger shows wrinkles or creases.
Procedure according to invention enables partial or total (depending on type) cellulite elimination, by using dosed quantity of stevia extract in form of capsule in 30 days period, for the first time till now, without physical acitivity .
During terapy it must be taken 1500ml to 2000ml of water. Using this invention, in relatively short time, in very elegant and simple way, cellulite type 3 and type 2 is totaly eliminated, and with cellulite type 1 and type 0 stevia extract returnes lost tonicity and livelines of the skin. Besides, by this invention, stevia extract can be used in form of pills in appropriate dose in period of 30 days to acheive the same effect in cellulite elimination as in usage in form of capsules. Pills are suitable pharmaceutical form of product for persons with problems when taking capsules.
According to this invention, stevia extract when applied in form of undivided powder, more times during day, and in period of 30 days, dissolved in water immediately before usage, accheives the same effect as applied in form of two above mentioned pharmaceutical forms.
Application of stevia extract in form of solution, more times during day, with or without vitamin and aromatic supplement, according to this invention, achieves the same result in cellulite elimination as solid forms of application of this extract.
Cellulite is subcutaneous change that appears mostly at woman. Due to fast life tempo and serious obligations which modern woman carries everyday in familly and society, time left for her to keep in shape and good looking is mainly not enough. By using this invention, modern woman is enabled to wipe out cellulite on a very simple way, to restore and to keep tonicity and fresheness of the skin of the whole body which contributes her confidence and serenity, saves her time and familly budget.
Detailed description of invention
Stevia extract can be used in form of capsule and/or pill two times during day with necessary consumption of mineral still water and lower consumption of kitchen salt. Mineral water rich with iodium is recomended as it effects at total combustion of food carried in organism.
Preparation is applied everyday, without break in period of 30 days.
Efficiency of stevia extract to cellulite elimination is controlled on following prameters basis:
•A thighs volume, hips volume, waist volume, volume of brachium (cm) A body weight (kg) and A test by squeezing with thumg and index finger (descriptive and classification by type of cellulite according to Nurnberger-Muller scale) Control of efficiency of stevia extract to the reduction of cellulite is performed every seven days.
Beverages could be made just before consumption or by making solution which will be consumed during longer time period. Stevia extract in form of powder ought to be taken 6 to 8 times during the day, everyday, without break, during one month period.
Stevia extract can be used in form of liquid (concentrated solution), in that form it is added to beverages or groceries. Consumption in this form do not influence the efficiency of stevia in eliminating cellulite, id est. gained results mach the effects made by consuming capsules, pills or powder.
Considering that cellulite is one of the most frequent esthetic problems that women have, use of some herbal species for this problem is known. According to this invention, stevia can be used in combination with other extracts, but it's efficiency remains the same. Stevia extract gives the possibility of combining with vitamins which make whole state of the organism better, rising of immunity and resistance to stress which often contributes to gaining cellulite.
Mode of realization invention
Example 1.
Stevia extract is dosed in hard galatinous white capsules.
The quantity of capsules included in testing is 60 pieces.
Method of consumption: capsules are to be taken two times during the day. First capsule is to be taken half an hour before breakfast with 250 ml of still mineral water. Second capsule is to be taken half an hour before lunch with 250 ml of water. Left over quantity of water to 1500 ml or
2000 ml is to be taken into the organism according to own needs. Eating habbits and other usual activities are not to be changed.
Paramethers that are monitored during the testing are: volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ❖ Age: 30 years ❖ Height: 160 cm ❖ Body weight: 51,30 kg ❖ Volume of thighs: 54,00cm ❖ Volume of hips: 94,00cm ❖ Volume of waist: 69,00cm ❖ Test by squeezing: type 3
Results of testing:
Comparative example - monitoring changes with person who uses placebo
Placebo is an inert substance which is dosed in hard gelatinous white capsules. The quantity of capsules included in testing is 60 pieces. Method of consumption: capsules are to be taken two times during the day. First capsule is to be taken half an hour before breakfast with 250 ml of still mineral water. Second capsule is to be taken half an hour before lunch with 250 ml of water. Left over quantity of water to 1500 ml or 2000 ml is to be taken into the organism according to own needs. Eating habbits and other usual activities are not to be changed. Paramethers that are monitored during the testing are: A' volume of thighs, volume of hips, volume of waist( cm) A~ body weight (kg) and
A test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ❖ Age: 29 years ❖ Height: 161 cm ❖ Body weight: 50,50 kg ❖ Volume of thighs: 53,50cm ❖ Volume of hips: 95,00cm ❖ Volume of waist: 69,00cm ❖ Test by squeezing: type 3
Results of testing:
Application of stevia extract in form of white, round shaped pills of 500 mg.
The quantity of pills included in testing is 60 pieces.
Method of consumption: pills are to be taken two times during the day. First pill is to be taken half an hour before breakfast with 250 ml of still mineral water. Second pill is to be taken half an hour before lunch with 250 ml of water.Left over quantity of water to 1500 ml or 2000 ml is to be taken into the organism according to own needs. Eating habbits and other usual activities are not to be changed.
Paramethers that are monitored during the testing are: A volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and A test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ❖ Age: 33 years ❖ Height: 165 cm ❖ Body weight: 53,00 kg ❖ Volume of thighs: 57,00cm ❖ Volume of hips: 96,00cm ❖ Volume of waist: 71 ,00cm ❖ Test by squeezing: type 3
Results of testing:
Comparative example - monitoring changes with persone who uses placebo
Placebo is pill formulated without stevia extract. The quantity of pills included in testing is 60 pieces. Method of consumption: pills are to be taken two times during the day. First pill is to be taken half an hour before breakfast with 250 ml of still mineral water. Second pill is to be taken half an hour before lunch with 250 ml of water. Left over quantity of water to 1500 ml or 2000 ml is to be taken into the organism according to own needs. Eating habbits and other usual activities are not to be changed. Paramethers that are monitored during the testing are: A volume of thighs, volume of hips, volume of waist( cm)
A body weight (kg) and A test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ❖ Age: 31 godina ❖ Height: 161,0 cm ❖ Body weight: 52,00 kg ❖ Volume of thighs: 54,00cm ❖ Volume of hips: 93,00cm ❖ Volume of waist: 69,00cm ❖ Test by sqeezing: type 3
Results of testing:
Results of testing:
Comparative example - monitoring changes with person who uses placebo Placebo is white inert powder (sorbitol). Placebo is packed in 100 gram jars with little spoon which enables control of taken quantity of powder (individual or overall dosage) Method of consumption: Placebo is taken 6 times during the day (at every two hour) by soluting the content of a little spoon in 250 ml to 300 ml of any kind of beverage. Eating habbits and other usual activities are not to be changed. Paramethers that are monitored during the testing are: A' volume of thighs, volume of hips, volume of waist( cm) " body weight (kg) and " test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale)
Data about tested individual: ❖ Age: 29 years ❖ Height: 161 cm ❖ Body weight: 50,50 kg ❖ Volume of thighs: 53,50cm ❖ Volume of hips: 95,00cm ❖ Volume of waist: 69,00cm ❖ Test by sqeezing: type 3
Results of testing:
Results of testing:
Comparative example - monitoring changes with person who uses placebo Placebo is transparent, uncolored solution (solution of sorbitol). Placebo is packed in 100 ml smoll botle with droper which enables control of taken quantity of powder (individual or overall dosage) Method of consumption: Placebo is taken 6 times during the day (at every two hour) by soluting the 6-8 drops in 250 ml to 300 ml of any kind of beverage. Eating habbits and other usual activities are not to be changed. Paramethers that are monitored during the testing are: ■A" volume of thighs, volume of hips, volume of waist( cm) A body weight (kg) and
^ test by sqeezing with thumb and index finger (descriptive and classification according to cellulite type by Nurnberger-Muller scale) Data about tested individual: ❖ Age: 31 years ❖ Height: 167,00 cm ❖ Body weight: 54,30 kg ❖ Volume of thighs: 55,50cm ❖ Volume of hips: 97,00cm ❖ Volume of waist: 74,00cm ❖ Test by sqeezing: type 3
Results of testing:
Claims
1. Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, for cellulite eliminaion is characterized by taking oraly
2. Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, for cellulite eliminaion is characterized by taking in pharmaceutical form of capsules
3. Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, for cellulite eliminaion is characterized by taking in pharmaceutical form of pills
4. Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, for cellulite eliminaion is characterized by taking in pharmaceutical form of solution
5. Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, for cellulite eliminaion is characterized by taking in pharmaceutical form of powder
6. Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, for cellulite eliminaion is characterized by taking in combination with herb extracts
7. Application of extract alone, and all it's active substances (individualy), their microbiological and chemical modifiers and derivates, obtained from all varieties of Stevia Rebaudiana cultivated from seed and nursery, for cellulite eliminaion is characterized by taking in combination with vitamins.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003300482A AU2003300482A1 (en) | 2003-11-20 | 2003-11-21 | Oral application of extract of stevia rebaudiana or its active substances for the elimination of cellulite |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YUP092203 | 2003-11-20 | ||
| YUP-922/03 | 2003-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2005048973A1 true WO2005048973A1 (en) | 2005-06-02 |
Family
ID=34620868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/YU2003/000033 WO2005048973A1 (en) | 2003-11-20 | 2003-11-21 | Oral application of extract of stevia rebaudiana or its active substances for the elimination of cellulite |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003300482A1 (en) |
| WO (1) | WO2005048973A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006116814A1 (en) * | 2005-05-02 | 2006-11-09 | Vanadis Bioscience Ltd | Composition and uses thereof |
| WO2006116815A1 (en) * | 2005-05-02 | 2006-11-09 | Vanadis Bioscience Ltd | Composition for the control of cholesterol levels |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0525740A1 (en) * | 1991-08-01 | 1993-02-03 | Dozono, Fumio | Stevia extract-containing liquid internal medicine and method of preparing the same |
| US5262161A (en) * | 1991-09-30 | 1993-11-16 | Fumio Dozono | Stevia extract-containing medicine |
| CN1105557A (en) * | 1994-10-11 | 1995-07-26 | 吴宏伟 | Method for preparation of weight-loosing medicine and its products |
| CN1347668A (en) * | 2001-10-22 | 2002-05-08 | 黄宝生 | Slimming health product producing process |
| US20020054857A1 (en) * | 1997-06-12 | 2002-05-09 | C. S. Bioscience, Inc. | Dental formulation |
| JP2003304846A (en) * | 2002-04-11 | 2003-10-28 | Ts Aasu:Kk | Drink or food |
-
2003
- 2003-11-21 AU AU2003300482A patent/AU2003300482A1/en not_active Abandoned
- 2003-11-21 WO PCT/YU2003/000033 patent/WO2005048973A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0525740A1 (en) * | 1991-08-01 | 1993-02-03 | Dozono, Fumio | Stevia extract-containing liquid internal medicine and method of preparing the same |
| US5262161A (en) * | 1991-09-30 | 1993-11-16 | Fumio Dozono | Stevia extract-containing medicine |
| CN1105557A (en) * | 1994-10-11 | 1995-07-26 | 吴宏伟 | Method for preparation of weight-loosing medicine and its products |
| US20020054857A1 (en) * | 1997-06-12 | 2002-05-09 | C. S. Bioscience, Inc. | Dental formulation |
| CN1347668A (en) * | 2001-10-22 | 2002-05-08 | 黄宝生 | Slimming health product producing process |
| JP2003304846A (en) * | 2002-04-11 | 2003-10-28 | Ts Aasu:Kk | Drink or food |
Non-Patent Citations (4)
| Title |
|---|
| DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HIRANO, ATSUSHI: "Skin-lightening, -conditioning, and -antiaging beverage or foods containing pearl", XP002288259, retrieved from STN Database accession no. 2003:840787 * |
| DATABASE WPI Section Ch Week 199730, Derwent World Patents Index; Class B04, AN 1997-320443, XP002288260 * |
| DATABASE WPI Section Ch Week 200258, Derwent World Patents Index; Class B04, AN 2002-539400, XP002288296 * |
| REILLY W ET AL: "BODY CONTOURING USING AN ORAL HERBAL ANTIOXIDANT FORMULATION - CENTELAPLUS: A DOSE CONTROLLED OBSERVATIONAL STUDY", REDOX REPORT, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 5, no. 2/3, 2000, pages 144 - 145, XP000990069, ISSN: 1351-0002 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006116814A1 (en) * | 2005-05-02 | 2006-11-09 | Vanadis Bioscience Ltd | Composition and uses thereof |
| WO2006116815A1 (en) * | 2005-05-02 | 2006-11-09 | Vanadis Bioscience Ltd | Composition for the control of cholesterol levels |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003300482A1 (en) | 2005-06-08 |
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