WO2005048923A3 - Extended release venlafaxine formulation - Google Patents

Extended release venlafaxine formulation Download PDF

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Publication number
WO2005048923A3
WO2005048923A3 PCT/US2004/036083 US2004036083W WO2005048923A3 WO 2005048923 A3 WO2005048923 A3 WO 2005048923A3 US 2004036083 W US2004036083 W US 2004036083W WO 2005048923 A3 WO2005048923 A3 WO 2005048923A3
Authority
WO
WIPO (PCT)
Prior art keywords
extended release
release venlafaxine
venlafaxine formulation
formulation
extended
Prior art date
Application number
PCT/US2004/036083
Other languages
French (fr)
Other versions
WO2005048923A2 (en
Inventor
Manesh Dixit
Xiu Xiu Cheng
Avinash Nangia
Chih-Ming Chen
Original Assignee
Andrx Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andrx Pharmaceuticals Llc filed Critical Andrx Pharmaceuticals Llc
Priority to JP2006539571A priority Critical patent/JP2007511510A/en
Priority to EP04796796A priority patent/EP1684689A4/en
Priority to CA2540159A priority patent/CA2540159C/en
Publication of WO2005048923A2 publication Critical patent/WO2005048923A2/en
Publication of WO2005048923A3 publication Critical patent/WO2005048923A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Abstract

A controlled release dosage form of venlafaxine that comprises an immediate release pellet and an extended release pellet.
PCT/US2004/036083 2003-11-17 2004-10-29 Extended release venlafaxine formulation WO2005048923A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006539571A JP2007511510A (en) 2003-11-17 2004-10-29 Sustained release venlafaxine formulation
EP04796796A EP1684689A4 (en) 2003-11-17 2004-10-29 Extended release venlafaxine formulation
CA2540159A CA2540159C (en) 2003-11-17 2004-10-29 Extended release venlafaxine formulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/715,219 US7470435B2 (en) 2003-11-17 2003-11-17 Extended release venlafaxine formulation
US10/715,219 2003-11-17

Publications (2)

Publication Number Publication Date
WO2005048923A2 WO2005048923A2 (en) 2005-06-02
WO2005048923A3 true WO2005048923A3 (en) 2006-08-17

Family

ID=34574166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/036083 WO2005048923A2 (en) 2003-11-17 2004-10-29 Extended release venlafaxine formulation

Country Status (6)

Country Link
US (3) US7470435B2 (en)
EP (1) EP1684689A4 (en)
JP (1) JP2007511510A (en)
CN (2) CN101843590A (en)
CA (1) CA2540159C (en)
WO (1) WO2005048923A2 (en)

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CN103181916A (en) * 2011-12-30 2013-07-03 昆明积大制药股份有限公司 Venlafaxine hydrochloride slow-release capsule and preparation method thereof
US10561618B2 (en) * 2012-04-18 2020-02-18 Contera Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders
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Also Published As

Publication number Publication date
US7470435B2 (en) 2008-12-30
US20050106248A1 (en) 2005-05-19
US8668932B2 (en) 2014-03-11
CA2540159C (en) 2013-07-16
CN100589797C (en) 2010-02-17
JP2007511510A (en) 2007-05-10
CA2540159A1 (en) 2005-06-02
US20090081286A1 (en) 2009-03-26
CN101843590A (en) 2010-09-29
US20110165234A1 (en) 2011-07-07
WO2005048923A2 (en) 2005-06-02
EP1684689A4 (en) 2007-11-28
EP1684689A2 (en) 2006-08-02
CN1893929A (en) 2007-01-10
US7931915B2 (en) 2011-04-26

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